-----BEGIN PRIVACY-ENHANCED MESSAGE----- Proc-Type: 2001,MIC-CLEAR Originator-Name: webmaster@www.sec.gov Originator-Key-Asymmetric: MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB MIC-Info: RSA-MD5,RSA, T83kqjtRZ7PRRzlQ/S5wHQx71uUs0EWLwyrV5JNetmjUbMW/ETJA3rWF8ndgf5Wx gPXk+AgaQY1gH59chIPd4A== 0001172661-08-000852.txt : 20081114 0001172661-08-000852.hdr.sgml : 20081114 20081114155410 ACCESSION NUMBER: 0001172661-08-000852 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 1 CONFORMED PERIOD OF REPORT: 20080930 FILED AS OF DATE: 20081114 DATE AS OF CHANGE: 20081114 EFFECTIVENESS DATE: 20081114 FILER: COMPANY DATA: COMPANY CONFORMED NAME: ORBIMED ADVISORS LLC CENTRAL INDEX KEY: 0001055951 IRS NUMBER: 133976876 STATE OF INCORPORATION: DE FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-06774 FILM NUMBER: 081191084 BUSINESS ADDRESS: STREET 1: 767 3RD AVENUE STREET 2: 30TH FLOOR CITY: NEW YORK STATE: NY ZIP: 10017 BUSINESS PHONE: 2126845700 MAIL ADDRESS: STREET 1: 767 3RD AVENUE STREET 2: 30TH FLOOR CITY: NEW YORK STATE: NY ZIP: 10017 13F-HR 1 orb3q08.txt FORM 13F HOLDINGS REPORT UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 13F Form 13F COVER PAGE Report for the Calendar Year or Quarter Ended: September 30, 2008 Check here if Amendment [ ]; Amendment Number: This Amendment (Check only one.): [ ] is a restatement. [ ] adds new holdings entries. Institutional Investment Manager Filing this Report: Name: OrbiMed Advisors, LLC Address: 767 3rd Avenue 30th Floor New York, NY 10017 13F File Number: 28-06774 The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form. Person Signing this Report on Behalf of Reporting Manager: Name: Samuel D. Isaly Title: Managing Member Phone: (212) 739-6400 Signature, Place, and Date of Signing: /s/ Samuel D. Isaly New York, NY November 14, 2008 Report Type (Check only one.): [ X] 13F HOLDINGS REPORT. [ ] 13F NOTICE. [ ] 13F COMBINATION REPORT. FORM 13F SUMMARY PAGE Report Summary: Number of Other Included Managers: 1 Form13F Information Table Entry Total: 94 Form13F Information Table Value Total: $3,475,809 (thousands) List of Other Included Managers: Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional managers with respect to which this report is filed, other than the manager filing this report. No. 13F File Number Name 1 28-10410 Orbimed Capital LLC FORM 13F INFORMATION TABLE VALUE SHARES/ SH/ PUT/ INVSTMT OTHER VOTING AUTHORITY NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DSCRETN MANAGERS SOLE SHARED NONE - ------------------------------ ---------------- --------- -------- -------- --- ---- ------- ------------ -------- -------- -------- ABBOTT LABS COM 002824100 105688 1835500 SH DEFINED 1 1690500 0 145000 ACHILLION PHARMACEUTICALS IN COM 00448Q201 80 61600 SH SOLE 61600 0 0 AFFYMETRIX INC COM 00826T108 6331 818000 SH DEFINED 1 818000 0 0 AFFYMETRIX INC COM 00826T108 3870 500000 SH CALL DEFINED 1 390000 0 110000 ALEXZA PHARMACEUTICALS INC COM 015384100 2179 441100 SH DEFINED 1 441100 0 0 ALIGN TECHNOLOGY INC COM 016255101 46777 4319200 SH DEFINED 1 3662700 0 656500 ALLOS THERAPEUTICS INC COM 019777101 36005 4859000 SH DEFINED 1 3859000 0 1000000 ALPHARMA INC CL A 020813101 3689 100000 SH CALL DEFINED 1 75000 0 25000 ALTUS PHARMACEUTICALS INC COM 02216N105 930 845900 SH DEFINED 1 845900 0 0 AMARIN CORP PLC SPONS ADR NEW 023111206 2935 3260870 SH SOLE 3260870 0 0 AMERICAN ORIENTAL BIOENGR IN COM 028731107 2680 413000 SH DEFINED 1 413000 0 0 AMGEN INC COM 031162100 190915 3221100 SH DEFINED 1 2716200 0 504900 AMYLIN PHARMACEUTICALS INC COM 032346108 24792 1226100 SH DEFINED 1 922600 0 303500 ANTARES PHARMA INC COM 036642106 1380 1890400 SH DEFINED 1 1316100 0 574300 AP PHARMA INC COM NEW 00202J203 1645 2193400 SH DEFINED 1 2193400 0 0 APPLIED BIOSYSTEMS INC DEL COM 038149100 3425 100000 SH SOLE 0 0 100000 ARIAD PHARMACEUTICALS INC COM 04033A100 5074 2054200 SH DEFINED 1 2054200 0 0 ARYX THERAPEUTICS INC COM 043387109 13008 2125493 SH DEFINED 1 2125493 0 0 ASPECT MED SYS INC COM 045235108 5874 1127400 SH DEFINED 1 827000 0 300400 ATHERSYS INC COM 04744L106 6000 3448000 SH SOLE 3448000 0 0 AVANIR PHARMACEUTICALS CL A NEW 05348P401 2690 4638759 SH DEFINED 1 4638759 0 0 AVIGEN INC COM 053690103 3855 963800 SH DEFINED 1 963800 0 0 BAXTER INTL INC COM 071813109 73427 1118800 SH DEFINED 1 976300 0 142500 BECKMAN COULTER INC COM 075811109 8164 115000 SH SOLE 0 0 115000 BECTON DICKINSON & CO COM 075887109 8829 110000 SH SOLE 0 0 110000 BIOCRYST PHARMACEUTICALS COM 09058V103 5888 1869231 SH DEFINED 1 1869231 0 0 BIODEL INC COM 09064M105 6072 1812574 SH DEFINED 1 1812574 0 0 BIOGEN IDEC INC COM 09062X103 155864 3099300 SH DEFINED 1 2643400 0 455900 BIOMARIN PHARMACEUTICAL INC COM 09061G101 75653 2855900 SH DEFINED 1 2505900 0 350000 BRISTOL MYERS SQUIBB CO COM 110122108 148569 7125600 SH DEFINED 1 6175600 0 950000 CELGENE CORP COM 151020104 8834 139600 SH DEFINED 1 139600 0 0 CEPHEID COM 15670R107 4965 359000 SH DEFINED 1 359000 0 0 COVANCE INC COM 222816100 4244 48000 SH SOLE 0 0 48000 COVIDIEN LTD COM G2552X108 87994 1636800 SH DEFINED 1 1315800 0 321000 CUBIST PHARMACEUTICALS INC COM 229678107 34161 1536700 SH DEFINED 1 1536700 0 0 CURIS INC COM 231269101 5892 5123711 SH DEFINED 1 5123711 0 0 CYTOKINETICS INC COM 23282W100 18337 3868600 SH DEFINED 1 3868600 0 0 DENDREON CORP COM 24823Q107 571 100000 SH CALL DEFINED 1 100000 0 0 DENDREON CORP COM 24823Q107 6778 1187000 SH DEFINED 1 792000 0 395000 DENDREON CORP COM 24823Q107 334 58500 SH PUT DEFINED 1 58500 0 0 ELAN PLC ADR 284131208 19003 1781000 SH DEFINED 1 1351000 0 430000 ENTEROMEDICS INC COM 29365M109 1400 450000 SH SOLE 0 0 450000 EXELIXIS INC COM 30161Q104 42006 6908800 SH DEFINED 1 5708800 0 1200000 GEN-PROBE INC NEW COM 36866T103 128657 2425200 SH DEFINED 1 2184600 0 240600 GENELABS TECHNOLOGIES INC COM NEW 368706206 1168 2717392 SH DEFINED 1 2717392 0 0 GENENTECH INC COM NEW 368710406 274650 3097090 SH DEFINED 1 2735090 0 362000 GENENTECH INC COM NEW 368710406 44340 500000 SH CALL DEFINED 1 375000 0 125000 GENOMIC HEALTH INC COM 37244C101 27681 1222100 SH DEFINED 1 1222100 0 0 GENZYME CORP COM 372917104 217554 2689500 SH DEFINED 1 2369500 0 320000 GILEAD SCIENCES INC COM 375558103 135567 2971000 SH DEFINED 1 2411000 0 560000 GILEAD SCIENCES INC COM 375558103 13689 300000 SH CALL DEFINED 1 200000 0 100000 HUMAN GENOME SCIENCES INC COM 444903108 10795 1700000 SH DEFINED 1 1252800 0 447200 IMCLONE SYS INC COM 45245W109 239791 3842800 SH DEFINED 1 3394800 0 448000 INDEVUS PHARMACEUTICALS INC COM 454072109 19254 5747400 SH DEFINED 1 4747400 0 1000000 INFINITY PHARMACEUTICALS INC COM 45665G303 9282 1197650 SH DEFINED 1 1197650 0 0 INSULET CORP COM 45784P101 21838 1568819 SH DEFINED 1 1568819 0 0 INTERMUNE INC COM 45884X103 54001 3156100 SH DEFINED 1 2708400 0 447700 INVITROGEN CORP COM 46185R100 5708 151000 SH DEFINED 1 51000 0 100000 ISHARES TR NASDQ BIO INDX 464287556 40680 500000 SH CALL DEFINED 1 350000 0 150000 MASIMO CORP COM 574795100 54863 1474800 SH DEFINED 1 1254800 0 220000 MEDTRONIC INC COM 585055106 25301 505000 SH SOLE 0 0 505000 MERCK & CO INC COM 589331107 4734 150000 SH CALL DEFINED 1 114000 0 36000 MILLIPORE CORP COM 601073109 3922 57000 SH SOLE 0 0 57000 MYLAN INC COM 628530107 26768 2344000 SH DEFINED 1 1969000 0 375000 NEOSE TECHNOLOGIES INC COM 640522108 602 1881000 SH DEFINED 1 1881000 0 0 NEUROBIOLOGICAL TECH INC COM NEW 64124W304 266 435600 SH SOLE 0 0 435600 NEUROGEN CORP COM 64124E106 1070 4457994 SH DEFINED 1 4457994 0 0 NPS PHARMACEUTICALS INC COM 62936P103 31133 4360400 SH DEFINED 1 4360400 0 0 NXSTAGE MEDICAL INC COM 67072V103 24131 5718256 SH SOLE 5718256 0 0 ONYX PHARMACEUTICALS INC COM 683399109 102502 2833100 SH DEFINED 1 2637600 0 195500 OREXIGEN THERAPEUTICS INC COM 686164104 1009 93500 SH DEFINED 1 93500 0 0 OSCIENT PHARMACEUTICALS CORP NOTE 3.500% 4/1 68812RAC9 4964 28365000 SH DEFINED 1 28365000 0 0 XOMA LTD ORD G9825R107 35802 17048469 SH DEFINED 1 13644069 0 3404400 OSI PHARMACEUTICALS INC COM 671040103 51893 1052800 SH DEFINED 1 942800 0 110000 PAR PHARMACEUTICAL COS INC COM 69888P106 40119 3264400 SH DEFINED 1 2746800 0 517600 PFIZER INC COM 717081103 161870 8778200 SH DEFINED 1 8003200 0 775000 PHARMACOPEIA INC COM 7171EP101 894 600000 SH DEFINED 1 600000 0 0 PONIARD PHARMACEUTICALS INC COM NEW 732449301 11240 2614000 SH DEFINED 1 2614000 0 0 QLT INC COM 746927102 5284 1621000 SH DEFINED 1 1288100 0 332900 SCHERING PLOUGH CORP COM 806605101 43488 2354500 SH DEFINED 1 2354500 0 0 SHIRE LIMITED SPONSORED ADR 82481R106 100695 2108800 SH DEFINED 1 1848800 0 260000 ST JUDE MED INC COM 790849103 6524 150000 SH SOLE 0 0 150000 STRYKER CORP COM 863667101 4050 65000 SH SOLE 0 0 65000 TARGANTA THERAPEUTICS CORP COM 87612C100 12280 1843909 SH SOLE 1843909 0 0 TARGETED GENETICS CORP COM NEW 87612M306 557 1325000 SH DEFINED 1 1325000 0 0 TEVA PHARMACEUTICAL INDS LTD ADR 881624209 5128 112000 SH DEFINED 1 112000 0 0 THERMO FISHER SCIENTIFIC INC COM 883556102 13750 250000 SH SOLE 0 0 250000 TRIMERIS INC COM 896263100 7306 1859000 SH DEFINED 1 1859000 0 0 UNITED THERAPEUTICS CORP DEL COM 91307C102 60588 576100 SH DEFINED 1 535800 0 40300 VERTEX PHARMACEUTICALS INC COM 92532F100 134469 4045400 SH DEFINED 1 3605400 0 440000 VIVUS INC COM 928551100 14367 1809500 SH DEFINED 1 1809500 0 0 VOLCANO CORPORATION COM 928645100 36395 2104999 SH DEFINED 1 2104999 0 0 WATERS CORP COM 941848103 3491 60000 SH SOLE 0 0 60000 WYETH COM 983024100 12892 349000 SH SOLE 0 0 349000
-----END PRIVACY-ENHANCED MESSAGE-----