X0304 4 2012-01-20 0 0001107421 ZIOPHARM ONCOLOGY INC ZIOP 0001091823 KIRK RANDAL J C/O LEGAL DEPARTMENT 1881 GROVE AVENUE RADFORD VA 24141 1 0 1 0 0001356090 INTREXON CORP C/O LEGAL DEPARTMENT 20358 SENECA MEADOWS PARKWAY GERMANTOWN MD 20876 0 0 1 0 Common Stock 2012-01-20 4 P 0 1923075 5.20 A 9896236 I By Intrexon Corporation Common Stock 1346462 I By Kapital Joe, LLC Common Stock 42577 D Randal J. Kirk, directly and through certain affiliates, has voting and dispositive power over a majority of the outstanding capital stock of Intrexon Corporation. Mr. Kirk may therefore be deemed to have voting and dispositive power over the shares of the issuer owned by Intrexon Corporation. Shares held by Intrexon Corporation may be deemed to be indirectly beneficially owned (as defined under Rule 13d-3 promulgated under the Securities Exchange Act of 1934, as amended) by Mr. Kirk. Mr. Kirk disclaims beneficial ownership of such shares, except to the extent of any pecuniary interest therein. Randal J. Kirk controls Kapital Joe, LLC ("Kapital Joe"). Shares held by Kapital Joe may be deemed to be indirectly beneficially owned (as defined under Rule 13d-3 promulgated under the Securities Exchange Act of 1934, as amended) by Mr. Kirk. Mr. Kirk disclaims beneficial ownership of such shares, except to the extent of any pecuniary interest therein. /s/ Randal J. Kirk, CEO of Intrexon Corporation 2012-01-23 /s/ Randal J. Kirk 2012-01-23