X0304 4 2011-12-30 0 0001107421 ZIOPHARM ONCOLOGY INC ZIOP 0001525899 Youssoufian Hagop C/O ZIOPHARM ONCOLOGY, INC., ONE FIRST AVENUE, BLDG. 14 BOSTON MA 02129 0 1 0 0 Executive VP, CMO Common Stock 2011-12-30 4 A 0 65380 0.00 A 115380 D 21,794 shares vest on 12/30/12; and 21,793 shares vest on each of 12/30/2013 and 12/30/2014. Richard E. Bagley, Attorney-In-Fact 2012-01-04