0001172661-16-004318.txt : 20161114
0001172661-16-004318.hdr.sgml : 20161111
20161114162710
ACCESSION NUMBER: 0001172661-16-004318
CONFORMED SUBMISSION TYPE: 13F-HR
PUBLIC DOCUMENT COUNT: 2
CONFORMED PERIOD OF REPORT: 20160930
FILED AS OF DATE: 20161114
DATE AS OF CHANGE: 20161114
EFFECTIVENESS DATE: 20161114
FILER:
COMPANY DATA:
COMPANY CONFORMED NAME: ORBIMED ADVISORS LLC
CENTRAL INDEX KEY: 0001055951
IRS NUMBER: 133976876
STATE OF INCORPORATION: DE
FILING VALUES:
FORM TYPE: 13F-HR
SEC ACT: 1934 Act
SEC FILE NUMBER: 028-06774
FILM NUMBER: 161995132
BUSINESS ADDRESS:
STREET 1: 601 LEXINGTON AVENUE
STREET 2: 54TH FLOOR
CITY: NEW YORK
STATE: NY
ZIP: 10022
BUSINESS PHONE: (212) 739-6400
MAIL ADDRESS:
STREET 1: 601 LEXINGTON AVENUE
STREET 2: 54TH FLOOR
CITY: NEW YORK
STATE: NY
ZIP: 10022
13F-HR
1
primary_doc.xml
13F-HR
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0001055951
XXXXXXXX
09-30-2016
09-30-2016
false
ORBIMED ADVISORS LLC
601 Lexington Avenue
54th Floor
New York
NY
10022
13F HOLDINGS REPORT
028-06774
N
Samuel D. Isaly
Managing Member
212-739-6400
/s/ Samuel D. Isaly
New York
NY
11-14-2016
1
140
8780843
1
0001157524
028-10410
ORBIMED CAPITAL LLC
INFORMATION TABLE
2
infotable.xml
ABBOTT LABS
COM
002824100
18629
440500
SH
DFND
1
185300
0
255200
ABBVIE INC
COM
00287Y109
266780
4229900
SH
DFND
1
1406100
0
2823800
ACHILLION PHARMACEUTICALS IN
COM
00448Q201
106168
13107200
SH
DFND
1
5140500
0
7966700
ADAPTIMMUNE THERAPEUTICS PLC
SPONDS ADR
00653A107
5105
724184
SH
SOLE
724184
0
0
AEGLEA BIOTHERAPEUTICS INC
COM
00773J103
8719
1360224
SH
SOLE
1360224
0
0
AERIE PHARMACEUTICALS INC
COM
00771V108
30083
797100
SH
DFND
1
320300
0
476800
AETNA INC NEW
COM
00817Y108
13461
116600
SH
DFND
1
46200
0
70400
AFFIMED N V
COM
N01045108
9383
3375000
SH
SOLE
3375000
0
0
AGILENT TECHNOLOGIES INC
COM
00846U101
174930
3714800
SH
DFND
1
1590200
0
2124600
ALEXION PHARMACEUTICALS INC
COM
015351109
323262
2638011
SH
DFND
1
875300
0
1762711
ALIMERA SCIENCES INC
COM
016259103
373
250000
SH
DFND
1
98300
0
151700
ALLERGAN PLC
SHS
G0177J108
179340
778690
SH
DFND
1
288500
0
490190
ALLERGAN PLC
SHS
G0177J108
11516
50000
SH
Call
DFND
1
22000
0
28000
ALLERGAN PLC
PFD CONV SER A
G0177J116
72455
88200
SH
DFND
1
30300
0
57900
AMARIN CORP PLC
SPONS ADR NEW
023111206
1117
350000
SH
SOLE
350000
0
0
AMEDISYS INC
COM
023436108
3392
71500
SH
DFND
1
32400
0
39100
AMGEN INC
COM
031162100
406466
2436700
SH
DFND
1
725000
0
1711700
ARALEZ PHARMACEUTICALS INC
COM
03852X100
330
68143
SH
DFND
1
27339
0
40804
ARRAY BIOPHARMA INC
COM
04269X105
95714
14179900
SH
DFND
1
5395600
0
8784300
ARROWHEAD PHARMACEUTICALS IN
COM
04280A100
15876
2159973
SH
DFND
1
987200
0
1172773
ASCENDIS PHARMA A S
SPONSORED ADR
04351P101
44039
2191000
SH
SOLE
2191000
0
0
ASSEMBLY BIOSCIENCES INC
COM
045396108
10073
1397100
SH
DFND
1
647100
0
750000
AUDENTES THERAPEUTICS INC
COM
05070R104
85517
4801638
SH
SOLE
4801638
0
0
BARD C R INC
COM
067383109
13008
58000
SH
DFND
1
26300
0
31700
BIOGEN INC
COM
09062X103
417551
1333900
SH
DFND
1
403600
0
930300
BIOLINERX LTD
SPONSORED ADR
09071M106
1194
1038600
SH
SOLE
1038600
0
0
BIOMARIN PHARMACEUTICAL INC
COM
09061G101
106574
1151900
SH
DFND
1
331700
0
820200
BIOMARIN PHARMACEUTICAL INC
NOTE 0.750%10/1
09061GAE1
600
500000
PRN
DFND
1
215000
0
285000
BIOMARIN PHARMACEUTICAL INC
NOTE 1.500%10/1
09061GAF8
624
500000
PRN
DFND
1
215000
0
285000
BLUEBIRD BIO INC
COM
09609G100
80374
1185800
SH
DFND
1
475600
0
710200
BOSTON SCIENTIFIC CORP
COM
101137107
409638
17211700
SH
DFND
1
6316400
0
10895300
BRISTOL MYERS SQUIBB CO
COM
110122108
117945
2187400
SH
DFND
1
730200
0
1457200
BRISTOL MYERS SQUIBB CO
COM
110122108
5392
100000
SH
Call
DFND
1
45500
0
54500
CELGENE CORP
COM
151020104
308215
2948577
SH
DFND
1
1062200
0
1886377
CELLECTIS S A
SPONSORED ADS
15117K103
8428
350000
SH
DFND
1
162100
0
187900
CIGNA CORPORATION
COM
125509109
42445
325700
SH
DFND
1
143300
0
182400
COGENTIX MED INC
COM
19243A104
1598
878145
SH
DFND
1
386807
0
491338
COHERUS BIOSCIENCES INC
COM
19249H103
17985
671600
SH
DFND
1
139300
0
532300
COOPER COS INC
COM NEW
216648402
44833
250100
SH
DFND
1
83500
0
166600
CORVUS PHARMACEUTICALS INC
COM
221015100
88490
5379349
SH
SOLE
5379349
0
0
CYNAPSUS THERAPEUTICS INC
COM PAR NO PAR
23257Y859
20114
499999
SH
SOLE
499999
0
0
DBV TECHNOLOGIES S A
SPONSORED ADR
23306J101
12559
345700
SH
SOLE
345700
0
0
DERMIRA INC
COM
24983L104
14394
425600
SH
SOLE
425600
0
0
DIMENSION THERAPEUTICS INC
COM
25433V105
43128
5397698
SH
SOLE
5397698
0
0
EAGLE PHARMACEUTICALS INC
COM
269796108
72527
1036100
SH
DFND
1
457200
0
578900
EDWARDS LIFESCIENCES CORP
COM
28176E108
165553
1373200
SH
DFND
1
500700
0
872500
EHEALTH INC
COM
28238P109
20346
1815000
SH
DFND
1
833900
0
981100
EXACT SCIENCES CORP
COM
30063P105
20457
1101600
SH
SOLE
1101600
0
0
EXELIXIS INC
COM
30161Q104
79379
6206300
SH
DFND
1
2430400
0
3775900
EXPRESS SCRIPTS HLDG CO
COM
30219G108
102403
1451900
SH
DFND
1
551800
0
900100
FLUIDIGM CORP DEL
COM
34385P108
13986
1746100
SH
DFND
1
215500
0
1530600
FLUIDIGM CORP DEL
NOTE 2.750% 2/0
34385PAA6
6213
10000000
PRN
DFND
1
4466000
0
5534000
FORWARD PHARMA A/S
SPONSORED ADR
34986J105
16750
798000
SH
DFND
1
226500
0
571500
GALAPAGOS NV
SPON ADR
36315X101
29608
457900
SH
DFND
1
32000
0
425900
GILEAD SCIENCES INC
COM
375558103
159087
2010700
SH
DFND
1
618400
0
1392300
GLAUKOS CORP
COM
377322102
82273
2180000
SH
SOLE
2180000
0
0
GW PHARMACEUTICALS PLC
ADS
36197T103
4805
36200
SH
SOLE
36200
0
0
HCA HOLDINGS INC
COM
40412C101
99242
1312200
SH
DFND
1
344800
0
967400
HUMANA INC
COM
444859102
74913
423500
SH
DFND
1
132800
0
290700
ILLUMINA INC
COM
452327109
90013
495500
SH
DFND
1
108100
0
387400
IMMUNOGEN INC
COM
45253H101
16336
6095647
SH
DFND
1
1919480
0
4176167
IMMUNOMEDICS INC
COM
452907108
12357
3802000
SH
DFND
1
2050550
0
1751450
IMMUNOMEDICS INC
NOTE 4.750% 2/1
452907AK4
25479
30000000
PRN
DFND
1
16014000
0
13986000
IMPAX LABORATORIES INC
COM
45256B101
89764
3787500
SH
DFND
1
1348300
0
2439200
INCYTE CORP
COM
45337C102
174453
1850178
SH
DFND
1
475200
0
1374978
INCYTE CORP
NOTE 0.375%11/1
45337CAM4
8090
4250000
PRN
DFND
1
1816000
0
2434000
INCYTE CORP
NOTE 1.250%11/1
45337CAN2
8267
4250000
PRN
DFND
1
1816000
0
2434000
INFINITY PHARMACEUTICALS INC
COM
45665G303
5070
3250300
SH
DFND
1
1064000
0
2186300
INOTEK PHARMACEUTICALS CORP
COM
45780V102
17531
1849300
SH
DFND
1
846500
0
1002800
INOTEK PHARMACEUTICALS CORP
NOTE 5.750% 8/0
45780VAB8
9547
7000000
PRN
DFND
1
3200000
0
3800000
INSMED INC
COM PAR $.01
457669307
76246
5251100
SH
DFND
1
2329260
0
2921840
INSYS THERAPEUTICS INC NEW
COM NEW
45824V209
64871
5502240
SH
DFND
1
2228100
0
3274140
INTELLIA THERAPEUTICS INC
COM
45826J105
45310
2662180
SH
SOLE
2662180
0
0
INTERCEPT PHARMACEUTICALS IN
COM
45845P108
184341
1120000
SH
SOLE
1120000
0
0
INTRA CELLULAR THERAPIES INC
COM
46116X101
1373
90000
SH
Call
DFND
1
41200
0
48800
INTUITIVE SURGICAL INC
COM NEW
46120E602
136123
187800
SH
DFND
1
40600
0
147200
INVITAE CORP
COM
46185L103
4000
456666
SH
SOLE
456666
0
0
IRONWOOD PHARMACEUTICALS INC
COM CL A
46333X108
157990
9949000
SH
DFND
1
3595700
0
6353300
JAZZ PHARMACEUTICALS PLC
SHS USD
G50871105
29993
246900
SH
DFND
1
83500
0
163400
JOHNSON & JOHNSON
COM
478160104
101356
858000
SH
DFND
1
370700
0
487300
LILLY ELI & CO
COM
532457108
163771
2040500
SH
DFND
1
671000
0
1369500
LILLY ELI & CO
COM
532457108
20065
250000
SH
Call
DFND
1
112500
0
137500
LION BIOTECHNOLOGIES INC
COM
53619R102
27841
3382900
SH
DFND
1
1446500
0
1936400
LOXO ONCOLOGY INC
COM
548862101
45239
1728000
SH
SOLE
1728000
0
0
MAGELLAN HEALTH INC
COM NEW
559079207
37595
699700
SH
DFND
1
310900
0
388800
MALLINCKRODT PUB LTD CO
SHS
G5785G107
81657
1170200
SH
DFND
1
510200
0
660000
MARINUS PHARMACEUTICALS INC
COM
56854Q101
1033
567600
SH
SOLE
567600
0
0
MEDIGUS LTD
SPONSORED ADR
58471G102
756
600000
SH
SOLE
600000
0
0
MEDTRONIC PLC
SHS
G5960L103
66234
766600
SH
DFND
1
322100
0
444500
MERCK & CO INC
COM
58933Y105
218859
3506800
SH
DFND
1
1197100
0
2309700
MERCK & CO INC
COM
58933Y105
21847
350000
SH
Call
DFND
1
160500
0
189500
MINERVA NEUROSCIENCES INC
COM
603380106
7851
556200
SH
SOLE
556200
0
0
MOLINA HEALTHCARE INC
COM
60855R100
153656
2634700
SH
DFND
1
900000
0
1734700
NABRIVA THERAPEUTICS AG
SPONSORED ADR
62957M104
9271
1315000
SH
SOLE
1315000
0
0
NATERA INC
COM
632307104
14178
1276190
SH
SOLE
1276190
0
0
NEUROCRINE BIOSCIENCES INC
COM
64125C109
91936
1815474
SH
DFND
1
743370
0
1072104
NEWLINK GENETICS CORP
COM
651511107
29113
1938300
SH
DFND
1
721200
0
1217100
NIVALIS THERAPEUTICS INC
COM
65481J109
480
59000
SH
SOLE
59000
0
0
NUVASIVE INC
COM
670704105
8233
123500
SH
SOLE
123500
0
0
OPHTHOTECH CORP
COM
683745103
53797
1166200
SH
DFND
1
419460
0
746740
OREXIGEN THERAPEUTICS INC
NOTE 2.750%12/0
686164AB0
1441
5210000
PRN
DFND
1
2210000
0
3000000
OTONOMY INC
COM
68906L105
33653
1850094
SH
SOLE
1850094
0
0
PERNIX THERAPEUTICS HLDGS IN
COM
71426V108
668
1073000
SH
DFND
1
485000
0
588000
PERNIX THERAPEUTICS HLDGS IN
DBCV 4.250% 4/0
71426VAK4
3514
12000000
PRN
DFND
1
6500000
0
5500000
PFIZER INC
COM
717081103
119636
3532200
SH
DFND
1
1486000
0
2046200
PIERIS PHARMACEUTICALS INC
COM
720795103
13267
7259620
SH
SOLE
7259620
0
0
PORTOLA PHARMACEUTICALS INC
COM
737010108
8423
370900
SH
SOLE
370900
0
0
PROQR THRAPEUTICS N V
SHS EURO
N71542109
15377
2305446
SH
DFND
1
973446
0
1332000
PUMA BIOTECHNOLOGY INC
COM
74587V107
159815
2383525
SH
DFND
1
949000
0
1434525
QLT INC
COM
746927102
1030
500000
SH
DFND
1
200600
0
299400
REDHILL BIOPHARMA LTD
SPONSORED ADS
757468103
7846
564900
SH
SOLE
564900
0
0
REGENERON PHARMACEUTICALS
COM
75886F107
142838
355300
SH
DFND
1
101200
0
254100
ROKA BIOSCIENCE INC
COM
775431109
2238
3220429
SH
SOLE
3220429
0
0
SAGE THERAPEUTICS INC
COM
78667J108
10840
235400
SH
DFND
1
107500
0
127900
SANGAMO BIOSCIENCES INC
COM
800677106
3850
831500
SH
SOLE
831500
0
0
SAREPTA THERAPEUTICS INC
COM
803607100
16077
261800
SH
DFND
1
116300
0
145500
SELECTA BIOSCIENCES INC
COM
816212104
26260
1842797
SH
SOLE
1842797
0
0
SHIRE PLC
SPONSORED ADR
82481R106
206141
1063351
SH
DFND
1
368100
0
695251
SIENTRA INC
COM
82621J105
8248
917500
SH
SOLE
917500
0
0
SINOVAC BIOTECH LTD
SHS
P8696W104
15738
2667500
SH
DFND
1
1219500
0
1448000
STEADYMED LTD
SHS
M84920103
11029
3072196
SH
SOLE
3072196
0
0
STRYKER CORP
COM
863667101
24679
212000
SH
DFND
1
77000
0
135000
SYNDAX PHARMACEUTICALS INC
COM
87164F105
11482
757365
SH
SOLE
757365
0
0
SYNERGY PHARMACEUTICALS DEL
COM NEW
871639308
32931
5976648
SH
DFND
1
3262300
0
2714348
TENET HEALTHCARE CORP
COM NEW
88033G407
45161
1993000
SH
DFND
1
888900
0
1104100
TEVA PHARMACEUTICAL INDS LTD
ADR
881624209
84263
1831400
SH
DFND
1
695800
0
1135600
THERMO FISHER SCIENTIFIC INC
COM
883556102
129872
816500
SH
DFND
1
308200
0
508300
ULTRAGENYX PHARMACEUTICAL IN
COM
90400D108
12010
169300
SH
DFND
1
58300
0
111000
UNIQURE NV
SHS
N90064101
3741
489000
SH
SOLE
489000
0
0
UNITEDHEALTH GROUP INC
COM
91324P102
85652
611800
SH
DFND
1
197000
0
414800
VALEANT PHARMACEUTICALS INTL
COM
91911K102
4785
194900
SH
DFND
1
76800
0
118100
VANDA PHARMACEUTICALS INC
COM
921659108
12480
750000
SH
Call
DFND
1
343000
0
407000
VERTEX PHARMACEUTICALS INC
COM
92532F100
140583
1612000
SH
DFND
1
395000
0
1217000
VIEWRAY INC
COM
92672L107
41259
9127990
SH
SOLE
9127990
0
0
WELLCARE HEALTH PLANS INC
COM
94946T106
146128
1248000
SH
DFND
1
437600
0
810400
WRIGHT MED GROUP N V
ORD SHS 0.03 PAR
N96617118
180448
7356233
SH
DFND
1
2456550
0
4899683
XENCOR INC
COM
98401F105
18233
744522
SH
SOLE
744522
0
0
XENON PHARMACEUTICALS INC
COM
98420N105
8100
1000000
SH
SOLE
1000000
0
0
XTANT MED HLDGS INC
COM
98420P100
537
475439
SH
SOLE
475439
0
0
ZIMMER BIOMET HLDGS INC
COM
98956P102
93289
717500
SH
DFND
1
315700
0
401800