Managing Member

0001172661-14-000746.txt : 20140214 0001172661-14-000746.hdr.sgml : 20140214 20140214162505 ACCESSION NUMBER: 0001172661-14-000746 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20131231 FILED AS OF DATE: 20140214 DATE AS OF CHANGE: 20140214 EFFECTIVENESS DATE: 20140214 FILER: COMPANY DATA: COMPANY CONFORMED NAME: ORBIMED ADVISORS LLC CENTRAL INDEX KEY: 0001055951 IRS NUMBER: 133976876 STATE OF INCORPORATION: DE FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-06774 FILM NUMBER: 14617094 BUSINESS ADDRESS: STREET 1: 601 LEXINGTON AVENUE STREET 2: 54TH FLOOR CITY: NEW YORK STATE: NY ZIP: 10022 BUSINESS PHONE: (212) 739-6400 MAIL ADDRESS: STREET 1: 601 LEXINGTON AVENUE STREET 2: 54TH FLOOR CITY: NEW YORK STATE: NY ZIP: 10022 13F-HR 1 primary_doc.xml 13F-HR LIVE false true false 0001055951 XXXXXXXX 12-31-2013 12-31-2013 false ORBIMED ADVISORS LLC

601 Lexington Avenue 54th Floor New York NY 10022

13F HOLDINGS REPORT 028-06774 N Samuel D. Isaly Managing Member 212-739-6400 /s/ Samuel D. Isaly New York NY 02-14-2014 1 120 6804448 1 0001157524 028-10410 ORBIMED CAPITAL LLC INFORMATION TABLE 2 infotable.xml ABBOTT LABS COM 002824100 11691 305000 SH DFND 1 22000 0 283000 ABBVIE INC COM 00287Y109 198613 3760900 SH DFND 1 1309000 0 2451900 ABBVIE INC COM 00287Y109 13203 250000 SH Call DFND 1 82700 0 167300 ACADIA PHARMACEUTICALS INC COM 004225108 3374 135000 SH DFND 1 0 0 135000 ACCELERON PHARMA INC COM 00434H108 83859 2117648 SH SOLE 2117648 0 0 ACTAVIS PLC SHS G0083B108 119784 713000 SH DFND 1 239000 0 474000 AETNA INC NEW COM 00817Y108 80463 1173100 SH DFND 1 464100 0 709000 AFFYMETRIX INC COM 00826T108 58362 6810000 SH DFND 1 1560000 0 5250000 AGILENT TECHNOLOGIES INC COM 00846U101 172577 3017600 SH DFND 1 1204600 0 1813000 ALEXION PHARMACEUTICALS INC COM 015351109 30949 232900 SH DFND 1 14000 0 218900 ALLERGAN INC COM 018490102 86109 775200 SH DFND 1 231500 0 543700 AMARIN CORP PLC SPONS ADR NEW 023111206 1182 600000 SH SOLE 600000 0 0 AMBIT BIOSCIENCES CORP COM 02318X100 14371 1490769 SH SOLE 1490769 0 0 AMGEN INC COM 031162100 286945 2515300 SH DFND 1 887000 0 1628300 ANTARES PHARMA INC COM 036642106 20531 4592000 SH DFND 1 1739200 0 2852800 ANTHERA PHARMACEUTICALS INC COM NEW 03674U201 2864 932750 SH SOLE 932750 0 0 ARQULE INC COM 04269E107 12259 5702000 SH DFND 1 1623100 0 4078900 ARRAY BIOPHARMA INC COM 04269X105 26678 5325000 SH DFND 1 1862000 0 3463000 ARROWHEAD RESH CORP COM NEW 042797209 23099 2128900 SH DFND 1 618500 0 1510400 BACTERIN INTL HLDGS INC COM 05644R101 1627 3254386 SH SOLE 3254386 0 0 BAXTER INTL INC COM 071813109 16970 244000 SH DFND 1 19600 0 224400 BIODEL INC COM NEW 09064M204 1248 547443 SH SOLE 547443 0 0 BIOGEN IDEC INC COM 09062X103 306159 1095100 SH DFND 1 366900 0 728200 BIOLINERX LTD SPONSORED ADR 09071M106 3189 1135000 SH SOLE 1135000 0 0 BIOMARIN PHARMACEUTICAL INC COM 09061G101 99482 1414100 SH DFND 1 513200 0 900900 BIOMARIN PHARMACEUTICAL INC NOTE 0.750%10/1 09061GAE1 537 500000 PRN DFND 1 215000 0 285000 BIOMARIN PHARMACEUTICAL INC NOTE 1.500%10/1 09061GAF8 538 500000 PRN DFND 1 215000 0 285000 BRISTOL MYERS SQUIBB CO COM 110122108 290465 5465000 SH DFND 1 2024000 0 3441000 BRISTOL MYERS SQUIBB CO COM 110122108 29233 550000 SH Call DFND 1 181500 0 368500 CARDINAL HEALTH INC COM 14149Y108 15386 230300 SH DFND 1 34000 0 196300 CAREFUSION CORP COM 14170T101 86469 2171500 SH DFND 1 835700 0 1335800 CATALYST PHARM PARTNERS INC COM 14888U101 3695 1895000 SH DFND 1 835000 0 1060000 CELGENE CORP COM 151020104 296894 1757100 SH DFND 1 538200 0 1218900 CELLDEX THERAPEUTICS INC NEW COM 15117B103 31730 1310600 SH DFND 1 507700 0 802900 CERUS CORP COM 157085101 21769 3375000 SH DFND 1 1226400 0 2148600 CHINDEX INTERNATIONAL INC COM 169467107 627 36000 SH SOLE 36000 0 0 COVANCE INC COM 222816100 5196 59000 SH DFND 1 8000 0 51000 CUBIST PHARMACEUTICALS INC COM 229678107 6198 90000 SH DFND 1 0 0 90000 CURIS INC COM 231269101 5499 1950100 SH DFND 1 0 0 1950100 DAVITA HEALTHCARE PARTNERS I COM 23918K108 9062 143000 SH DFND 1 8000 0 135000 DURATA THERAPEUTICS INC COM 26658A107 22839 1785714 SH SOLE 1785714 0 0 ENDOLOGIX INC NOTE 2.250%12/1 29266SAA4 1016 1000000 PRN DFND 1 0 0 1000000 EXACT SCIENCES CORP COM 30063P105 58624 4989300 SH DFND 1 2035300 0 2954000 EXACT SCIENCES CORP COM 30063P105 1013 86200 SH Put DFND 1 28200 0 58000 EXELIXIS INC COM 30161Q104 57555 9389000 SH DFND 1 2579200 0 6809800 EXPRESS SCRIPTS HLDG CO COM 30219G108 90399 1287000 SH DFND 1 445000 0 842000 FATE THERAPEUTICS INC COM 31189P102 4409 702000 SH DFND 1 300000 0 402000 FLUIDIGM CORP DEL COM 34385P108 55356 1446008 SH DFND 1 189000 0 1257008 FOREST LABS INC COM 345838106 8344 139000 SH DFND 1 12000 0 127000 FOREST LABS INC COM 345838106 9005 150000 SH Call DFND 1 49600 0 100400 GILEAD SCIENCES INC COM 375558103 374944 4992600 SH DFND 1 1692000 0 3300600 GW PHARMACEUTICALS PLC ADS 36197T103 13301 320200 SH DFND 1 87100 0 233100 HCA HOLDINGS INC COM 40412C101 179294 3758000 SH DFND 1 1757000 0 2001000 HEALTH NET INC COM 42222G108 46327 1561400 SH DFND 1 589600 0 971800 HOSPIRA INC COM 441060100 3509 85000 SH DFND 1 8000 0 77000 ILLUMINA INC COM 452327109 176590 1596800 SH DFND 1 598900 0 997900 ILLUMINA INC COM 452327109 11059 100000 SH Call DFND 1 33100 0 66900 IMPAX LABORATORIES INC COM 45256B101 106533 4237600 SH DFND 1 1442700 0 2794900 INCYTE CORP COM 45337C102 206013 4069000 SH DFND 1 1786000 0 2283000 INCYTE CORP COM 45337C102 3544 70000 SH Call DFND 1 22900 0 47100 INCYTE CORP NOTE 4.750%10/0 45337CAJ1 28454 4992000 PRN DFND 1 0 0 4992000 INFINITY PHARMACEUTICALS INC COM 45665G303 66209 4794300 SH DFND 1 1766600 0 3027700 INSPIREMD INC COM NEW 45779A309 8352 3395000 SH SOLE 3395000 0 0 INSULET CORP COM 45784P101 107163 2888500 SH DFND 1 1298500 0 1590000 INTERCEPT PHARMACEUTICALS IN COM 45845P108 118461 1734934 SH SOLE 1734934 0 0 INTERMUNE INC COM 45884X103 113377 7697000 SH DFND 1 2738000 0 4959000 INTUITIVE SURGICAL INC COM NEW 46120E602 28614 74500 SH DFND 1 16500 0 58000 JAZZ PHARMACEUTICALS PLC SHS USD G50871105 14554 115000 SH DFND 1 0 0 115000 JOHNSON & JOHNSON COM 478160104 57335 626000 SH DFND 1 76000 0 550000 MACROGENICS INC COM 556099109 13493 491897 SH DFND 1 481869 0 10028 MCKESSON CORP COM 58155Q103 57297 355000 SH DFND 1 134000 0 221000 MEDIVATION INC COM 58501N101 199342 3123500 SH DFND 1 1265800 0 1857700 MEDTRONIC INC COM 585055106 18537 323000 SH DFND 1 18000 0 305000 MEI PHARMA INC COM NEW 55279B202 15936 1989500 SH DFND 1 859500 0 1130000 MERCK & CO INC NEW COM 58933Y105 127477 2547000 SH DFND 1 922000 0 1625000 MERGE HEALTHCARE INC COM 589499102 10738 4628500 SH DFND 1 1621000 0 3007500 MIMEDX GROUP INC COM 602496101 6118 700000 SH DFND 1 273600 0 426400 MIRATI THERAPEUTICS INC COM 60468T105 21192 1274332 SH SOLE 1274332 0 0 MOLINA HEALTHCARE INC COM 60855R100 71693 2063100 SH DFND 1 887900 0 1175200 MYLAN INC COM 628530107 182909 4214500 SH DFND 1 1746000 0 2468500 NEUROCRINE BIOSCIENCES INC COM 64125C109 24574 2631000 SH DFND 1 983000 0 1648000 NXSTAGE MEDICAL INC COM 67072V103 26792 2679216 SH SOLE 2679216 0 0 OPHTHOTECH CORP COM 683745103 1116 34500 SH DFND 1 0 0 34500 ORASURE TECHNOLOGIES INC COM 68554V108 31375 4988000 SH DFND 1 2226800 0 2761200 OREXIGEN THERAPEUTICS INC NOTE 2.750%12/0 686164AA2 7317 7500000 PRN DFND 1 2210000 0 5290000 PERNIX THERAPEUTICS HLDGS IN COM 71426V108 5848 2320800 SH DFND 1 682400 0 1638400 PERRIGO CO COM 714290103 118625 773000 SH DFND 1 291000 0 482000 PERRIGO CO COM 714290103 26856 175000 SH Call DFND 1 57400 0 117600 PFIZER INC COM 717081103 108828 3553000 SH DFND 1 1298000 0 2255000 PORTOLA PHARMACEUTICALS INC COM 737010108 24661 957700 SH DFND 1 255400 0 702300 PROTHENA CORP PLC SHS G72800108 31877 1202000 SH DFND 1 413500 0 788500 QIAGEN NV REG SHS N72482107 45882 1927000 SH DFND 1 437000 0 1490000 QLT INC COM 746927102 2507 450000 SH DFND 1 92200 0 357800 QUESTCOR PHARMACEUTICALS INC COM 74835Y101 4356 80000 SH DFND 1 0 0 80000 QUESTCOR PHARMACEUTICALS INC COM 74835Y101 4628 85000 SH Call DFND 1 28100 0 56900 REGENERON PHARMACEUTICALS COM 75886F107 203347 738800 SH DFND 1 280500 0 458300 RELYPSA INC COM 759531106 248539 9941549 SH SOLE 9941549 0 0 SHIRE PLC SPONSORED ADR 82481R106 102294 724000 SH DFND 1 271000 0 453000 SINOVAC BIOTECH LTD SHS P8696W104 10022 1637500 SH DFND 1 759500 0 878000 SPDR S&P 500 ETF TR TR UNIT 78462F103 370 250000 SH Put DFND 1 82700 0 167300 ST JUDE MED INC COM 790849103 51642 833600 SH DFND 1 324400 0 509200 STRYKER CORP COM 863667101 53853 716700 SH DFND 1 248600 0 468100 SUPERNUS PHARMACEUTICALS INC COM 868459108 4373 580000 SH DFND 1 0 0 580000 SYNAGEVA BIOPHARMA CORP COM 87159A103 8414 130000 SH DFND 1 34300 0 95700 TECHNE CORP COM 878377100 4734 50000 SH DFND 1 0 0 50000 TEVA PHARMACEUTICAL INDS LTD ADR 881624209 152 200000 SH Put DFND 1 65600 0 134400 THERMO FISHER SCIENTIFIC INC COM 883556102 170833 1534200 SH DFND 1 621200 0 913000 UNITED THERAPEUTICS CORP DEL COM 91307C102 6219 55000 SH DFND 1 0 0 55000 UNITEDHEALTH GROUP INC COM 91324P102 59562 791000 SH DFND 1 232000 0 559000 UROPLASTY INC COM NEW 917277204 3941 1443500 SH DFND 1 600600 0 842900 VALEANT PHARMACEUTICALS INTL COM 91911K102 18432 157000 SH DFND 1 17000 0 140000 VANDA PHARMACEUTICALS INC COM 921659108 12286 990000 SH DFND 1 262300 0 727700 VERTEX PHARMACEUTICALS INC COM 92532F100 18947 255000 SH DFND 1 8000 0 247000 VOCERA COMMUNICATIONS INC COM 92857F107 6985 447500 SH DFND 1 189700 0 257800 WELLPOINT INC COM 94973V107 39635 429000 SH DFND 1 148000 0 281000 XENCOR INC COM 98401F105 6422 702600 SH DFND 1 0 0 702600 XENOPORT INC COM 98411C100 26397 4590800 SH DFND 1 1706300 0 2884500 XOMA CORP DEL COM 98419J107 19043 2829627 SH DFND 1 758800 0 2070827 ZIMMER HLDGS INC COM 98956P102 77832 835200 SH DFND 1 310700 0 524500 ZOETIS INC CL A 98978V103 9121 279000 SH DFND 1 28000 0 251000