EX-10.29

                     SECOND AMENDMENT TO SUBLEASE AGREEMENT

     This Second Amendment (the "Amendment") is dated for reference purposes
this 6th day of March, 2002, and amends that certain Sublease Agreement dated
March 30, 2001 made by and between F5 Networks, Inc., a Washington corporation,
as Sublandlord, and Cell Therapeutics, Inc., a Washington corporation, as
Subtenant, as previously amended by the First Amendment dated April 13, 2001
(collectively, "Sublease"). The capitalized terms in this Amendment shall have
the meaning given to those same terms in the Sublease, unless a different
meaning has been provided herein

NOW, THEREFORE, the parties hereby amend the Sublease as follows:

1. Area 2A. Effective July 15, 2002, the Subleased Premises shall include Area
2A, comprising 14,666 rentable square feet on the second floor. The Commencement
Date for Area 2A shall be July 15,2002, and the Rent Commencement Date for Area
2A shall be August 1, 2002. Subtenant has had an opportunity to inspect Area 2A
and accepts Area 2A in its current, "AS-IS" condition. All other terms and
conditions of the Sublease shall apply to Area 2A the same as other portions of
the Subleased Premises, including, but not limited to the Expiration Date.

2. Base Rent and Operating Expenses. The Base Rent for Area 2A shall be as
stated in Section 3.1 (b) of the Sublease. Effective July 15, 2002 when Area 2A
is included as part of the Premises, Subtenant will have leased the entire
Building and Subtenant's proportionate share for purposes of calculating
Additional Rent shall be 100%, all as provided in Section 3.2 of the Sublease.

3. Miscellaneous. In the event of any conflict between the terms of this
Amendment and the Sublease, this Amendment shall control. The parties hereby
ratify and confirm their obligations under the Sublease as amended by this
Amendment. This Amendment and the Sublease constitute the entire agreement
between Sublandlord and Subtenant with respect to the Subleased Premises, and
may not be amended or altered except by written agreement executed by both
parties. This Amendment may be executed in one or more counterparts, each signed
counterpart shall be deemed an original, and all counterparts together shall
constitute a single, integrated agreement. Facsimile transmission of any signed
original document, and retransmission of any signed facsimile transmission,
shall be the same as delivery of an original. At the request of either party,
the parties will confirm facsimile transmitted signatures by signing an original
document.



IN WITNESS WHEREOF, the parties have entered into this Amendment effective as of
the date stated above.

                                        SUBLANDLORD:

                                        F5 Networks, Inc., a Washington
                                        corporation


                                        By:
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                                        Name:
                                              ----------------------------------
                                        Title:
                                               ---------------------------------


                                        SUBTENANT:

                                        Cell Therapeutics, Inc., a Washington
                                        corporation


                                        By:
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                                        Name:
                                              ----------------------------------
                                        Title:
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