SECURITIES AND EXCHANGE COMMISSION
                                  Washington, D.C.  20549

                                        SCHEDULE 13G

                         Under the Securities Exchange Act of 1934
                                     (Amendment No. 1)*

                                 INTROGEN THERAPEUTICS, INC.
                                      (Name of Issuer)

                                        Common Stock
                               (Title of Class of Securities)

                                          46119F107
                                       (CUSIP Number)

                                     December 31, 2003
                  (Date of Event Which Requires Filing of this Statement)

     Check the appropriate box to designate the rule pursuant to which this
Schedule is filed:

     / /  Rule 13d-1(b)
     /X/  Rule 13d-1(c)
     / /  Rule 13d-1(d)

*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities,
and for any subsequent amendment containing information which would alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be
deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 ("Act") or otherwise subject to the liabilities of that section of
the Act but shall be subject to all other provisions of the Act (however, see
the Notes).




Pursuant to Rule 13d-2(b) of Regulation 13D-G of the General Rules and
Regulations under the Securities Exchange Act of 1934, as amended (the "Act"),
the undersigned hereby amends its Schedule 13G statement dated June 27,
2003 (the "Schedule 13G") relating to the shares of common stock of Introgen
Therapeutics, Inc. (the "Issuer").  Unless otherwise indicated, all defined
terms used herein shall have the same meanings as those set forth in the
Schedule 13G.

Item 2(a).     Names of Persons Filing.

     Pursuant to Rules 13d-1(k)(1)-(2) of Regulation 13D-G of the General Rules
and Regulations under the Act, the Schedule 13G is hereby amended by HBK
Investments L.P., a Delaware limited partnership (the "Reporting Person").
Additionally, information is included herein with respect to the following
persons (collectively, the "Controlling Persons"): HBK Partners II L.P., a
Delaware limited partnership ("Partners II"), HBK Management L.L.C., a Delaware
limited liability company ("Management") and Harlan B. Korenvaes, Kenneth M.
Hirsh, Laurence H. Lebowitz, William E. Rose, Richard L. Booth, David C. Haley
and Jamiel A. Akhtar, members of Management, who may control Management
("Managers").  The Reporting Person and the Controlling Persons are sometimes
hereinafter collectively referred to as the "Item 2 Persons."

Item 5.  Ownership of Five Percent or Less of a Class.

     Item 5 is hereby amended and restated in its entirety as follows:

     The Reporting Person has ceased to be the beneficial owners of five
percent or more of the Common Stock of the Issuer.






    After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete
and correct.

    DATED:    February 13, 2004

                                                  HBK INVESTMENTS L.P.


                                                  By:  /s/ William E. Rose
                                                       William E. Rose
                                                       Authorized Signatory (1)

(1)  An Authorization Certificate authorizing William E. Rose to act on behalf
     of HBK Investments L.P. was previously filed.