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  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardPurchasePriceOfCommonStockPercentageOnFirstDayOfOfferingPeriod" id="rigl_ShareBasedCompensationArrangementByShareBasedPaymentAwardPurchasePriceOfCommonStockPercentageOnFirstDayOfOfferingPeriod" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardPurchasePriceOfCommonStockPercentOnPurchaseDate" id="rigl_ShareBasedCompensationArrangementByShareBasedPaymentAwardPurchasePriceOfCommonStockPercentOnPurchaseDate" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardOfferingPeriod" id="rigl_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardOfferingPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfPurchasePeriodsPerAwardOfferingPeriod" id="rigl_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfPurchasePeriodsPerAwardOfferingPeriod" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardPurchasePeriod" id="rigl_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardPurchasePeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="NumberOfActiveCollaborations" id="rigl_NumberOfActiveCollaborations" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="AstraZenecaMember" id="rigl_AstraZenecaMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DaiichiSankyoMember" id="rigl_DaiichiSankyoMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="OtherAgreementsMember" id="rigl_OtherAgreementsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DeliverablesSingleUnitOfAccountingMember" id="rigl_DeliverablesSingleUnitOfAccountingMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="MilestoneAchievementGroupOneMember" id="rigl_MilestoneAchievementGroupOneMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="AchievementOfMilestoneAxis" id="rigl_AchievementOfMilestoneAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="AchievementOfMilestoneDomain" id="rigl_AchievementOfMilestoneDomain" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="SpecifiedDevelopmentRegulatoryAndLaunchEventsMember" id="rigl_SpecifiedDevelopmentRegulatoryAndLaunchEventsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="SpecifiedSalesLevelsMember" id="rigl_SpecifiedSalesLevelsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="BerGenBioASMember" id="rigl_BerGenBioASMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="CollaborativeArrangementUpfrontFeeReceived" id="rigl_CollaborativeArrangementUpfrontFeeReceived" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="CollaborativeArrangementNumberOfUnitsOfAccounting" id="rigl_CollaborativeArrangementNumberOfUnitsOfAccounting" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="CollaborativeArrangementRevenueRecognized" id="rigl_CollaborativeArrangementRevenueRecognized" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="CollaborativeArrangementMaximumAmountOfPaymentReceivable" id="rigl_CollaborativeArrangementMaximumAmountOfPaymentReceivable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element name="CollaborativeArrangementPotentialAmountOfPaymentReceivable" id="rigl_CollaborativeArrangementPotentialAmountOfPaymentReceivable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element name="CollaborativeArrangementCumulativePaymentsEarnedThroughoutArrangement" id="rigl_CollaborativeArrangementCumulativePaymentsEarnedThroughoutArrangement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="CollaborativeArrangementTerminationOfAgreementUncuredBreachPeriod" id="rigl_CollaborativeArrangementTerminationOfAgreementUncuredBreachPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="CollaborativeArrangementNoticePeriodForTerminationOfAgreementWithoutCause" id="rigl_CollaborativeArrangementNoticePeriodForTerminationOfAgreementWithoutCause" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="CollaborativeArrangementNoticePeriodForTerminationOfAgreementDueToChangeOfControl" id="rigl_CollaborativeArrangementNoticePeriodForTerminationOfAgreementDueToChangeOfControl" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="CollaborativeArrangementPaymentsReceived" id="rigl_CollaborativeArrangementPaymentsReceived" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="CollaborativeArrangementPeriodInResearchPhase" id="rigl_CollaborativeArrangementPeriodInResearchPhase" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="CollaborativeArrangementUpfrontPaymentReceivable" id="rigl_CollaborativeArrangementUpfrontPaymentReceivable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element name="CollaborativeArrangementMaximumPeriodForUpfrontPaymentFromAgreementDate" id="rigl_CollaborativeArrangementMaximumPeriodForUpfrontPaymentFromAgreementDate" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="CorporateBondSecuritiesAndCommercialPaperMember" id="rigl_CorporateBondSecuritiesAndCommercialPaperMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="CashAndCashEquivalentsAndAvailableForSaleSecurities" id="rigl_CashAndCashEquivalentsAndAvailableForSaleSecurities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element name="CashEquivalentsAndAvailableForSaleSecuritiesWeightedAverageMaturityPeriod" id="rigl_CashEquivalentsAndAvailableForSaleSecuritiesWeightedAverageMaturityPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="AvailableForSaleSecuritiesDebtSecuritiesCurrentStatedMaturityPeriodMayBeGreaterThan" id="rigl_AvailableForSaleSecuritiesDebtSecuritiesCurrentStatedMaturityPeriodMayBeGreaterThan" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="LossContingencyNumberOfLawsuitsConsolidatedIntoSingleAction" id="rigl_LossContingencyNumberOfLawsuitsConsolidatedIntoSingleAction" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ScheduleOfCashAndCashEquivalentsAndAvailableForSaleSecuritiesTable" id="rigl_ScheduleOfCashAndCashEquivalentsAndAvailableForSaleSecuritiesTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="CashAndCashEquivalentsAndAvailableForSaleSecuritiesLineItems" id="rigl_CashAndCashEquivalentsAndAvailableForSaleSecuritiesLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="CashEquivalentsAndAvailableForSaleSecuritiesAbstract" id="rigl_CashEquivalentsAndAvailableForSaleSecuritiesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="CashEquivalentsAndAvailableForSaleSecuritiesAmortizedCost" id="rigl_CashEquivalentsAndAvailableForSaleSecuritiesAmortizedCost" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element name="CashEquivalentsAndAvailableForSaleSecuritiesGrossUnrealizedGain" id="rigl_CashEquivalentsAndAvailableForSaleSecuritiesGrossUnrealizedGain" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element name="CashEquivalentsAndAvailableForSaleSecuritiesGrossUnrealizedLosses" id="rigl_CashEquivalentsAndAvailableForSaleSecuritiesGrossUnrealizedLosses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="CashAndCashEquivalentsAndAvailableForSaleSecuritiesDebtSecuritiesCurrent" id="rigl_CashAndCashEquivalentsAndAvailableForSaleSecuritiesDebtSecuritiesCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element name="CashEquivalentsAndAvailableForSaleSecuritiesDebtSecuritiesUnrealizedGainLossFairValueDisclosure" id="rigl_CashEquivalentsAndAvailableForSaleSecuritiesDebtSecuritiesUnrealizedGainLossFairValueDisclosure" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element name="CashEquivalentsAndAvailableForSaleSecuritiesDebtMaturitiesFairValueRollingMaturityAbstract" id="rigl_CashEquivalentsAndAvailableForSaleSecuritiesDebtMaturitiesFairValueRollingMaturityAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="CashEquivalentsAndAvailableForSaleSecuritiesDebtMaturitiesNextRollingTwelveMonthsFairValue" id="rigl_CashEquivalentsAndAvailableForSaleSecuritiesDebtMaturitiesNextRollingTwelveMonthsFairValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element name="CashEquivalentsAndAvailableForSaleSecuritiesDebtMaturitiesRollingYearTwoThroughFiveFairValue" id="rigl_CashEquivalentsAndAvailableForSaleSecuritiesDebtMaturitiesRollingYearTwoThroughFiveFairValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element name="NatureOfOperationsPolicyTextBlock" id="rigl_NatureOfOperationsPolicyTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="R256Member" id="rigl_R256Member" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="MerckSeronoSAMember" id="rigl_MerckSeronoSAMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="CollaborativeArrangementFinalPaymentReceived" id="rigl_CollaborativeArrangementFinalPaymentReceived" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="CommonStockSharesAuthorizedBeforeAmendment" id="rigl_CommonStockSharesAuthorizedBeforeAmendment" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <xsd:element name="SpecifiedDevelopmentEventsMember" id="rigl_SpecifiedDevelopmentEventsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="SpecifiedRegulatoryEventsMember" id="rigl_SpecifiedRegulatoryEventsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
</xsd:schema>
