0001172661-16-003893.txt : 20160815
0001172661-16-003893.hdr.sgml : 20160815
20160815161640
ACCESSION NUMBER: 0001172661-16-003893
CONFORMED SUBMISSION TYPE: 13F-HR
PUBLIC DOCUMENT COUNT: 2
CONFORMED PERIOD OF REPORT: 20160630
FILED AS OF DATE: 20160815
DATE AS OF CHANGE: 20160815
EFFECTIVENESS DATE: 20160815
FILER:
COMPANY DATA:
COMPANY CONFORMED NAME: ORBIMED ADVISORS LLC
CENTRAL INDEX KEY: 0001055951
IRS NUMBER: 133976876
STATE OF INCORPORATION: DE
FILING VALUES:
FORM TYPE: 13F-HR
SEC ACT: 1934 Act
SEC FILE NUMBER: 028-06774
FILM NUMBER: 161832934
BUSINESS ADDRESS:
STREET 1: 601 LEXINGTON AVENUE
STREET 2: 54TH FLOOR
CITY: NEW YORK
STATE: NY
ZIP: 10022
BUSINESS PHONE: (212) 739-6400
MAIL ADDRESS:
STREET 1: 601 LEXINGTON AVENUE
STREET 2: 54TH FLOOR
CITY: NEW YORK
STATE: NY
ZIP: 10022
13F-HR
1
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0001055951
XXXXXXXX
06-30-2016
06-30-2016
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ORBIMED ADVISORS LLC
601 Lexington Avenue
54th Floor
New York
NY
10022
13F HOLDINGS REPORT
028-06774
N
Samuel D. Isaly
Managing Member
212-739-6400
/s/ Samuel D. Isaly
New York
NY
08-15-2016
1
137
9583046
1
0001157524
028-10410
ORBIMED CAPITAL LLC
INFORMATION TABLE
2
infotable.xml
ABBOTT LABS
COM
002824100
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237000
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ABBVIE INC
COM
00287Y109
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6573100
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DFND
1
3114600
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3458500
ACHILLION PHARMACEUTICALS IN
COM
00448Q201
91116
11681600
SH
DFND
1
5140500
0
6541100
ADAPTIMMUNE THERAPEUTICS PLC
SPONDS ADR
00653A107
5902
724184
SH
SOLE
724184
0
0
ADVAXIS INC
COM NEW
007624208
3603
445400
SH
DFND
1
0
0
445400
AEGLEA BIOTHERAPEUTICS INC
COM
00773J103
6611
1360224
SH
SOLE
1360224
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AETNA INC NEW
COM
00817Y108
14240
116600
SH
DFND
1
46200
0
70400
AFFIMED N V
COM
N01045108
9362
3775000
SH
SOLE
3775000
0
0
AGILENT TECHNOLOGIES INC
COM
00846U101
158152
3565200
SH
DFND
1
1581000
0
1984200
ALEXION PHARMACEUTICALS INC
COM
015351109
348110
2981411
SH
DFND
1
1244900
0
1736511
ALIMERA SCIENCES INC
COM
016259103
308
250000
SH
DFND
1
98300
0
151700
ALKERMES PLC
SHS
G01767105
7434
172000
SH
DFND
1
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172000
ALLERGAN PLC
SHS
G0177J108
310727
1344615
SH
DFND
1
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ALLERGAN PLC
SHS
G0177J108
34664
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SH
Call
DFND
1
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88500
ALLERGAN PLC
PFD CONV SER A
G0177J116
86859
104200
PRN
DFND
1
30300
0
73900
AMARIN CORP PLC
SPONS ADR NEW
023111206
756
350000
SH
SOLE
350000
0
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AMEDISYS INC
COM
023436108
1010
20000
SH
DFND
1
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11200
AMGEN INC
COM
031162100
461547
3033500
SH
DFND
1
1202500
0
1831000
ARALEZ PHARMACEUTICALS INC
COM
03852X100
225
68143
SH
DFND
1
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0
40804
ARRAY BIOPHARMA INC
COM
04269X105
39067
10973900
SH
DFND
1
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ASCENDIS PHARMA A S
SPONSORED ADR
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29075
2191000
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SOLE
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0
0
ASSEMBLY BIOSCIENCES INC
COM
045396108
7754
1397100
SH
DFND
1
647100
0
750000
BARD C R INC
COM
067383109
5409
23000
SH
DFND
1
9600
0
13400
BEIGENE LTD
SPONSORED ADR
07725L102
385
12925
SH
DFND
1
0
0
12925
BIOGEN INC
COM
09062X103
362827
1500400
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DFND
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930300
BIOLINERX LTD
SPONSORED ADR
09071M106
831
1038600
SH
SOLE
1038600
0
0
BIOMARIN PHARMACEUTICAL INC
COM
09061G101
118139
1518500
SH
DFND
1
698300
0
820200
BIOMARIN PHARMACEUTICAL INC
NOTE 0.750%10/1
09061GAE1
555
500000
PRN
DFND
1
215000
0
285000
BIOMARIN PHARMACEUTICAL INC
NOTE 1.500%10/1
09061GAF8
579
500000
PRN
DFND
1
215000
0
285000
BLUEBIRD BIO INC
COM
09609G100
51333
1185800
SH
DFND
1
475600
0
710200
BOSTON SCIENTIFIC CORP
COM
101137107
540529
23129200
SH
DFND
1
10956100
0
12173100
BRISTOL MYERS SQUIBB CO
COM
110122108
371839
5055600
SH
DFND
1
2331700
0
2723900
CARDINAL HEALTH INC
COM
14149Y108
12950
166000
SH
DFND
1
60000
0
106000
CELGENE CORP
COM
151020104
237173
2404677
SH
DFND
1
906100
0
1498577
CELLECTIS S A
SPONSORED ADS
15117K103
9307
350000
SH
DFND
1
162100
0
187900
CIGNA CORPORATION
COM
125509109
42186
329600
SH
DFND
1
138500
0
191100
COGENTIX MED INC
COM
19243A104
953
990745
SH
DFND
1
436407
0
554338
COOPER COS INC
COM NEW
216648402
116033
676300
SH
DFND
1
359200
0
317100
CORVUS PHARMACEUTICALS INC
COM
221015100
76710
5379349
SH
SOLE
5379349
0
0
CYNAPSUS THERAPEUTICS INC
COM PAR NO PAR
23257Y859
17470
1140325
SH
SOLE
1140325
0
0
DIMENSION THERAPEUTICS INC
COM
25433V105
32386
5397698
SH
SOLE
5397698
0
0
DYNAVAX TECHNOLOGIES CORP
COM NEW
268158201
35040
2403300
SH
DFND
1
650800
0
1752500
EAGLE PHARMACEUTICALS INC
COM
269796108
40190
1036100
SH
DFND
1
457200
0
578900
EDWARDS LIFESCIENCES CORP
COM
28176E108
51002
511400
SH
DFND
1
252000
0
259400
EHEALTH INC
COM
28238P109
18226
1300000
SH
DFND
1
600000
0
700000
EXACT SCIENCES CORP
COM
30063P105
26107
2131200
SH
SOLE
2131200
0
0
EXPRESS SCRIPTS HLDG CO
COM
30219G108
128754
1698600
SH
DFND
1
861000
0
837600
FLUIDIGM CORP DEL
COM
34385P108
15767
1746100
SH
DFND
1
215500
0
1530600
FLUIDIGM CORP DEL
NOTE 2.750% 2/0
34385PAA6
6098
10000000
PRN
DFND
1
4466000
0
5534000
FORWARD PHARMA A/S
SPONSORED ADR
34986J105
14500
798000
SH
DFND
1
226500
0
571500
GALAPAGOS NV
SPON ADR
36315X101
19564
352700
SH
SOLE
352700
0
0
GILEAD SCIENCES INC
COM
375558103
256341
3072900
SH
DFND
1
1172300
0
1900600
GLAUKOS CORP
COM
377322102
84504
2897938
SH
SOLE
2897938
0
0
HCA HOLDINGS INC
COM
40412C101
315610
4098300
SH
DFND
1
1925400
0
2172900
HUMANA INC
COM
444859102
61105
339700
SH
DFND
1
144600
0
195100
ILLUMINA INC
COM
452327109
118790
846200
SH
DFND
1
345700
0
500500
IMMUNOGEN INC
COM
45253H101
18775
6095647
SH
DFND
1
1919480
0
4176167
IMMUNOMEDICS INC
COM
452907108
8821
3802000
SH
DFND
1
2050550
0
1751450
IMMUNOMEDICS INC
NOTE 4.750% 2/1
452907AK4
20827
30000000
PRN
DFND
1
16014000
0
13986000
IMPAX LABORATORIES INC
COM
45256B101
169655
5886700
SH
DFND
1
1992000
0
3894700
INCYTE CORP
COM
45337C102
185928
2324678
SH
DFND
1
883900
0
1440778
INCYTE CORP
NOTE 0.375%11/1
45337CAM4
7055
4250000
PRN
DFND
1
1816000
0
2434000
INCYTE CORP
NOTE 1.250%11/1
45337CAN2
7169
4250000
PRN
DFND
1
1816000
0
2434000
INFINITY PHARMACEUTICALS INC
COM
45665G303
4323
3250300
SH
DFND
1
1064000
0
2186300
INOTEK PHARMACEUTICALS CORP
COM
45780V102
10349
1391000
SH
DFND
1
637000
0
754000
INSMED INC
COM PAR $.01
457669307
41004
4158600
SH
DFND
1
1764960
0
2393640
INSMED INC
COM PAR $.01
457669307
1972
200000
SH
Call
DFND
1
89500
0
110500
INSYS THERAPEUTICS INC NEW
COM NEW
45824V209
60666
4688240
SH
DFND
1
1813500
0
2874740
INTELLIA THERAPEUTICS INC
COM
45826J105
56838
2662180
SH
SOLE
2662180
0
0
INTERCEPT PHARMACEUTICALS IN
COM
45845P108
159802
1120000
SH
SOLE
1120000
0
0
INTRA CELLULAR THERAPIES INC
COM
46116X101
34371
885400
SH
DFND
1
405000
0
480400
INTUITIVE SURGICAL INC
COM NEW
46120E602
196968
297800
SH
DFND
1
150600
0
147200
INVITAE CORP
COM
46185L103
3375
456666
SH
SOLE
456666
0
0
IRONWOOD PHARMACEUTICALS INC
COM CL A
46333X108
130083
9949000
SH
DFND
1
3595700
0
6353300
ISHARES TR
NASDQ BIOTEC ETF
464287556
13716
53300
SH
DFND
1
24000
0
29300
JAZZ PHARMACEUTICALS PLC
SHS USD
G50871105
12718
90000
SH
SOLE
90000
0
0
JOHNSON & JOHNSON
COM
478160104
94323
777600
SH
DFND
1
325500
0
452100
LILLY ELI & CO
COM
532457108
116298
1476800
SH
DFND
1
835500
0
641300
LION BIOTECHNOLOGIES INC
COM
53619R102
27401
3382900
SH
DFND
1
1446500
0
1936400
LOXO ONCOLOGY INC
COM
548862101
50436
2175857
SH
SOLE
2175857
0
0
MACROGENICS INC
COM
556099109
4032
149400
SH
DFND
1
69200
0
80200
MAGELLAN HEALTH INC
COM NEW
559079207
71729
1090600
SH
DFND
1
472300
0
618300
MALLINCKRODT PUB LTD CO
SHS
G5785G107
79561
1309000
SH
DFND
1
558000
0
751000
MARINUS PHARMACEUTICALS INC
COM
56854Q101
1102
867600
SH
SOLE
867600
0
0
MCKESSON CORP
COM
58155Q103
8101
43400
SH
DFND
1
17100
0
26300
MEDIGUS LTD
SPONSORED ADR
58471G102
1092
600000
SH
SOLE
600000
0
0
MEDIVATION INC
COM
58501N101
120684
2001400
SH
DFND
1
855300
0
1146100
MEDTRONIC PLC
SHS
G5960L103
57815
666299
SH
DFND
1
234199
0
432100
MERCK & CO INC
COM
58933Y105
110352
1915500
SH
DFND
1
910500
0
1005000
MINERVA NEUROSCIENCES INC
COM
603380106
3283
321500
SH
SOLE
321500
0
0
MOLINA HEALTHCARE INC
COM
60855R100
91716
1838000
SH
DFND
1
867600
0
970400
MOLINA HEALTHCARE INC
COM
60855R100
17465
350000
SH
Call
DFND
1
157000
0
193000
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SPONSORED ADR
62957M104
9863
1315000
SH
SOLE
1315000
0
0
NATERA INC
COM
632307104
15397
1276190
SH
SOLE
1276190
0
0
NEUROCRINE BIOSCIENCES INC
COM
64125C109
82513
1815474
SH
DFND
1
743370
0
1072104
NEWLINK GENETICS CORP
COM
651511107
17808
1581506
SH
DFND
1
591500
0
990006
NUVASIVE INC
COM
670704105
14757
247100
SH
SOLE
247100
0
0
OPHTHOTECH CORP
COM
683745103
109618
2148100
SH
DFND
1
954880
0
1193220
OREXIGEN THERAPEUTICS INC
NOTE 2.750%12/0
686164AB0
2200
5210000
PRN
DFND
1
2210000
0
3000000
OTONOMY INC
COM
68906L105
29379
1850094
SH
SOLE
1850094
0
0
PERNIX THERAPEUTICS HLDGS IN
COM
71426V108
481
1073000
SH
DFND
1
485000
0
588000
PERNIX THERAPEUTICS HLDGS IN
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71426VAK4
2549
12000000
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DFND
1
6500000
0
5500000
PFIZER INC
COM
717081103
149421
4243700
SH
DFND
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0
2450900
PIERIS PHARMACEUTICALS INC
COM
720795103
11688
7259620
SH
SOLE
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0
0
PORTOLA PHARMACEUTICALS INC
COM
737010108
8753
370900
SH
SOLE
370900
0
0
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SHS EURO
N71542109
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2305446
SH
DFND
1
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0
1332000
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COM
74587V107
88298
2964025
SH
DFND
1
1263800
0
1700225
QLT INC
COM
746927102
710
500000
SH
DFND
1
200600
0
299400
REDHILL BIOPHARMA LTD
SPONSORED ADS
757468103
6138
564900
SH
SOLE
564900
0
0
REGENERON PHARMACEUTICALS
COM
75886F107
178072
509900
SH
DFND
1
209400
0
300500
RELYPSA INC
COM
759531106
136900
7400000
SH
SOLE
7400000
0
0
ROKA BIOSCIENCE INC
COM
775431109
1842
3220429
SH
SOLE
3220429
0
0
SELECTA BIOSCIENCES INC
COM
816212104
25781
1842797
SH
SOLE
1842797
0
0
SERES THERAPEUTICS INC
COM
81750R102
2498
86000
SH
SOLE
86000
0
0
SHIRE PLC
SPONSORED ADR
82481R106
72529
394009
SH
DFND
1
164276
0
229733
SIENTRA INC
COM
82621J105
8932
1357500
SH
SOLE
1357500
0
0
SINOVAC BIOTECH LTD
SHS
P8696W104
15818
2667500
SH
DFND
1
1219500
0
1448000
SPDR S&P 500 ETF TR
TR UNIT
78462F103
41894
200000
SH
Put
DFND
1
91000
0
109000
SPDR SERIES TRUST
S&P BIOTECH
78464A870
40306
745300
SH
DFND
1
401100
0
344200
STRYKER CORP
COM
863667101
25404
212000
SH
DFND
1
77000
0
135000
SYNDAX PHARMACEUTICALS INC
COM
87164F105
7460
757365
SH
SOLE
757365
0
0
SYNERGY PHARMACEUTICALS DEL
COM NEW
871639308
22711
5976648
SH
DFND
1
3262300
0
2714348
TENET HEALTHCARE CORP
COM NEW
88033G407
25299
915300
SH
DFND
1
394100
0
521200
TEVA PHARMACEUTICAL INDS LTD
ADR
881624209
138625
2759800
SH
DFND
1
1406800
0
1353000
THERMO FISHER SCIENTIFIC INC
COM
883556102
203495
1377200
SH
DFND
1
621700
0
755500
ULTRAGENYX PHARMACEUTICAL IN
COM
90400D108
8280
169300
SH
DFND
1
58300
0
111000
UNIQURE NV
SHS
N90064101
1440
195400
SH
SOLE
195400
0
0
UNITEDHEALTH GROUP INC
COM
91324P102
170598
1208200
SH
DFND
1
551400
0
656800
VALEANT PHARMACEUTICALS INTL
COM
91911K102
3925
194900
SH
DFND
1
76800
0
118100
VERTEX PHARMACEUTICALS INC
COM
92532F100
188324
2189300
SH
DFND
1
942600
0
1246700
VIEWRAY INC
COM
92672L107
32679
7989916
SH
SOLE
7989916
0
0
WELLCARE HEALTH PLANS INC
COM
94946T106
205817
1918500
SH
DFND
1
912600
0
1005900
WRIGHT MED GROUP N V
ORD SHS 0.03 PAR
N96617118
113689
6545163
SH
DFND
1
1964850
0
4580313
WRIGHT MED GROUP N V
ORD SHS 0.03 PAR
N96617118
6948
400000
SH
Call
DFND
1
178500
0
221500
XENCOR INC
COM
98401F105
16537
870822
SH
SOLE
870822
0
0
XTANT MED HLDGS INC
COM
98420P100
908
475439
SH
SOLE
475439
0
0
ZIMMER BIOMET HLDGS INC
COM
98956P102
103828
862500
SH
DFND
1
378200
0
484300