EXHIBIT 5.1

March 21, 2003                                                 Morris M. Sherman
                                                                    612-335-1561

                                                      morris.sherman@leonard.com

Antares Pharma, Inc.
707 Eagleview Boulevard
Suite 414
Exton, PA  19341

         Re:  Registration Statement on Form S-3

Ladies and Gentlemen:

This opinion is furnished to you in connection with a Registration Statement on
Form S-3 (the "Registration Statement") to be filed with the Securities and
Exchange Commission (the "Commission") under the Securities Act of 1933, as
amended (the "Securities Act"), for the registration of an aggregate of
4,511,518 shares of Common Stock, $.01 par value (the "Shares"), of Antares
Pharma, Inc., a Minnesota corporation (the "Company").

We are acting as counsel for the Company in connection with the registration for
resale of the Shares. We have examined signed copies of the Registration
Statement as filed with the Commission. We have also examined and relied upon
the minutes of meetings of the shareholders and the Board of Directors of the
Company as provided to us by the Company, the Articles of Incorporation and
By-Laws of the Company, each as restated and/or amended to date, and such other
documents as we have deemed necessary for purposes of rendering the opinions
hereinafter set forth.

In our examination of the foregoing documents, we have assumed the genuineness
of all signatures, the authenticity of all documents submitted to us as
originals, the conformity to original documents of all documents submitted to us
as copies, the authenticity of the originals of such latter documents and the
legal competence of all signatories to such documents.

We assume that the appropriate action will be taken, prior to the offer and
re-sale of the Shares, to register and qualify the Shares for sale under all
applicable state securities or "blue sky" laws.

We express no opinion herein as to the laws of any state or jurisdiction other
than the state laws of the State of Minnesota and the federal laws of the United
States of America.



Based upon and subject to the foregoing, we are of the opinion that the Shares
have been duly authorized and are validly issued, fully paid and nonassessable.

It is understood that this opinion is to be used only in connection with the
offer and sale of the Shares while the Registration Statement is in effect. It
is understood that this opinion is as of the date of this letter and we disclaim
any undertaking to advise you of changes which thereafter may be brought to our
attention.

Please note that we are opining only as to the matters expressly set forth
herein and no opinion should be inferred as to any other matters.

We hereby consent to the filing of this opinion with the Commission as an
exhibit to the Registration Statement in accordance with the requirements of
Item 601(b)(5) of Regulation S-K under the Securities Act and to the use of our
name therein and in the related Prospectus under the caption "Legal Matters." In
giving such consent, we do not hereby admit that we are in the category of
persons whose consent is required under Section 7 of the Securities Act or the
rules and regulations of the Commission.

Very truly yours,

LEONARD, STREET AND DEINARD
PROFESSIONAL ASSOCIATION


/s/ Morris M. Sherman
Morris  M. Sherman