UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 14A

Proxy Statement Pursuant to Section 14(a) of the

Securities Exchange Act of 1934

Filed by the Registrant  x                             Filed by a Party other than the Registrant  ¨

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¨ Preliminary Proxy Statement

¨ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))

¨ Definitive Proxy Statement

x Definitive Additional Materials

¨ Soliciting Material Under Rule 14a-12

Illumina, Inc.

(Name of Registrant as Specified In Its Charter)

(Name of Person(s) Filing Proxy Statement, if other than the Registrant)

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*** Exercise Your Right to Vote ***

Important Notice Regarding the Availability of Proxy Materials for the

Stockholder Meeting to Be Held on May 18, 2016.

	ILLUMINA, INC.	Meeting Information
		Meeting Type:            Annual Meeting
		For holders as of:      March 21, 2016
		Date:   May 18, 2016       Time:   10:00 AM Pacific Time
		Location:    Meeting live via the Internet-please  visit
		www.virtualshareholdermeeting.com/ILMN2016.
		The company will be hosting the meeting live via the Internet this year. To attend the meeting via the Internet please visit www.virtualshareholdermeeting.com/ILMN2016 and be sure to have the information that is printed in the box marked by the arrow (located on the following page).
	ILLUMINA, INC. 5200 ILLUMINA WAY SAN DIEGO, CA 92122 ATTN: REBECCA CHAMBERS	You are receiving this communication because you hold shares in the company named above.
		This is not a ballot. You cannot use this notice to vote these shares. This communication presents only an overview of the more complete proxy materials that are available to you on the Internet. You may view the proxy materials online at www.proxyvote.com or easily request a paper copy (see reverse side).
		We encourage you to access and review all of the important information contained in the proxy materials before voting.
		See the reverse side of this notice to obtain  proxy materials and voting instructions.

—  Before You Vote   — How to Access the Proxy Materials
Proxy Materials Available to VIEW or RECEIVE:
NOTICE AND PROXY STATEMENT            FORM 10-K
How to View Online:
Have the information that is printed in the box marked by the arrow     (located on the following page) and visit: www.proxyvote.com.
How to Request and Receive a PAPER or E-MAIL Copy:
If you want to receive a paper or e-mail copy of these documents, you must request one. There is NO charge for requesting a copy. Please choose one of the following methods to make your request:
1) BY INTERNET:	www.proxyvote.com
2) BY TELEPHONE:	1-800-579-1639
3) BY E-MAIL*:	sendmaterial@proxyvote.com
*  If requesting materials by e-mail, please send a blank e-mail with the information that is printed in the box marked by the arrow      (located on the following page) in the subject line. Requests, instructions and other inquiries sent to this e-mail address will NOT be forwarded to your investment advisor. Please make the request as instructed above on or before May 4, 2016 to facilitate timely delivery.

	—  How To Vote   — Please Choose One of the Following Voting Methods
	Vote By Internet:
	Before The Meeting:
	Go to www.proxyvote.com. Have the information that is printed in the box marked by the arrow (located on the following page) available and follow the instructions.
	During The Meeting:
	Go to www.virtualshareholdermeeting.com/ILMN2016. Have the information that is printed in the box marked by the arrow (located on the following page) available and follow the instructions.
	Vote By Mail:  You can vote by mail by requesting a paper copy of the materials, which will include a proxy card.

                  Voting Items                   

	The Board of Directors recommends you vote FOR the following:
	1.	Election of Directors with Terms Expiring in 2019
		Nominees:
		1a.     Frances Arnold, Ph.D.
		1b.     Francis A. deSouza
		1c.     Karin Eastham, CPA
	The Board of Directors recommends you vote FOR proposals 2, 3 and 4.
	2.	To ratify the appointment of Ernst & Young LLP as our independent registered public accounting firm for the fiscal year ending January 1, 2017.
	3.	To approve, on an advisory basis, the compensation of the named executive officers as disclosed in the Proxy Statement.
	4.	To approve, on an advisory basis, the ratification of certain supermajority voting provisions in our certificate of incorporation and bylaws.
	NOTE: Such other business as may properly come before the meeting or any adjournment thereof.