0001172661-12-000896.txt : 20120814
0001172661-12-000896.hdr.sgml : 20120814
20120814160252
ACCESSION NUMBER: 0001172661-12-000896
CONFORMED SUBMISSION TYPE: 13F-HR
PUBLIC DOCUMENT COUNT: 1
CONFORMED PERIOD OF REPORT: 20120630
FILED AS OF DATE: 20120814
DATE AS OF CHANGE: 20120814
EFFECTIVENESS DATE: 20120814
FILER:
COMPANY DATA:
COMPANY CONFORMED NAME: ORBIMED ADVISORS LLC
CENTRAL INDEX KEY: 0001055951
IRS NUMBER: 133976876
STATE OF INCORPORATION: DE
FILING VALUES:
FORM TYPE: 13F-HR
SEC ACT: 1934 Act
SEC FILE NUMBER: 028-06774
FILM NUMBER: 121032723
BUSINESS ADDRESS:
STREET 1: 601 LEXINGTON AVENUE
STREET 2: 54TH FLOOR
CITY: NEW YORK
STATE: NY
ZIP: 10022
BUSINESS PHONE: (212) 739-6400
MAIL ADDRESS:
STREET 1: 601 LEXINGTON AVENUE
STREET 2: 54TH FLOOR
CITY: NEW YORK
STATE: NY
ZIP: 10022
13F-HR
1
orbimedadvisors2q12.txt
FORM 13F HOLDINGS REPORT
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
Form 13F
Form 13F COVER PAGE
Report for the Calendar Year or Quarter Ended: June 30, 2012
Check here if Amendment [ ]; Amendment Number:
This Amendment (Check only one.): [ ] is a restatement.
[ ] adds new holdings entries.
Institutional Investment Manager Filing this Report:
Name: OrbiMed Advisors LLC
Address: 601 Lexington Avenue
54th Floor
New York, NY 10022
13F File Number: 028-06774
The institutional investment manager filing this report and the person by whom
it is signed hereby represent that the person signing the report is authorized
to submit it, that all information contained herein is true, correct and
complete, and that it is understood that all required items, statements,
schedules, lists, and tables, are considered integral parts of this form.
Person Signing this Report on Behalf of Reporting Manager:
Name: Samuel D. Isaly
Title: Managing Member
Phone: (212) 739-6400
Signature, Place, and Date of Signing:
/s/ Samuel D. Isaly New York, NY August 14, 2012
Report Type (Check only one.):
[ X] 13F HOLDINGS REPORT.
[ ] 13F NOTICE.
[ ] 13F COMBINATION REPORT.
FORM 13F SUMMARY PAGE
Report Summary:
Number of Other Included Managers: 1
Form 13F Information Table Entry Total: 117
Form 13F Information Table Value Total: $3,637,917 (thousands)
List of Other Included Managers:
Provide a numbered list of the name(s) and Form 13F file number(s) of all
institutional managers with respect to which this report is filed, other
than the manager filing this report.
No. 13F File Number Name
1 028-10410 OrbiMed Capital LLC
FORM 13F INFORMATION TABLE
VALUE SHARES/ SH/ PUT/ INVSTMT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DSCRETN MANAGERS SOLE SHARED NONE
------------------------------ ---------------- --------- -------- -------- --- ---- ------- ------------ -------- -------- --------
3SBIO INC SPONSORED ADR 88575Y105 28505 2088300 SH DEFINED 1 1123600 0 964700
ABBOTT LABS COM 002824100 128166 1988000 SH DEFINED 1 660500 0 1327500
AETNA INC NEW COM 00817Y108 42166 1087600 SH DEFINED 1 320000 0 767600
AFFYMAX INC COM 00826A109 25259 1961100 SH DEFINED 1 1123000 0 838100
AFFYMETRIX INC COM 00826T108 31859 6793000 SH DEFINED 1 2978000 0 3815000
AGILENT TECHNOLOGIES INC COM 00846U101 6161 157000 SH DEFINED 1 0 0 157000
ALEXION PHARMACEUTICALS INC COM 015351109 21201 213500 SH DEFINED 1 0 0 213500
ALLERGAN INC COM 018490102 57884 625300 SH DEFINED 1 301000 0 324300
AMARIN CORP PLC SPONS ADR NEW 023111206 17352 1200000 SH SOLE 1200000 0 0
AMGEN INC COM 031162100 18629 255500 SH DEFINED 1 0 0 255500
AMYLIN PHARMACEUTICALS INC COM 032346108 2115 75000 SH DEFINED 1 0 0 75000
ANTARES PHARMA INC COM 036642106 26638 7338400 SH DEFINED 1 4085700 0 3252700
ARENA PHARMACEUTICALS INC COM 040047102 998 100000 SH PUT DEFINED 1 43000 0 57000
ARENA PHARMACEUTICALS INC COM 040047102 5985 600000 SH DEFINED 1 520100 0 79900
ARIAD PHARMACEUTICALS INC COM 04033A100 14962 869400 SH DEFINED 1 238000 0 631400
ARRAY BIOPHARMA INC COM 04269X105 18770 5409100 SH DEFINED 1 2690200 0 2718900
ATHERSYS INC COM 04744L106 2601 1615700 SH SOLE 1615700 0 0
AUXILIUM PHARMACEUTICALS INC COM 05334D107 70454 2620100 SH DEFINED 1 1244500 0 1375600
BAXTER INTL INC COM 071813109 58837 1107000 SH DEFINED 1 552000 0 555000
BIODEL INC COM NEW 09064M204 3600 1395510 SH SOLE 1395510 0 0
BIOGEN IDEC INC COM 09062X103 112241 777400 SH DEFINED 1 385000 0 392400
BIOMARIN PHARMACEUTICAL INC COM 09061G101 54577 1378900 SH DEFINED 1 810800 0 568100
BOSTON SCIENTIFIC CORP COM 101137107 3686 650000 SH DEFINED 1 0 0 650000
BRISTOL MYERS SQUIBB CO COM 110122108 182594 5079100 SH DEFINED 1 2439800 0 2639300
BRISTOL MYERS SQUIBB CO COM 110122108 17867 497000 SH CALL DEFINED 1 209000 0 288000
CARDINAL HEALTH INC COM 14149Y108 5670 135000 SH DEFINED 1 0 0 135000
CAREFUSION CORP COM 14170T101 3978 154900 SH DEFINED 1 0 0 154900
CELGENE CORP COM 151020104 34454 537000 SH DEFINED 1 0 0 537000
CELSION CORPORATION COM NEW 15117N305 4587 1494000 SH DEFINED 1 1264000 0 230000
CHEMOCENTRYX INC COM 16383L106 36071 2404715 SH SOLE 2404715 0 0
CIGNA CORPORATION COM 125509109 15312 348000 SH DEFINED 1 300000 0 48000
COMPLETE GENOMICS INC COM 20454K104 7775 4157936 SH SOLE 4157936 0 0
COVANCE INC COM 222816100 2297 48000 SH DEFINED 1 0 0 48000
CUBIST PHARMACEUTICALS INC COM 229678107 5470 144300 SH DEFINED 1 0 0 144300
CUBIST PHARMACEUTICALS INC NOTE 2.500%11/0 229678AD9 2881 2000000 PRN DEFINED 1 0 0 2000000
DAVITA INC COM 23918K108 6384 65000 SH DEFINED 1 0 0 65000
DENDREON CORP COM 24823Q107 34244 4627600 SH DEFINED 1 2760900 0 1866700
DENDREON CORP NOTE 2.875% 1/1 24823QAC1 4498 6500000 PRN DEFINED 1 0 0 6500000
EDWARDS LIFESCIENCES CORP COM 28176E108 5165 50000 SH DEFINED 1 0 0 50000
ELAN PLC ADR 284131208 48439 3320000 SH DEFINED 1 2127700 0 1192300
ELAN PLC ADR 284131208 2918 200000 SH CALL DEFINED 1 86500 0 113500
ENDOCYTE INC COM 29269A102 15256 1856000 SH DEFINED 1 891000 0 965000
EXACT SCIENCES CORP COM 30063P105 40636 3790700 SH DEFINED 1 2055300 0 1735400
EXACT SCIENCES CORP COM 30063P105 1072 100000 SH CALL DEFINED 1 43000 0 57000
EXACT SCIENCES CORP COM 30063P105 1072 100000 SH PUT DEFINED 1 43000 0 57000
EXPRESS SCRIPTS HLDG CO COM 30219G108 100358 1797570 SH DEFINED 1 919800 0 877770
EXPRESS SCRIPTS HLDG CO COM 30219G108 19401 347500 SH CALL DEFINED 1 145000 0 202500
FLUIDIGM CORP DEL COM 34385P108 15551 1034000 SH DEFINED 1 272000 0 762000
FOREST LABS INC COM 345838106 4199 120000 SH DEFINED 1 0 0 120000
GILEAD SCIENCES INC COM 375558103 150199 2929000 SH DEFINED 1 1353000 0 1576000
GIVEN IMAGING ORD SHS M52020100 12940 819000 SH DEFINED 1 424000 0 395000
HCA HOLDINGS INC COM 40412C101 42864 1408600 SH DEFINED 1 765600 0 643000
HI-TECH PHARMACAL INC COM 42840B101 5378 166000 SH DEFINED 1 99000 0 67000
HOLOGIC INC COM 436440101 4510 250000 SH DEFINED 1 0 0 250000
HOSPIRA INC COM 441060100 5247 150000 SH PUT DEFINED 1 64500 0 85500
HUMANA INC COM 444859102 58041 749500 SH DEFINED 1 359000 0 390500
IDENIX PHARMACEUTICALS INC COM 45166R204 4503 438000 SH DEFINED 1 378000 0 60000
ILLUMINA INC COM 452327109 8078 200000 SH CALL DEFINED 1 86000 0 114000
ILLUMINA INC COM 452327109 66813 1654200 SH DEFINED 1 804300 0 849900
IMMUNOGEN INC COM 45253H101 38638 2308100 SH DEFINED 1 1276500 0 1031600
IMPAX LABORATORIES INC COM 45256B101 48715 2403300 SH DEFINED 1 1225300 0 1178000
INCYTE CORP COM 45337C102 84051 3702700 SH DEFINED 1 1976400 0 1726300
INCYTE CORP COM 45337C102 6810 300000 SH CALL DEFINED 1 137500 0 162500
INCYTE CORP NOTE 4.750%10/0 45337CAJ1 23007 8679000 PRN DEFINED 1 3187000 0 5492000
INSULET CORP COM 45784P101 16669 780000 SH SOLE 780000 0 0
ISHARES TR NASDQ BIO INDX 464287556 19494 150000 SH PUT DEFINED 1 64500 0 85500
JOHNSON & JOHNSON COM 478160104 30463 450900 SH DEFINED 1 0 0 450900
LIFE TECHNOLOGIES CORP COM 53217V109 91960 2044000 SH DEFINED 1 1019000 0 1025000
LILLY ELI & CO COM 532457108 11650 271500 SH CALL DEFINED 1 229500 0 42000
MAP PHARMACEUTICALS INC COM 56509R108 12579 841400 SH DEFINED 1 616000 0 225400
MASIMO CORP COM 574795100 5617 251000 SH DEFINED 1 191000 0 60000
MCKESSON CORP COM 58155Q103 7125 76000 SH DEFINED 1 0 0 76000
MEDIVATION INC COM 58501N101 3108 34000 SH DEFINED 1 0 0 34000
MEDTRONIC INC COM 585055106 4260 110000 SH DEFINED 1 0 0 110000
MERCK & CO INC NEW COM 58933Y105 145353 3481500 SH DEFINED 1 1312700 0 2168800
NATUS MEDICAL INC DEL COM 639050103 16497 1419700 SH DEFINED 1 876800 0 542900
NEUROCRINE BIOSCIENCES INC COM 64125C109 32892 4166200 SH DEFINED 1 2035200 0 2131000
NPS PHARMACEUTICALS INC COM 62936P103 21003 2439400 SH DEFINED 1 1368000 0 1071400
NXSTAGE MEDICAL INC COM 67072V103 45757 2730143 SH SOLE 2730143 0 0
ONCOTHYREON INC COM 682324108 6767 1446000 SH DEFINED 1 701000 0 745000
ONYX PHARMACEUTICALS INC COM 683399109 110194 1658300 SH DEFINED 1 836900 0 821400
ORASURE TECHNOLOGIES INC COM 68554V108 53896 4795000 SH DEFINED 1 2965000 0 1830000
OREXIGEN THERAPEUTICS INC COM 686164104 2632 475000 SH DEFINED 1 0 0 475000
PACIRA PHARMACEUTICALS INC COM 695127100 32080 2000000 SH SOLE 2000000 0 0
PERNIX THERAPEUTICS HLDGS IN COM 71426V108 17613 2416000 SH DEFINED 1 1545000 0 871000
PERRIGO CO COM 714290103 13892 117800 SH DEFINED 1 0 0 117800
PFIZER INC COM 717081103 234269 10185600 SH DEFINED 1 3913200 0 6272400
QUESTCOR PHARMACEUTICALS INC COM 74835Y101 70399 1322300 SH DEFINED 1 619200 0 703100
REGENERON PHARMACEUTICALS COM 75886F107 23164 202800 SH DEFINED 1 106000 0 96800
SALIX PHARMACEUTICALS INC COM 795435106 3816 70100 SH DEFINED 1 0 0 70100
SELECT SECTOR SPDR TR SBI HEALTHCARE 81369Y209 11403 300000 SH PUT DEFINED 1 129500 0 170500
SEQUENOM INC COM NEW 817337405 26431 6510000 SH DEFINED 1 3821000 0 2689000
SHIRE PLC SPONSORED ADR 82481R106 27325 316300 SH DEFINED 1 136900 0 179400
SINOVAC BIOTECH LTD SHS P8696W104 317 150000 SH SOLE 150000 0 0
SOLTA MED INC COM 83438K103 1338 456800 SH DEFINED 1 245300 0 211500
ST JUDE MED INC COM 790849103 5787 145000 SH DEFINED 1 0 0 145000
STRYKER CORP COM 863667101 6325 114800 SH DEFINED 1 0 0 114800
SUPERNUS PHARMACEUTICALS INC COM 868459108 33696 3599998 SH SOLE 3599998 0 0
SYNERON MEDICAL LTD ORD SHS M87245102 3633 350000 SH DEFINED 1 199000 0 151000
THERMO FISHER SCIENTIFIC INC COM 883556102 55876 1076400 SH DEFINED 1 554600 0 521800
UNITEDHEALTH GROUP INC COM 91324P102 82485 1410000 SH DEFINED 1 637000 0 773000
UROPLASTY INC COM NEW 917277204 7280 1586000 SH DEFINED 1 1366000 0 220000
VALEANT PHARMACEUTICALS INTL COM 91911K102 6181 138000 SH DEFINED 1 0 0 138000
VERASTEM INC COM 92337C104 3961 408800 SH DEFINED 1 297500 0 111300
VERTEX PHARMACEUTICALS INC COM 92532F100 6654 119000 SH DEFINED 1 0 0 119000
VERTEX PHARMACEUTICALS INC COM 92532F100 16776 300000 SH PUT DEFINED 1 127500 0 172500
VIVUS INC COM 928551100 73716 2582900 SH DEFINED 1 1290800 0 1292100
VIVUS INC COM 928551100 4281 150000 SH CALL DEFINED 1 63500 0 86500
VOLCANO CORPORATION COM 928645100 5300 185000 SH DEFINED 1 0 0 185000
VOLCANO CORPORATION NOTE 2.875% 9/0 928645AA8 1806 1500000 PRN DEFINED 1 0 0 1500000
WARNER CHILCOTT PLC IRELAND SHS A G94368100 65224 3637700 SH DEFINED 1 2047200 0 1590500
WARNER CHILCOTT PLC IRELAND SHS A G94368100 5379 300000 SH CALL DEFINED 1 129500 0 170500
WATSON PHARMACEUTICALS INC COM 942683103 84186 1137800 SH DEFINED 1 693200 0 444600
WATSON PHARMACEUTICALS INC COM 942683103 7399 100000 SH CALL DEFINED 1 43000 0 57000
WELLPOINT INC COM 94973V107 84011 1317000 SH DEFINED 1 638000 0 679000
XOMA CORP DEL COM 98419J107 10016 3361100 SH DEFINED 1 2192000 0 1169100
ZIMMER HLDGS INC COM 98956P102 37393 581000 SH DEFINED 1 227000 0 354000