UNITED STATES
SECURITIES EXCHANGE COMMISSION
Washington, D.C.  20549



		SCHEDULE 13G/A
Under the Securities Exchange Act of 1934
		Amendment No. 1

    	      Connetics Corp.

	     (Name of Issuer)

               Common Stock

       (Title of Class of Securities)

                208192104

   	      (CUSIP Number)



           December 31, 2005

(Date of Event which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to
which this Schedule is filed:

[ X ]	Rule 13d-1(b)
[   ]	Rule 13d-1(c)
[   ]	Rule 13d-1(d)


CUSIP No.  208192104

1.Names of Reporting Persons.

Longwood Investment Advisors, Inc.

I.R.S. Identification Nos. of above persons (entities only).

23-2745059

2.Check the Appropriate Box if a Member of a Group

(a) [   ]
(b) [ X ]

3.SEC Use Only

4.Citizenship or Place of Incorporaion

Pennsylvania, United States


Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With

5.Sole Voting Power	0

6.Shared Voting Power	None

7.Sole Dispositive Power  	0

8.Shared Dispositive Power	None

9.Aggregate Amount Beneficially Owned by Each Reporting Person	0

10.Check if the Aggregate Amount in Row (9) Excludes Certain Shares  [   ]

11.Percent of Class Represented by Amount in Row (9) 0%

12.Type of Reporting Person:  IA

Item 1(a).	Name of Issuer:

		Connetics Corp.

Item 1(b).	Address of Issuer's Principal Executive Offices:

		3400 W BAYSHORE RD
		PALO ALTO CA 94303

Item 2(a).	Name of Person Filing
Item 2(b).	Address of Principal Business Office or, if None, Residence
Item 2(c).	Citizenship

		Longwood Investment Advisors, Inc.
		1275 Drummers Lane, Suite 207
		Wayne, Pennsylvania  19087

Item 2(d).	Title of Class of Securities:

		Common Stock

Item 2(e).	CUSIP Number:

		208192104

Item 3.	If This Statement is Filed Pursuant to 240.13d-1(b) or 240.13d-2(b)
	or (c), Check Whether the Person Filing is a:

	(a) - Broker or dealer registered under Section 15 of the Act.
	(b) - Bank as defined in Section 3(a)(6) of the Act.
	(c) - Insurance company as defined in Section 3(a)(19) of the Act.
	(d) - Investment company registered under Section 8 of the Investment Company
        	Act of 1940.
	(e) X An investment adviser in accordance with 240.13d-1(b)(1)(ii)(E);
	(f) - An employee benefit plan or endowment fund in accordance with
		240.13d-1(b)(1)(ii)(F);
	(g) - A parent holding company or control person in accordance with 240.13d-
		1(b)(1)(ii)(G);
	(h) - A savings association as defined in Section 3(b) of the Federal Deposit
		 Insurance Act;
	(i) - A church plan that is excluded from the definition of an investment
		 company under Section 3(c)(14) of the Investment Company Act of 1940;
	(j) - Group, in accordance with 240.13d-1(b)(1)(ii)(J).

Item 4.	Ownership:

	a. Amount beneficially owned: 0

	b. Percent of Class: 0%

	c. Number of shares as to which the person has:

		(i) Sole power to vote or to direct the vote  0

		(ii) Shared power to vote or to direct the vote	None

		(iii)Sole power to dispose or to direct the disposition of 0

		(iv) Shared power to dispose or to direct the disposition None

Item 5.	Ownership of Five Percent or Less of a Class:

	Not Applicable

Item 6.	Ownership of More than Five Percent on Behalf of Another Person:

	Not Applicable

Item 7.	Identification and Classification of the Subsidiary Which Acquired the
	Security Being Reported on By the Parent Holding Company of Control
	Person:

	Not applicable.

Item 8.	Identification and Classification of Members of the Group:

	Not applicable.

Item 9.	Notice of Dissolution of Group:

	Not applicable.

Item 10.Certification:

By signing below I certify that, to the best of my knowledge and belief, the
securities referred to above were not acquired and are not held for
the purpose of or with the effect of changing or influencing the control
of the issuer of the securities and were not acquired and are not held in
connection with or as a participant in any transaction having that purpose
or effect.


		SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this statement is true, complete and correct.

Date	February 6, 2006


	By:/s/ Robert A. Davidson

Robert A. Davidson
Title:   President