POWER OF ATTORNEY
For Executing Forms 3, 4 and 5
Know all by these presents, that the undersigned hereby constitutes and appoints
Jonathan Lewis and Richard E. Bagley, signing individually, his true and lawful
attorneys-in-fact to:
1.	Execute for and on behalf of the undersigned Initial Statements of Beneficial
Ownership of Securities on Form 3, Statements of Changes of Beneficial Ownership
of Securities on Form 4 and Annual Statements of Beneficial Ownership of
Securities on Form 5, for the purpose of reporting transactions by the
undersigned in securities issued by ZIOPHARM Oncology, Inc. in accordance with
Section 16(a) of the Securities Exchange Act of 1934 and the rules thereunder;
2.	Do and perform any and all acts for and on behalf of the undersigned which
may be necessary or desirable to complete the execution of any such Form 3, 4 or
5 and the timely filing thereof with the United States Securities and Exchange
Commission and any other applicable governmental or regulatory authority; and
3.	Take any other action of any type whatsoever in connection with the foregoing
which in the opinion of such attorney-in-fact, may be of benefit to, in the best
interest of, or legally required by, the undersigned, it being understood that
the documents executed by such attorney-in-fact on behalf of the undersigned
pursuant to this Power of Attorney shall be in such form and shall contain such
terms and conditions as such attorney-in-fact may approve in his discretion.
The undersigned hereby grants to each such attorney-in-fact full power and
authority to do and perform all and every act and thing whatsoever requisite,
necessary and proper to be done in the exercise of any of the rights and powers
herein granted, as fully to all intents and purposes as such attorney-in-fact
might or could do if personally present, with full power of substitution or
revocation, hereby ratifying and confirming all that such attorney-in-fact, or
his substitute or substitutes, shall lawfully do or cause to be done by virtue
of this power of attorney and the rights and powers herein granted. The
undersigned acknowledges that the foregoing attorneys-in-fact, in serving in
such capacity at the request of the undersigned, are not assuming any of the
undersigned's responsibilities to comply with Section 16 of the Securities
Exchange Act of 1934.
This Power of Attorney shall remain in full force and effect until the
undersigned is no longer required to file Forms 3, 4 and 5 with respect to the
undersigned's holdings of and transactions in securities issued by Ziopharm
Oncology, Inc., unless earlier revoked by the undersigned in a signed writing
delivered to the foregoing attorneys-in-fact.
IN WITNESS WHEREOF, the undersigned has executed this Power of Attorney as of
this 15th day of July, 2011.

/s/ H. Youssoufian
(signature)

Hagop Youssoufian
(print name)