0001172661-12-000217.txt : 20120214
0001172661-12-000217.hdr.sgml : 20120214
20120214134854
ACCESSION NUMBER: 0001172661-12-000217
CONFORMED SUBMISSION TYPE: 13F-HR
PUBLIC DOCUMENT COUNT: 1
CONFORMED PERIOD OF REPORT: 20111231
FILED AS OF DATE: 20120214
DATE AS OF CHANGE: 20120214
EFFECTIVENESS DATE: 20120214
FILER:
COMPANY DATA:
COMPANY CONFORMED NAME: ORBIMED ADVISORS LLC
CENTRAL INDEX KEY: 0001055951
IRS NUMBER: 133976876
STATE OF INCORPORATION: DE
FILING VALUES:
FORM TYPE: 13F-HR
SEC ACT: 1934 Act
SEC FILE NUMBER: 028-06774
FILM NUMBER: 12607379
BUSINESS ADDRESS:
STREET 1: 601 LEXINGTON AVENUE
STREET 2: 54TH FLOOR
CITY: NEW YORK
STATE: NY
ZIP: 10022
BUSINESS PHONE: (212) 739-6400
MAIL ADDRESS:
STREET 1: 601 LEXINGTON AVENUE
STREET 2: 54TH FLOOR
CITY: NEW YORK
STATE: NY
ZIP: 10022
13F-HR
1
orbimedadvisors4q11.txt
FORM 13F HOLDINGS REPORT
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
Form 13F
Form 13F COVER PAGE
Report for the Calendar Year or Quarter Ended: December 31, 2011
Check here if Amendment [ ]; Amendment Number:
This Amendment (Check only one.): [ ] is a restatement.
[ ] adds new holdings entries.
Institutional Investment Manager Filing this Report:
Name: OrbiMed Advisors LLC
Address: 601 Lexington Avenue
54th Floor
New York, NY 10022
13F File Number: 028-06774
The institutional investment manager filing this report and the person by whom
it is signed hereby represent that the person signing the report is authorized
to submit it, that all information contained herein is true, correct and
complete, and that it is understood that all required items, statements,
schedules, lists, and tables, are considered integral parts of this form.
Person Signing this Report on Behalf of Reporting Manager:
Name: Samuel D. Isaly
Title: Managing Member
Phone: (212) 739-6400
Signature, Place, and Date of Signing:
/s/ Samuel D. Isaly New York, NY February 14, 2012
Report Type (Check only one.):
[ X] 13F HOLDINGS REPORT.
[ ] 13F NOTICE.
[ ] 13F COMBINATION REPORT.
FORM 13F SUMMARY PAGE
Report Summary:
Number of Other Included Managers: 1
Form 13F Information Table Entry Total: 115
Form 13F Information Table Value Total: $3,049,023 (thousands)
List of Other Included Managers:
Provide a numbered list of the name(s) and Form 13F file number(s) of all
institutional managers with respect to which this report is filed, other
than the manager filing this report.
No. 13F File Number Name
1 028-10410 OrbiMed Capital LLC
FORM 13F INFORMATION TABLE
VALUE SHARES/ SH/ PUT/ INVSTMT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DSCRETN MANAGERS SOLE SHARED NONE
------------------------------ ---------------- --------- -------- -------- --- ---- ------- ------------ -------- -------- --------
3SBIO INC SPONSORED ADR 88575Y105 22209 2173100 SH DEFINED 1 745200 0 1427900
ABBOTT LABS COM 002824100 34413 612000 SH DEFINED 1 0 0 612000
AETNA INC NEW COM 00817Y108 85899 2036000 SH DEFINED 1 880400 0 1155600
AFFYMAX INC COM 00826A109 19810 2996900 SH DEFINED 1 875900 0 2121000
AFFYMAX INC COM 00826A109 1322 200000 SH CALL DEFINED 1 51500 0 148500
AFFYMETRIX INC COM 00826T108 28017 6850100 SH DEFINED 1 1885500 0 4964600
AGILENT TECHNOLOGIES INC COM 00846U101 5484 157000 SH DEFINED 1 0 0 157000
ALEXION PHARMACEUTICALS INC COM 015351109 15637 218700 SH DEFINED 1 3200 0 215500
ALIGN TECHNOLOGY INC COM 016255101 24294 1024000 SH DEFINED 1 675000 0 349000
ALLERGAN INC COM 018490102 110044 1254200 SH DEFINED 1 629500 0 624700
AMARIN CORP PLC SPONS ADR NEW 023111206 13610 1817100 SH SOLE 1817100 0 0
AMGEN INC COM 031162100 9221 143600 SH DEFINED 1 3600 0 140000
AMGEN INC COM 031162100 12842 200000 SH PUT DEFINED 1 52000 0 148000
ANTARES PHARMA INC COM 036642106 18963 8619700 SHS DEFINED 1 2943300 0 5676400
ANTHERA PHARMACEUTICALS INC COM 03674U102 17387 2831800 SH SOLE 2831800 0 0
ARIAD PHARMACEUTICALS INC COM 04033A100 26003 2122700 SH DEFINED 1 527500 0 1595200
ATHERSYS INC COM 04744L106 2795 1615700 SH SOLE 1615700 0 0
BAXTER INTL INC COM 071813109 27907 564000 SH DEFINED 1 190000 0 374000
BIODEL INC COM 09064M105 2166 3550300 SH SOLE 3550300 0 0
BIOGEN IDEC INC COM 09062X103 54893 498800 SH DEFINED 1 134300 0 364500
BIOMARIN PHARMACEUTICAL INC COM 09061G101 56356 1639200 SH DEFINED 1 895100 0 744100
BOSTON SCIENTIFIC CORP COM 101137107 3471 650000 SH DEFINED 1 0 0 650000
BRISTOL MYERS SQUIBB CO COM 110122108 136745 3880400 SH DEFINED 1 1712500 0 2167900
BRISTOL MYERS SQUIBB CO COM 110122108 17620 500000 SH CALL DEFINED 1 130000 0 370000
CARDINAL HEALTH INC COM 14149Y108 17625 434000 SH DEFINED 1 185000 0 249000
CAREFUSION CORP COM 14170T101 11132 438100 SH DEFINED 1 34600 0 403500
CELGENE CORP COM 151020104 56378 834000 SH DEFINED 1 172300 0 661700
CELSION CORPORATION COM NEW 15117N305 2573 1513514 SH DEFINED 1 788514 0 725000
CHINA NUOKANG BIO-PHARM INC SPONSORED ADS 16949B113 1042 377358 SH DEFINED 1 205100 0 172258
CIGNA CORPORATION COM 125509109 16800 400000 SH DEFINED 1 207000 0 193000
COMPLETE GENOMICS INC COM 20454K104 12178 4156270 SH SOLE 4156270 0 0
COVANCE INC COM 222816100 2195 48000 SH DEFINED 1 0 0 48000
CUBIST PHARMACEUTICALS INC COM 229678107 5876 148300 SH DEFINED 1 4000 0 144300
CUBIST PHARMACEUTICALS INC COM 229678107 3962 100000 SH CALL DEFINED 1 25500 0 74500
CUBIST PHARMACEUTICALS INC NOTE 2.500%11/0 229678AD9 3003 2000000 PRN DEFINED 1 0 0 2000000
CYNOSURE INC CL A 232577205 2358 200500 SH DEFINED 1 96600 0 103900
DAVITA INC COM 23918K108 4928 65000 SH DEFINED 1 0 0 65000
DENDREON CORP COM 24823Q107 31683 4168800 SH DEFINED 1 2250400 0 1918400
DENDREON CORP NOTE 2.875% 1/1 24823QAC1 13825 20000000 PRN DEFINED 1 0 0 20000000
EDWARDS LIFESCIENCES CORP COM 28176E108 3535 50000 SH DEFINED 1 0 0 50000
ELAN PLC ADR 284131208 42682 3106400 SH DEFINED 1 1629800 0 1476600
ENDOCYTE INC COM 29269A102 7274 1934600 SH DEFINED 1 582600 0 1352000
EXACT SCIENCES CORP COM 30063P105 32679 4024500 SH DEFINED 1 1722100 0 2302400
EXPRESS SCRIPTS INC COM 302182100 9385 210000 SH DEFINED 1 0 0 210000
FLUIDIGM CORP DEL COM 34385P108 9563 726700 SH DEFINED 1 7700 0 719000
FOREST LABS INC COM 345838106 20123 665000 SH DEFINED 1 300000 0 365000
FOREST LABS INC COM 345838106 3026 100000 SH CALL DEFINED 1 25000 0 75000
GILEAD SCIENCES INC COM 375558103 89256 2180700 SH DEFINED 1 402100 0 1778600
GIVEN IMAGING ORD SHS M52020100 15635 897000 SH DEFINED 1 500000 0 397000
GRIFOLS S A SPONSORED ADR 398438309 6382 1154000 SH DEFINED 1 597000 0 557000
HCA HOLDINGS INC COM 40412C101 12967 588600 SH DEFINED 1 330000 0 258600
HOLOGIC INC COM 436440101 4378 250000 SH DEFINED 1 0 0 250000
HUMAN GENOME SCIENCES INC COM 444903108 17642 2387300 SH DEFINED 1 877400 0 1509900
HUMAN GENOME SCIENCES INC COM 444903108 1848 250000 SH CALL DEFINED 1 64000 0 186000
HUMANA INC COM 444859102 75178 858100 SH DEFINED 1 349100 0 509000
IMPAX LABORATORIES INC COM 45256B101 14169 702500 SH DEFINED 1 259500 0 443000
INCYTE CORP COM 45337C102 3002 200000 SH CALL DEFINED 1 52000 0 148000
INCYTE CORP COM 45337C102 79149 5273100 SH DEFINED 1 2642600 0 2630500
INCYTE CORP NOTE 4.750%10/0 45337CAJ1 14547 7720000 PRN DEFINED 1 1286200 0 6433800
INHIBITEX INC COM 45719T103 12450 1138000 SH SOLE 1138000 0 0
INSULET CORP COM 45784P101 27469 1458805 SH SOLE 1458805 0 0
INTERMUNE INC COM 45884X103 6217 493400 SH DEFINED 1 198500 0 294900
JOHNSON & JOHNSON COM 478160104 29570 450900 SH DEFINED 1 0 0 450900
K V PHARMACEUTICAL CO CL A 482740206 9032 6451400 SH DEFINED 1 1823900 0 4627500
LIFE TECHNOLOGIES CORP COM 53217V109 59797 1536800 SH DEFINED 1 594500 0 942300
LILLY ELI & CO COM 532457108 11429 275000 SH CALL DEFINED 1 142500 0 132500
MAP PHARMACEUTICALS INC COM 56509R108 18546 1408200 SH DEFINED 1 478000 0 930200
MCKESSON CORP COM 58155Q103 18153 233000 SH DEFINED 1 97000 0 136000
MEDCO HEALTH SOLUTIONS INC COM 58405U102 60786 1087400 SH DEFINED 1 479400 0 608000
MEDCO HEALTH SOLUTIONS INC COM 58405U102 19565 350000 SH CALL DEFINED 1 86500 0 263500
MEDIVATION INC COM 58501N101 19823 429900 SH DEFINED 1 58000 0 371900
MEDTRONIC INC COM 585055106 41409 1082600 SH DEFINED 1 138600 0 944000
MERCK & CO INC NEW COM 58933Y105 89933 2385500 SH DEFINED 1 1085100 0 1300400
NPS PHARMACEUTICALS INC COM 62936P103 21328 3236400 SH DEFINED 1 1486700 0 1749700
NXSTAGE MEDICAL INC COM 67072V103 48542 2730143 SH SOLE 2730143 0 0
ORASURE TECHNOLOGIES INC COM 68554V108 26500 2908900 SH DEFINED 1 1236600 0 1672300
PACIFIC BIOSCIENCES CALIF IN COM 69404D108 790 282000 SH DEFINED 1 0 0 282000
PACIRA PHARMACEUTICALS INC COM 695127100 23627 2731500 SH SOLE 2731500 0 0
PERNIX THERAPEUTICS HLDGS IN COM 71426V108 19778 2135800 SH DEFINED 1 782800 0 1353000
PERRIGO CO COM 714290103 7210 74100 SH DEFINED 1 1900 0 72200
PFIZER INC COM 717081103 174323 8055600 SH DEFINED 1 2619600 0 5436000
PHARMACYCLICS INC COM 716933106 29033 1959050 SH DEFINED 1 430600 0 1528450
PHARMACYCLICS INC COM 716933106 3260 220000 SH CALL DEFINED 1 55000 0 165000
PHARMASSET INC COM 71715N106 108932 849700 SH DEFINED 1 332000 0 517700
PHARMASSET INC COM 71715N106 83330 650000 SH CALL DEFINED 1 77500 0 572500
QUEST DIAGNOSTICS INC COM 74834L100 4238 73000 SH DEFINED 1 0 0 73000
QUESTCOR PHARMACEUTICALS INC COM 74835Y101 14353 345200 SH DEFINED 1 87200 0 258000
REGENERON PHARMACEUTICALS COM 75886F107 30919 557800 SH DEFINED 1 249900 0 307900
SALIX PHARMACEUTICALS INC COM 795435106 3096 64700 SH DEFINED 1 1700 0 63000
SEQUENOM INC COM NEW 817337405 27381 6153000 SH DEFINED 1 3010000 0 3143000
SEQUENOM INC COM NEW 817337405 2670 600000 SH CALL DEFINED 1 126000 0 474000
SHIRE PLC SPONSORED ADR 82481R106 43867 422200 SH DEFINED 1 230900 0 191300
SINOVAC BIOTECH LTD SHS P8696W104 548 249000 SH SOLE 249000 0 0
SOLTA MED INC COM 83438K103 1535 488700 SH DEFINED 1 163000 0 325700
ST JUDE MED INC COM 790849103 4974 145000 SH DEFINED 1 0 0 145000
STRYKER CORP COM 863667101 19576 393800 SH DEFINED 1 220000 0 173800
SYNERON MEDICAL LTD ORD SHS M87245102 3136 283300 SH DEFINED 1 83600 0 199700
TARGACEPT INC COM 87611R306 173 31100 SH DEFINED 1 1100 0 30000
THERMO FISHER SCIENTIFIC INC COM 883556102 61613 1370100 SH DEFINED 1 584200 0 785900
TRANZYME INC COM 89413J102 2023 700000 SH DEFINED 1 0 0 700000
TRIUS THERAPEUTICS INC COM 89685K100 1496 209300 SH DEFINED 1 0 0 209300
UNITED THERAPEUTICS CORP DEL COM 91307C102 4725 100000 SH CALL DEFINED 1 26000 0 74000
UNITED THERAPEUTICS CORP DEL COM 91307C102 4607 97500 SH DEFINED 1 2500 0 95000
UNITEDHEALTH GROUP INC COM 91324P102 89141 1758900 SH DEFINED 1 764900 0 994000
UROPLASTY INC COM NEW 917277204 4254 1001000 SH DEFINED 1 521000 0 480000
VALEANT PHARMACEUTICALS INTL COM 91911K102 11579 248000 SH DEFINED 1 0 0 248000
VIVUS INC COM 928551100 60099 6164000 SH DEFINED 1 2337000 0 3827000
VIVUS INC COM 928551100 3413 350000 SH CALL DEFINED 1 88900 0 261100
VOLCANO CORPORATION COM 928645100 4401 185000 SH DEFINED 1 0 0 185000
VOLCANO CORPORATION NOTE 2.875% 9/0 928645AA8 1609 1500000 PRN DEFINED 1 0 0 1500000
WARNER CHILCOTT PLC IRELAND SHS A G94368100 64243 4246100 SH DEFINED 1 1896400 0 2349700
WATSON PHARMACEUTICALS INC COM 942683103 70013 1160300 SH DEFINED 1 632400 0 527900
WELLPOINT INC COM 94973V107 111757 1686900 SH DEFINED 1 786900 0 900000
XENOPORT INC COM 98411C100 95 25000 SH PUT DEFINED 1 6500 0 18500
ZIMMER HLDGS INC COM 98956P102 31571 591000 SH DEFINED 1 229500 0 361500