0001172661-11-000741.txt : 20111114
0001172661-11-000741.hdr.sgml : 20111111
20111114163730
ACCESSION NUMBER: 0001172661-11-000741
CONFORMED SUBMISSION TYPE: 13F-HR
PUBLIC DOCUMENT COUNT: 1
CONFORMED PERIOD OF REPORT: 20110930
FILED AS OF DATE: 20111114
DATE AS OF CHANGE: 20111114
EFFECTIVENESS DATE: 20111114
FILER:
COMPANY DATA:
COMPANY CONFORMED NAME: ORBIMED ADVISORS LLC
CENTRAL INDEX KEY: 0001055951
IRS NUMBER: 133976876
STATE OF INCORPORATION: DE
FILING VALUES:
FORM TYPE: 13F-HR
SEC ACT: 1934 Act
SEC FILE NUMBER: 028-06774
FILM NUMBER: 111203351
BUSINESS ADDRESS:
STREET 1: 767 3RD AVENUE
STREET 2: 30TH FLOOR
CITY: NEW YORK
STATE: NY
ZIP: 10017
BUSINESS PHONE: 2126845700
MAIL ADDRESS:
STREET 1: 767 3RD AVENUE
STREET 2: 30TH FLOOR
CITY: NEW YORK
STATE: NY
ZIP: 10017
13F-HR
1
orb3q11.txt
FORM 13F HOLDINGS REPORT
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
Form 13F
Form 13F COVER PAGE
Report for the Calendar Year or Quarter Ended: September 30, 2011
Check here if Amendment [ ]; Amendment Number:
This Amendment (Check only one.): [ ] is a restatement.
[ ] adds new holdings entries.
Institutional Investment Manager Filing this Report:
Name: OrbiMed Advisors LLC
Address: 767 3rd Avenue
30th Floor
New York, NY 10017
13F File Number: 028-06774
The institutional investment manager filing this report and the person by whom
it is signed hereby represent that the person signing the report is authorized
to submit it, that all information contained herein is true, correct and
complete, and that it is understood that all required items, statements,
schedules, lists, and tables, are considered integral parts of this form.
Person Signing this Report on Behalf of Reporting Manager:
Name: Samuel D. Isaly
Title: Managing Member
Phone: (212) 739-6400
Signature, Place, and Date of Signing:
/s/ Samuel D. Isaly New York, NY November 14, 2011
Report Type (Check only one.):
[ X] 13F HOLDINGS REPORT.
[ ] 13F NOTICE.
[ ] 13F COMBINATION REPORT.
FORM 13F SUMMARY PAGE
Report Summary:
Number of Other Included Managers: 1
Form 13F Information Table Entry Total: 115
Form 13F Information Table Value Total: $2,693,953 (thousands)
List of Other Included Managers:
Provide a numbered list of the name(s) and Form 13F file number(s) of all
institutional managers with respect to which this report is filed, other
than the manager filing this report.
No. 13F File Number Name
1 028-10410 OrbiMed Capital LLC
FORM 13F INFORMATION TABLE
VALUE SHARES/ SH/ PUT/ INVSTMT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DSCRETN MANAGERS SOLE SHARED NONE
------------------------------ ---------------- --------- -------- -------- --- ---- ------- ------------ -------- -------- --------
3SBIO INC SPONSORED ADR 88575Y105 20336 1704600 SH DEFINED 1 1704600 0 0
AETNA INC NEW COM 00817Y108 67374 1854000 SH DEFINED 1 1337300 0 516700
AFFYMAX INC COM 00826A109 15232 3400000 SH DEFINED 1 2666500 0 733500
AFFYMETRIX INC COM 00826T108 29988 6120100 SH DEFINED 1 4733400 0 1386700
AGILENT TECHNOLOGIES INC COM 00846U101 4906 157000 SH DEFINED 1 0 0 157000
ALEXION PHARMACEUTICALS INC COM 015351109 14106 220200 SH DEFINED 1 125200 0 95000
ALIGN TECHNOLOGY INC COM 016255101 15746 1038000 SH DEFINED 1 940000 0 98000
ALLERGAN INC COM 018490102 115357 1400300 SH DEFINED 1 1103400 0 296900
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 294 44700 SH DEFINED 1 44700 0 0
AMARIN CORP PLC SPONS ADR NEW 023111206 16717 1817100 SH SOLE 1817100 0 0
AMGEN INC COM 031162100 7991 145400 SH DEFINED 1 145400 0 0
ANADYS PHARMACEUTICALS INC COM 03252Q408 3768 4140800 SH DEFINED 1 3290800 0 850000
ANTARES PHARMA INC COM 036642106 21099 9094300 SH DEFINED 1 5686300 0 3408000
ANTHERA PHARMACEUTICALS INC COM 03674U102 14310 3000000 SH SOLE 3000000 0 0
ARIAD PHARMACEUTICALS INC COM 04033A100 1705 194000 SH DEFINED 1 194000 0 0
ARQULE INC COM 04269E107 6267 1240900 SH DEFINED 1 1070900 0 170000
ATHERSYS INC COM 04744L106 2844 1615700 SH SOLE 1615700 0 0
BAXTER INTL INC COM 071813109 31888 568000 SH DEFINED 1 340000 0 228000
BIODEL INC COM 09064M105 1608 2977777 SH SOLE 2977777 0 0
BIOGEN IDEC INC COM 09062X103 17633 189300 SH DEFINED 1 43300 0 146000
BIOMARIN PHARMACEUTICAL INC COM 09061G101 52649 1652000 SH DEFINED 1 1379500 0 272500
BOSTON SCIENTIFIC CORP COM 101137107 3842 650000 SH DEFINED 1 0 0 650000
BRISTOL MYERS SQUIBB CO COM 110122108 105587 3364800 SH DEFINED 1 2494400 0 870400
CARDINAL HEALTH INC COM 14149Y108 18302 437000 SH DEFINED 1 275000 0 162000
CAREFUSION CORP COM 14170T101 10394 434000 SH DEFINED 1 279100 0 154900
CELGENE CORP COM 151020104 16035 259000 SH DEFINED 1 84000 0 175000
CHINA NUOKANG BIO-PHARM INC SPONSORED ADS 16949B113 207 43300 SH DEFINED 1 43300 0 0
CIGNA CORP COM 125509109 56711 1352200 SH DEFINED 1 923200 0 429000
COMPLETE GENOMICS INC COM 20454K104 24397 4156270 SH SOLE 4156270 0 0
COVANCE INC COM 222816100 2182 48000 SH DEFINED 1 0 0 48000
CUBIST PHARMACEUTICALS INC COM 229678107 2208 62500 SH DEFINED 1 62500 0 0
CUBIST PHARMACEUTICALS INC COM 229678107 3532 100000 SH CALL DEFINED 1 100000 0 0
CUBIST PHARMACEUTICALS INC NOTE 2.500%11/0 229678AD9 2730 2000000 PRN DEFINED 1 0 0 2000000
CYNOSURE INC CL A 232577205 1769 175300 SH DEFINED 1 136100 0 39200
DAVITA INC COM 23918K108 4074 65000 SH DEFINED 1 0 0 65000
DENDREON CORP COM 24823Q107 7227 803000 SH DEFINED 1 803000 0 0
DENDREON CORP NOTE 2.875% 1/1 24823QAC1 9425 13000000 PRN DEFINED 1 13000000 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 3564 50000 SH DEFINED 1 0 0 50000
ELAN PLC ADR 284131208 33003 3134200 SH DEFINED 1 2556800 0 577400
ENDOCYTE INC COM 29269A102 8154 769200 SH DEFINED 1 533100 0 236100
EXACT SCIENCES CORP COM 30063P105 21219 3200400 SH DEFINED 1 2693900 0 506500
EXPRESS SCRIPTS INC COM 302182100 49162 1326200 SH DEFINED 1 956200 0 370000
FLUIDIGM CORP DEL COM 34385P108 10152 728800 SH DEFINED 1 538800 0 190000
FOREST LABS INC COM 345838106 3079 100000 SH CALL DEFINED 1 100000 0 0
FOREST LABS INC COM 345838106 20629 670000 SH DEFINED 1 450000 0 220000
GILEAD SCIENCES INC COM 375558103 93589 2412100 SH DEFINED 1 1842100 0 570000
GIVEN IMAGING ORD SHS M52020100 13656 905000 SH DEFINED 1 715000 0 190000
GRIFOLS S A SPONSORED ADR 398438309 6940 1086000 SH DEFINED 1 1086000 0 0
HCA HOLDINGS INC COM 40412C101 12114 600900 SH DEFINED 1 500000 0 100900
HOLOGIC INC COM 436440101 3803 250000 SH DEFINED 1 0 0 250000
HOSPIRA INC COM 441060100 18870 510000 SH DEFINED 1 415000 0 95000
HUMAN GENOME SCIENCES INC COM 444903108 27622 2176700 SH DEFINED 1 1687600 0 489100
HUMAN GENOME SCIENCES INC COM 444903108 2221 175000 SH CALL DEFINED 1 175000 0 0
HUMANA INC COM 444859102 64366 885000 SH DEFINED 1 628000 0 257000
ILLUMINA INC COM 452327109 33632 821900 SH DEFINED 1 692400 0 129500
IMPAX LABORATORIES INC COM 45256B101 4839 270200 SH DEFINED 1 180200 0 90000
INCYTE CORP COM 45337C102 61497 4402100 SH DEFINED 1 3560500 0 841600
INCYTE CORP NOTE 4.750%10/0 45337CAJ1 13664 7720000 PRN DEFINED 1 7720000 0 0
INHIBITEX INC COM 45719T103 6977 2836000 SH SOLE 2836000 0 0
INSULET CORP COM 45784P101 22261 1458805 SH SOLE 1458805 0 0
ISHARES TR NASDQ BIO INDX 464287556 32673 350000 SH Put DEFINED 1 350000 0 0
JOHNSON & JOHNSON COM 478160104 34456 541000 SH DEFINED 1 0 0 541000
K V PHARMACEUTICAL CO CL A 482740206 8715 6455500 SH DEFINED 1 5535500 0 920000
LIFE TECHNOLOGIES CORP COM 53217V109 55462 1443200 SH DEFINED 1 1145300 0 297900
MAP PHARMACEUTICALS INC COM 56509R108 21768 1488900 SH DEFINED 1 1004700 0 484200
MCKESSON CORP COM 58155Q103 22544 310100 SH DEFINED 1 145000 0 165100
MEDCO HEALTH SOLUTIONS INC COM 58405U102 8065 172000 SH DEFINED 1 0 0 172000
MEDCO HEALTH SOLUTIONS INC COM 58405U102 16412 350000 SH CALL DEFINED 1 350000 0 0
MEDIVATION INC COM 58501N101 13635 803000 SH DEFINED 1 803000 0 0
MEDIVATION INC COM 58501N101 1274 75000 SH CALL DEFINED 1 75000 0 0
MEDTRONIC INC COM 585055106 41789 1257200 SH DEFINED 1 684200 0 573000
MERCK & CO INC NEW COM 58933Y105 89886 2748800 SH DEFINED 1 1735100 0 1013700
NPS PHARMACEUTICALS INC COM 62936P103 20721 3183000 SH DEFINED 1 2647600 0 535400
NXSTAGE MEDICAL INC COM 67072V103 56951 2730143 SH SOLE 2730143 0 0
ONCOTHYREON INC COM 682324108 4186 700000 SH DEFINED 1 619000 0 81000
ONYX PHARMACEUTICALS INC COM 683399109 2407 80200 SH DEFINED 1 80200 0 0
ONYX PHARMACEUTICALS INC COM 683399109 7503 250000 SH CALL DEFINED 1 250000 0 0
ORASURE TECHNOLOGIES INC COM 68554V108 19963 2507900 SH DEFINED 1 1840900 0 667000
PACIFIC BIOSCIENCES CALIF IN COM 69404D108 905 282000 SH DEFINED 1 282000 0 0
PACIRA PHARMACEUTICALS INC COM 695127100 28091 2828941 SH SOLE 2828941 0 0
PERNIX THERAPEUTICS HLDGS IN COM 71426V108 17640 2000000 SH DEFINED 1 1375000 0 625000
PERRIGO CO COM 714290103 6254 64400 SH DEFINED 1 64400 0 0
PFIZER INC COM 717081103 137110 7755100 SH DEFINED 1 4048000 0 3707100
PHARMACYCLICS INC COM 716933106 41852 3537800 SH DEFINED 1 2687800 0 850000
PHARMACYCLICS INC COM 716933106 2958 250000 SH CALL DEFINED 1 250000 0 0
PHARMASSET INC COM 71715N106 64397 781800 SH DEFINED 1 667300 0 114500
PHARMASSET INC COM 71715N106 8237 100000 SH PUT DEFINED 1 100000 0 0
PHARMASSET INC COM 71715N106 8237 100000 SH CALL DEFINED 1 100000 0 0
QUEST DIAGNOSTICS INC COM 74834L100 3603 73000 SH DEFINED 1 0 0 73000
REGENERON PHARMACEUTICALS COM 75886F107 2479 42600 SH DEFINED 1 42600 0 0
SAVIENT PHARMACEUTICALS INC COM 80517Q100 1025 250000 SH PUT DEFINED 1 250000 0 0
SEQUENOM INC COM NEW 817337405 27903 5471200 SH DEFINED 1 4311200 0 1160000
SEQUENOM INC COM NEW 817337405 3060 600000 SH CALL DEFINED 1 600000 0 0
SHIRE PLC SPONSORED ADR 82481R106 40174 427700 SH DEFINED 1 394800 0 32900
SOLTA MED INC COM 83438K103 611 488700 SH DEFINED 1 317300 0 171400
ST JUDE MED INC COM 790849103 5248 145000 SH DEFINED 1 0 0 145000
STRYKER CORP COM 863667101 18786 398600 SH DEFINED 1 220000 0 178600
SYNERON MEDICAL LTD ORD SHS M87245102 3127 315500 SH DEFINED 1 195500 0 120000
TEVA PHARMACEUTICAL INDS LTD ADR 881624209 19983 536900 SH DEFINED 1 472600 0 64300
THERMO FISHER SCIENTIFIC INC COM 883556102 66075 1304800 SH DEFINED 1 1017700 0 287100
TRANZYME INC COM 89413J102 1848 700000 SH DEFINED 1 700000 0 0
TRIUS THERAPEUTICS INC COM 89685K100 2835 450000 SH DEFINED 1 450000 0 0
UNITEDHEALTH GROUP INC COM 91324P102 84183 1825300 SH DEFINED 1 1211800 0 613500
UROPLASTY INC COM NEW 917277204 4475 922600 SH DEFINED 1 922600 0 0
VALEANT PHARMACEUTICALS INTL COM 91911K102 9206 248000 SH DEFINED 1 110000 0 138000
VALEANT PHARMACEUTICALS INTL COM 91911K102 5568 150000 SH CALL DEFINED 1 150000 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 10226 230000 SH PUT DEFINED 1 230000 0 0
VIVUS INC COM 928551100 43756 5422000 SH DEFINED 1 4377000 0 1045000
VIVUS INC COM 928551100 2421 300000 SH CALL DEFINED 1 300000 0 0
VOLCANO CORPORATION COM 928645100 5482 185000 SH DEFINED 1 185000 0 0
VOLCANO CORPORATION NOTE 2.875% 9/0 928645AA8 1826 1500000 PRN DEFINED 1 1500000 0 0
WARNER CHILCOTT PLC IRELAND SHS A G94368100 60081 4201500 SH DEFINED 1 3283100 0 918400
WATSON PHARMACEUTICALS INC COM 942683103 78631 1152100 SH DEFINED 1 926200 0 225900
WELLPOINT INC COM 94973V107 119998 1838200 SH DEFINED 1 1378300 0 459900
ZIMMER HLDGS INC COM 98956P102 31799 594600 SH DEFINED 1 385000 0 209600