0001172661-14-001118.txt : 20140515 0001172661-14-001118.hdr.sgml : 20140515 20140515162601 ACCESSION NUMBER: 0001172661-14-001118 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20140331 FILED AS OF DATE: 20140515 DATE AS OF CHANGE: 20140515 EFFECTIVENESS DATE: 20140515 FILER: COMPANY DATA: COMPANY CONFORMED NAME: ORBIMED ADVISORS LLC CENTRAL INDEX KEY: 0001055951 IRS NUMBER: 133976876 STATE OF INCORPORATION: DE FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-06774 FILM NUMBER: 14847710 BUSINESS ADDRESS: STREET 1: 601 LEXINGTON AVENUE STREET 2: 54TH FLOOR CITY: NEW YORK STATE: NY ZIP: 10022 BUSINESS PHONE: (212) 739-6400 MAIL ADDRESS: STREET 1: 601 LEXINGTON AVENUE STREET 2: 54TH FLOOR CITY: NEW YORK STATE: NY ZIP: 10022 13F-HR 1 primary_doc.xml 13F-HR LIVE false true false 0001055951 XXXXXXXX 03-31-2014 03-31-2014 false ORBIMED ADVISORS LLC

601 Lexington Avenue 54th Floor New York NY 10022

13F HOLDINGS REPORT 028-06774 N Samuel D. Isaly 212-739-6400 /s/ Samuel D. Isaly New York NY 05-15-2014 1 140 8131588 1 0001157524 028-10410 ORBIMED CAPITAL LLC INFORMATION TABLE 2 infotable.xml ABBOTT LABS COM 002824100 6701 174000 SH DFND 1 22000 0 152000 ABBVIE INC COM 00287Y109 246401 4793800 SH DFND 1 1949400 0 2844400 ABBVIE INC COM 00287Y109 12850 250000 SH Call DFND 1 85500 0 164500 ACCELERON PHARMA INC COM 00434H108 64439 1867800 SH SOLE 1867800 0 0 ACTAVIS PLC SHS G0083B108 101896 495000 SH DFND 1 177000 0 318000 AEGERION PHARMACEUTICALS INC COM 00767E102 9236 200000 SH Call DFND 1 68400 0 131600 AEGERION PHARMACEUTICALS INC COM 00767E102 9236 200000 SH Put DFND 1 68400 0 131600 AETNA INC NEW COM 00817Y108 4723 63000 SH DFND 1 8000 0 55000 AFFYMETRIX INC COM 00826T108 47721 6693000 SH DFND 1 1560000 0 5133000 AGENUS INC COM NEW 00847G705 16009 5050000 SH DFND 1 2255200 0 2794800 AGILENT TECHNOLOGIES INC COM 00846U101 170142 3042600 SH DFND 1 1159600 0 1883000 ALEXION PHARMACEUTICALS INC COM 015351109 40619 267000 SH DFND 1 14000 0 253000 ALIMERA SCIENCES INC COM 016259103 11835 1500000 SH DFND 1 670000 0 830000 ALLERGAN INC COM 018490102 281707 2270000 SH DFND 1 931000 0 1339000 ALLERGAN INC COM 018490102 24820 200000 SH Call DFND 1 68400 0 131600 AMARIN CORP PLC SPONS ADR NEW 023111206 724 400000 SH SOLE 400000 0 0 AMBIT BIOSCIENCES CORP COM 02318X100 13596 1490769 SH SOLE 1490769 0 0 AMGEN INC COM 031162100 285643 2315900 SH DFND 1 865700 0 1450200 ANGIODYNAMICS INC COM 03475V101 3150 200000 SH Call DFND 1 66700 0 133300 ANTARES PHARMA INC COM 036642106 11249 3213900 SH DFND 1 1279800 0 1934100 ANTHERA PHARMACEUTICALS INC COM NEW 03674U201 3125 932750 SH SOLE 932750 0 0 ARQULE INC COM 04269E107 11689 5702000 SH DFND 1 1623100 0 4078900 ARRAY BIOPHARMA INC COM 04269X105 29596 6297000 SH DFND 1 2083200 0 4213800 ARROWHEAD RESH CORP COM NEW 042797209 64202 3910000 SH DFND 1 1061600 0 2848400 ASTRAZENECA PLC SPONSORED ADR 046353108 12976 200000 SH Call DFND 1 68400 0 131600 BACTERIN INTL HLDGS INC COM 05644R101 3994 4754386 SH SOLE 4754386 0 0 BIODEL INC COM NEW 09064M204 1092 400000 SH SOLE 400000 0 0 BIOGEN IDEC INC COM 09062X103 324436 1060700 SH DFND 1 348500 0 712200 BIOLINERX LTD SPONSORED ADR 09071M106 2531 1135000 SH SOLE 1135000 0 0 BIOMARIN PHARMACEUTICAL INC COM 09061G101 101838 1493000 SH DFND 1 500600 0 992400 BIOMARIN PHARMACEUTICAL INC NOTE 0.750%10/1 09061GAE1 546 500000 PRN DFND 1 215000 0 285000 BIOMARIN PHARMACEUTICAL INC NOTE 1.500%10/1 09061GAF8 553 500000 PRN DFND 1 215000 0 285000 BLUEBIRD BIO INC COM 09609G100 6572 289000 SH DFND 1 105100 0 183900 BOSTON SCIENTIFIC CORP COM 101137107 3673 271700 SH DFND 1 34700 0 237000 BRISTOL MYERS SQUIBB CO COM 110122108 309954 5966400 SH DFND 1 2310400 0 3656000 BRISTOL MYERS SQUIBB CO COM 110122108 38963 750000 SH Call DFND 1 255600 0 494400 CARDINAL HEALTH INC COM 14149Y108 18685 267000 SH DFND 1 34000 0 233000 CAREFUSION CORP COM 14170T101 80923 2012000 SH DFND 1 797000 0 1215000 CAREFUSION CORP COM 14170T101 10055 250000 SH Call DFND 1 85500 0 164500 CATALYST PHARM PARTNERS INC COM 14888U101 4283 1895000 SH DFND 1 835000 0 1060000 CELGENE CORP COM 151020104 191447 1371400 SH DFND 1 451000 0 920400 CELLDEX THERAPEUTICS INC NEW COM 15117B103 41482 2347600 SH DFND 1 895800 0 1451800 CERUS CORP COM 157085101 20342 4238000 SH DFND 1 1607300 0 2630700 CERUS CORP COM 157085101 2400 500000 SH Call DFND 1 171000 0 329000 COVANCE INC COM 222816100 6546 63000 SH DFND 1 8000 0 55000 CUBIST PHARMACEUTICALS INC COM 229678107 6584 90000 SH DFND 1 0 0 90000 CURIS INC COM 231269101 5499 1950100 SH DFND 1 0 0 1950100 DAVITA HEALTHCARE PARTNERS I COM 23918K108 9846 143000 SH DFND 1 8000 0 135000 DERMA SCIENCES INC COM PAR $.01 249827502 3804 300000 SH DFND 1 134300 0 165700 DURATA THERAPEUTICS INC COM 26658A107 24046 1785714 SH SOLE 1785714 0 0 ENDOLOGIX INC NOTE 2.250%12/1 29266SAA4 964 1000000 PRN DFND 1 0 0 1000000 EXACT SCIENCES CORP COM 30063P105 26824 1893000 SH DFND 1 769000 0 1124000 EXACT SCIENCES CORP COM 30063P105 1417 100000 SH Put DFND 1 32900 0 67100 EXELIXIS INC COM 30161Q104 10224 2888000 SH DFND 1 867000 0 2021000 EXPRESS SCRIPTS HLDG CO COM 30219G108 157464 2097000 SH DFND 1 784000 0 1313000 FATE THERAPEUTICS INC COM 31189P102 6749 692900 SH DFND 1 296100 0 396800 FIVE PRIME THERAPEUTICS INC COM 33830X104 21142 1075400 SH DFND 1 460000 0 615400 FLUIDIGM CORP DEL COM 34385P108 63778 1447200 SH DFND 1 189000 0 1258200 FLUIDIGM CORP DEL COM 34385P108 11409 100000 SH Call DFND 1 34200 0 65800 FLUIDIGM CORP DEL NOTE 2.750% 2/0 34385PAA6 19395 17000000 PRN DFND 1 5330000 0 11670000 FOREST LABS INC COM 345838106 8673 94000 SH DFND 1 12000 0 82000 GILEAD SCIENCES INC COM 375558103 376607 5314800 SH DFND 1 1775000 0 3539800 GILEAD SCIENCES INC COM 375558103 5315 75000 SH Put DFND 1 25600 0 49400 GW PHARMACEUTICALS PLC ADS 36197T103 5670 95500 SH DFND 1 30700 0 64800 HCA HOLDINGS INC COM 40412C101 221288 4215000 SH DFND 1 1911000 0 2304000 HEALTH NET INC COM 42222G108 87066 2560000 SH DFND 1 1067000 0 1493000 HORIZON PHARMA INC COM 44047T109 2964 196000 SH DFND 1 0 0 196000 ILLUMINA INC COM 452327109 202252 1360500 SH DFND 1 471700 0 888800 IMPAX LABORATORIES INC COM 45256B101 141231 5345600 SH DFND 1 1840700 0 3504900 INCYTE CORP COM 45337C102 167196 3124000 SH DFND 1 1361100 0 1762900 INCYTE CORP NOTE 4.750%10/0 45337CAJ1 24975 4242000 PRN DFND 1 0 0 4242000 INFINITY PHARMACEUTICALS INC COM 45665G303 56322 4736900 SH DFND 1 1766600 0 2970300 INOVIO PHARMACEUTICALS INC COM 45773H102 13277 3987000 SH DFND 1 981000 0 3006000 INSPIREMD INC COM NEW 45779A309 10355 3395000 SH SOLE 3395000 0 0 INSULET CORP COM 45784P101 91687 1933500 SH DFND 1 885300 0 1048200 INTERCEPT PHARMACEUTICALS IN COM 45845P108 572164 1734934 SH SOLE 1734934 0 0 INTERMUNE INC COM 45884X103 199213 5952000 SH DFND 1 2194000 0 3758000 INTUITIVE SURGICAL INC COM NEW 46120E602 147296 336300 SH DFND 1 141500 0 194800 IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 13331 1082100 SH DFND 1 253800 0 828300 IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 3696 300000 SH Call DFND 1 102500 0 197500 ISHARES NASDQ BIOTEC ETF 464287556 23640 100000 SH Put DFND 1 34200 0 65800 JAZZ PHARMACEUTICALS PLC SHS USD G50871105 15948 115000 SH DFND 1 0 0 115000 JOHNSON & JOHNSON COM 478160104 58643 597000 SH DFND 1 76000 0 521000 LILLY ELI & CO COM 532457108 31961 543000 SH DFND 1 50000 0 493000 MACROGENICS INC COM 556099109 13689 491897 SH SOLE 491897 0 0 MANNKIND CORP COM 56400P201 1608 400000 SH Put DFND 1 190700 0 209300 MCKESSON CORP COM 58155Q103 102234 579000 SH DFND 1 220000 0 359000 MEDIVATION INC COM 58501N101 175350 2724100 SH DFND 1 1079000 0 1645100 MEDTRONIC INC COM 585055106 19877 323000 SH DFND 1 18000 0 305000 MEI PHARMA INC COM NEW 55279B202 21420 1924500 SH DFND 1 859500 0 1065000 MERCK & CO INC NEW COM 58933Y105 144593 2547000 SH DFND 1 922000 0 1625000 MERGE HEALTHCARE INC COM 589499102 11294 4628500 SH DFND 1 1621000 0 3007500 MIMEDX GROUP INC COM 602496101 4876 795400 SH DFND 1 273600 0 521800 MIRATI THERAPEUTICS INC COM 60468T105 24302 1274332 SH SOLE 1274332 0 0 MOLINA HEALTHCARE INC COM 60855R100 84623 2253000 SH DFND 1 952000 0 1301000 MYLAN INC COM 628530107 190706 3905500 SH DFND 1 1645100 0 2260400 MYLAN INC COM 628530107 9766 200000 SH Call DFND 1 68400 0 131600 NEUROCRINE BIOSCIENCES INC COM 64125C109 87761 5451000 SH DFND 1 1903000 0 3548000 NUVASIVE INC COM 670704105 12138 316000 SH DFND 1 177000 0 139000 NXSTAGE MEDICAL INC COM 67072V103 26920 2113000 SH SOLE 2113000 0 0 ORASURE TECHNOLOGIES INC COM 68554V108 42815 5372000 SH DFND 1 2430000 0 2942000 PERNIX THERAPEUTICS HLDGS IN COM 71426V108 11762 2198500 SH DFND 1 682400 0 1516100 PERRIGO CO PLC SHS G97822103 163445 1056800 SH DFND 1 366700 0 690100 PERRIGO CO PLC SHS G97822103 7733 50000 SH Call DFND 1 17100 0 32900 PFIZER INC COM 717081103 117591 3661000 SH DFND 1 1358000 0 2303000 PORTOLA PHARMACEUTICALS INC COM 737010108 24804 957700 SH DFND 1 255400 0 702300 PROTHENA CORP PLC SHS G72800108 72368 1889000 SH DFND 1 658000 0 1231000 PTC THERAPEUTICS INC COM 69366J200 21699 830100 SH DFND 1 215900 0 614200 QLT INC COM 746927102 1668 300000 SH DFND 1 63300 0 236700 QUESTCOR PHARMACEUTICALS INC COM 74835Y101 5194 80000 SH DFND 1 0 0 80000 QUESTCOR PHARMACEUTICALS INC COM 74835Y101 3247 50000 SH Call DFND 1 17100 0 32900 RAPTOR PHARMACEUTICAL CORP COM 75382F106 6000 600000 SH DFND 1 200400 0 399600 REDHILL BIOPHARMA LTD SPONSORED ADS 757468103 8899 631580 SH SOLE 631580 0 0 REGENERON PHARMACEUTICALS COM 75886F107 161851 539000 SH DFND 1 231000 0 308000 RELYPSA INC COM 759531106 296358 9941551 SH SOLE 9941551 0 0 SHIRE PLC SPONSORED ADR 82481R106 87187 587000 SH DFND 1 195000 0 392000 SINOVAC BIOTECH LTD SHS P8696W104 11790 1637500 SH DFND 1 759500 0 878000 SPDR S&P 500 ETF TR TR UNIT 78462F103 74804 400000 SH Put DFND 1 136700 0 263300 ST JUDE MED INC COM 790849103 74976 1146600 SH DFND 1 466800 0 679800 STRYKER CORP COM 863667101 51057 626700 SH DFND 1 214600 0 412100 SUNESIS PHARMACEUTICALS INC COM NEW 867328601 7932 1200000 SH DFND 1 538400 0 661600 SUPERNUS PHARMACEUTICALS INC COM 868459108 5185 580000 SH DFND 1 0 0 580000 SYNAGEVA BIOPHARMA CORP COM 87159A103 9218 111100 SH DFND 1 34300 0 76800 TESARO INC COM 881569107 24993 847800 SH DFND 1 272900 0 574900 THERMO FISHER SCIENTIFIC INC COM 883556102 167518 1393200 SH DFND 1 600200 0 793000 TORNIER N V SHS N87237108 31302 1475100 SH DFND 1 644600 0 830500 UNITEDHEALTH GROUP INC COM 91324P102 8363 102000 SH DFND 1 13000 0 89000 UROPLASTY INC COM NEW 917277204 4950 1363500 SH DFND 1 600600 0 762900 VALEANT PHARMACEUTICALS INTL COM 91911K102 17533 133000 SH DFND 1 17000 0 116000 VANDA PHARMACEUTICALS INC COM 921659108 7514 462400 SH DFND 1 72100 0 390300 VERTEX PHARMACEUTICALS INC COM 92532F100 11315 160000 SH DFND 1 0 0 160000 VERTEX PHARMACEUTICALS INC COM 92532F100 6867 97100 SH Put DFND 1 33200 0 63900 VOCERA COMMUNICATIONS INC COM 92857F107 7308 447500 SH DFND 1 189700 0 257800 VOLCANO CORPORATION NOTE 1.750%12/0 928645AB6 14887 15000000 PRN DFND 1 4683000 0 10317000 XENCOR INC COM 98401F105 9404 801700 SH DFND 1 0 0 801700 XENOPORT INC COM 98411C100 28673 5546100 SH DFND 1 2098700 0 3447400 XOMA CORP DEL COM 98419J107 12697 2437000 SH DFND 1 641800 0 1795200 ZIMMER HLDGS INC COM 98956P102 67738 716200 SH DFND 1 270700 0 445500 ZOETIS INC CL A 98978V103 6396 221000 SH DFND 1 28000 0 193000 ZOGENIX INC COM 98978L105 875 307600 SH Call DFND 1 105200 0 202400