13F-HR 1 oracleinvestment4q2012.txt ORACLE INVESTMENT MANAGEMENT, INC. UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 13F Form 13F COVER PAGE Report for the Calendar Year or Quarter Ended: December 31, 2012 Check here if Amendment [ ]; Amendment Number: This Amendment (Check only one.): [ ] is a restatement. [ ] adds new holdings entries. Institutional Investment Manager Filing this Report: Name: Oracle Investment Management, Inc. Address: 200 Greenwich Avenue Greenwich, CT 06830 13F File Number: 028-05592 The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form. Person Signing this Report on Behalf of Reporting Manager: Name: Aileen K. Wiate Title: CFO Phone: (203) 862-7900 Signature, Place, and Date of Signing: /s/ Aileen K. Wiate Greenwich, CT February 14, 2013 Report Type (Check only one.): [ X] 13F HOLDINGS REPORT. [ ] 13F NOTICE. [ ] 13F COMBINATION REPORT. FORM 13F SUMMARY PAGE Report Summary: Number of Other Included Managers: 0 Form 13F Information Table Entry Total: 23 Form 13F Information Table Value Total: $445,681,783 List of Other Included Managers: Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional managers with respect to which this report is filed, other than the manager filing this report. NONE FORM 13F INFORMATION TABLE SHARES/ SH/ PUT/ INVSTMT OTHER VOTING AUTHORITY NAME OF ISSUER TITLE OF CLASS CUSIP VALUE PRN AMT PRN CALL DSCRETN MANAGERS SOLE SHARED NONE ------------------------------ ---------------- --------- -------- -------- --- ---- ------- ------------ -------- -------- -------- ACCELR8 TECHNOLOGY CORP COM NEW 004304200 15112109 2150300 SH SOLE 2150300 0 0 ACCURAY INC COM 004397105 18572572 2888425 SH SOLE 2888425 0 0 ACHILLION PHARMACEUTICALS IN COM 00448Q201 7139641 891341 SH SOLE 891341 0 0 ACORDA THERAPEUTICS INC COM 00484M106 49632194 1996468 SH SOLE 1996468 0 0 AGENUS INC 00847G101 4405150 1074426 SH SOLE 1074426 0 0 BIOGEN IDEC INC COM 09062X103 1802985 12318 SH SOLE 12318 0 0 GENTIVA HEALTH SERVICES INC COM 37247A102 12833156 1276931 SH SOLE 1276931 0 0 GTX INC DEL COM 40052B108 16884012 4020003 SH SOLE 4020003 0 0 HANSEN MEDICAL INC COM 411307101 16598709 7980149 SH SOLE 7980149 0 0 HEALTH NET INC COM 42222G108 1822500 75000 SH SOLE 75000 0 0 IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 8402850 758380 SH SOLE 758380 0 0 LADENBURG THALMAN FIN SVCS I COM 50575Q102 280000 200000 SH SOLE 200000 0 0 MAKO SURGICAL CORP COM 560879108 13519125 1052072 SH SOLE 1052072 0 0 MAP PHARMACEUTICALS INC COM 56509R108 17079111 1091317 SH SOLE 1091317 0 0 METABOLIX INC COM 591018809 2454026 1658126 SH SOLE 1658126 0 0 NXSTAGE MEDICAL INC COM 67072V103 5799903 515547 SH SOLE 515547 0 0 OPKO HEALTH INC COM 68375N103 24325575 5057292 SH SOLE 5057292 0 0 QUIDEL CORP COM 74838J101 61266669 3281557 SH SOLE 3281557 0 0 TENET HEALTHCARE CORP 88033G100 90369952 2783183 SH SOLE 2783183 0 0 TESARO INC COM 881569107 11132963 656812 SH SOLE 656812 0 0 THORATEC CORP COM NEW 885175307 55805334 1487349 SH SOLE 1487349 0 0 TRANSITION THERAPEUTICS INC COM NEW 893716209 8105483 3586497 SH SOLE 3586497 0 0 VIVUS INC COM 928551100 2337764 174200 SH SOLE 174200 0 0