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  <element id="cris_UniversityLicensorsMember" name="UniversityLicensorsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="cris_RelatedPartyTransactionTextualAbstract" name="RelatedPartyTransactionTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="cris_IssuanceOfCommonStockToLicensees" name="IssuanceOfCommonStockToLicensees" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" />
  <element id="cris_CollaborationAgreementContingentConsiderationPotentialCashPayment" name="CollaborationAgreementContingentConsiderationPotentialCashPayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" />
  <element id="cris_StockIssuedDuringPeriodDueToExerciseOfWarrants" name="StockIssuedDuringPeriodDueToExerciseOfWarrants" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <element id="cris_CollaborationAgreementsAbstract" name="CollaborationAgreementsAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="cris_SublicenseFeesPaid" name="SublicenseFeesPaid" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" />
  <element id="cris_PercentageOfSublicenseFeesPaidOnRoyaltiesEarned" name="PercentageOfSublicenseFeesPaidOnRoyaltiesEarned" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="cris_PercentageOfContributionToFund" name="PercentageOfContributionToFund" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="cris_ContingentObligations" name="ContingentObligations" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" />
  <element id="cris_ChangeInFairValueUponWarrantExercise" name="ChangeInFairValueUponWarrantExercise" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" />
  <element id="cris_ExpectedLivesOfWarrantsYears" name="ExpectedLivesOfWarrantsYears" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="cris_SharesIssuedToSublicensees" name="SharesIssuedToSublicensees" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <element id="cris_ProceedsFromContributionOfFund" name="ProceedsFromContributionOfFund" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" />
  <element id="cris_MaximumFinancialSupportToRelatedParty" name="MaximumFinancialSupportToRelatedParty" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" />
  <element id="cris_SeveranceAgreementToRelatedParty" name="SeveranceAgreementToRelatedParty" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="cris_MilestonesRecognizedFromPartner" name="MilestonesRecognizedFromPartner" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" />
  <element id="cris_AdditionalMilestoneRecognizedFromPartner" name="AdditionalMilestoneRecognizedFromPartner" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" />
  <element id="cris_CollaborationAgreementContingentConsiderationReceivedFromPartner" name="CollaborationAgreementContingentConsiderationReceivedFromPartner" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" />
  <element id="cris_CommonStockIssuedOneTimeIssuanceToUniversityLicensesNumber" name="CommonStockIssuedOneTimeIssuanceToUniversityLicensesNumber" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="cris_RegisteredDirectOfferingNumberOfCommonStockPerUnit" name="RegisteredDirectOfferingNumberOfCommonStockPerUnit" type="us-types:perUnitItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <element id="cris_RegisteredDirectOfferingUnitNumberOfCommonStockToWarrant" name="RegisteredDirectOfferingUnitNumberOfCommonStockToWarrant" type="xbrli:decimalItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <element id="cris_RegisteredDirectOfferingNumberOfWarrantPerUnit" name="RegisteredDirectOfferingNumberOfWarrantPerUnit" type="us-types:perUnitItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <element id="cris_ZeroPointSevenNineUsDollarsToOnePointThreeUsDollarsMember" name="ZeroPointSevenNineUsDollarsToOnePointThreeUsDollarsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="cris_OnePointFourThreeUsDollarsToTwoPointOneFiveUsDollarsMember" name="OnePointFourThreeUsDollarsToTwoPointOneFiveUsDollarsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="cris_TwoPointTwoSevenUsDollarsToThreePointSevenSixUsDollarsMember" name="TwoPointTwoSevenUsDollarsToThreePointSevenSixUsDollarsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="cris_ThreePointNineEightUsDollarsToFourPointFiveTwoUsDollarsMember" name="ThreePointNineEightUsDollarsToFourPointFiveTwoUsDollarsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="cris_FourPointFiveSixUsDollarsToFivePointSixZeroUsDollarsMember" name="FourPointFiveSixUsDollarsToFivePointSixZeroUsDollarsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="cris_OutOfPeriodAdjustmentMember" name="OutOfPeriodAdjustmentMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="cris_CorporateBondsNotesAndStockMember" name="CorporateBondsNotesAndStockMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="cris_UsGovernmentObligationsMember" name="UsGovernmentObligationsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="cris_FoodAndDrugAdministrationMember" name="FoodAndDrugAdministrationMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="cris_FHoffmannLaRocheLimitedMember" name="FHoffmannLaRocheLimitedMember" abstract="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="cris_MarketIssuanceSalesAgreementMember" name="MarketIssuanceSalesAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="cris_CommonStockOfferingCostIncludingCommission" name="CommonStockOfferingCostIncludingCommission" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" />
  <element id="cris_ProceedsFromAtMarketIssuanceOfCommonStockNetOfIssuanceCosts" name="ProceedsFromAtMarketIssuanceOfCommonStockNetOfIssuanceCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" />
  <element id="cris_CommonStockAggregateOfferingPrice" name="CommonStockAggregateOfferingPrice" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" />
  <element id="cris_CommonStockCommissionAsPercentageOfGrossSalePricePerShareSold" name="CommonStockCommissionAsPercentageOfGrossSalePricePerShareSold" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="cris_InvestmentTextualAbstract" name="InvestmentTextualAbstract" abstract="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="cris_InvestmentDomesticGovernmentMaturityUnrealizedCost" name="InvestmentDomesticGovernmentMaturityUnrealizedCost" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" />
  <element id="cris_RevenueRecognitionMilestoneMethodNumberOfMilestoneAchieved" name="RevenueRecognitionMilestoneMethodNumberOfMilestoneAchieved" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="cris_AmortizedCostOfLongTermInvestment" name="AmortizedCostOfLongTermInvestment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" />
  <element id="cris_RevenueRecognitionReceivedUnderAgreement" name="RevenueRecognitionReceivedUnderAgreement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" />
  <element id="cris_MilestonesEarnedFromCollaborator" name="MilestonesEarnedFromCollaborator" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" />
</schema>
