N-CSR 1 acmf103121n-csr.htm N-CSR Document

UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

FORM N-CSR

CERTIFIED SHAREHOLDER REPORT OF REGISTERED
MANAGEMENT INVESTMENT COMPANIES

Investment Company Act file number811-00816
AMERICAN CENTURY MUTUAL FUNDS, INC.
(Exact name of registrant as specified in charter)
4500 MAIN STREET, KANSAS CITY, MISSOURI64111
(Address of principal executive offices)(Zip Code)
JOHN PAK
4500 MAIN STREET, KANSAS CITY, MISSOURI 64111
(Name and address of agent for service)
Registrant’s telephone number, including area code:816-531-5575
Date of fiscal year end:10-31
Date of reporting period:10-31-2021






ITEM 1. REPORTS TO STOCKHOLDERS.

(a) Provided under separate cover.






    


image8.jpg
Annual Report
October 31, 2021
Balanced Fund
Investor Class (TWBIX)
I Class (ABINX)
R5 Class (ABGNX)




























Table of Contents
President’s Letter
Performance
Portfolio Commentary
Fund Characteristics
Shareholder Fee Example
Schedule of Investments
Statement of Assets and Liabilities
Statement of Operations
Statement of Changes in Net Assets
Notes to Financial Statements
Financial Highlights
Report of Independent Registered Public Accounting Firm
Management
Approval of Management Agreement
Additional Information



















Any opinions expressed in this report reflect those of the author as of the date of the report, and do not necessarily represent the opinions of American Century Investments® or any other person in the American Century Investments organization. Any such opinions are subject to change at any time based upon market or other conditions and American Century Investments disclaims any responsibility to update such opinions. These opinions may not be relied upon as investment advice and, because investment decisions made by American Century Investments funds are based on numerous factors, may not be relied upon as an indication of trading intent on behalf of any American Century Investments fund. Security examples are used for representational purposes only and are not intended as recommendations to purchase or sell securities. Performance information for comparative indices and securities is provided to American Century Investments by third party vendors. To the best of American Century Investments’ knowledge, such information is accurate at the time of printing.



President’s Letter
image30.jpg Jonathan Thomas

Dear Investor:

Thank you for reviewing this annual report for the period ended October 31, 2021. Annual reports help convey important information about fund returns, including market factors that affected performance. For additional investment insights, please visit americancentury.com.
Economic, Earnings Gains Fueled Rally Among Risk-On Assets

Stocks and other risk-on assets rallied for the 12-month period, despite lingering pandemic-related challenges. Upbeat data on U.S. manufacturing, employment and housing, along with central bank and federal government support and positive vaccine developments, helped boost corporate earnings and promote investor optimism. Outside the U.S., most economies recovered, but generally at a slower pace. Virus outbreaks and slower vaccine rollouts, particularly in emerging markets, led to lingering lockdowns in some regions.

As the period progressed, steady economic gains combined with ongoing monetary and fiscal support, rising energy prices and severe supply chain disruptions pushed global interest rates and inflation higher. In the U.S., year-over-year headline inflation climbed to 6.2% in October 2021, the largest 12-month increase in nearly 31 years.
Late in the period, the Federal Reserve (Fed) confirmed it would start tapering its bond buying in November. Yet despite inflation’s surge, the Fed left short-term interest rates unchanged. Central banks in Europe and the U.K. maintained their supportive interest rate and bond-buying programs as inflation ticked higher.

Overall, stocks delivered stellar performance for the 12-month period, highlighted by the S&P 500 Index’s gain of nearly 43%. Assets offering inflation-fighting potential, including real estate investment trusts, fared even better. Meanwhile, global bonds retreated as interest rates rose. However, emerging markets bonds largely advanced, benefiting from risk-on sentiment.
Several Factors Shaping Market Dynamics

The return to pre-pandemic life is progressing, albeit somewhat cautiously due to COVID-19’s lingering effects. As the economy and markets respond to this fluid backdrop, investors will face opportunities and ongoing challenges. Economic growth, inflation, the virus’s trajectory, supply chain normalization and fiscal and monetary policy likely will sway market dynamics.

We appreciate your confidence in us during these extraordinary times. Our firm has a long history of helping clients weather unpredictable markets, and we’re confident we will continue to meet today’s challenges.

Sincerely,
image19.jpg
Jonathan Thomas
President and Chief Executive Officer
American Century Investments
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Performance
Total Returns as of October 31, 2021
Average Annual Returns
Ticker
Symbol
1 year5 years10 yearsSince
Inception
Inception
Date
Investor ClassTWBIX23.34%11.41%9.74%10/20/88
Blended Index24.02%12.67%10.99%
S&P 500 Index42.91%18.91%16.20%
Bloomberg U.S. Aggregate Bond Index-0.48%3.09%3.00%
I ClassABINX23.58%11.62%9.96%5/1/00
R5 ClassABGNX23.58%11.31%4/10/17
Average annual returns since inception are presented when ten years of performance history is not available.

The blended index combines monthly returns of two widely known indices in proportion to the asset mix of the fund. The S&P 500 Index represents 60% of the index and the remaining 40% is represented by the Bloomberg U.S. Aggregate Bond Index.




























Data presented reflect past performance. Past performance is no guarantee of future results. Current performance may be higher or lower than the performance shown. Total returns for periods less than one year are not annualized. Investment return and principal value will fluctuate, and redemption value may be more or less than original cost. Data assumes reinvestment of dividends and capital gains, and none of the charts reflect the deduction of taxes that a shareholder would pay on fund distributions or the redemption of fund shares. To obtain performance data current to the most recent month end, please call 1-800-345-2021 or visit americancentury.com. For additional information about the fund, please consult the prospectus.
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Growth of $10,000 Over 10 Years
$10,000 investment made October 31, 2011
Performance for other share classes will vary due to differences in fee structure.
chart-f0d037b8975247e3b1ca.jpg
Value on October 31, 2021
Investor Class — $25,351
Blended Index — $28,367
S&P 500 Index — $44,939
Bloomberg U.S. Aggregate Bond Index — $13,437
Total Annual Fund Operating Expenses
Investor ClassI ClassR5 Class
0.91%0.71%0.71%
The total annual fund operating expenses shown is as stated in the fund’s prospectus current as of the date of this report. The prospectus may vary from the expense ratio shown elsewhere in this report because it is based on a different time period, includes acquired fund fees and expenses, and, if applicable, does not include fee waivers or expense reimbursements.















Data presented reflect past performance. Past performance is no guarantee of future results. Current performance may be higher or lower than the performance shown. Total returns for periods less than one year are not annualized. Investment return and principal value will fluctuate, and redemption value may be more or less than original cost. Data assumes reinvestment of dividends and capital gains, and none of the charts reflect the deduction of taxes that a shareholder would pay on fund distributions or the redemption of fund shares. To obtain performance data current to the most recent month end, please call 1-800-345-2021 or visit americancentury.com. For additional information about the fund, please consult the prospectus.
4


Portfolio Commentary
 
Equity Portfolio Managers: Joseph Reiland, Justin Brown and Robert Bove

As of September 1, 2021, Joseph Reiland, Justin Brown and Robert Bove joined the portfolio management team, replacing Steve Rossi and Guan Wang. This reflects the equity allocation’s transition to the U.S. Sustainable Large Cap Core strategy. The equity allocation retains the S&P 500 Index as its benchmark.

Fixed-Income Portfolio Managers: Bob Gahagan, Charles Tan and Jason Greenblath

Brian Howell left the portfolio management team August 1, 2021. He is retiring, effective December 31, 2021. Jason Greenblath joined the team in his place.

Performance Summary

Balanced returned 23.34%* for the 12 months ended October 31, 2021. By comparison, the fund’s benchmark (a blended index consisting of 60% S&P 500 Index and 40% Bloomberg U.S. Aggregate Bond Index) returned 24.02%. Balanced seeks long-term capital growth and current income by investing approximately 60% of its assets in equity securities and the remainder in bonds and other fixed-income securities. The purpose of the broad bond market exposure is to reduce the volatility of the equity portfolio, providing a more attractive overall risk/return profile for investors. The total fund’s drivers of both absolute and relative returns, however, are typically a function of the equity allocation. Therefore, the performance attribution discussion focuses primarily on the equity segment.

Within Equities, Communication Services, Financials and Energy Detracted

The equity allocation performed very well in absolute terms but trailed the S&P 500 Index. The largest detractors from relative performance in the equity portfolio were the communication services, financials and energy sectors. In the communication services sector, an overweight to Take-Two Interactive Software, a gaming company, hindered relative returns. The company posted strong results as the pandemic surged in 2020 but shares were volatile as lockdowns were lifted and the economy reopened. We exited this position. An underweight position in The Walt Disney Co. also hampered the fund’s relative performance. The company experienced a surge in revenue from its streaming services late in 2020, which continued into 2021. An underweight position in the interactive media and services industry, especially in Alphabet, parent company of Google, also detracted from performance. Shares performed well on a surge in advertising revenues. We had some exposure to the stock, but less than the benchmark.

Performance in the financials sector was hampered by positioning in the capital markets, banking and insurance industries. The financials sector as a whole benefited from a rebound in the economy, strong financial markets and higher long-term bond yields.

In the energy sector, an underweight position hindered relative returns. An underweight position in the oil, gas and consumable fuels industry was the primary detractor. Shares of companies such as Exxon Mobil and Chevron performed well as prices for crude oil rose sharply from lows hit during the pandemic. The fund took advantage of this and exited its positions in Exxon Mobil and Chevron.

Materials and Health Care Led Equity Gains

The materials sector was the primary contributor to relative performance, reflecting the global economic recovery and increase in commodities prices. Positioning in the metals and mining industry was the primary driver of performance as companies such as Cleveland-Cliffs and Freeport-McMoRan benefited from surging prices for metals such as copper and gold. The fund took advantage of this and exited its positions in these shares. In the containers and packaging

*All fund returns referenced in this commentary are for Investor Class shares. Performance for other share classes will vary due to differences in fee structure; when Investor Class performance exceeds that of the fund’s benchmark, other share classes may not. See page 3 for returns for all share classes.
5


industry, an overweighting of International Paper also contributed. We exited the position in this company.

The health care sector also helped relative performance, driven largely by stock selection in the biotechnology industry, where Moderna was the primary contributor. The company benefited from a surge in revenues due to sales of its COVID-19 vaccine. We locked in profits and exited the position. Selections in the health care providers and services industry also made a significant contribution. Companies in this industry benefited from the reopening of the economy, which resulted in a rise in elective surgeries that had been postponed during the height of the pandemic.

Other top contributors to relative performance for the 12-month period included an underweight position in the utilities sector. Rising bond yields hurt this sector due to its heavy dependence on debt financing and its status as a bond proxy. Elsewhere, selections in the semiconductors and semiconductor equipment industry contributed significantly to returns. Companies in the semiconductor equipment industry, especially Applied Materials and Lam Research, benefited from the shortage of computer chips, which prompted investment in the equipment used to make them. The fund exited its position in Lam Research.

Bond Allocation Limited Performance

Bond returns were limited as yields rose during the year (bond prices and yields move in opposite directions). Late in 2020, the approval of coronavirus vaccines resulted in a shift in sentiment as investors anticipated the lifting of lockdowns and an acceleration of economic growth. In addition, inflation concerns grew during the period due to a stronger economic outlook, loose monetary policy and massive fiscal spending. Inflation concerns and uncertainty about the Federal Reserve’s (Fed) plans to begin reducing its bond purchases weighed further on the market toward the end of the period. Nevertheless, at times bonds benefited from uncertainty when the delta variant of the coronavirus emerged and threatened to interfere with the economic recovery. Rising inflation throughout the economy led the Fed to raise its inflation forecast from 3.4% to 4.2% for 2021 and from 2.1% to 2.2% for 2022.

In that environment, Treasury bonds performed poorly. Investment-grade corporate bonds held up better, benefiting from the profit recovery in corporate America. The high-yield market also produced positive results, buoyed by attractive yields and the prospect of an improvement in the economy.

Outlook

The economic recovery is moderating even as inflation is rising. However, corporate profit growth remains strong and the federal government continues to apply massive fiscal stimulus to the economy. But with the major stock market indices at record highs, we will be on the lookout for volatility if investors’ assumptions about inflation, interest rates and corporate earnings disappoint. In addition, the coronavirus remains a source of uncertainty as we head into the winter months. We will continue to monitor the situation and invest appropriately. We believe that the continued economic and market uncertainty highlights the benefits of a balanced approach involving exposure to both stocks and bonds, which is intended to reduce overall price fluctuations and improve risk-adjusted performance.

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Fund Characteristics
OCTOBER 31, 2021
Types of Investments in Portfolio% of net assets
Common Stocks61.3%
U.S. Treasury Securities15.1%
Corporate Bonds10.7%
U.S. Government Agency Mortgage-Backed Securities4.0%
Collateralized Loan Obligations2.8%
Collateralized Mortgage Obligations2.3%
Asset-Backed Securities2.0%
Commercial Mortgage-Backed Securities0.8%
Municipal Securities0.7%
Exchange-Traded Funds0.4%
U.S. Government Agency Securities0.3%
Sovereign Governments and Agencies0.1%
Bank Loan Obligations0.1%
Preferred Stocks
—*
Temporary Cash Investments1.2%
Other Assets and Liabilities(1.8)%
*Category is less than 0.05% of total net assets.
Top Five Common Stocks Industries*% of net assets
Software6.6%
Interactive Media and Services4.0%
Semiconductors and Semiconductor Equipment3.7%
Capital Markets3.1%
IT Services2.9%
*Exposure indicated excludes Exchange-Traded Funds. The Schedule of Investments provides additional information on the fund's portfolio holdings.
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Shareholder Fee Example 

Fund shareholders may incur two types of costs: (1) transaction costs, including sales charges (loads) on purchase payments and redemption/exchange fees; and (2) ongoing costs, including management fees; distribution and service (12b-1) fees; and other fund expenses. This example is intended to help you understand your ongoing costs (in dollars) of investing in your fund and to compare these costs with the ongoing cost of investing in other mutual funds.

The example is based on an investment of $1,000 made at the beginning of the period and held for the entire period from May 1, 2021 to October 31, 2021.

Actual Expenses

The table provides information about actual account values and actual expenses for each class. You may use the information, together with the amount you invested, to estimate the expenses that you paid over the period. First, identify the share class you own. Then simply divide your account value by $1,000 (for example, an $8,600 account value divided by $1,000 = 8.6), then multiply the result by the number under the heading “Expenses Paid During Period” to estimate the expenses you paid on your account during this period.

If you hold Investor Class shares of any American Century Investments fund, or I Class shares of the American Century Diversified Bond Fund, in an American Century Investments account (i.e., not through a financial intermediary or employer-sponsored retirement plan account), American Century Investments may charge you a $25.00 annual account maintenance fee if the value of those shares is less than $10,000. We will redeem shares automatically in one of your accounts to pay the $25.00 fee. In determining your total eligible investment amount, we will include your investments in all personal accounts (including American Century Investments brokerage accounts) registered under your Social Security number. Personal accounts include individual accounts, joint accounts, UGMA/UTMA accounts, personal trusts, Coverdell Education Savings Accounts and IRAs (including traditional, Roth, Rollover, SEP-, SARSEP- and SIMPLE-IRAs), and certain other retirement accounts. If you have only business, business retirement, employer-sponsored or American Century Investments brokerage accounts, you are currently not subject to this fee. If you are subject to the account maintenance fee, your account value could be reduced by the fee amount.

Hypothetical Example for Comparison Purposes

The table also provides information about hypothetical account values and hypothetical expenses based on the actual expense ratio of each class of your fund and an assumed rate of return of 5% per year before expenses, which is not the actual return of a fund’s share class. The hypothetical account values and expenses may not be used to estimate the actual ending account balance or expenses you paid for the period. You may use this information to compare the ongoing costs of investing in your fund and other funds. To do so, compare this 5% hypothetical example with the 5% hypothetical examples that appear in the shareholder reports of the other funds.

Please note that the expenses shown in the table are meant to highlight your ongoing costs only and do not reflect any transactional costs, such as sales charges (loads) or redemption/exchange fees. Therefore, the table is useful in comparing ongoing costs only, and will not help you determine the relative total costs of owning different funds. In addition, if these transactional costs were included, your costs would have been higher.

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Beginning
Account Value
5/1/21
Ending
Account Value
10/31/21
Expenses Paid
During Period(1)
5/1/21 - 10/31/21
Annualized
Expense Ratio(1)
Actual
Investor Class$1,000$1,067.80$4.690.90%
I Class$1,000$1,068.90$3.650.70%
R5 Class$1,000$1,068.90$3.650.70%
Hypothetical
Investor Class$1,000$1,020.67$4.580.90%
I Class$1,000$1,021.68$3.570.70%
R5 Class$1,000$1,021.68$3.570.70%
(1)Expenses are equal to the class's annualized expense ratio listed in the table above, multiplied by the average account value over the period, multiplied by 184, the number of days in the most recent fiscal half-year, divided by 365, to reflect the one-half year period. Annualized expense ratio reflects actual expenses, including any applicable fee waivers or expense reimbursements and excluding any acquired fund fees and expenses.
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Schedule of Investments

OCTOBER 31, 2021
Shares/
Principal Amount
Value
COMMON STOCKS — 61.3%


Aerospace and Defense — 0.5%
Lockheed Martin Corp.16,684 $5,544,427 
Air Freight and Logistics — 0.6%
Expeditors International of Washington, Inc.3,754 462,719 
United Parcel Service, Inc., Class B31,116 6,642,332 
7,105,051 
Auto Components — 0.7%
Aptiv plc(1)
45,189 7,812,726 
Automobiles — 0.8%
Tesla, Inc.(1)
8,105 9,028,970 
Banks — 2.9%
Bank of America Corp.225,947 10,795,747 
JPMorgan Chase & Co.74,062 12,582,393 
Regions Financial Corp.366,005 8,666,999 
32,045,139 
Beverages — 0.9%
PepsiCo, Inc.58,529 9,458,286 
Biotechnology — 0.3%
Amgen, Inc.13,080 2,707,168 
Vertex Pharmaceuticals, Inc.(1)
6,094 1,126,963 
3,834,131 
Building Products — 1.1%
Johnson Controls International plc111,955 8,214,138 
Masco Corp.59,442 3,896,423 
12,110,561 
Capital Markets — 3.1%
Ameriprise Financial, Inc.15,081 4,556,422 
BlackRock, Inc.6,823 6,437,228 
Intercontinental Exchange, Inc.24,240 3,356,270 
Morgan Stanley114,861 11,805,414 
S&P Global, Inc.17,341 8,222,409 
34,377,743 
Chemicals — 1.7%
Air Products and Chemicals, Inc.10,511 3,151,303 
Ecolab, Inc.12,987 2,885,971 
Linde plc26,483 8,453,373 
Sherwin-Williams Co. (The)13,990 4,429,374 
18,920,021 
Communications Equipment — 0.7%
Cisco Systems, Inc.134,905 7,550,633 
Consumer Finance — 0.5%
American Express Co.32,193 5,594,499 
Containers and Packaging — 0.4%
Ball Corp.46,064 4,213,935 
Diversified Telecommunication Services — 0.1%
Verizon Communications, Inc.25,505 1,351,510 
10


Shares/
Principal Amount
Value
Electric Utilities — 1.2%
NextEra Energy, Inc.150,217 $12,818,017 
Electrical Equipment — 0.8%
Eaton Corp. plc29,843 4,916,933 
Rockwell Automation, Inc.13,640 4,356,616 
9,273,549 
Electronic Equipment, Instruments and Components — 1.3%
CDW Corp.29,040 5,420,316 
Cognex Corp.36,973 3,238,465 
Keysight Technologies, Inc.(1)
35,196 6,335,984 
14,994,765 
Energy Equipment and Services — 0.6%
Schlumberger NV201,189 6,490,357 
Entertainment — 1.2%
Electronic Arts, Inc.20,275 2,843,569 
Walt Disney Co. (The)(1)
59,074 9,987,641 
12,831,210 
Equity Real Estate Investment Trusts (REITs) — 1.3%
Prologis, Inc.102,329 14,833,612 
Food and Staples Retailing — 1.0%
Costco Wholesale Corp.8,454 4,155,479 
Sysco Corp.83,680 6,434,992 
10,590,471 
Food Products — 0.5%
Mondelez International, Inc., Class A77,611 4,714,092 
Vital Farms, Inc.(1)
25,270 414,933 
5,129,025 
Health Care Equipment and Supplies — 1.2%
Edwards Lifesciences Corp.(1)
58,216 6,975,441 
Medtronic plc43,227 5,181,188 
ResMed, Inc.5,679 1,493,066 
13,649,695 
Health Care Providers and Services — 2.3%
Cigna Corp.32,991 7,047,207 
CVS Health Corp.71,107 6,348,433 
Humana, Inc.6,554 3,035,551 
UnitedHealth Group, Inc.20,551 9,463,119 
25,894,310 
Hotels, Restaurants and Leisure — 1.2%
Booking Holdings, Inc.(1)
1,820 4,405,820 
Chipotle Mexican Grill, Inc.(1)
1,978 3,518,921 
Expedia Group, Inc.(1)
31,713 5,213,934 
13,138,675 
Household Products — 0.9%
Colgate-Palmolive Co.36,034 2,745,431 
Procter & Gamble Co. (The)47,866 6,844,359 
9,589,790 
Industrial Conglomerates — 0.7%
Honeywell International, Inc.36,848 8,055,710 
Insurance — 1.0%
Marsh & McLennan Cos., Inc.24,725 4,124,130 
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Shares/
Principal Amount
Value
Prudential Financial, Inc.29,414 $3,237,011 
Travelers Cos., Inc. (The)25,042 4,028,757 
11,389,898 
Interactive Media and Services — 4.0%
Alphabet, Inc., Class A(1)
10,013 29,647,692 
Alphabet, Inc., Class C(1)
2,236 6,630,657 
Meta Platforms, Inc., Class A(1)
26,757 8,657,762 
44,936,111 
Internet and Direct Marketing Retail — 2.3%
Amazon.com, Inc.(1)
7,680 25,900,262 
IT Services — 2.9%
Accenture plc, Class A23,597 8,466,368 
Mastercard, Inc., Class A23,276 7,809,563 
PayPal Holdings, Inc.(1)
35,541 8,266,481 
Visa, Inc., Class A38,297 8,110,156 
32,652,568 
Life Sciences Tools and Services — 1.3%
Agilent Technologies, Inc.44,652 7,032,244 
Thermo Fisher Scientific, Inc.11,518 7,291,700 
14,323,944 
Machinery — 1.4%
Cummins, Inc.21,896 5,251,537 
Parker-Hannifin Corp.20,911 6,201,994 
Xylem, Inc.28,677 3,744,929 
15,198,460 
Media — 0.3%
Comcast Corp., Class A71,466 3,675,496 
Multiline Retail — 0.3%
Target Corp.14,160 3,676,219 
Oil, Gas and Consumable Fuels — 0.8%
ConocoPhillips114,291 8,513,537 
Personal Products — 0.3%
Estee Lauder Cos., Inc. (The), Class A9,787 3,174,218 
Pharmaceuticals — 2.0%
Bristol-Myers Squibb Co.108,301 6,324,778 
Merck & Co., Inc.68,409 6,023,412 
Novo Nordisk A/S, B Shares33,860 3,712,914 
Zoetis, Inc.31,263 6,759,061 
22,820,165 
Professional Services — 0.1%
IHS Markit Ltd.11,290 1,475,829 
Road and Rail — 0.7%
Norfolk Southern Corp.15,066 4,415,091 
Union Pacific Corp.14,069 3,396,257 
7,811,348 
Semiconductors and Semiconductor Equipment — 3.7%
Advanced Micro Devices, Inc.(1)
35,173 4,228,850 
Applied Materials, Inc.45,768 6,254,197 
ASML Holding NV8,868 7,208,794 
NVIDIA Corp.62,501 15,979,631 
Texas Instruments, Inc.38,938 7,300,096 
40,971,568 
12


Shares/
Principal Amount
Value
Software — 6.6%
Adobe, Inc.(1)
10,308 $6,703,911 
Microsoft Corp.176,595 58,562,434 
salesforce.com, Inc.(1)
16,993 5,092,632 
ServiceNow, Inc.(1)
2,426 1,692,766 
Workday, Inc., Class A(1)
7,324 2,123,813 
74,175,556 
Specialty Retail — 1.7%
Home Depot, Inc. (The)34,896 12,972,239 
TJX Cos., Inc. (The)64,609 4,231,243 
Tractor Supply Co.10,147 2,203,624 
19,407,106 
Technology Hardware, Storage and Peripherals — 2.4%
Apple, Inc.182,420 27,326,516 
Textiles, Apparel and Luxury Goods — 1.0%
Deckers Outdoor Corp.(1)
6,184 2,444,597 
NIKE, Inc., Class B52,613 8,801,629 
11,246,226 
TOTAL COMMON STOCKS
(Cost $541,115,001)
684,911,845 
U.S. TREASURY SECURITIES — 15.1%


U.S. Treasury Bonds, 5.00%, 5/15/37$200,000 291,418 
U.S. Treasury Bonds, 4.625%, 2/15/401,300,000 1,860,422 
U.S. Treasury Bonds, 1.375%, 11/15/40500,000 451,582 
U.S. Treasury Bonds, 1.875%, 2/15/414,600,000 4,523,094 
U.S. Treasury Bonds, 2.25%, 5/15/41600,000 626,438 
U.S. Treasury Bonds, 4.375%, 5/15/411,400,000 1,963,117 
U.S. Treasury Bonds, 3.125%, 11/15/411,000,000 1,193,906 
U.S. Treasury Bonds, 3.00%, 5/15/421,400,000 1,645,383 
U.S. Treasury Bonds, 2.75%, 11/15/422,000,000 2,262,656 
U.S. Treasury Bonds, 2.875%, 5/15/431,300,000 1,503,023 
U.S. Treasury Bonds, 3.125%, 8/15/44500,000 604,668 
U.S. Treasury Bonds, 3.00%, 11/15/44600,000 713,367 
U.S. Treasury Bonds, 2.50%, 2/15/45(2)
1,500,000 1,644,434 
U.S. Treasury Bonds, 2.75%, 8/15/47200,000 232,598 
U.S. Treasury Bonds, 3.375%, 11/15/48(2)
1,800,000 2,350,863 
U.S. Treasury Bonds, 2.25%, 8/15/491,300,000 1,386,811 
U.S. Treasury Bonds, 2.375%, 11/15/492,400,000 2,628,234 
U.S. Treasury Bonds, 2.00%, 2/15/50900,000 911,127 
U.S. Treasury Bonds, 1.875%, 2/15/511,700,000 1,672,906 
U.S. Treasury Bonds, 2.375%, 5/15/513,600,000 3,957,750 
U.S. Treasury Bonds, 2.00%, 8/15/512,500,000 2,536,328 
U.S. Treasury Inflation Indexed Notes, 0.125%, 10/15/253,162,990 3,438,074 
U.S. Treasury Inflation Indexed Notes, 0.25%, 7/15/29855,584 958,980 
U.S. Treasury Inflation Indexed Notes, 0.125%, 7/15/30533,495 594,100 
U.S. Treasury Inflation Indexed Notes, 0.125%, 7/15/31510,345 568,596 
U.S. Treasury Notes, 0.50%, 3/15/237,600,000 7,620,930 
U.S. Treasury Notes, 0.125%, 3/31/237,000,000 6,981,543 
U.S. Treasury Notes, 0.25%, 4/15/23400,000 399,594 
U.S. Treasury Notes, 0.125%, 5/31/232,000,000 1,992,461 
U.S. Treasury Notes, 0.25%, 6/15/23500,000 498,994 
U.S. Treasury Notes, 0.125%, 8/31/234,000,000 3,977,344 
13


Shares/
Principal Amount
Value
U.S. Treasury Notes, 0.25%, 9/30/23$3,500,000 $3,486,055 
U.S. Treasury Notes, 0.375%, 10/31/23(3)
1,000,000 997,695 
U.S. Treasury Notes, 2.875%, 11/30/236,600,000 6,920,461 
U.S. Treasury Notes, 0.125%, 12/15/231,000,000 991,230 
U.S. Treasury Notes, 2.375%, 2/29/241,500,000 1,561,582 
U.S. Treasury Notes, 0.25%, 3/15/2416,000,000 15,862,812 
U.S. Treasury Notes, 0.375%, 4/15/248,500,000 8,443,389 
U.S. Treasury Notes, 1.125%, 2/28/258,700,000 8,775,105 
U.S. Treasury Notes, 0.25%, 5/31/251,000,000 975,664 
U.S. Treasury Notes, 0.25%, 8/31/257,800,000 7,578,492 
U.S. Treasury Notes, 2.625%, 12/31/252,200,000 2,340,852 
U.S. Treasury Notes, 0.50%, 2/28/264,200,000 4,092,539 
U.S. Treasury Notes, 0.75%, 5/31/263,500,000 3,438,887 
U.S. Treasury Notes, 0.875%, 6/30/26900,000 888,328 
U.S. Treasury Notes, 0.75%, 8/31/265,000,000 4,900,195 
U.S. Treasury Notes, 1.375%, 8/31/261,400,000 1,413,891 
U.S. Treasury Notes, 1.625%, 10/31/26100,000 102,164 
U.S. Treasury Notes, 1.75%, 12/31/26700,000 719,045 
U.S. Treasury Notes, 1.50%, 1/31/272,000,000 2,028,242 
U.S. Treasury Notes, 1.125%, 2/28/272,700,000 2,684,232 
U.S. Treasury Notes, 0.625%, 3/31/2710,000,000 9,670,508 
U.S. Treasury Notes, 0.50%, 6/30/27500,000 478,271 
U.S. Treasury Notes, 0.50%, 8/31/271,600,000 1,525,719 
U.S. Treasury Notes, 0.625%, 12/31/273,500,000 3,344,209 
U.S. Treasury Notes, 1.125%, 2/29/281,000,000 984,434 
U.S. Treasury Notes, 1.25%, 3/31/281,700,000 1,683,697 
U.S. Treasury Notes, 1.25%, 4/30/285,050,000 4,998,612 
U.S. Treasury Notes, 1.25%, 6/30/282,400,000 2,370,891 
U.S. Treasury Notes, 1.25%, 9/30/28500,000 493,164 
U.S. Treasury Notes, 1.625%, 5/15/31500,000 503,633 
U.S. Treasury Notes, 1.25%, 8/15/312,500,000 2,429,688 
TOTAL U.S. TREASURY SECURITIES
(Cost $166,232,413)
168,674,427 
CORPORATE BONDS — 10.7%


Aerospace and Defense — 0.2%
Boeing Co. (The), 2.20%, 2/4/26420,000 420,843 
Boeing Co. (The), 3.625%, 2/1/31380,000 404,913 
Boeing Co. (The), 5.81%, 5/1/50230,000 315,745 
Raytheon Technologies Corp., 4.125%, 11/16/28570,000 646,290 
1,787,791 
Air Freight and Logistics
GXO Logistics, Inc., 2.65%, 7/15/31(4)
335,000 331,695 
Airlines — 0.1%
American Airlines 2021-1 Class A Pass Through Trust, 2.875%, 1/11/36(3)
181,000 182,357 
British Airways Pass Through Trust, Series 2021-1, Class A, 2.90%, 9/15/36(4)
220,000 222,884 
Delta Air Lines, Inc. / SkyMiles IP Ltd., 4.75%, 10/20/28(4)
568,000 631,020 
1,036,261 
Automobiles — 0.3%
Ford Motor Credit Co. LLC, 3.10%, 5/4/23700,000 712,250 
General Motors Co., 5.15%, 4/1/38370,000 447,381 
14


Shares/
Principal Amount
Value
General Motors Financial Co., Inc., 2.75%, 6/20/25$780,000 $810,213 
General Motors Financial Co., Inc., 2.70%, 8/20/27269,000 274,725 
General Motors Financial Co., Inc., 2.40%, 10/15/28465,000 462,331 
Toyota Motor Credit Corp., MTN, 1.90%, 4/6/28420,000 423,108 
3,130,008 
Banks — 1.4%
Banco Santander SA, 2.96%, 3/25/31600,000 611,606 
Banco Santander SA, VRN, 1.72%, 9/14/27200,000 197,060 
Bank of America Corp., MTN, VRN, 2.68%, 6/19/41713,000 687,830 
Bank of America Corp., VRN, 3.42%, 12/20/28265,000 283,520 
Bank of America Corp., VRN, 2.57%, 10/20/321,561,000 1,565,511 
Bank of America Corp., VRN, 2.48%, 9/21/36290,000 282,212 
Bank of Ireland Group plc, VRN, 2.03%, 9/30/27(4)
329,000 325,043 
Barclays plc, 4.84%, 5/9/28375,000 418,047 
BNP Paribas SA, VRN, 2.16%, 9/15/29(4)
243,000 238,779 
BNP Paribas SA, VRN, 4.375%, 3/1/33(4)
290,000 316,930 
BPCE SA, 4.50%, 3/15/25(4)
385,000 419,433 
Citigroup, Inc., VRN, 0.78%, 10/30/241,325,000 1,322,527 
Citigroup, Inc., VRN, 3.52%, 10/27/28858,000 922,169 
Citigroup, Inc., VRN, 2.52%, 11/3/32(3)
378,000 377,220 
Commonwealth Bank of Australia, VRN, 3.61%, 9/12/34(4)
440,000 463,240 
DNB Bank ASA, VRN, 1.61%, 3/30/28(4)
262,000 257,507 
FNB Corp., 2.20%, 2/24/23460,000 465,416 
HSBC Holdings plc, VRN, 2.80%, 5/24/32280,000 282,089 
JPMorgan Chase & Co., VRN, 1.58%, 4/22/27315,000 312,102 
JPMorgan Chase & Co., VRN, 2.07%, 6/1/29780,000 772,574 
JPMorgan Chase & Co., VRN, 3.16%, 4/22/42695,000 726,246 
National Australia Bank Ltd., 2.99%, 5/21/31(4)
500,000 502,784 
Royal Bank of Canada, MTN, 2.30%, 11/3/31210,000 209,646 
Societe Generale SA, VRN, 1.79%, 6/9/27(4)
500,000 492,422 
Truist Bank, VRN, 2.64%, 9/17/29275,000 285,035 
Truist Financial Corp., MTN, VRN, 1.89%, 6/7/29200,000 198,008 
US Bancorp, VRN, 2.49%, 11/3/36(3)
425,000 423,421 
Wells Fargo & Co., MTN, VRN, 2.16%, 2/11/261,055,000 1,079,956 
Wells Fargo & Co., VRN, 3.07%, 4/30/41605,000 621,971 
15,060,304 
Beverages — 0.1%
Anheuser-Busch Cos. LLC / Anheuser-Busch InBev Worldwide, Inc., 4.90%, 2/1/46500,000 638,604 
Anheuser-Busch InBev Worldwide, Inc., 4.75%, 1/23/29630,000 739,993 
1,378,597 
Biotechnology — 0.2%
AbbVie, Inc., 3.20%, 11/21/29440,000 470,485 
AbbVie, Inc., 4.40%, 11/6/42240,000 288,585 
Amgen, Inc., 1.65%, 8/15/28540,000 524,881 
Gilead Sciences, Inc., 3.65%, 3/1/26840,000 911,179 
2,195,130 
Building Products
Lennox International, Inc., 1.70%, 8/1/27140,000 137,955 
Capital Markets — 1.3%
Bain Capital Specialty Finance, Inc., 2.95%, 3/10/261,215,000 1,225,628 
Blackstone Secured Lending Fund, 2.85%, 9/30/28(4)
285,000 279,769 
15


Shares/
Principal Amount
Value
Blue Owl Finance LLC, 3.125%, 6/10/31(4)
$151,000 $148,581 
Blue Owl Finance LLC, 4.125%, 10/7/51(4)
425,000 438,766 
Deutsche Bank AG, VRN, 3.96%, 11/26/25625,000 668,579 
Deutsche Bank AG, VRN, 4.30%, 5/24/28200,000 207,288 
FS KKR Capital Corp., 4.25%, 2/14/25(4)
303,000 319,010 
FS KKR Capital Corp., 3.125%, 10/12/28595,000 586,723 
Goldman Sachs Group, Inc. (The), MTN, VRN, 2.38%, 7/21/321,126,000 1,107,612 
Goldman Sachs Group, Inc. (The), VRN, 2.91%, 6/5/231,315,000 1,332,451 
Goldman Sachs Group, Inc. (The), VRN, 1.95%, 10/21/27256,000 256,344 
Goldman Sachs Group, Inc. (The), VRN, 2.91%, 7/21/42435,000 434,768 
Golub Capital BDC, Inc., 2.05%, 2/15/27282,000 274,193 
Hercules Capital, Inc., 2.625%, 9/16/26348,000 343,017 
Main Street Capital Corp., 3.00%, 7/14/26460,000 464,541 
Morgan Stanley, MTN, VRN, 0.53%, 1/25/241,335,000 1,332,638 
Morgan Stanley, MTN, VRN, 2.24%, 7/21/32198,000 193,461 
Morgan Stanley, VRN, 1.59%, 5/4/271,163,000 1,152,511 
Morgan Stanley, VRN, 2.48%, 9/16/36525,000 510,452 
Owl Rock Core Income Corp., 3.125%, 9/23/26(4)
735,000 718,806 
Owl Rock Technology Finance Corp., 6.75%, 6/30/25(4)
334,000 380,265 
Owl Rock Technology Finance Corp., 3.75%, 6/17/26(4)
175,000 182,755 
Owl Rock Technology Finance Corp., 2.50%, 1/15/27530,000 524,952 
Prospect Capital Corp., 3.71%, 1/22/26420,000 427,994 
Prospect Capital Corp., 3.44%, 10/15/28420,000 404,227 
UBS Group AG, VRN, 1.49%, 8/10/27(4)
425,000 416,503 
14,331,834 
Chemicals
International Flavors & Fragrances, Inc., 1.83%, 10/15/27(4)
177,000 174,748 
Westlake Chemical Corp., 2.875%, 8/15/41150,000 145,206 
319,954 
Commercial Services and Supplies — 0.1%
Republic Services, Inc., 2.30%, 3/1/30358,000 361,851 
Waste Connections, Inc., 2.60%, 2/1/30120,000 123,511 
Waste Connections, Inc., 2.95%, 1/15/52231,000 230,267 
Waste Management, Inc., 2.50%, 11/15/50150,000 142,568 
858,197 
Construction and Engineering
Quanta Services, Inc., 2.35%, 1/15/32465,000 455,707 
Construction Materials
Eagle Materials, Inc., 2.50%, 7/1/31310,000 307,060 
Consumer Finance — 0.3%
AerCap Ireland Capital DAC / AerCap Global Aviation Trust, 3.00%, 10/29/28308,000 312,503 
AerCap Ireland Capital DAC / AerCap Global Aviation Trust, 3.30%, 1/30/32545,000 555,172 
AerCap Ireland Capital DAC / AerCap Global Aviation Trust, 3.40%, 10/29/33176,000 179,346 
AerCap Ireland Capital DAC / AerCap Global Aviation Trust, 3.85%, 10/29/41154,000 159,691 
Ally Financial, Inc., 2.20%, 11/2/28(3)
530,000 523,624 
Avolon Holdings Funding Ltd., 4.25%, 4/15/26(4)
258,000 277,336 
Avolon Holdings Funding Ltd., 4.375%, 5/1/26(4)
14,000 15,112 
Capital One Financial Corp., VRN, 1.88%, 11/2/27(3)
645,000 643,415 
SLM Corp., 3.125%, 11/2/26(3)
554,000 549,845 
3,216,044 
16


Shares/
Principal Amount
Value
Containers and Packaging
Berry Global, Inc., 1.57%, 1/15/26$230,000 $227,494 
WRKCo, Inc., 3.00%, 9/15/24201,000 211,087 
438,581 
Diversified Consumer Services — 0.1%
Novant Health, Inc., 3.17%, 11/1/51245,000 263,592 
Pepperdine University, 3.30%, 12/1/59355,000 378,416 
642,008 
Diversified Financial Services — 0.2%
Antares Holdings LP, 2.75%, 1/15/27(4)
256,000 253,567 
Blackstone Private Credit Fund, 1.75%, 9/15/24(4)
194,000 192,267 
Blackstone Private Credit Fund, 2.625%, 12/15/26(4)
312,000 306,264 
Block Financial LLC, 3.875%, 8/15/30240,000 255,907 
GE Capital Funding LLC, 4.40%, 5/15/30300,000 350,831 
GE Capital International Funding Co. Unlimited Co., 4.42%, 11/15/35420,000 511,407 
1,870,243 
Diversified Telecommunication Services — 0.4%
AT&T, Inc., 2.55%, 12/1/33622,000 604,580 
AT&T, Inc., 3.55%, 9/15/55634,000 643,140 
British Telecommunications plc, 3.25%, 11/8/29(4)
845,000 875,405 
Ooredoo International Finance Ltd., 2.625%, 4/8/31(4)
550,000 556,284 
Telefonica Emisiones SA, 4.90%, 3/6/48700,000 853,078 
Verizon Communications, Inc., 4.33%, 9/21/28333,000 380,292 
Verizon Communications, Inc., 1.75%, 1/20/31445,000 420,503 
Verizon Communications, Inc., 2.65%, 11/20/40301,000 284,818 
Verizon Communications, Inc., 2.99%, 10/30/56215,000 204,543 
4,822,643 
Electric Utilities — 0.7%
AEP Texas, Inc., 2.10%, 7/1/30370,000 358,753 
Alfa Desarrollo SpA, 4.55%, 9/27/51(4)
200,000 195,713 
Baltimore Gas and Electric Co., 2.25%, 6/15/31237,000 236,544 
Berkshire Hathaway Energy Co., 3.50%, 2/1/25180,000 191,923 
Comision Federal de Electricidad, 4.68%, 2/9/51(4)
550,000 513,458 
Commonwealth Edison Co., 3.20%, 11/15/49355,000 377,437 
DTE Electric Co., 2.25%, 3/1/30330,000 334,021 
Duke Energy Carolinas LLC, 2.55%, 4/15/31154,000 158,514 
Duke Energy Corp., 2.55%, 6/15/31180,000 181,012 
Duke Energy Florida LLC, 1.75%, 6/15/30370,000 357,700 
Duke Energy Florida LLC, 3.85%, 11/15/42220,000 251,344 
Duke Energy Progress LLC, 2.00%, 8/15/31440,000 431,528 
Duke Energy Progress LLC, 4.15%, 12/1/44335,000 399,252 
Entergy Arkansas LLC, 2.65%, 6/15/51180,000 172,476 
Exelon Corp., 4.45%, 4/15/46150,000 185,747 
Florida Power & Light Co., 4.125%, 2/1/42169,000 205,145 
Indiana Michigan Power Co., 3.25%, 5/1/51157,000 167,862 
MidAmerican Energy Co., 4.40%, 10/15/44290,000 359,727 
NextEra Energy Capital Holdings, Inc., 3.55%, 5/1/27290,000 314,727 
Northern States Power Co., 3.20%, 4/1/52240,000 261,371 
Pacific Gas and Electric Co., 4.20%, 6/1/41155,000 156,479 
PacifiCorp, 3.30%, 3/15/51310,000 328,768 
PacifiCorp, 2.90%, 6/15/52190,000 189,272 
17


Shares/
Principal Amount
Value
Public Service Co. of Colorado, 1.875%, 6/15/31$312,000 $305,233 
Southern Co. Gas Capital Corp., 1.75%, 1/15/31360,000 339,096 
Southern Co. Gas Capital Corp., 3.95%, 10/1/4690,000 102,246 
Xcel Energy, Inc., 3.40%, 6/1/30330,000 358,409 
7,433,757 
Electrical Equipment
Rockwell Automation, Inc., 2.80%, 8/15/61156,000 155,236 
Electronic Equipment, Instruments and Components
Teledyne Technologies, Inc., 2.25%, 4/1/28290,000 291,830 
Energy Equipment and Services
Halliburton Co., 2.92%, 3/1/30300,000 310,197 
Entertainment
Netflix, Inc., 3.625%, 6/15/25(4)
83,000 88,353 
Netflix, Inc., 4.875%, 4/15/28303,000 347,505 
435,858 
Equity Real Estate Investment Trusts (REITs) — 0.8%
Broadstone Net Lease LLC, 2.60%, 9/15/31235,000 230,670 
Corporate Office Properties LP, 2.00%, 1/15/29480,000 465,935 
Crown Castle International Corp., 3.30%, 7/1/30335,000 354,337 
EPR Properties, 4.75%, 12/15/26276,000 300,069 
EPR Properties, 4.95%, 4/15/28735,000 805,312 
EPR Properties, 3.60%, 11/15/31171,000 171,606 
GLP Capital LP / GLP Financing II, Inc., 5.375%, 4/15/26370,000 417,708 
Host Hotels & Resorts LP, 4.00%, 6/15/25430,000 457,511 
Lexington Realty Trust, 2.375%, 10/1/31590,000 568,245 
Life Storage LP, 2.40%, 10/15/31585,000 578,029 
National Health Investors, Inc., 3.00%, 2/1/31885,000 851,152 
National Retail Properties, Inc., 3.00%, 4/15/52386,000 378,712 
Office Properties Income Trust, 2.40%, 2/1/27354,000 345,372 
Omega Healthcare Investors, Inc., 3.375%, 2/1/31239,000 242,759 
Phillips Edison Grocery Center Operating Partnership I LP, 2.625%, 11/15/31223,000 218,655 
Physicians Realty LP, 2.625%, 11/1/31531,000 530,675 
Piedmont Operating Partnership LP, 2.75%, 4/1/32378,000 370,483 
Rexford Industrial Realty LP, 2.15%, 9/1/31154,000 147,489 
Sabra Health Care LP, 3.20%, 12/1/31588,000 575,824 
STORE Capital Corp., 4.625%, 3/15/29163,000 183,745 
Tanger Properties LP, 2.75%, 9/1/31520,000 497,931 
8,692,219 
Food and Staples Retailing — 0.1%
Kroger Co. (The), 3.875%, 10/15/46350,000 395,581 
Sysco Corp., 5.95%, 4/1/30464,000 587,664 
Walmart, Inc., 1.80%, 9/22/31153,000 150,876 
1,134,121 
Food Products — 0.1%
JDE Peet's NV, 2.25%, 9/24/31(4)
475,000 464,189 
Mondelez International, Inc., 2.75%, 4/13/30452,000 471,149 
935,338 
Health Care Providers and Services — 0.4%
Centene Corp., 2.45%, 7/15/28560,000 558,800 
Centene Corp., 3.375%, 2/15/30399,000 409,994 
CVS Health Corp., 1.75%, 8/21/30310,000 295,466 
18


Shares/
Principal Amount
Value
CVS Health Corp., 4.78%, 3/25/38$160,000 $195,936 
DaVita, Inc., 4.625%, 6/1/30(4)
215,000 216,344 
Duke University Health System, Inc., 3.92%, 6/1/47160,000 194,544 
HCA, Inc., 2.375%, 7/15/31710,000 694,348 
HCA, Inc., 3.50%, 7/15/51330,000 334,946 
Humana, Inc., 2.15%, 2/3/32304,000 294,333 
Kaiser Foundation Hospitals, 3.00%, 6/1/51260,000 270,703 
Universal Health Services, Inc., 1.65%, 9/1/26(4)
427,000 420,676 
Universal Health Services, Inc., 2.65%, 10/15/30(4)
330,000 327,926 
4,214,016 
Hotels, Restaurants and Leisure
Marriott International, Inc., 3.50%, 10/15/32372,000 393,753 
Household Durables
D.R. Horton, Inc., 2.50%, 10/15/24310,000 322,695 
Industrial Conglomerates
General Electric Co., 4.35%, 5/1/50350,000 446,243 
Insurance — 0.5%
American International Group, Inc., 6.25%, 5/1/36460,000 634,014 
American International Group, Inc., 4.50%, 7/16/44355,000 434,017 
Assured Guaranty US Holdings, Inc., 3.60%, 9/15/51410,000 431,051 
Athene Global Funding, 1.99%, 8/19/28(4)
757,000 736,806 
Athene Global Funding, 2.67%, 6/7/31(4)
760,000 761,868 
Brighthouse Financial Global Funding, 2.00%, 6/28/28(4)
631,000 623,181 
Equitable Financial Life Global Funding, 1.80%, 3/8/28(4)
290,000 285,299 
Global Atlantic Fin Co., 3.125%, 6/15/31(4)
238,000 239,015 
Guardian Life Global Funding, 1.625%, 9/16/28(4)
472,000 460,048 
Sammons Financial Group, Inc., 3.35%, 4/16/31(4)
584,000 607,576 
SBL Holdings, Inc., 5.125%, 11/13/26(4)
330,000 362,841 
SBL Holdings, Inc., 5.00%, 2/18/31(4)
300,000 318,655 
5,894,371 
Internet and Direct Marketing Retail — 0.1%
Amazon.com, Inc., 2.875%, 5/12/41820,000 850,689 
Life Sciences Tools and Services — 0.1%
Agilent Technologies, Inc., 2.30%, 3/12/31712,000 708,991 
Illumina, Inc., 2.55%, 3/23/31527,000 528,171 
1,237,162 
Machinery
Cummins, Inc., 2.60%, 9/1/50260,000 249,059 
Media — 0.4%
Charter Communications Operating LLC / Charter Communications Operating Capital, 4.91%, 7/23/25368,000 409,367 
Charter Communications Operating LLC / Charter Communications Operating Capital, 3.50%, 6/1/41385,000 378,553 
Charter Communications Operating LLC / Charter Communications Operating Capital, 5.125%, 7/1/49645,000 764,558 
Comcast Corp., 3.75%, 4/1/40440,000 493,637 
Cox Communications, Inc., 2.60%, 6/15/31(4)
273,000 275,674 
Discovery Communications LLC, 4.65%, 5/15/50245,000 289,186 
Grupo Televisa SAB, 5.00%, 5/13/45550,000 669,445 
Time Warner Cable LLC, 4.50%, 9/15/42615,000 673,127 
ViacomCBS, Inc., 4.375%, 3/15/43265,000 303,433 
4,256,980 
19


Shares/
Principal Amount
Value
Metals and Mining — 0.1%
Glencore Funding LLC, 2.625%, 9/23/31(4)
$440,000 $429,161 
Steel Dynamics, Inc., 3.45%, 4/15/30215,000 231,170 
Teck Resources Ltd., 6.25%, 7/15/41390,000 522,111 
1,182,442 
Multi-Utilities — 0.3%
Ameren Corp., 3.50%, 1/15/31430,000 465,854 
CenterPoint Energy, Inc., 4.25%, 11/1/28369,000 417,680 
CenterPoint Energy, Inc., 2.65%, 6/1/31285,000 289,938 
Dominion Energy, Inc., 2.25%, 8/15/31210,000 207,225 
Dominion Energy, Inc., 4.90%, 8/1/41270,000 339,498 
NiSource, Inc., 5.65%, 2/1/45290,000 405,485 
Sempra Energy, 3.25%, 6/15/27180,000 191,848 
WEC Energy Group, Inc., 1.375%, 10/15/27490,000 477,061 
2,794,589 
Oil, Gas and Consumable Fuels — 0.8%
Aker BP ASA, 3.75%, 1/15/30(4)
440,000 470,389 
Aker BP ASA, 4.00%, 1/15/31(4)
160,000 173,971 
BP Capital Markets America, Inc., 3.06%, 6/17/41250,000 252,832 
Chevron Corp., 2.00%, 5/11/27240,000 244,753 
Diamondback Energy, Inc., 3.50%, 12/1/29300,000 319,815 
Enbridge, Inc., 3.40%, 8/1/51310,000 319,421 
Energy Transfer LP, 3.60%, 2/1/23160,000 164,383 
Energy Transfer LP, 4.25%, 3/15/23370,000 383,686 
Energy Transfer LP, 3.75%, 5/15/30400,000 426,567 
Energy Transfer LP, 4.90%, 3/15/35270,000 307,081 
Enterprise Products Operating LLC, 4.85%, 3/15/44460,000 557,047 
Enterprise Products Operating LLC, 3.30%, 2/15/53220,000 220,833 
Equinor ASA, 3.25%, 11/18/49230,000 249,455 
Flex Intermediate Holdco LLC, 3.36%, 6/30/31(4)
280,000 283,621 
Galaxy Pipeline Assets Bidco Ltd., 2.94%, 9/30/40(4)
900,000 886,746 
Kinder Morgan Energy Partners LP, 6.50%, 9/1/39250,000 342,990 
Lundin Energy Finance BV, 3.10%, 7/15/31(4)
220,000 221,924 
Petroleos Mexicanos, 3.50%, 1/30/23300,000 303,525 
Petroleos Mexicanos, 6.625%, 6/15/3550,000 48,529 
Petroleos Mexicanos, 5.50%, 6/27/44230,000 187,058 
SA Global Sukuk Ltd., 2.69%, 6/17/31(4)
1,000,000 1,003,400 
Sabine Pass Liquefaction LLC, 5.625%, 3/1/25640,000 718,824 
TransCanada PipeLines Ltd., 2.50%, 10/12/31450,000 447,169 
Transcontinental Gas Pipe Line Co. LLC, 3.25%, 5/15/30250,000 265,324 
8,799,343 
Paper and Forest Products
Georgia-Pacific LLC, 2.10%, 4/30/27(4)
370,000 376,302 
Pharmaceuticals — 0.1%
Astrazeneca Finance LLC, 1.75%, 5/28/28256,000 255,117 
Bristol-Myers Squibb Co., 2.55%, 11/13/50337,000 322,841 
Royalty Pharma plc, 2.20%, 9/2/30235,000 227,643 
Viatris, Inc., 4.00%, 6/22/50
139,000 149,228 
954,829 
Real Estate Management and Development — 0.1%
Essential Properties LP, 2.95%, 7/15/31460,000 459,105 
20


Shares/
Principal Amount
Value
Ontario Teachers' Cadillac Fairview Properties Trust, 2.50%, 10/15/31(4)
$201,000 $201,576 
660,681 
Road and Rail — 0.3%
Ashtead Capital, Inc., 1.50%, 8/12/26(4)
320,000 314,185 
Burlington Northern Santa Fe LLC, 4.15%, 4/1/45300,000 369,290 
Burlington Northern Santa Fe LLC, 3.30%, 9/15/51200,000 221,953 
CSX Corp., 3.25%, 6/1/27390,000 419,921 
DAE Funding LLC, 1.55%, 8/1/24(4)
395,000 390,161 
DAE Funding LLC, 3.375%, 3/20/28(4)
642,000 656,723 
Union Pacific Corp., 2.40%, 2/5/30270,000 278,003 
Union Pacific Corp., MTN, 3.55%, 8/15/39450,000 503,541 
3,153,777 
Semiconductors and Semiconductor Equipment — 0.2%
Intel Corp., 2.80%, 8/12/41580,000 579,433 
Microchip Technology, Inc., 4.25%, 9/1/251,036,000 1,077,803 
Qorvo, Inc., 4.375%, 10/15/29450,000 483,750 
Qorvo, Inc., 3.375%, 4/1/31(4)
227,000 234,970 
2,375,956 
Software — 0.1%
Autodesk, Inc., 2.40%, 12/15/31321,000 315,944 
Oracle Corp., 3.60%, 4/1/40645,000 673,227 
989,171 
Specialty Retail — 0.2%
AutoNation, Inc., 1.95%, 8/1/28307,000 299,664 
Home Depot, Inc. (The), 3.90%, 6/15/4750,000 60,154 
Home Depot, Inc. (The), 2.375%, 3/15/51720,000 671,622 
Lowe's Cos., Inc., 2.625%, 4/1/31690,000 705,948 
1,737,388 
Technology Hardware, Storage and Peripherals — 0.3%
Apple, Inc., 2.65%, 2/8/51880,000 870,362 
Dell International LLC / EMC Corp., 4.90%, 10/1/26605,000 689,634 
Dell International LLC / EMC Corp., 8.10%, 7/15/36289,000 438,348 
Dell International LLC / EMC Corp., 8.35%, 7/15/46280,000 466,032 
HP, Inc., 2.65%, 6/17/31(4)
580,000 571,387 
Western Digital Corp., 4.75%, 2/15/26753,000 828,300 
3,864,063 
Thrifts and Mortgage Finance — 0.1%
Nationwide Building Society, VRN, 4.125%, 10/18/32(4)
595,000 642,323 
Trading Companies and Distributors
Aircastle Ltd., 5.25%, 8/11/25(4)
371,000 410,154 
Water Utilities
Essential Utilities, Inc., 2.70%, 4/15/30380,000 388,839 
Wireless Telecommunication Services — 0.2%
T-Mobile USA, Inc., 4.75%, 2/1/28534,000 564,038 
T-Mobile USA, Inc., 3.50%, 4/15/31395,000 409,321 
T-Mobile USA, Inc., 3.40%, 10/15/52(4)
455,000 453,660 
Vodafone Group plc, VRN, 4.125%, 6/4/81465,000 462,842 
1,889,861 
TOTAL CORPORATE BONDS
(Cost $118,226,711)
119,793,254 
21


Shares/
Principal Amount
Value
U.S. GOVERNMENT AGENCY MORTGAGE-BACKED SECURITIES — 4.0%
Adjustable-Rate U.S. Government Agency Mortgage-Backed Securities — 0.1%
FHLMC, VRN, 2.34%, (1-year H15T1Y plus 2.25%), 9/1/35$82,527 $88,326 
FHLMC, VRN, 2.17%, (12-month LIBOR plus 1.87%), 7/1/3620,766 21,970 
FHLMC, VRN, 2.20%, (1-year H15T1Y plus 2.14%), 10/1/3679,779 85,876 
FHLMC, VRN, 2.35%, (1-year H15T1Y plus 2.26%), 4/1/3788,113 94,126 
FHLMC, VRN, 2.12%, (12-month LIBOR plus 1.86%), 7/1/4173,148 77,585 
FHLMC, VRN, 2.89%, (12-month LIBOR plus 1.63%), 1/1/4490,069 92,959 
FHLMC, VRN, 2.62%, (12-month LIBOR plus 1.60%), 6/1/4554,151 56,558 
FHLMC, VRN, 1.875%, (12-month LIBOR plus 1.63%), 8/1/46154,648 160,976 
FHLMC, VRN, 3.05%, (12-month LIBOR plus 1.64%), 9/1/47246,008 255,090 
FNMA, VRN, 1.82%, (6-month LIBOR plus 1.57%), 6/1/3551,875 54,075 
FNMA, VRN, 1.82%, (6-month LIBOR plus 1.57%), 6/1/3547,876 49,900 
FNMA, VRN, 2.22%, (1-year H15T1Y plus 2.16%), 3/1/3867,087 71,995 
FNMA, VRN, 3.20%, (12-month LIBOR plus 1.61%), 3/1/47145,358 150,886 
FNMA, VRN, 3.10%, (12-month LIBOR plus 1.61%), 4/1/4796,744 100,466 
FNMA, VRN, 3.24%, (12-month LIBOR plus 1.62%), 5/1/47165,480 171,630 
1,532,418 
Fixed-Rate U.S. Government Agency Mortgage-Backed Securities — 3.9%
FHLMC, 3.00%, 6/1/513,201,139 3,342,757 
FHLMC, 3.00%, 7/1/512,093,914 2,187,246 
FHLMC, 2.50%, 8/1/512,166,129 2,226,942 
FHLMC, 2.50%, 9/1/511,647,136 1,694,080 
FHLMC, 3.50%, 9/1/51587,370 621,529 
FHLMC, 2.50%, 10/1/511,647,672 1,693,929 
FNMA, 3.50%, 3/1/34165,237 176,422 
FNMA, 4.50%, 9/1/41172,507 192,988 
FNMA, 3.50%, 5/1/42839,654 911,385 
FNMA, 3.50%, 6/1/42268,328 291,289 
FNMA, 3.00%, 6/1/50510,026 535,062 
FNMA, 2.50%, 6/1/511,943,221 1,998,468 
FNMA, 3.00%, 6/1/51196,803 208,137 
FNMA, 3.50%, 7/1/513,868,654 4,118,724 
FNMA, 3.50%, 8/1/51276,490 293,667 
FNMA, 3.50%, 9/1/51581,744 618,328 
GNMA, 2.50%, TBA4,219,000 4,337,247 
GNMA, 7.00%, 4/20/2613,295 14,511 
GNMA, 7.50%, 8/15/268,869 9,770 
GNMA, 7.00%, 2/15/281,734 1,740 
GNMA, 7.00%, 5/15/3121,417 24,778 
GNMA, 5.50%, 11/15/3256,173 65,328 
GNMA, 4.50%, 6/15/41187,436 214,873 
GNMA, 3.50%, 6/20/42338,537 364,364 
GNMA, 3.50%, 3/15/461,462,974 1,571,562 
GNMA, 3.50%, 6/20/511,399,537 1,467,108 
GNMA, 3.00%, 7/20/51515,546 535,975 
GNMA, 3.00%, 8/20/51519,386 541,148 
GNMA, 2.50%, 9/20/511,401,356 1,441,540 
GNMA, 3.00%, 9/20/511,044,241 1,089,369 
UMBS, 2.50%, TBA9,900,000 10,168,190 
42,958,456 
TOTAL U.S. GOVERNMENT AGENCY MORTGAGE-BACKED SECURITIES
(Cost $44,495,563)
44,490,874 
22


Shares/
Principal Amount
Value
COLLATERALIZED LOAN OBLIGATIONS — 2.8%


ABPCI Direct Lending Fund CLO IV Ltd., Series 2017-2A, Class BR, VRN, 2.03%, (3-month LIBOR plus 1.90%), 10/27/33(4)
$600,000 $600,033 
Aimco CLO Ltd., Series 2019-10A, Class BR, VRN, 1.73%,
(3-month LIBOR plus 1.60%), 7/22/32(4)
1,090,000 1,090,543 
Anchorage Capital CLO Ltd., Series 2021-19A, Class B1, VRN, 2.01%, (3-month LIBOR plus 1.85%), 10/15/34(4)
825,000 826,203 
Anchorage Credit Opportunities CLO Ltd., Series 2019-1A, Class A1, VRN, 2.08%, (3-month LIBOR plus 1.95%), 1/20/32(4)
800,000 801,834 
Apidos CLO XXVI, Series 2017-26A, Class BR, VRN, 2.07%,
(3-month LIBOR plus 1.95%), 7/18/29(4)
775,000 775,773 
ARES LII CLO Ltd., Series 2019-52A, Class BR, VRN, 1.78%, (3-month LIBOR plus 1.65%), 4/22/31(4)
550,000 550,274 
ARES LII CLO Ltd., Series 2019-52A, Class CR, VRN, 2.23%, (3-month LIBOR plus 2.10%), 4/22/31(4)
575,000 575,998 
Bain Capital Credit CLO Ltd., Series 2019-2A, Class BR, VRN, 1.72%, (3-month LIBOR plus 1.60%), 10/17/32(4)
625,000 624,494 
BDS Ltd., Series 2021-FL7, Class C, VRN, 1.79%, (1-month LIBOR plus 1.70%), 6/16/36(4)
1,125,000 1,114,708 
Bean Creek CLO Ltd., Series 2015-1A, Class AR, VRN, 1.15%, (3-month LIBOR plus 1.02%), 4/20/31(4)
575,000 575,343 
Canyon Capital CLO Ltd., Series 2017-1A, Class BR, VRN, 1.72%, (3-month LIBOR plus 1.60%), 7/15/30(4)
725,000 724,796 
Carlyle Global Market Strategies CLO Ltd., Series 2013-1A, Class BRR, VRN, 2.32%, (3-month LIBOR plus 2.20%), 8/14/30(4)
700,000 701,039 
CarVal CLO III Ltd., Series 2019-2A, Class BR, VRN, 1.73%,
(3-month LIBOR plus 1.60%), 7/20/32(4)
500,000 500,249 
Cedar Funding Ltd., Series 2019-10A, Class BR, VRN, 1.73%, (3-month LIBOR plus 1.60%), 10/20/32(4)
600,000 598,733 
Cerberus Loan Funding XXXIII LP, Series 2021-3A, Class A, VRN, 1.68%, (3-month LIBOR plus 1.56%), 7/23/33(4)
800,000 801,008 
Elmwood CLO II Ltd., Series 2019-2A, Class DR, VRN, 3.13%, (3-month LIBOR plus 3.00%), 4/20/34(4)
500,000 503,209 
Elmwood CLO V Ltd., Series 2020-2A, Class BR, VRN, 1.78%, (3-month LIBOR plus 1.65%), 10/20/34(4)
425,000 423,804 
Elmwood CLO X Ltd., Series 2021-3A, Class B, VRN, 1.69%,
(3-month LIBOR plus 1.60%), 10/20/34(4)
1,075,000 1,072,838 
Elmwood CLO X Ltd., Series 2021-3A, Class C, VRN, 2.04%,
(3-month LIBOR plus 1.95%), 10/20/34(4)
625,000 624,573 
Goldentree Loan Management US CLO Ltd., Series 2019-5A, Class BR, VRN, 1.68%, (3-month LIBOR plus 1.55%), 10/20/32(4)
1,000,000 1,000,000 
KKR CLO Ltd., Series 18, Class BR, VRN, 1.72%, (3-month LIBOR plus 1.60%), 7/18/30(4)
575,000 575,004 
KKR CLO Ltd., Series 2022A, Class A, VRN, 1.28%, (3-month LIBOR plus 1.15%), 7/20/31(4)
450,000 450,369 
KKR CLO Ltd., Series 30A, Class BR, VRN, 2.85%, (3-month LIBOR plus 1.60%), 10/17/31(3)(4)
1,025,000 1,025,000 
KREF Ltd., Series 2021-FL2, Class AS, VRN, 1.39%, (1-month LIBOR plus 1.30%), 2/15/39(4)
800,000 799,250 
KREF Ltd., Series 2021-FL2, Class B, VRN, 1.74%, (1-month LIBOR plus 1.65%), 2/15/39(4)
800,000 799,110 
Madison Park Funding XXI Ltd., Series 2016-21A, Class A2RR, VRN, 1.78%, (3-month LIBOR plus 1.65%), 10/15/32(4)
525,000 525,000 
Madison Park Funding XXII Ltd., Series 2016-22A, Class A1R, VRN, 1.38%, (3-month LIBOR plus 1.26%), 1/15/33(4)
450,000 450,406 
Madison Park Funding XXXVII Ltd., Series 2019-37A, Class BR, VRN, 1.77%, (3-month LIBOR plus 1.65%), 7/15/33(4)
1,075,000 1,075,535 
23


Shares/
Principal Amount
Value
Magnetite CLO XXXI Ltd., Series 2021-31 A, Class B, VRN, 1.76%, (3-month LIBOR plus 1.65%), 7/15/34(4)
$600,000 $600,800 
MF1 Ltd., Series 2021-FL7, Class AS, VRN, 1.54%, (1-month LIBOR plus 1.45%), 10/16/36(4)
1,350,000 1,349,319 
Octagon Investment Partners XV Ltd., Series 2013-1A, Class BRR, VRN, 1.63%, (3-month LIBOR plus 1.50%), 7/19/30(4)
800,000 798,607 
Parallel Ltd., Series 2019-1A, Class BR, VRN, 1.93%, (3-month LIBOR plus 1.80%), 7/20/32(4)
825,000 823,423 
Park Avenue Institutional Advisers CLO Ltd., Series 2018-1A, Class BR, VRN, 2.23%, (3-month LIBOR plus 2.10%), 10/20/31(4)
750,000 747,972 
Regata XII Funding Ltd., Series 2019-1A, Class BR, VRN, 1.72%, (3-month LIBOR plus 1.60%), 10/15/32(4)
750,000 748,521 
Rockford Tower CLO Ltd., Series 2017-3A, Class A, VRN, 1.32%, (3-month LIBOR plus 1.19%), 10/20/30(4)
650,000 650,326 
Sound Point CLO XXII Ltd., Series 2019-1A, Class BR, VRN, 1.83%, (3-month LIBOR plus 1.70%), 1/20/32(4)
1,350,000 1,350,672 
THL Credit Wind River CLO Ltd., Series 2013-2A, Class BR2, VRN, 1.69%, (3-month LIBOR plus 1.57%), 10/18/30(4)
1,150,000 1,148,061 
THL Credit Wind River CLO Ltd., Series 2019-3A, Class BR, VRN, 1.77%, (3-month LIBOR plus 1.65%), 4/15/31(4)
850,000 850,351 
Voya CLO Ltd., Series 2013-2A, Class A1R, VRN, 1.09%,
(3-month LIBOR plus 0.97%), 4/25/31(4)
700,000 700,696 
Voya CLO Ltd., Series 2016-4A, Class B2R, VRN, 1.68%,
(3-month LIBOR plus 1.55%), 7/20/29(4)
1,100,000 1,100,175 
TOTAL COLLATERALIZED LOAN OBLIGATIONS
(Cost $31,043,680)
31,054,049 
COLLATERALIZED MORTGAGE OBLIGATIONS — 2.3%


Private Sponsor Collateralized Mortgage Obligations — 1.6%
ABN Amro Mortgage Corp., Series 2003-4, Class A4, 5.50%, 3/25/334,285 4,378 
Adjustable Rate Mortgage Trust, Series 2004-4, Class 4A1, VRN, 2.53%, 3/25/35101,632 103,782 
Banc of America Mortgage Trust, Series 2004-E, Class 2A6 SEQ, VRN, 2.79%, 6/25/3470,230 72,105 
Bellemeade Re Ltd., Series 2019-3A, Class B1, VRN, 2.59%,
(1-month LIBOR plus 2.50%), 7/25/29(4)
400,000 400,656 
Bellemeade Re Ltd., Series 2019-3A, Class M1C, VRN, 2.04%, (1-month LIBOR plus 1.95%), 7/25/29(4)
360,000 360,518 
Bellemeade Re Ltd., Series 2020-2A, Class M1C, VRN, 4.09%, (1-month LIBOR plus 4.00%), 8/26/30(4)
480,000 488,250 
Chase Mortgage Finance Corp., Series 2021-CL1, Class M1, VRN, 1.25%, (SOFR plus 1.20%), 2/25/50(4)
479,874 481,138 
Citigroup Mortgage Loan Trust, Inc., Series 2004-UST1, Class A5, VRN, 1.94%, 8/25/34220,869 227,384 
Countrywide Home Loan Mortgage Pass-Through Trust, Series 2005-17, Class 1A11, 5.50%, 9/25/351,510 1,473 
Credit Suisse Mortgage Trust, Series 2021-NQM2, Class A2 SEQ, VRN, 1.38%, 2/25/66(4)
478,336 476,741 
Credit Suisse Mortgage Trust, Series 2021-NQM3, Class A3 SEQ, VRN, 1.63%, 4/25/66(4)
362,785 362,871 
Credit Suisse Mortgage Trust, Series 2021-RPL3, Class A1 SEQ, VRN, 2.00%, 1/25/60(4)
499,811 505,685 
Deephaven Residential Mortgage Trust, Series 2021-3, Class A3, VRN, 1.55%, 8/25/66(4)
391,996 390,308 
Eagle RE Ltd., Series 2021-1, Class M1C, VRN, 2.75%, (SOFR plus 2.70%), 10/25/33(4)
525,000 533,458 
First Horizon Alternative Mortgage Securities Trust, Series 2004-AA4, Class A1, VRN, 2.31%, 10/25/34107,170 111,648 
24


Shares/
Principal Amount
Value
GCAT Trust, Series 2021-NQM1, Class A3 SEQ, VRN, 1.15%, 1/25/66(4)
$465,939 $462,888 
GSR Mortgage Loan Trust, Series 2004-7, Class 3A1, VRN, 2.16%, 6/25/3425,052 25,034 
GSR Mortgage Loan Trust, Series 2004-AR5, Class 3A3, VRN, 2.60%, 5/25/3449,837 49,219 
GSR Mortgage Loan Trust, Series 2005-AR1, Class 3A1, VRN, 2.77%, 1/25/3563,513 65,795 
Home RE Ltd., Series 2020-1, Class M1B, VRN, 3.34%,
(1-month LIBOR plus 3.25%), 10/25/30(4)
947,973 950,721 
Home RE Ltd., Series 2021-1 Class M1B, VRN, 1.64%,
(1-month LIBOR plus 1.55%), 7/25/33(4)
360,000 358,555 
JP Morgan Mortgage Trust, Series 2013-1, Class 2A2 SEQ, VRN, 2.50%, 3/25/43(4)
23,479 23,660 
JP Morgan Mortgage Trust, Series 2017-1, Class A2, VRN, 3.48%, 1/25/47(4)
178,575 180,405 
JP Morgan Mortgage Trust, Series 2020-3, Class A15, VRN, 3.50%, 8/25/50(4)
289,881 293,811 
JP Morgan Mortgage Trust, Series 2021-12, Class A4 SEQ, VRN, 2.50%, 2/25/52(4)
1,146,539 1,163,759 
JP Morgan Mortgage Trust, Series 2021-13, Class A3, VRN, 2.50%, 4/25/52(4)
1,225,000 1,230,934 
MASTR Adjustable Rate Mortgages Trust, Series 2004-13, Class 3A7, VRN, 2.72%, 11/21/3494,901 96,459 
Merrill Lynch Mortgage Investors Trust, Series 2005-3, Class 2A, VRN, 2.15%, 11/25/3543,870 43,998 
Merrill Lynch Mortgage Investors Trust, Series 2005-A2, Class A1, VRN, 2.84%, 2/25/3584,872 86,347 
Newrez Warehouse Securitization Trust, Series 2021-1, Class A, VRN, 0.84%, (1-month LIBOR plus 0.75%), 5/25/55(4)
750,000 749,979 
Oaktown Re V Ltd., Series 2020-2A, Class M1A, VRN, 2.49%, (1-month LIBOR plus 2.40%), 10/25/30(4)
36,499 36,501 
Oceanview Mortgage Trust, Series 2021-3, Class A4 SEQ, VRN, 2.50%, 6/25/51(4)
1,169,664 1,190,302 
Oceanview Mortgage Trust, Series 2021-5, Class A4 SEQ, VRN, 2.50%, 10/25/51(4)
1,100,000 1,117,965 
PRMI Securitization Trust, Series 2021-1, Class A5, VRN, 2.50%, 4/25/51(4)
923,080 915,578 
PSMC Trust, Series 2021-1, Class A11 SEQ, VRN, 2.50%, 3/25/51(4)
668,228 680,019 
PSMC Trust, Series 2021-2, Class A3 SEQ, VRN, 2.50%, 5/25/51(4)
396,781 403,781 
PSMC Trust, Series 2021-3, Class A3 SEQ, VRN, 2.50%, 8/25/51(4)
1,157,482 1,177,905 
Sequoia Mortgage Trust, Series 2021-5, Class A4 SEQ, VRN, 2.50%, 7/25/51(4)
476,426 484,532 
Sofi Mortgage Trust, Series 2016-1A, Class 1A4 SEQ, VRN, 3.00%, 11/25/46(4)
55,499 56,424 
Starwood Mortgage Residential Trust, Series 2020-2, Class B1E, VRN, 3.00%, 4/25/60(4)
446,000 447,078 
Structured Adjustable Rate Mortgage Loan Trust, Series 2004-8, Class 2A1, VRN, 2.40%, 7/25/3435,857 36,958 
Verus Securitization Trust, Series 2021-R2, Class A2, VRN, 1.12%, 2/25/64(4)
407,477 406,883 
Verus Securitization Trust, Series 2021-R2, Class A3, VRN, 1.23%, 2/25/64(4)
465,963 465,159 
Wells Fargo Mortgage Backed Securities Trust, Series 2021-2, Class A3, VRN, 2.50%, 6/25/51(4)
859,699 874,326 
18,595,370 
25


Shares/
Principal Amount
Value
U.S. Government Agency Collateralized Mortgage Obligations — 0.7%
FHLMC, Series 2014-DN3, Class M3, VRN, 4.09%, (1-month LIBOR plus 4.00%), 8/25/24$121,681 $124,736 
FHLMC, Series 2015-HQ2, Class M3, VRN, 3.34%, (1-month LIBOR plus 3.25%), 5/25/2574,673 75,821 
FHLMC, Series 2016-DNA2, Class M3, VRN, 4.74%, (1-month LIBOR plus 4.65%), 10/25/28403,797 419,196 
FHLMC, Series 2019-DNA2, Class M2, VRN, 2.54%, (1-month LIBOR plus 2.45%), 3/25/49(4)
306,546 311,456 
FHLMC, Series 2020-DNA3, Class M2, VRN, 3.09%, (1-month LIBOR plus 3.00%), 6/25/50(4)
139,907 140,476 
FHLMC, Series 2020-DNA5, Class M2, VRN, 2.85%, (SOFR plus 2.80%), 10/25/50(4)
633,887 641,439 
FHLMC, Series 2020-HQA3, Class M2, VRN, 3.69%, (1-month LIBOR plus 3.60%), 7/25/50(4)
131,920 132,906 
FHLMC, Series 2021-DNA6, Class M2, VRN, 1.55%, (SOFR plus 1.50%), 10/25/41(4)
1,715,000 1,718,216 
FHLMC, Series 5123, Class HI, IO, 5.00%, 1/25/421,580,376 279,597 
FHLMC, Series 5146, Class DI, IO, 5.50%, 7/25/39490,765 91,786 
FNMA, Series 2013-C01, Class M2, VRN, 5.34%, (1-month LIBOR plus 5.25%), 10/25/23649,670 676,476 
FNMA, Series 2014-C02, Class 2M2, VRN, 2.69%, (1-month LIBOR plus 2.60%), 5/25/24206,409 209,922 
FNMA, Series 2014-C04, Class 1M2, VRN, 4.99%, (1-month LIBOR plus 4.90%), 11/25/24216,812 225,750 
FNMA, Series 2015-C04, Class 1M2, VRN, 5.79%, (1-month LIBOR plus 5.70%), 4/25/28475,077 503,314 
FNMA, Series 2015-C04, Class 2M2, VRN, 5.64%, (1-month LIBOR plus 5.55%), 4/25/28973,238 1,021,757 
FNMA, Series 2016-C01, Class 2M2, VRN, 7.04%, (1-month LIBOR plus 6.95%), 8/25/28597,103 634,108 
FNMA, Series 2016-C06, Class 1M2, VRN, 4.34%, (1-month LIBOR plus 4.25%), 4/25/29251,598 261,634 
FNMA, Series 2017-C03, Class 1M2C, VRN, 3.09%, (1-month LIBOR plus 3.00%), 10/25/29110,000 114,167 
7,582,757 
TOTAL COLLATERALIZED MORTGAGE OBLIGATIONS
(Cost $26,065,904)
26,178,127 
ASSET-BACKED SECURITIES — 2.0%


Blackbird Capital Aircraft, Series 2021-1A, Class A SEQ, 2.44%, 7/15/46(4)
885,938 888,165 
CARS-DB5 LP, Series 2021-1A, Class A4 SEQ, 2.76%, 8/15/51(4)
800,000 796,076 
Castlelake Aircraft Structured Trust, Series 2017-1R, Class A SEQ, 2.74%, 8/15/41(4)
732,345 729,697 
CLI Funding VI LLC, Series 2020-1A, Class A SEQ, 2.08%, 9/18/45(4)
484,963 484,594 
DI Issuer LLC, Series 2021-1A, Class A2 SEQ, 3.72%, 9/15/51(4)
1,900,000 1,900,000 
FirstKey Homes Trust, Series 2020-SFR2, Class D, 1.97%, 10/19/37(4)
1,200,000 1,181,922 
FirstKey Homes Trust, Series 2021-SFR1, Class D, 2.19%, 8/17/38(4)
950,000 937,159 
FirstKey Homes Trust, Series 2021-SFR1, Class E1, 2.39%, 8/17/38(4)
1,100,000 1,085,351 
Global SC Finance SRL, Series 2021-2A, Class A SEQ, 1.95%, 8/17/41(4)
1,324,921 1,318,750 
Goodgreen Trust, Series 2018-1A, Class A, VRN, 3.93%, 10/15/53(4)
428,954 450,929 
26


Shares/
Principal Amount
Value
Goodgreen Trust, Series 2020-1A, Class A SEQ, 2.63%, 4/15/55(4)
$818,771 $824,754 
Goodgreen Trust, Series 2021-1A, Class A SEQ, 2.66%, 10/15/56(4)
563,739 562,157 
J.G. Wentworth XL LLC, Series 2017-3A, Class B, 5.43%, 2/15/69(4)
93,000 114,536 
J.G. Wentworth XXXIX LLC, Series 2017-2A, Class B, 5.09%, 9/17/74(4)
173,379 204,834 
J.G. Wentworth XXXVIII LLC, Series 2017-1A, Class B, 5.43%, 8/15/62(4)
210,884 255,122 
JG Wentworth XLII LLC, Series 2018-2A, Class B, 4.70%, 10/15/77(4)
550,000 631,664 
MAPS Trust, Series 2021-1A, Class A SEQ, 2.52%, 6/15/46(4)
1,676,942 1,671,368 
New Economy Assets Phase 1 Sponsor LLC, Series 2021-1, Class A1 SEQ, 1.91%, 10/20/61(4)
1,625,000 1,600,815 
New Economy Assets Phase 1 Sponsor LLC, Series 2021-1, Class B1, 2.41%, 10/20/61(4)
1,925,000 1,920,864 
Progress Residential Trust, Series 2021-SFR2, Class D, 2.20%, 4/19/38(4)
600,000 593,504 
Progress Residential Trust, Series 2021-SFR3, Class C, 2.09%, 5/17/26(4)
500,000 498,272 
Progress Residential Trust, Series 2021-SFR8, Class E1, 2.38%, 10/17/38(4)
900,000 887,419 
Sierra Timeshare Receivables Funding LLC, Series 2021-1A, Class C, 1.79%, 11/20/37(4)
421,760 419,471 
Slam Ltd., Series 2021-1A, Class A SEQ, 2.43%, 6/15/46(4)
645,293 640,500 
Taco Bell Funding LLC, Series 2021-1A, Class A23 SEQ, 2.54%, 8/25/51(4)
525,000 528,929 
TAL Advantage VII LLC, Series 2020-1A, Class A SEQ, 2.05%, 9/20/45(4)
487,438 487,231 
Towd Point Mortgage Trust, Series 2018-2, Class A1, VRN, 3.25%, 3/25/58(4)
667,110 684,814 
VSE VOI Mortgage LLC, Series 2016-A, Class A SEQ, 2.54%, 7/20/33(4)
137,460 137,414 
VSE VOI Mortgage LLC, Series 2018-A, Class B, 3.72%, 2/20/36(4)
299,634 310,121 
TOTAL ASSET-BACKED SECURITIES
(Cost $22,841,097)
22,746,432 
COMMERCIAL MORTGAGE-BACKED SECURITIES — 0.8%


BDS Ltd., Series 2021-FL8, Class C, VRN, 1.63%, (1-month LIBOR plus 1.55%), 1/18/36(4)
500,000 499,659 
BDS Ltd., Series 2021-FL8, Class D, VRN, 1.98%, (1-month LIBOR plus 1.90%), 1/18/36(4)
400,000 397,820 
BX Commercial Mortgage Trust, Series 2020-VIV2, Class C, VRN, 3.54%, 3/9/44(4)
975,000 1,017,839 
BX Commercial Mortgage Trust, Series 2020-VIVA, Class D, VRN, 3.55%, 3/11/44(4)
1,100,000 1,116,963 
BX Commercial Mortgage Trust, Series 2021-VOLT, Class F, VRN, 2.49%, (1-month LIBOR plus 2.40%), 9/15/36(4)
1,200,000 1,201,803 
BXMT, Ltd., Series 2020-FL2, Class C, VRN, 1.81%, (SOFR plus 1.76%), 2/15/38(4)
1,090,000 1,084,570 
OPG Trust, Series 2021-PORT, Class E, VRN, 1.63%, (1-month LIBOR plus 1.53%), 10/15/36(4)
1,431,000 1,419,171 
PFP Ltd., Series 2021-8, Class C, VRN, 1.89%, (1-month LIBOR plus 1.80%), 8/9/37(4)
1,175,000 1,172,862 
PFP Ltd., Series 2019-5, Class B, VRN, 1.74%, (1-month LIBOR plus 1.65%), 4/14/36(4)
550,000 549,457 
TOTAL COMMERCIAL MORTGAGE-BACKED SECURITIES
(Cost $8,494,139)
8,460,144 
27


Shares/
Principal Amount
Value
MUNICIPAL SECURITIES — 0.7%


Bay Area Toll Authority Rev., 6.92%, 4/1/40$295,000 $447,038 
California State University Rev., 2.98%, 11/1/51500,000 513,590 
Foothill-Eastern Transportation Corridor Agency Rev., 4.09%, 1/15/49275,000 289,545 
Golden State Tobacco Securitization Corp. Rev., 2.75%, 6/1/34660,000 665,743 
Grand Parkway Transportation Corp. Rev., 3.24%, 10/1/52225,000 235,000 
Houston GO, 3.96%, 3/1/47120,000 142,817 
Metropolitan Transportation Authority Rev., 6.69%, 11/15/40105,000 149,649 
Metropolitan Transportation Authority Rev., 6.81%, 11/15/4060,000 86,810 
Metropolitan Water Reclamation District of Greater Chicago GO, 5.72%, 12/1/38650,000 911,455 
Michigan Strategic Fund Rev., (Flint Water Advocacy Fund), 3.23%, 9/1/47570,000 583,601 
Missouri Highway & Transportation Commission Rev., 5.45%, 5/1/33130,000 163,371 
New Jersey Turnpike Authority Rev., 7.41%, 1/1/40200,000 327,776 
New Jersey Turnpike Authority Rev., 7.10%, 1/1/4195,000 151,963 
New York City GO, 6.27%, 12/1/3795,000 138,147 
Ohio Turnpike & Infrastructure Commission Rev., 3.22%, 2/15/48330,000 341,405 
Ohio Water Development Authority Water Pollution Control Loan Fund Rev., 4.88%, 12/1/34110,000 129,927 
Port Authority of New York & New Jersey Rev., 4.93%, 10/1/5150,000 71,558 
Regents of the University of California Medical Center Pooled Rev., 3.26%, 5/15/60245,000 265,417 
Rutgers The State University of New Jersey Rev., 5.67%, 5/1/40300,000 407,278 
Sacramento Municipal Utility District Rev., 6.16%, 5/15/36210,000 291,148 
San Francisco Public Utilities Commission Water Rev., 6.00%, 11/1/40105,000 144,077 
Santa Clara Valley Transportation Authority Rev., 5.88%, 4/1/32120,000 148,199 
State of California GO, 4.60%, 4/1/38355,000 411,897 
State of California GO, 7.55%, 4/1/39100,000 168,595 
State of California GO, 7.30%, 10/1/39160,000 254,566 
State of California GO, 7.60%, 11/1/4080,000 138,899 
State of Washington GO, 5.14%, 8/1/4020,000 27,485 
TOTAL MUNICIPAL SECURITIES
(Cost $6,487,418)
7,606,956 
EXCHANGE-TRADED FUNDS — 0.4%


SPDR Bloomberg Barclays Short Term High Yield Bond ETF
(Cost $3,885,194)
143,100 3,908,061 
U.S. GOVERNMENT AGENCY SECURITIES — 0.3%


FNMA, 0.75%, 10/8/27$2,000,000 1,929,544 
FNMA, 6.625%, 11/15/30600,000 850,094 
Tennessee Valley Authority, 1.50%, 9/15/31300,000 295,571 
TOTAL U.S. GOVERNMENT AGENCY SECURITIES
(Cost $3,017,099)
3,075,209 
SOVEREIGN GOVERNMENTS AND AGENCIES — 0.1%


Chile
Chile Government International Bond, 3.625%, 10/30/42100,000 106,015 
Mexico — 0.1%
Mexico Government International Bond, 4.15%, 3/28/27600,000 670,707 
Peru
Peruvian Government International Bond, 5.625%, 11/18/50170,000 232,162 
28


Shares/
Principal Amount
Value
Philippines
Philippine Government International Bond, 6.375%, 10/23/34$150,000 $206,492 
Poland
Republic of Poland Government International Bond, 3.00%, 3/17/23140,000 144,235 
South Africa
Republic of South Africa Government International Bond, 4.67%, 1/17/24110,000 117,128 
Uruguay
Uruguay Government International Bond, 4.125%, 11/20/45120,000 142,058 
TOTAL SOVEREIGN GOVERNMENTS AND AGENCIES
(Cost $1,417,182)
1,618,797 
BANK LOAN OBLIGATIONS(5) — 0.1%


Media — 0.1%
DirecTV Financing, LLC, Term Loan, 7/22/27(6)
855,000 856,603 
Pharmaceuticals
Horizon Therapeutics USA Inc., 2021 Term Loan B, 2.50%,
(1-month LIBOR plus 2.00%), 3/15/28
501,480 500,986 
TOTAL BANK LOAN OBLIGATIONS
(Cost $1,359,207)
1,357,589 
PREFERRED STOCKS


Banks
SVB Financial Group, 4.25%
(Cost $425,000)
425,000 427,072 
TEMPORARY CASH INVESTMENTS — 1.2%


State Street Institutional U.S. Government Money Market Fund, Premier Class
(Cost $13,725,310)
13,725,310 13,725,310 
TOTAL INVESTMENT SECURITIES — 101.8%
(Cost $988,830,918)

1,138,028,146 
OTHER ASSETS AND LIABILITIES — (1.8)%

(20,363,162)
TOTAL NET ASSETS — 100.0%

$1,117,664,984 

FORWARD FOREIGN CURRENCY EXCHANGE CONTRACTS
Currency PurchasedCurrency SoldCounterpartySettlement DateUnrealized Appreciation
(Depreciation)
EUR169,601 USD198,536 Credit Suisse AG12/31/21$(2,165)
EUR389,704 USD453,086 Credit Suisse AG12/31/21(1,869)
EUR131,912 USD152,956 Credit Suisse AG12/31/21(223)
EUR114,575 USD133,343 Credit Suisse AG12/31/21(684)
EUR157,540 USD183,163 Credit Suisse AG12/31/21(756)
EUR195,229 USD227,220 Credit Suisse AG12/31/21(1,175)
USD6,534,853 EUR5,573,449 Credit Suisse AG12/31/2181,669 
USD220,461 EUR190,706 Credit Suisse AG12/31/21(347)
USD256,333 EUR220,858 Credit Suisse AG12/31/21614 
USD147,723 EUR126,635 Credit Suisse AG12/31/211,099 
USD292,487 EUR251,763 Credit Suisse AG12/31/21986 
$77,149 

29


FUTURES CONTRACTS PURCHASED
Reference EntityContractsExpiration
Date
Notional
Amount
Unrealized
Appreciation
(Depreciation)^
U.S. Treasury 2-Year Notes54December 2021$11,839,500 $(6,105)
U.S. Treasury 5-Year Notes87December 202110,592,250 (84,420)
U.S. Treasury 10-Year Ultra Notes14December 20212,030,437 11,785 
U.S. Treasury Long Bonds37December 20215,951,219 62,430 
U.S. Treasury Ultra Bonds19December 20213,731,719 61,807 
$34,145,125 $45,497 
^Amount represents value and unrealized appreciation (depreciation).

FUTURES CONTRACTS SOLD
Reference EntityContractsExpiration
Date
Notional
Amount
Unrealized
Appreciation
(Depreciation)^
U.S. Treasury 10-Year Notes51December 2021$6,665,859 $(18,946)
^Amount represents value and unrealized appreciation (depreciation).

CENTRALLY CLEARED TOTAL RETURN SWAP AGREEMENTS
Floating Rate IndexPay/Receive Floating
Rate Index
at Termination
Fixed
Rate
Termination
Date
Notional
Amount
Premiums Paid (Received)Unrealized
Appreciation
(Depreciation)
Value
CPURNSAReceive1.78%8/5/24$3,500,000$(528)$271,170 $270,642 
CPURNSAReceive2.34%2/5/26$2,300,000302 154,300 154,602 
CPURNSAReceive2.33%2/8/26$4,000,000524 268,824 269,348 
CPURNSAReceive2.30%2/24/26$4,000,000524 272,020 272,544 
CPURNSAReceive2.40%2/9/31$2,000,000521 142,101 142,622 
$1,343 $1,108,415 $1,109,758 


30


NOTES TO SCHEDULE OF INVESTMENTS
CPURNSA-U.S. Consumer Price Index Urban Consumers Not Seasonally Adjusted Index
EUR-Euro
FHLMC-Federal Home Loan Mortgage Corporation
FNMA-Federal National Mortgage Association
GNMA-Government National Mortgage Association
GO-General Obligation
H15T1Y-Constant Maturity U.S. Treasury Note Yield Curve Rate Index
IO-Interest Only
LIBOR-London Interbank Offered Rate
MTN-Medium Term Note
SEQ-Sequential Payer
SOFR-Secured Overnight Financing Rate
TBA-To-Be-Announced. Security was purchased on a forward commitment basis with an approximate principal amount and maturity date. Actual principal amount and maturity date will be determined upon settlement.
UMBS-
Uniform Mortgage-Backed Securities
USD-United States Dollar
VRN-
Variable Rate Note. The rate adjusts periodically based upon the terms set forth in the security’s offering documents. The rate shown is effective at the period end and the reference rate and spread, if any, is indicated. The security's effective maturity date may be shorter than the final maturity date shown.
Category is less than 0.05% of total net assets.
(1)Non-income producing.
(2)Security, or a portion thereof, has been pledged at the custodian bank or with a broker for collateral requirements on forward commitments, forward foreign currency exchange contracts, futures contracts and/or swap agreements. At the period end, the aggregate value of securities pledged was $957,055.
(3)When-issued security. The issue price and yield are fixed on the date of the commitment, but payment and delivery are scheduled for a future date.
(4)Security was purchased pursuant to Rule 144A or Section 4(2) under the Securities Act of 1933 and may be sold in transactions exempt from registration, normally to qualified institutional investors. The aggregate value of these securities at the period end was $107,231,358, which represented 9.6% of total net assets.
(5)The interest rate on a bank loan obligation adjusts periodically based on a predetermined schedule. Rate or range of rates shown is effective at period end. The maturity date on a bank loan obligation may be less than indicated as a result of contractual or optional prepayments. These prepayments cannot be predicted with certainty.
(6)The interest rate will be determined upon settlement of the bank loan obligation after period end.


See Notes to Financial Statements.
31


Statement of Assets and Liabilities
OCTOBER 31, 2021
Assets
Investment securities, at value (cost of $988,830,918)$1,138,028,146 
Cash2,359 
Receivable for investments sold1,539,430 
Receivable for capital shares sold147,924 
Receivable for variation margin on futures contracts33,767 
Unrealized appreciation on forward foreign currency exchange contracts84,368 
Dividends and interest receivable2,237,592 
1,142,073,586 
Liabilities
Payable for investments purchased23,194,016 
Payable for capital shares redeemed365,532 
Payable for variation margin on swap agreements33,343 
Unrealized depreciation on forward foreign currency exchange contracts7,219 
Accrued management fees808,492 
24,408,602 
Net Assets$1,117,664,984 
Net Assets Consist of:
Capital (par value and paid-in surplus)$774,332,188 
Distributable earnings343,332,796 
$1,117,664,984 

Net AssetsShares OutstandingNet Asset Value Per Share
Investor Class, $0.01 Par Value$1,002,740,16143,661,755$22.97
I Class, $0.01 Par Value$107,875,1504,693,536$22.98
R5 Class, $0.01 Par Value$7,049,673306,765$22.98


See Notes to Financial Statements.
32


Statement of Operations
YEAR ENDED OCTOBER 31, 2021
Investment Income (Loss)
Income:
Dividends (net of foreign taxes withheld of $8,391)$9,012,265 
Interest (net of foreign taxes withheld of $41)7,570,406 
16,582,671 
Expenses:
Management fees9,247,090 
Directors' fees and expenses27,073 
Other expenses7,917 
9,282,080 
Net investment income (loss)7,300,591 
Realized and Unrealized Gain (Loss)
Net realized gain (loss) on:
Investment transactions205,662,734 
Futures contract transactions2,184,983 
Swap agreement transactions(65,821)
Foreign currency translation transactions(11,220)
207,770,676 
Change in net unrealized appreciation (depreciation) on:
Investments906,234 
Forward foreign currency exchange contracts77,149 
Futures contracts67,522 
Swap agreements1,145,684 
2,196,589 
Net realized and unrealized gain (loss)209,967,265 
Net Increase (Decrease) in Net Assets Resulting from Operations$217,267,856 


See Notes to Financial Statements.
33


Statement of Changes in Net Assets
YEARS ENDED OCTOBER 31, 2021 AND OCTOBER 31, 2020
Increase (Decrease) in Net Assets
October 31, 2021October 31, 2020
Operations
Net investment income (loss)
$7,300,591 $9,729,769 
Net realized gain (loss)
207,770,676 53,394,706 
Change in net unrealized appreciation (depreciation)
2,196,589 2,590,228 
Net increase (decrease) in net assets resulting from operations
217,267,856 65,714,703 
Distributions to Shareholders
From earnings:
Investor Class(51,263,128)(40,169,645)
I Class(6,239,355)(3,755,952)
R5 Class(238,351)(156,553)
Decrease in net assets from distributions(57,740,834)(44,082,150)
Capital Share Transactions
Net increase (decrease) in net assets from capital share transactions (Note 5)13,739,758 12,514,699 
Net increase (decrease) in net assets173,266,780 34,147,252 
Net Assets
Beginning of period944,398,204 910,250,952 
End of period$1,117,664,984 $944,398,204 


See Notes to Financial Statements.
34


Notes to Financial Statements

OCTOBER 31, 2021

1. Organization

American Century Mutual Funds, Inc. (the corporation) is registered under the Investment Company Act of 1940, as amended (the 1940 Act), as an open-end management investment company and is organized as a Maryland corporation. Balanced Fund (the fund) is one fund in a series issued by the corporation. The fund’s investment objective is to seek long-term capital growth and current income by investing approximately 60% of its assets in equity securities and the remainder in bonds and other fixed-income securities. The fund offers the Investor Class, I Class and R5 Class.

2. Significant Accounting Policies

The following is a summary of significant accounting policies consistently followed by the fund in preparation of its financial statements. The fund is an investment company and follows accounting and reporting guidance in accordance with accounting principles generally accepted in the United States of America. This may require management to make certain estimates and assumptions at the date of the financial statements. Actual results could differ from these estimates. Management evaluated the impact of events or transactions occurring through the date the financial statements were issued that would merit recognition or disclosure.

Investment Valuations — The fund determines the fair value of its investments and computes its net asset value (NAV) per share at the close of regular trading (usually 4 p.m. Eastern time) on the New York Stock Exchange (NYSE) on each day the NYSE is open. The Board of Directors has adopted valuation policies and procedures to guide the investment advisor in the fund’s investment valuation process and to provide methodologies for the oversight of the fund’s pricing function.

Equity securities that are listed or traded on a domestic securities exchange are valued at the last reported sales price or at the official closing price as provided by the exchange. Equity securities traded on foreign securities exchanges are generally valued at the closing price of such securities on the exchange where primarily traded or at the close of the NYSE, if that is earlier. If no last sales price is reported, or if local convention or regulation so provides, the mean of the latest bid and asked prices may be used. Securities traded over-the-counter are valued at the mean of the latest bid and asked prices, the last sales price, or the official closing price. Equity securities initially expressed in local currencies are translated into U.S. dollars at the mean of the appropriate currency exchange rate at the close of the NYSE as provided by an independent pricing service.

Fixed income securities are valued at the evaluated mean as provided by independent pricing services or at the mean of the most recent bid and asked prices as provided by investment dealers. Corporate bonds, U.S. Treasury and Government Agency securities, convertible bonds, bank loan obligations, municipal securities, and sovereign governments and agencies are valued using market models that consider trade data, quotations from dealers and active market makers, relevant yield curve and spread data, creditworthiness, trade data or market information on comparable securities, and other relevant security specific information. Mortgage-related and asset-backed securities are valued based on models that consider trade data, prepayment and default projections, benchmark yield and spread data and estimated cash flows of each tranche of the issuer. Collateralized loan obligations are valued based on discounted cash flow models that consider trade and economic data, prepayment assumptions and default projections.

Hybrid securities are valued at the evaluated mean as provided by independent pricing services or at the mean of the most recent bid and asked prices as provided by investment dealers. Preferred stocks and convertible preferred stocks with perpetual maturities are valued using market models that consider trade data, quotations from dealers and active market makers, relevant yield curve and spread data, creditworthiness, trade data or market information on comparable securities, and other relevant security specific information.

Open-end management investment companies are valued at the reported NAV per share. Exchange-traded futures contracts are valued at the settlement price as provided by the appropriate exchange. Swap agreements are valued at an evaluated mean as provided by independent pricing services or independent brokers. Forward foreign currency exchange contracts are valued at the mean of the appropriate forward exchange rate at the close of the NYSE as provided by an independent pricing service.
35



If the fund determines that the market price for an investment is not readily available or the valuation methods mentioned above do not reflect an investment’s fair value, such investment is valued as determined in good faith by the Board of Directors or its delegate, in accordance with policies and procedures adopted by the Board of Directors. In its determination of fair value, the fund may review several factors including, but not limited to, market information regarding the specific investment or comparable investments and correlation with other investment types, futures indices or general market indicators. Circumstances that may cause the fund to use these procedures to value an investment include, but are not limited to: an investment has been declared in default or is distressed; trading in a security has been suspended during the trading day or a security is not actively trading on its principal exchange; prices received from a regular pricing source are deemed unreliable; or there is a foreign market holiday and no trading occurred.

The fund monitors for significant events occurring after the close of an investment’s primary exchange but before the fund’s NAV per share is determined. Significant events may include, but are not limited to: corporate announcements and transactions; governmental action and political unrest that could impact a specific investment or an investment sector; or armed conflicts, natural disasters and similar events that could affect investments in a specific country or region. The fund also monitors for significant fluctuations between domestic and foreign markets, as evidenced by the U.S. market or such other indicators that the Board of Directors, or its delegate, deems appropriate. The fund may apply a model-derived factor to the closing price of equity securities traded on foreign securities exchanges. The factor is based on observable market data as provided by an independent pricing service.

Security Transactions — Security transactions are accounted for as of the trade date. Net realized gains and losses are determined on the identified cost basis, which is also used for federal income tax purposes.

Foreign Currency Translations — All assets and liabilities initially expressed in foreign currencies are translated into U.S. dollars at prevailing exchange rates at period end. The fund may enter into spot foreign currency exchange contracts to facilitate transactions denominated in a foreign currency. Purchases and sales of investment securities, dividend and interest income, spot foreign currency exchange contracts, and expenses are translated at the rates of exchange prevailing on the respective dates of such transactions. Net realized and unrealized foreign currency exchange gains or losses related to investment securities are a component of net realized gain (loss) on investment transactions and change in net unrealized appreciation (depreciation) on investments, respectively.

Investment Income — Dividend income less foreign taxes withheld, if any, is recorded as of the ex-dividend date. Distributions received on securities that represent a return of capital or long-term capital gain are recorded as a reduction of cost of investments and/or as a realized gain. The fund may estimate the components of distributions received that may be considered nontaxable distributions or long-term capital gain distributions for income tax purposes. Interest income less foreign taxes withheld, if any, is recorded on the accrual basis and includes paydown gain (loss) and accretion of discounts and amortization of premiums. Inflation adjustments related to inflation-linked debt securities are reflected as interest income.

Forward Commitments — The fund may engage in securities transactions on a forward commitment basis. In these transactions, the securities’ prices and yields are fixed on the date of the commitment. The fund may sell a to-be-announced (TBA) security and at the same time make a commitment to purchase the same security at a future date at a specified price. Conversely, the fund may purchase a TBA security and at the same time make a commitment to sell the same security at a future date at a specified price. These types of transactions are known as “TBA roll” transactions and are accounted for as purchases and sales. The fund will segregate cash, cash equivalents or other appropriate liquid securities on its records in amounts sufficient to meet the purchase price.

Segregated Assets — In accordance with the 1940 Act, the fund segregates assets on its books and records to cover certain types of investment securities and other financial instruments. American Century Investment Management, Inc. (ACIM) (the investment advisor) monitors, on a daily basis, the securities segregated to ensure the fund designates a sufficient amount of liquid assets, marked-to-market daily. The fund may also receive assets or be required to pledge assets at the custodian bank or with a broker for collateral requirements.

36


Income Tax Status — It is the fund’s policy to distribute substantially all net investment income and net realized gains to shareholders and to otherwise qualify as a regulated investment company under provisions of the Internal Revenue Code. Accordingly, no provision has been made for income taxes. The fund files U.S. federal, state, local and non-U.S. tax returns as applicable. The fund's tax returns are subject to examination by the relevant taxing authority until expiration of the applicable statute of limitations, which is generally three years from the date of filing but can be longer in certain jurisdictions. At this time, management believes there are no uncertain tax positions which, based on their technical merit, would not be sustained upon examination and for which it is reasonably possible that the total amounts of unrecognized tax benefits will significantly change in the next twelve months.

Multiple Class — All shares of the fund represent an equal pro rata interest in the net assets of the class to which such shares belong, and have identical voting, dividend, liquidation and other rights and the same terms and conditions, except for class specific expenses and exclusive rights to vote on matters affecting only individual classes. Income, non-class specific expenses, and realized and unrealized capital gains and losses of the fund are allocated to each class of shares based on their relative net assets.

Distributions to Shareholders — Distributions from net investment income, if any, are generally declared and paid quarterly. Distributions from net realized gains, if any, are generally declared and paid annually. The fund may elect to treat a portion of its payment to a redeeming shareholder, which represents the pro rata share of undistributed net investment income and net realized gains, as a distribution for federal income tax purposes (tax equalization).

Indemnifications — Under the corporation’s organizational documents, its officers and directors are indemnified against certain liabilities arising out of the performance of their duties to the fund. In addition, in the normal course of business, the fund enters into contracts that provide general indemnifications. The maximum exposure under these arrangements is unknown as this would involve future claims that may be made against a fund. The risk of material loss from such claims is considered by management to be remote.

3. Fees and Transactions with Related Parties

Certain officers and directors of the corporation are also officers and/or directors of American Century Companies, Inc. (ACC). The corporation’s investment advisor, ACIM, the corporation's distributor, American Century Investment Services, Inc., and the corporation’s transfer agent, American Century Services, LLC, are wholly owned, directly or indirectly, by ACC.

Management Fees — The corporation has entered into a management agreement with ACIM, under which ACIM provides the fund with investment advisory and management services in exchange for a single, unified management fee (the fee) per class. The agreement provides that ACIM will pay all expenses of managing and operating the fund, except brokerage expenses, taxes, interest, fees and expenses of the independent directors (including legal counsel fees), and extraordinary expenses. The fee is computed and accrued daily based on each class's daily net assets and paid monthly in arrears. The difference in the fee among the classes is a result of their separate arrangements for non-Rule 12b-1 shareholder services. It is not the result of any difference in advisory or custodial fees or other expenses related to the management of the fund’s assets, which do not vary by class. The rate of the fee is determined by applying a fee rate calculation formula. This formula takes into account the fund’s assets as well as certain assets, if any, of other clients of the investment advisor outside the American Century Investments family of funds (such as subadvised funds and separate accounts) that use very similar investment teams and strategies (strategy assets).

The management fee schedule range and the effective annual management fee for each class for the period ended October 31, 2021 are as follows:
Management Fee
Schedule Range
Effective Annual
Management Fee
Investor Class0.800% to 0.900%0.90%
I Class0.600% to 0.700%0.70%
R5 Class0.600% to 0.700%0.70%

Directors' Fees and Expenses — The Board of Directors is responsible for overseeing the investment advisor’s management and operations of the fund. The directors receive detailed information about the fund and its investment advisor regularly throughout the year, and meet at least quarterly with management of the investment advisor to review reports about fund operations. The fund’s officers do not receive compensation from the fund.
37


Interfund Transactions — The fund may enter into security transactions with other American Century Investments funds and other client accounts of the investment advisor, in accordance with the 1940 Act rules and procedures adopted by the Board of Directors. The rules and procedures require, among other things, that these transactions be effected at the independent current market price of the security. During the period, the interfund purchases and sales were $4,662,771 and $7,639,521, respectively. The effect of interfund transactions on the Statement of Operations was $912,440 in net realized gain (loss) on investment transactions.

4. Investment Transactions

Purchases of investment securities, excluding short-term investments, for the period ended October 31, 2021 totaled $2,387,533,166, of which $619,028,023 represented U.S. Treasury and Government Agency obligations.

Sales of investment securities, excluding short-term investments, for the period ended October 31, 2021 totaled $2,429,344,121, of which $632,945,420 represented U.S. Treasury and Government Agency obligations.

5. Capital Share Transactions

Transactions in shares of the fund were as follows:
Year ended
October 31, 2021
Year ended
October 31, 2020
SharesAmountSharesAmount
Investor Class/Shares Authorized530,000,000 530,000,000 
Sold4,157,746 $88,713,677 4,046,798 $78,184,412 
Issued in reinvestment of distributions2,448,377 49,436,486 2,048,400 39,160,124 
Redeemed(5,592,077)(119,705,514)(6,997,025)(132,646,617)
1,014,046 18,444,649 (901,827)(15,302,081)
I Class/Shares Authorized50,000,000 50,000,000 
Sold904,798 19,191,359 2,500,437 47,238,943 
Issued in reinvestment of distributions308,467 6,238,096 196,097 3,754,687 
Redeemed(1,561,092)(32,908,772)(1,231,351)(23,595,556)
(347,827)(7,479,317)1,465,183 27,398,074 
R5 Class/Shares Authorized30,000,000 30,000,000 
Sold132,639 2,910,360 26,145 502,174 
Issued in reinvestment of distributions11,751 238,351 8,180 156,553 
Redeemed(17,242)(374,285)(13,204)(240,021)
127,148 2,774,426 21,121 418,706 
Net increase (decrease)793,367 $13,739,758 584,477 $12,514,699 

6. Fair Value Measurements

The fund’s investments valuation process is based on several considerations and may use multiple inputs to determine the fair value of the investments held by the fund. In conformity with accounting principles generally accepted in the United States of America, the inputs used to determine a valuation are classified into three broad levels.

Level 1 valuation inputs consist of unadjusted quoted prices in an active market for identical investments.

Level 2 valuation inputs consist of direct or indirect observable market data (including quoted prices for comparable investments, evaluations of subsequent market events, interest rates, prepayment speeds, credit risk, etc.). These inputs also consist of quoted prices for identical investments initially expressed in local currencies that are adjusted through translation into U.S. dollars.

Level 3 valuation inputs consist of unobservable data (including a fund’s own assumptions).

38


The level classification is based on the lowest level input that is significant to the fair valuation measurement. The valuation inputs are not necessarily an indication of the risks associated with investing in these securities or other financial instruments.

The following is a summary of the level classifications as of period end. The Schedule of Investments provides additional information on the fund’s portfolio holdings.
Level 1Level 2Level 3
Assets
Investment Securities
Common Stocks$673,990,137 $10,921,708 — 
U.S. Treasury Securities— 168,674,427 — 
Corporate Bonds— 119,793,254 — 
U.S. Government Agency Mortgage-Backed Securities— 44,490,874 — 
Collateralized Loan Obligations— 31,054,049 — 
Collateralized Mortgage Obligations— 26,178,127 — 
Asset-Backed Securities— 22,746,432 — 
Commercial Mortgage-Backed Securities— 8,460,144 — 
Municipal Securities— 7,606,956 — 
Exchange-Traded Funds3,908,061 — — 
U.S. Government Agency Securities— 3,075,209 — 
Sovereign Governments and Agencies— 1,618,797 — 
Bank Loan Obligations— 1,357,589 — 
Preferred Stocks— 427,072 — 
Temporary Cash Investments13,725,310 — — 
$691,623,508 $446,404,638 — 
Other Financial Instruments
Futures Contracts$136,022 — — 
Swap Agreements— $1,109,758 — 
Forward Foreign Currency Exchange Contracts— 84,368 — 
$136,022 $1,194,126 — 
Liabilities
Other Financial Instruments
Futures Contracts$109,471 — — 
Forward Foreign Currency Exchange Contracts— $7,219 — 
$109,471 $7,219 — 

39


7. Derivative Instruments

Credit Risk — The fund is subject to credit risk in the normal course of pursuing its investment objectives. The value of a bond generally declines as the credit quality of its issuer declines. Credit default swap agreements enable a fund to buy/sell protection against a credit event of a specific issuer or index. A fund may attempt to enhance returns by selling protection or attempt to mitigate credit risk by buying protection. The buyer/seller of credit protection against a security or basket of securities may pay/receive an up-front or periodic payment to compensate for/against potential default events. Changes in value, including the periodic amounts of interest to be paid or received on swap agreements, are recorded as unrealized appreciation (depreciation) on swap agreements. Upon entering into a centrally cleared swap, a fund is required to deposit cash or securities (initial margin) with a financial intermediary in an amount equal to a certain percentage of the notional amount. Subsequent payments (variation margin) are made or received daily, in cash, by a fund. The variation margin is equal to the daily change in the value and is a component of unrealized gains and losses. Realized gain or loss is recorded upon receipt or payment of a periodic settlement or termination of swap agreements. Net realized and unrealized gains or losses occurring during the holding period of swap agreements are a component of net realized gain (loss) on swap agreement transactions and change in net unrealized appreciation (depreciation) on swap agreements, respectively. The risks of entering into swap agreements include the possible lack of liquidity, failure of the counterparty to meet its obligations, and that there may be unfavorable changes in the underlying investments or instruments. The fund's average notional amount held during the period was $8,866,667.

Equity Price Risk — The fund is subject to equity price risk in the normal course of pursuing its investment objectives. A fund may enter into futures contracts based on an equity index in order to manage its exposure to changes in market conditions. A fund may purchase futures contracts to gain exposure to increases in market value or sell futures contracts to protect against a decline in market value. Upon entering into a futures contract, a fund is required to deposit either cash or securities in an amount equal to a certain percentage of the contract value (initial margin). Subsequent payments (variation margin) are made or received daily, in cash, by a fund. The variation margin is equal to the daily change in the contract value and is recorded as unrealized gains and losses. A fund recognizes a realized gain or loss when the contract is closed or expires. Net realized and unrealized gains or losses occurring during the holding period of futures contracts are a component of net realized gain (loss) on futures contract transactions and change in net unrealized appreciation (depreciation) on futures contracts, respectively. One of the risks of entering into futures contracts is the possibility that the change in value of the contract may not correlate with the changes in value of the underlying securities. The fund's average notional exposure to equity price risk derivative instruments held during the period was $6,110,913 futures contracts purchased.

Foreign Currency Risk — The fund is subject to foreign currency exchange rate risk in the normal course of pursuing its investment objectives. The value of foreign investments held by a fund may be significantly affected by changes in foreign currency exchange rates. The dollar value of a foreign security generally decreases when the value of the dollar rises against the foreign currency in which the security is denominated and tends to increase when the value of the dollar declines against such foreign currency. A fund may enter into forward foreign currency exchange contracts to reduce a fund's exposure to foreign currency exchange rate fluctuations. The net U.S. dollar value of foreign currency underlying all contractual commitments held by a fund and the resulting unrealized appreciation or depreciation are determined daily. Realized gain or loss is recorded upon settlement of the contract. Net realized and unrealized gains or losses occurring during the holding period of forward foreign currency exchange contracts are a component of net realized gain (loss) on forward foreign currency exchange contract transactions and change in net unrealized appreciation (depreciation) on forward foreign currency exchange contracts, respectively. A fund bears the risk of an unfavorable change in the foreign currency exchange rate underlying the forward contract. Additionally, losses, up to the fair value, may arise if the counterparties do not perform under the contract terms. The fund's average U.S. dollar exposure to foreign currency risk derivative instruments held during the period was $8,069,795.

40


Interest Rate Risk — The fund is subject to interest rate risk in the normal course of pursuing its investment objectives. The value of bonds generally declines as interest rates rise. A fund may enter into futures contracts based on a bond index or a specific underlying security. A fund may purchase futures contracts to gain exposure to increases in market value or sell futures contracts to protect against a decline in market value. Upon entering into a futures contract, a fund will segregate cash, cash equivalents or other appropriate liquid securities on its records in amounts sufficient to meet requirements. Subsequent payments (variation margin) are made or received daily, in cash, by a fund. The variation margin is equal to the daily change in the contract value and is recorded as unrealized gains and losses. A fund recognizes a realized gain or loss when the futures contract is closed or expires. Net realized and unrealized gains or losses occurring during the holding period of futures contracts are a component of net realized gain (loss) on futures contract transactions and change in net unrealized appreciation (depreciation) on futures contracts, respectively. One of the risks of entering into futures contracts is the possibility that the change in value of the contract may not correlate with the changes in value of the underlying securities. The fund's average notional exposure to interest rate risk derivative instruments held during the period was $31,437,161 futures contracts purchased and $8,242,622 futures contracts sold.

Other Contracts — A fund may enter into total return swap agreements in order to attempt to obtain or preserve a particular return or spread at a lower cost than obtaining a return or spread through purchases and/or sales of instruments in other markets or gain exposure to certain markets in the most economical way possible. A fund will segregate cash, cash equivalents or other appropriate liquid securities on its records in amounts sufficient to meet requirements. Changes in value, including the periodic amounts of interest to be paid or received on swap agreements, are recorded as unrealized appreciation (depreciation) on swap agreements. Upon entering into a centrally cleared swap, a fund is required to deposit cash or securities (initial margin) with a financial intermediary in an amount equal to a certain percentage of the notional amount. Subsequent payments (variation margin) are made or received daily, in cash, by a fund. The variation margin is equal to the daily change in the value and is a component of unrealized gains and losses. Realized gain or loss is recorded upon receipt or payment of a periodic settlement or termination of swap agreements. Net realized and unrealized gains or losses occurring during the holding period of swap agreements are a component of net realized gain (loss) on swap agreement transactions and change in net unrealized appreciation (depreciation) on swap agreements, respectively. The risks of entering into swap agreements include the possible lack of liquidity, failure of the counterparty to meet its obligations, and that there may be unfavorable changes in the underlying investments or instruments, including inflationary risk. The fund's average notional amount held during the period was $13,575,000.

Value of Derivative Instruments as of October 31, 2021
Asset Derivatives
Liability Derivatives
Type of Risk ExposureLocation on Statement of Assets and Liabilities
Value
Location on Statement of Assets and Liabilities
Value
Foreign Currency RiskUnrealized appreciation on forward foreign currency exchange contracts$84,368 Unrealized depreciation on forward foreign currency exchange contracts$7,219 
Interest Rate RiskReceivable for variation margin on futures contracts*33,767 Payable for variation margin on futures contracts*— 
Other ContractsReceivable for variation margin on swap agreements*— Payable for variation margin on swap agreements*33,343 
$118,135 $40,562 
*Included in the unrealized appreciation (depreciation) on futures contracts or centrally cleared swap agreements, as applicable, as reported in the Schedule of Investments.

41


Effect of Derivative Instruments on the Statement of Operations for the Year Ended October 31, 2021
Net Realized Gain (Loss)Change in Net Unrealized Appreciation (Depreciation)
Type of Risk ExposureLocation on Statement of Operations
Value
Location on Statement of Operations
Value
Credit RiskNet realized gain (loss) on swap agreement transactions$(136,488)Change in net unrealized appreciation (depreciation) on swap agreements— 
Equity Price RiskNet realized gain (loss) on futures contract transactions1,970,351 Change in net unrealized appreciation (depreciation) on futures contracts$94,605 
Foreign Currency RiskNet realized gain (loss) on forward foreign currency exchange contract transactions— Change in net unrealized appreciation (depreciation) on forward foreign currency exchange contracts77,149 
Interest Rate RiskNet realized gain (loss) on futures contract transactions214,632 Change in net unrealized appreciation (depreciation) on futures contracts(27,083)
Other ContractsNet realized gain (loss) on swap agreement transactions70,667 Change in net unrealized appreciation (depreciation) on swap agreements1,145,684 
$2,119,162 $1,290,355 

8. Risk Factors

The value of the fund’s shares will go up and down, sometimes rapidly or unpredictably, based on the performance of the securities owned by the fund and other factors generally affecting the securities market. Market risks, including political, regulatory, economic and social developments, can affect the value of the fund’s investments. Natural disasters, public health emergencies, terrorism and other unforeseeable events may lead to increased market volatility and may have adverse long-term effects on world economies and markets generally.

The fund may invest in instruments that have variable or floating coupon rates based on the London Interbank Offered Rate (LIBOR). LIBOR is a benchmark interest rate intended to be representative of the rate at which certain major international banks lend to one another over short-terms. However, LIBOR is expected to be phased out and the transition process may lead to increased volatility or illiquidity in markets for instruments that rely on LIBOR. This could result in a change to the value of such instruments.

The fund’s investment process may result in high portfolio turnover, which could mean high transaction costs, affecting both performance and capital gains tax liabilities to investors.

9. Federal Tax Information

The tax character of distributions paid during the years ended October 31, 2021 and October 31, 2020 were as follows:
20212020
Distributions Paid From
Ordinary income$8,419,510 $13,199,357 
Long-term capital gains$49,321,324 $30,882,793 

The book-basis character of distributions made during the year from net investment income or net realized gains may differ from their ultimate characterization for federal income tax purposes. These differences reflect the differing character of certain income items and net realized gains and losses for financial statement and tax purposes, and may result in reclassification among certain capital accounts on the financial statements.


42


As of period end, the federal tax cost of investments and the components of distributable earnings on a tax-basis were as follows:

Federal tax cost of investments$990,517,547 
Gross tax appreciation of investments$159,643,267 
Gross tax depreciation of investments(12,132,668)
Net tax appreciation (depreciation) of investments147,510,599 
Net tax appreciation (depreciation) on derivatives and translation of assets and
liabilities in foreign currencies
1,108,415 
Net tax appreciation (depreciation)$148,619,014 
Other book-to-tax adjustments$(156,390)
Undistributed ordinary income $87,967,892 
Accumulated long-term gains$106,902,280 

The difference between book-basis and tax-basis unrealized appreciation (depreciation) is attributable primarily to the tax deferral of losses on wash sales. Other book-to-tax adjustments are attributable primarily to the tax deferral of losses on straddle positions.



43


Financial Highlights
For a Share Outstanding Throughout the Years Ended October 31 (except as noted)
Per-Share DataRatios and Supplemental Data
  Income From Investment Operations:Distributions From:  Ratio to Average Net Assets of:  
 Net Asset
Value,
Beginning
of Period
Net
Investment
Income
(Loss)(1)
Net
Realized and Unrealized
Gain (Loss)
Total From Investment OperationsNet
Investment
Income
Net
Realized
Gains
Total
Distributions
Net
Asset Value,
End of Period
Total
Return(2)
Operating
Expenses
Net
Investment
Income
(Loss)
Portfolio
Turnover
Rate
Net Assets,
End of Period
(in thousands)
Investor Class
2021$19.730.144.304.44(0.17)(1.03)(1.20)$22.9723.34%0.90%0.67%225%$1,002,740 
2020$19.250.201.221.42(0.25)(0.69)(0.94)$19.737.54%0.90%1.03%165%$841,328 
2019$18.550.291.732.02(0.29)(1.03)(1.32)$19.2511.82%0.90%1.58%101%$838,309 
2018$19.310.250.090.34(0.25)(0.85)(1.10)$18.551.72%0.90%1.32%115%$798,120 
2017$17.390.262.102.36(0.28)(0.16)(0.44)$19.3113.78%0.91%1.44%112%$814,569 
I Class
2021$19.740.194.294.48(0.21)(1.03)(1.24)$22.9823.58%0.70%0.87%225%$107,875 
2020$19.260.231.231.46(0.29)(0.69)(0.98)$19.747.75%0.70%1.23%165%$99,524 
2019$18.560.331.722.05(0.32)(1.03)(1.35)$19.2612.04%0.70%1.78%101%$68,889 
2018$19.320.290.090.38(0.29)(0.85)(1.14)$18.561.92%0.70%1.52%115%$62,077 
2017$17.400.302.092.39(0.31)(0.16)(0.47)$19.3213.99%0.71%1.64%112%$73,385 
R5 Class
2021$19.740.184.304.48(0.21)(1.03)(1.24)$22.9823.58%0.70%0.87%225%$7,050 
2020$19.260.241.221.46(0.29)(0.69)(0.98)$19.747.75%0.70%1.23%165%$3,545 
2019$18.560.331.722.05(0.32)(1.03)(1.35)$19.2612.04%0.70%1.78%101%$3,053 
2018$19.320.300.080.38(0.29)(0.85)(1.14)$18.561.93%0.70%1.52%115%$2,574 
2017(3)
$18.180.171.141.31(0.17)(0.17)$19.327.21%
0.71%(4)
1.66%(4)
112%(5)
$5 




Notes to Financial Highlights
(1)Computed using average shares outstanding throughout the period.
(2)Total returns are calculated based on the net asset value of the last business day. Total returns for periods less than one year are not annualized.
(3)April 10, 2017 (commencement of sale) through October 31, 2017.
(4)Annualized.
(5)Portfolio turnover is calculated at the fund level. Percentage indicated was calculated for the year ended October 31, 2017.


See Notes to Financial Statements.



Report of Independent Registered Public Accounting Firm

To the Shareholders and the Board of Directors of American Century Mutual Funds, Inc.:

Opinion on the Financial Statements and Financial Highlights

We have audited the accompanying statement of assets and liabilities, including the schedule of investments, of Balanced Fund (the “Fund”), one of the funds constituting the American Century Mutual Funds, Inc., as of October 31, 2021, the related statement of operations for the year then ended, the statements of changes in net assets for each of the two years in the period then ended, the financial highlights for each of the five years in the period then ended, and the related notes. In our opinion, the financial statements and financial highlights present fairly, in all material respects, the financial position of Balanced Fund of the American Century Mutual Funds, Inc. as of October 31, 2021, and the results of its operations for the year then ended, the changes in its net assets for each of the two years in the period then ended, and the financial highlights for each of the five years in the period then ended, in conformity with accounting principles generally accepted in the United States of America.

Basis for Opinion

These financial statements and financial highlights are the responsibility of the Fund's management. Our responsibility is to express an opinion on the Fund’s financial statements and financial highlights based on our audits. We are a public accounting firm registered with the Public Company Accounting Oversight Board (United States) (PCAOB) and are required to be independent with respect to the Fund in accordance with the U.S. federal securities laws and the applicable rules and regulations of the Securities and Exchange Commission and the PCAOB.

We conducted our audits in accordance with the standards of the PCAOB. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements and financial highlights are free of material misstatement, whether due to error or fraud. The Fund is not required to have, nor were we engaged to perform, an audit of its internal control over financial reporting. As part of our audits we are required to obtain an understanding of internal control over financial reporting but not for the purpose of expressing an opinion on the effectiveness of the Fund’s internal control over financial reporting. Accordingly, we express no such opinion.

Our audits included performing procedures to assess the risks of material misstatement of the financial statements and financial highlights, whether due to error or fraud, and performing procedures that respond to those risks. Such procedures included examining, on a test basis, evidence regarding the amounts and disclosures in the financial statements and financial highlights. Our audits also included evaluating the accounting principles used and significant estimates made by management, as well as evaluating the overall presentation of the financial statements and financial highlights. Our procedures included confirmation of securities owned as of October 31, 2021, by correspondence with the custodian and brokers; when replies were not received from brokers, we performed other auditing procedures. We believe that our audits provide a reasonable basis for our opinion.

/s/ Deloitte & Touche LLP

Kansas City, Missouri
December 15, 2021

We have served as the auditor of one or more American Century investment companies since 1997.
46


Management

The Board of Directors

The individuals listed below serve as directors of the funds. Each director will continue to serve in this capacity until death, retirement, resignation or removal from office. The board has adopted a mandatory retirement age for directors who are not “interested persons,” as that term is defined in the Investment Company Act (independent directors). Independent directors shall retire by December 31 of the year in which they reach their 75th birthday.
Jonathan S.Thomas is an “interested person” because he currently serves as President and Chief Executive Officer of American Century Companies, Inc. (ACC), the parent company of American Century Investment Management, Inc. (ACIM or the advisor). The other directors (more than three-fourths of the total number) are independent. They are not employees, directors or officers of, and have no financial interest in, ACC or any of its wholly owned, direct or indirect, subsidiaries, including ACIM, American Century Investment Services, Inc. (ACIS) and American Century Services, LLC (ACS), and they do not have any other affiliations, positions or relationships that would cause them to be considered “interested persons” under the Investment Company Act. The directors serve in this capacity for seven (in the case of Jonathan S. Thomas, 16; and Stephen E. Yates, 8) registered investment companies in the American Century Investments family of funds.
The following table presents additional information about the directors. The mailing address for each director is 4500 Main Street, Kansas City, Missouri 64111.
Name
(Year of Birth)
Position(s) Held with FundsLength of Time ServedPrincipal Occupation(s) During Past 5 YearsNumber of American Century Portfolios Overseen by DirectorOther Directorships Held During Past 5 Years
Independent Directors
Thomas W. Bunn (1953)DirectorSince 2017Retired72SquareTwo Financial; Barings (formerly Babson Capital Funds Trust) (2013 to 2016)
Chris H. Cheesman
(1962)
DirectorSince 2019
Retired. Senior Vice President & Chief Audit Executive, AllianceBernstein (1999 to 2018)72Alleghany Corporation
Barry Fink
(1955)
DirectorSince 2012 (independent since 2016)Retired72None
Rajesh K. Gupta
(1960)
DirectorSince 2019
Partner Emeritus, SeaCrest Investment Management and SeaCrest Wealth Management (2019 to Present); Chief Executive Officer and Chief Investment Officer, SeaCrest Investment Management (2006 to 2019); Chief Executive Officer and Chief Investment Officer, SeaCrest Wealth Management (2008 to 2019)72None
47


Name
(Year of Birth)
Position(s) Held with FundsLength of Time ServedPrincipal Occupation(s) During Past 5 YearsNumber of American Century Portfolios Overseen by DirectorOther Directorships Held During Past 5 Years
Independent Directors
Lynn Jenkins
(1963)
DirectorSince 2019
Consultant, LJ Strategies (2019 to present); United States Representative, U.S. House of Representatives (2009 to 2018)72MGP Ingredients, Inc. (2019 to 2021)
Jan M. Lewis
(1957)
DirectorSince 2011Retired72None
John R. Whitten
(1946)
DirectorSince 2008Retired72Onto Innovation Inc. (2019 to 2020); Rudolph Technologies, Inc. (2006 to 2019)
Stephen E. Yates
(1948)
Director and Chairman of the BoardSince 2012 (Chairman since 2018)Retired107None
Interested Director
Jonathan S. Thomas
(1963)
DirectorSince 2007President and Chief Executive Officer, ACC (2007 to present). Also serves as Chief Executive Officer, ACS; Director, ACC and other ACC subsidiaries145None
The Statement of Additional Information has additional information about the fund's directors and is available without charge, upon request, by calling 1-800-345-2021.
48


Officers

The following table presents certain information about the executive officers of the funds. Each officer serves as an officer for 16 (in the case of Robert J. Leach, 15) investment companies in the American Century family of funds. No officer is compensated for his or her service as an officer of the funds. The listed officers are interested persons of the funds and are appointed or re-appointed on an annual basis. The mailing address for each officer listed below is 4500 Main Street, Kansas City, Missouri 64111.
Name
(Year of Birth)
Offices with the FundsPrincipal Occupation(s) During the Past Five Years
Patrick Bannigan
(1965)
President since 2019Executive Vice President and Director, ACC (2012 to present); Chief Financial Officer, Chief Accounting Officer and Treasurer, ACC (2015 to present). Also serves as President, ACS; Vice President, ACIM; Chief Financial Officer, Chief Accounting Officer and/or Director, ACIM, ACS and other ACC subsidiaries
R. Wes Campbell
(1974)
Chief Financial Officer and Treasurer since 2018Vice President, ACS, (2020 to present); Investment Operations and Investment Accounting, ACS (2000 to present)
Amy D. Shelton
(1964)
Chief Compliance Officer and Vice President since 2014Chief Compliance Officer, American Century funds, (2014 to present); Chief Compliance Officer, ACIM (2014 to present); Chief Compliance Officer, ACIS (2009 to present). Also serves as Vice President, ACIS
John Pak
(1968)
General Counsel and
Senior Vice President since 2021
General Counsel and Senior Vice President, ACC (2021 to present). Also serves as General Counsel and Senior Vice President, ACIM, ACS and ACIS. Chief Legal Officer of Investment and Wealth Management, The Bank of New York Mellon (2014 to 2021)
C. Jean Wade
(1964)
Vice President since 2012Senior Vice President, ACS (2017 to present); Vice President, ACS (2000 to 2017)
Robert J. Leach
(1966)
Vice President since 2006 Vice President, ACS (2000 to present)
David H. Reinmiller
(1963)
Vice President since 2000Attorney, ACC (1994 to present). Also serves as Vice President, ACIM and ACS
Ward D. Stauffer
(1960)
Secretary since 2005Attorney, ACC (2003 to present)





49


Approval of Management Agreement

At a meeting held on June 30, 2021, the Fund’s Board of Directors (the "Board") unanimously approved the renewal of the management agreement pursuant to which American Century Investment Management, Inc. (the “Advisor”) acts as the investment advisor for the Fund. Under Section 15(c) of the Investment Company Act, contracts for investment advisory services are required to be reviewed, evaluated, and approved by a majority of a fund’s directors (the “Directors”), including a majority of the independent Directors, each year.

Prior to its consideration of the renewal of the management agreement, the Directors requested and reviewed extensive data and information compiled by the Advisor and certain independent providers of evaluation data concerning the Fund and the services provided to the Fund by the Advisor. This review was in addition to the oversight and evaluation undertaken by the Board and its committees on a continual basis and the information received was supplemental to the extensive information that the Board and its committees receive and consider throughout the year.

In connection with its consideration of the renewal of the management agreement, the Board’s review and evaluation of the services provided by the Advisor and its affiliates included, but was not limited to, the following:

the nature, extent, and quality of investment management, shareholder services, and other services provided and to be provided to the Fund including without limitation portfolio management and trading services, shareholder and intermediary services, compliance and legal services, fund accounting and financial reporting, and fund share distribution;
the wide range of other programs and services provided and to be provided to the Fund and its shareholders on a routine and non-routine basis;
the Fund’s investment performance, including data comparing the Fund's performance to appropriate benchmarks and/or a peer group of other mutual funds with similar investment objectives and strategies;
the cost of owning the Fund compared to the cost of owning similar funds;
the compliance policies, procedures, and regulatory experience of the Advisor and the Fund's service providers;
the Advisor’s strategic plans, COVID-19 pandemic response, vendor management practices, and social justice initiatives;
the Advisor’s business continuity plans and cyber security practices;
financial data showing the cost of services provided to the Fund, the profitability of the Fund to the Advisor, and the overall profitability of the Advisor;
possible economies of scale associated with the Advisor’s management of the Fund and other accounts;
services provided and charges to the Advisor's other investment management clients;
acquired fund fees and expenses;
payments and practices in connection with financial intermediaries holding shares of the Fund and the services provided by intermediaries in connection therewith; and
possible collateral benefits to the Advisor from the management of the Fund.

The Board held two meetings to consider the renewal. The independent Directors also met in private session three times to review and discuss the information provided in response to their request. The independent Directors held active discussions with the Advisor regarding the renewal of the management agreement, requesting supplemental information, and reviewing information provided by the Advisor in response thereto. The independent Directors had the benefit of the advice of their independent counsel throughout the process.



50


Factors Considered

The Directors considered all of the information provided by the Advisor, the independent data providers, and independent counsel in connection with the approval. They determined that the information was sufficient for them to evaluate the management agreement for the Fund. In connection with their review, the Directors did not identify any single factor as being all-important or controlling, and each Director may have attributed different levels of importance to different factors. In deciding to renew the management agreement, the Board based its decision on a number of factors, including without limitation the following:

Nature, Extent and Quality of Services — Generally. Under the management agreement, the Advisor is responsible for providing or arranging for all services necessary for the operation of the Fund. The Board noted that the Advisor provides or arranges at its own expense a wide variety of services which include the following:

constructing and designing the Fund
portfolio research and security selection
initial capitalization/funding
securities trading
Fund administration
custody of Fund assets
daily valuation of the Fund’s portfolio
liquidity monitoring and management
risk management, including cyber security
shareholder servicing and transfer agency, including shareholder confirmations, recordkeeping, and communications
legal services (except the independent Directors’ counsel)
regulatory and portfolio compliance
financial reporting
marketing and distribution (except amounts paid by the Fund under Rule 12b-1 plans)

The Board noted that many of these services have expanded over time in terms of both quantity and complexity in response to shareholder demands, competition in the industry, changing distribution channels, and the changing regulatory environment.

Investment Management Services. The nature of the investment management services provided to the Fund is quite complex and allows Fund shareholders access to professional money management, instant diversification of their investments within an asset class, the opportunity to easily diversify among asset classes by investing in or exchanging among various American Century Investments funds, and liquidity. In evaluating investment performance, the Board expects the Advisor to manage the Fund in accordance with its investment objectives and approved strategies. Further, the Directors recognize that the Advisor has an obligation to monitor trading activities, and in particular to seek the best execution of fund trades, and to evaluate the use of and payment for research. In providing these services, the Advisor utilizes teams of investment professionals (portfolio managers, analysts, research assistants, and securities traders) who require extensive information technology, research, training, compliance, and other systems to conduct their business. The Board, directly and through its Fund Performance Review Committee, provides oversight of the investment performance process. It regularly reviews investment performance information for the Fund, together with comparative information for appropriate benchmarks and/or peer groups of similarly-managed funds, over different time horizons. The Directors also review investment performance information during the management agreement renewal process. If performance concerns are identified, the Fund receives special reviews until performance improves, during which the Board discusses with the Advisor the reasons for such results (e.g., market conditions, security selection) and any efforts being undertaken to improve performance. The Fund’s performance was below its benchmark for the one-, three-, five-, and ten-year periods reviewed by the Board. The Board discussed the Fund's performance with the Advisor, including steps being taken to address underperformance, and was satisfied with the efforts being undertaken by the Advisor. The Board found the investment management services
51


provided by the Advisor to the Fund to be satisfactory and consistent with the management agreement.

Shareholder and Other Services. Under the management agreement, the Advisor provides the Fund with a comprehensive package of transfer agency, shareholder, and other services. The Board, directly and through its various committees, regularly reviews reports and evaluations of such services at its regular meetings. These reports include, but are not limited to, information regarding the operational efficiency and accuracy of the shareholder and transfer agency services provided, staffing levels, shareholder satisfaction, technology support (including cyber security), new products and services offered to Fund shareholders, securities trading activities, portfolio valuation services, auditing services, and legal and operational compliance activities. The Board found the services provided by the Advisor to the Fund under the management agreement to be competitive and of high quality.

Costs of Services and Profitability. The Advisor provides detailed information concerning its cost of providing various services to the Fund, its profitability in managing the Fund (pre- and post-distribution), its overall profitability, and its financial condition. The Directors have reviewed with the Advisor the methodology used to prepare this financial information. This information is considered in evaluating the Advisor’s financial condition, its ability to continue to provide services under the management agreement, and the reasonableness of the current management fee. The Board concluded that the Advisor’s profits were reasonable in light of the services provided to the Fund.

Ethics. The Board generally considers the Advisor’s commitment to providing quality services to shareholders and to conducting its business ethically. They noted that the Advisor’s practices generally meet or exceed industry best practices.

Economies of Scale. The Board also reviewed information provided by the Advisor regarding the possible existence of economies of scale in connection with the management of the Fund. The Board concluded that economies of scale are difficult to measure and predict with precision, especially on a fund-by-fund basis. The Board concluded that the Advisor is sharing economies of scale, to the extent they exist, through its competitive fee structure, offering competitive fees from fund inception, and through reinvestment in its business, infrastructure, investment capabilities and initiatives to provide shareholders additional content and services. The Board also noted that economies of scale are shared with the Fund and its shareholders through management fee breakpoints that serve to reduce the effective management fee as the assets of the Fund grow.

Comparison to Other Funds’ Fees. The management agreement provides that the Fund pays the Advisor a single, all-inclusive (or unified) management fee for providing all services necessary for the management and operation of the Fund, other than brokerage expenses, expenses attributable to short sales, taxes, interest, extraordinary expenses, fees and expenses of the Fund’s independent Directors (including their independent legal counsel), and expenses incurred in connection with the provision of shareholder services and distribution services under a plan adopted pursuant to Rule 12b-1 under the Investment Company Act. Under the unified fee structure, the Advisor is responsible for providing all investment advisory, custody, audit, administrative, compliance, recordkeeping, marketing and shareholder services, or arranging and supervising third parties to provide such services. By contrast, most other funds are charged a variety of fees, including an investment advisory fee, a transfer agency fee, an administrative fee, distribution charges, and other expenses. Other than their investment advisory fees and any applicable Rule 12b-1 distribution fees, all other components of the total fees charged by these other funds may be increased without shareholder approval. The Board believes the unified fee structure is a benefit to Fund shareholders because it clearly discloses to shareholders the cost of owning Fund shares, and, since the unified fee cannot be increased without a vote of Fund shareholders, it shifts to the Advisor the risk of increased costs of operating the Fund and provides a direct incentive to minimize administrative inefficiencies. Part of the Board’s analysis of fee levels involves reviewing certain evaluative data compiled by an independent provider comparing the Fund’s unified fee to the total expense ratios of its peers. The unified fee charged to shareholders of the Fund was below the median of the total expense ratios of the Fund’s peer expense universe. In addition, the Board reviewed the Fund’s position relative to the narrower set of its expense group peers. The Board concluded that the management fee paid by the Fund to the Advisor under the
52


management agreement is reasonable in light of the services provided to the Fund.

Comparison to Fees and Services Provided to Other Clients of the Advisor. The Board also requested and received information from the Advisor concerning the nature of the services, fees, costs, and profitability of its advisory services to advisory clients other than the Fund. They observed that these varying types of client accounts require different services and involve different regulatory and entrepreneurial risks than the management of the Fund. The Board analyzed this information and concluded that the fees charged and services provided to the Fund were reasonable by comparison.

Payments to Intermediaries. The Directors also requested and received a description of payments made to intermediaries by the Fund and the Advisor and services provided in response thereto. These payments include various payments made by the Fund or the Advisor to different types of intermediaries and recordkeepers for distribution and service activities provided for the Fund. The Directors reviewed such information and received representations from the Advisor that all such payments by the Fund were made pursuant to the Fund's Rule 12b-1 Plan and that all such payments by the Advisor were made from the Advisor’s resources and reasonable profits. The Board found such payments to be reasonable in scope and purpose.

Collateral or “Fall-Out” Benefits Derived by the Advisor. The Board considered the possible existence of collateral benefits the Advisor may receive as a result of its relationship with the Fund. They concluded that the Advisor’s primary business is managing funds and it generally does not use fund or shareholder information to generate profits in other lines of business, and therefore does not derive any significant collateral benefits from them. To the extent there are potential collateral benefits, the Board has been advised and has taken this into consideration in its review of the management contract with the Fund. The Board noted that additional assets from other clients may offer the Advisor some benefit from increased leverage with service providers and counterparties. Additionally, the Advisor may receive proprietary research from broker-dealers that execute fund portfolio transactions, which the Board concluded is likely to benefit other clients of the Advisor, as well as Fund shareholders. The Board also determined that the Advisor is able to provide investment management services to certain clients other than the Fund, at least in part, due to its existing infrastructure built to serve the fund complex. The Board concluded that appropriate allocation methodologies had been employed to assign resources and the cost of those resources to these other clients and, where expressly provided, these other client assets may be included with the assets of the Fund to determine breakpoints in the management fee schedule.

Existing Relationship. The Board also considered whether there was any reason for not continuing the existing arrangement with the Advisor. In this regard, the Board was mindful of the potential disruptions of the Fund’s operations and various risks, uncertainties, and other effects that could occur as a result of a decision not to continue such relationship. In particular, the Board recognized that most shareholders have invested in the Fund on the strength of the Advisor’s industry standing and reputation and in the expectation that the Advisor will have a continuing role in providing advisory services to the Fund.

Conclusion of the Directors. As a result of this process, the Board, including all of the independent Directors, taking into account all of the factors discussed above and the information provided by the Advisor and others in connection with its review and throughout the year, determined that the management fee is fair and reasonable in light of the services provided and that the investment management agreement between the Fund and the Advisor should be renewed.
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Additional Information

Retirement Account Information

As required by law, distributions you receive from certain retirement accounts are subject to federal income tax withholding, unless you elect not to have withholding apply*. Tax will be withheld on the total amount withdrawn even though you may be receiving amounts that are not subject to withholding, such as nondeductible contributions. In such case, excess amounts of withholding could occur. You may adjust your withholding election so that a greater or lesser amount will be withheld.
If you don’t want us to withhold on this amount, you must notify us to not withhold the federal income tax. You may notify us in writing or in certain situations by telephone or through other electronic means. For systematic withdrawals, your withholding election will remain in effect until revoked or changed by filing a new election. You have the right to revoke your election at any time and change your withholding percentage for future distributions.
Remember, even if you elect not to have income tax withheld, you are liable for paying income tax on the taxable portion of your withdrawal. If you elect not to have income tax withheld or you don’t have enough income tax withheld, you may be responsible for payment of estimated tax. You may incur penalties under the estimated tax rules if your withholding and estimated tax payments are not sufficient. You can reduce or defer the income tax on a distribution by directly or indirectly rolling such distribution over to another IRA or eligible plan. You should consult your tax advisor for additional information.
State tax will be withheld if, at the time of your distribution, your address is within one of the mandatory withholding states and you have federal income tax withheld (or as otherwise required by state law). State taxes will be withheld from your distribution in accordance with the respective state rules.
*Some 403(b), 457 and qualified retirement plan distributions may be subject to 20% mandatory withholding, as they are subject to special tax and withholding rules.  Your plan administrator or plan sponsor is required to provide you with a special tax notice explaining those rules at the time you request a distribution.  If applicable, federal and/or state taxes may be withheld from your distribution amount.


Proxy Voting Policies

A description of the policies that the fund's investment advisor uses in exercising the voting rights associated with the securities purchased and/or held by the fund is available without charge, upon request, by calling 1-800-345-2021. It is also available on American Century Investments’ website at americancentury.com/proxy and on the Securities and Exchange Commission’s website at sec.gov. Information regarding how the investment advisor voted proxies relating to portfolio securities during the most recent 12-month period ended June 30 is available on americancentury.com/proxy. It is also available at sec.gov.


Quarterly Portfolio Disclosure

The fund files its complete schedule of portfolio holdings with the Securities and Exchange Commission (SEC) for the first and third quarters of each fiscal year as an exhibit to its reports on Form N-PORT. These portfolio holdings are available on the fund's website at americancentury.com and, upon request, by calling 1-800-345-2021. The fund’s Form N-PORT reports are available on the SEC’s website at sec.gov.





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Other Tax Information

The following information is provided pursuant to provisions of the Internal Revenue Code.

The fund hereby designates up to the maximum amount allowable as qualified dividend income for
the fiscal year ended October 31, 2021.

For corporate taxpayers, the fund hereby designates $7,740,458, or up to the maximum amount allowable, of ordinary income distributions paid during the fiscal year ended October 31, 2021 as qualified for the corporate dividends received deduction.

The fund hereby designates $54,936,633, or up to the maximum amount allowable, as long-term capital gain distributions (20% rate gain distributions) for the fiscal year ended October 31, 2021.

The fund hereby designates $4,614,219 as qualified short-term capital gain distributions for purposes of Internal Revenue Code Section 871 for the fiscal year ended October 31, 2021.

The fund utilized earnings and profits of $10,642,630 distributed to shareholders on redemption of shares as part of the dividends paid deduction (tax equalization).




































55


Notes




































































56






























































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Contact Usamericancentury.com
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or 816-531-5575
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American Century Mutual Funds, Inc.
Investment Advisor:
American Century Investment Management, Inc.
Kansas City, Missouri
This report and the statements it contains are submitted for the general information of our shareholders. The report is not authorized for distribution to prospective investors unless preceded or accompanied by an effective prospectus.
©2021 American Century Proprietary Holdings, Inc. All rights reserved.
CL-ANN-90968 2112




    


image8.jpg
Annual Report
October 31, 2021
Growth Fund
Investor Class (TWCGX)
I Class (TWGIX)
Y Class (AGYWX)
A Class (TCRAX)
C Class (TWRCX)
R Class (AGWRX)
R5 Class (AGWUX)
R6 Class (AGRDX)





















Table of Contents
President’s Letter
Performance
Portfolio Commentary
Fund Characteristics
Shareholder Fee Example
Schedule of Investments
Statement of Assets and Liabilities
Statement of Operations
Statement of Changes in Net Assets
Notes to Financial Statements
Financial Highlights
Report of Independent Registered Public Accounting Firm
Management
Approval of Management Agreement
Additional Information





















Any opinions expressed in this report reflect those of the author as of the date of the report, and do not necessarily represent the opinions of American Century Investments® or any other person in the American Century Investments organization. Any such opinions are subject to change at any time based upon market or other conditions and American Century Investments disclaims any responsibility to update such opinions. These opinions may not be relied upon as investment advice and, because investment decisions made by American Century Investments funds are based on numerous factors, may not be relied upon as an indication of trading intent on behalf of any American Century Investments fund. Security examples are used for representational purposes only and are not intended as recommendations to purchase or sell securities. Performance information for comparative indices and securities is provided to American Century Investments by third party vendors. To the best of American Century Investments’ knowledge, such information is accurate at the time of printing.



President’s Letter
image30.jpg Jonathan Thomas

Dear Investor:

Thank you for reviewing this annual report for the period ended October 31, 2021. Annual reports help convey important information about fund returns, including market factors that affected performance. For additional investment insights, please visit americancentury.com.
Economic, Earnings Gains Fueled Rally Among Risk-On Assets

Stocks and other risk-on assets rallied for the 12-month period, despite lingering pandemic-related challenges. Upbeat data on U.S. manufacturing, employment and housing, along with central bank and federal government support and positive vaccine developments, helped boost corporate earnings and promote investor optimism. Outside the U.S., most economies recovered, but generally at a slower pace. Virus outbreaks and slower vaccine rollouts, particularly in emerging markets, led to lingering lockdowns in some regions.

As the period progressed, steady economic gains combined with ongoing monetary and fiscal support, rising energy prices and severe supply chain disruptions pushed global interest rates and inflation higher. In the U.S., year-over-year headline inflation climbed to 6.2% in October 2021, the largest 12-month increase in nearly 31 years.
Late in the period, the Federal Reserve (Fed) confirmed it would start tapering its bond buying in November. Yet despite inflation’s surge, the Fed left short-term interest rates unchanged. Central banks in Europe and the U.K. maintained their supportive interest rate and bond-buying programs as inflation ticked higher.

Overall, stocks delivered stellar performance for the 12-month period, highlighted by the S&P 500 Index’s gain of nearly 43%. Assets offering inflation-fighting potential, including real estate investment trusts, fared even better. Meanwhile, global bonds retreated as interest rates rose. However, emerging markets bonds largely advanced, benefiting from risk-on sentiment.
Several Factors Shaping Market Dynamics

The return to pre-pandemic life is progressing, albeit somewhat cautiously due to COVID-19’s lingering effects. As the economy and markets respond to this fluid backdrop, investors will face opportunities and ongoing challenges. Economic growth, inflation, the virus’s trajectory, supply chain normalization and fiscal and monetary policy likely will sway market dynamics.

We appreciate your confidence in us during these extraordinary times. Our firm has a long history of helping clients weather unpredictable markets, and we’re confident we will continue to meet today’s challenges.

Sincerely,
image19.jpg
Jonathan Thomas
President and Chief Executive Officer
American Century Investments
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Performance

Total Returns as of October 31, 2021
   Average Annual Returns 
 Ticker
Symbol
1 year5 years10 yearsSince
Inception
Inception
Date
Investor ClassTWCGX43.66%24.51%17.86%6/30/71
Russell 1000 Growth Index43.21%25.47%19.41%
I ClassTWGIX43.95%24.76%18.10%6/16/97
Y ClassAGYWX44.13%24.53%4/10/17
A ClassTCRAX6/4/97
No sales charge43.31%24.20%17.57%
With sales charge35.07%22.74%16.88%
C ClassTWRCX42.23%23.28%16.69%3/1/10
R ClassAGWRX42.94%23.89%17.28%8/29/03
R5 ClassAGWUX43.96%24.34%4/10/17
R6 ClassAGRDX44.15%24.95%18.67%7/26/13
Average annual returns since inception are presented when ten years of performance history is not available. Fund returns would have been lower if a portion of the fees had not been waived. Extraordinary performance is attributable in part to unusually favorable market conditions and may not be repeated or consistently achieved in the future. Although the fund’s actual inception date was October 31, 1958, the Investor Class inception date corresponds with the investment advisor’s implementation of its current investment philosophy and practices.

C Class shares will automatically convert to A Class shares after being held for approximately eight years. C Class average annual returns do not reflect this conversion.

Sales charges include initial sales charges and contingent deferred sales charges (CDSCs), as applicable. A Class shares have a 5.75% maximum initial sales charge and may be subject to a maximum CDSC of 1.00%. C Class shares redeemed within 12 months of purchase are subject to a maximum CDSC of 1.00%. The SEC requires that mutual funds provide performance information net of maximum sales charges in all cases where charges could be applied.













Data presented reflect past performance. Past performance is no guarantee of future results. Current performance may be higher or lower than the performance shown. Total returns for periods less than one year are not annualized. Investment return and principal value will fluctuate, and redemption value may be more or less than original cost. Data assumes reinvestment of dividends and capital gains, and none of the charts reflect the deduction of taxes that a shareholder would pay on fund distributions or the redemption of fund shares. To obtain performance data current to the most recent month end, please call 1-800-345-2021 or visit americancentury.com. For additional information about the fund, please consult the prospectus.
3


Growth of $10,000 Over 10 Years
$10,000 investment made October 31, 2011
Performance for other share classes will vary due to differences in fee structure.
chart-bfc65ae27c764b97868a.jpg
Value on October 31, 2021
Investor Class — $51,803
Russell 1000 Growth Index — $59,008

Total Annual Fund Operating Expenses
Investor ClassI ClassY ClassA ClassC ClassR ClassR5 ClassR6 Class
0.97%0.77%0.62%1.22%1.97%1.47%0.77%0.62%
The total annual fund operating expenses shown is as stated in the fund’s prospectus current as of the date of this report. The prospectus may vary from the expense ratio shown elsewhere in this report because it is based on a different time period, includes acquired fund fees and expenses, and, if applicable, does not include fee waivers or expense reimbursements.


















Data presented reflect past performance. Past performance is no guarantee of future results. Current performance may be higher or lower than the performance shown. Total returns for periods less than one year are not annualized. Investment return and principal value will fluctuate, and redemption value may be more or less than original cost. Data assumes reinvestment of dividends and capital gains, and none of the charts reflect the deduction of taxes that a shareholder would pay on fund distributions or the redemption of fund shares. To obtain performance data current to the most recent month end, please call 1-800-345-2021 or visit americancentury.com. For additional information about the fund, please consult the prospectus.
4


Portfolio Commentary

Portfolio Managers: Joe Reiland, Justin Brown and Scott Marolf

Greg Woodhams left the portfolio management team September 1, 2021. He is retiring, effective December 31, 2021. Joe Reiland was named portfolio manager.

Performance Summary

Growth returned 43.66%* for the 12 months ended October 31, 2021, versus the 43.21% return of the fund’s benchmark, the Russell 1000 Growth Index.

U.S. stocks posted strong returns during the reporting period, supported by federal government stimulus and low interest rates. The rollout of COVID-19 vaccines allowed the economy to reopen, and despite concerns about the delta variant, inflationary pressures and supply chain constraints, several market indices ended the 12-month period at record highs. Within the Russell 1000 Growth Index, all sectors posted double-digit gains, led by energy, which surged on demand and limited supply as the economy began to reopen. Materials was the weakest sector.

Stock selection in the communication services and industrials sectors helped drive outperformance relative to the benchmark. Stock decisions in the financials and consumer staples sectors weighed on performance.

Communication Services Stocks Were Top Contributors

Interactive media and services stocks led outperformance in the communication services sector. Alphabet was a major industry contributor. Digital advertising remained a strength for Google’s parent company, driven by sustained e-commerce and reopening activity. Its YouTube business, in particular, was strong as new advertising products across both brand and direct response have been favorably received.

Other top contributors included ASML Holding. This Netherlands-based semiconductor equipment manufacturer outperformed due to strong demand for its extreme ultraviolet lithography technology that allows semiconductor manufacturers to make smaller and more efficient chips. Demand for semiconductors has been strong and manufacturers need new equipment to increase production. NVIDIA, a gaming and artificial intelligence chipmaker, benefited relative performance. NVIDIA reported better-than-expected earnings and offered positive forward guidance based on strength in data center and gaming CPUs.

Microsoft reported strong revenue and earnings growth, and the stock also received a tailwind from large-capitalization software returning to favor. The messaging software company Slack Technologies rose sharply following the announcement that it would be acquired by salesforce.com. As a result of the deal, Slack was eliminated from the portfolio. Not owning Zoom Video Communications helped performance. After benefiting from the pandemic in 2020, investors reallocated capital in 2021 to stocks expected to benefit from the reopening of the economy. Zoom was a victim of the market’s swing, and our lack of exposure was helpful.

Financials Hampered Performance

Stock choices in the insurance industry weighed on relative performance in the financials sector. SelectQuote offers consumers a platform to compare insurance policies. The company and the industry in general have struggled with plan persistency, the percentage of policyholders that continue paying premiums. As a result, SelectQuote offered disappointing guidance for next year.




*All fund returns referenced in this commentary are for Investor Class shares. Performance for other share classes will vary due to differences in fee structure; when Investor Class performance exceeds that of the fund’s benchmark, other share classes may not. See page 3 for returns for all share classes.
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Elsewhere, underweighting Tesla detracted. The electric carmaker continued to benefit from solid fundamental reports and strong demand for its vehicles. The stock also got a boost when it was added to the S&P 500 Index. Visa underperformed. The digital payments company’s stock lagged on concerns about potential renewed restrictions due to the COVID-19 delta variant, which could reduce travel and cross-border transaction volumes. Splunk offers cloud-based data analysis software that helps companies understand how efficiently their internal operations are running. Investors appeared concerned about increasing competition, and Splunk experienced some leadership changes.

Not owning Moderna detracted. The biotechnology company’s stock surged on excitement around its successful COVID-19 vaccine, booster shots and the potential for annual boosters beyond 2021. While we are impressed by the speed of development and effectiveness of Moderna’s messenger RNA drug development technology, the market seemed to be ascribing quite a bit of long-term value to COVID-19 vaccine revenue, which is highly uncertain. Zendesk, a cloud-based customer support software company, missed revenue and earnings forecasts due to lower revenue from one of its consumption-based products and a greater mix shift to enterprise deals, which have larger, longer-term contracts over time, but recognize less revenue up front. We view this as a positive long-term sign for the business despite the impact to revenue in the near term.

Outlook

We believe stock selection—rather than sector allocation or market timing via the use of cash—is the most efficient means of generating superior risk-adjusted returns. As a result of this approach, the portfolio’s sector and industry selection, as well as capitalization range allocations, are primarily due to identifying what we believe to be superior individual securities.

At period-end, our largest sector allocation relative to the benchmark was communication services. The largest underweight was financials.


6


Fund Characteristics
OCTOBER 31, 2021
Types of Investments in Portfolio% of net assets
Common Stocks99.6%
Temporary Cash Investments0.5%
Temporary Cash Investments - Securities Lending Collateral0.3%
Other Assets and Liabilities(0.4)%
Top Five Industries% of net assets
Software18.3%
Interactive Media and Services11.4%
Semiconductors and Semiconductor Equipment8.4%
Technology Hardware, Storage and Peripherals8.3%
Internet and Direct Marketing Retail7.9%
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Shareholder Fee Example 

Fund shareholders may incur two types of costs: (1) transaction costs, including sales charges (loads) on purchase payments and redemption/exchange fees; and (2) ongoing costs, including management fees; distribution and service (12b-1) fees; and other fund expenses. This example is intended to help you understand your ongoing costs (in dollars) of investing in your fund and to compare these costs with the ongoing cost of investing in other mutual funds.

The example is based on an investment of $1,000 made at the beginning of the period and held for the entire period from May 1, 2021 to October 31, 2021.

Actual Expenses

The table provides information about actual account values and actual expenses for each class. You may use the information, together with the amount you invested, to estimate the expenses that you paid over the period. First, identify the share class you own. Then simply divide your account value by $1,000 (for example, an $8,600 account value divided by $1,000 = 8.6), then multiply the result by the number under the heading “Expenses Paid During Period” to estimate the expenses you paid on your account during this period.

If you hold Investor Class shares of any American Century Investments fund, or I Class shares of the American Century Diversified Bond Fund, in an American Century Investments account (i.e., not through a financial intermediary or employer-sponsored retirement plan account), American Century Investments may charge you a $25.00 annual account maintenance fee if the value of those shares is less than $10,000. We will redeem shares automatically in one of your accounts to pay the $25.00 fee. In determining your total eligible investment amount, we will include your investments in all personal accounts (including American Century Investments brokerage accounts) registered under your Social Security number. Personal accounts include individual accounts, joint accounts, UGMA/UTMA accounts, personal trusts, Coverdell Education Savings Accounts and IRAs (including traditional, Roth, Rollover, SEP-, SARSEP- and SIMPLE-IRAs), and certain other retirement accounts. If you have only business, business retirement, employer-sponsored or American Century Investments brokerage accounts, you are currently not subject to this fee. If you are subject to the account maintenance fee, your account value could be reduced by the fee amount.

Hypothetical Example for Comparison Purposes

The table also provides information about hypothetical account values and hypothetical expenses based on the actual expense ratio of each class of your fund and an assumed rate of return of 5% per year before expenses, which is not the actual return of a fund’s share class. The hypothetical account values and expenses may not be used to estimate the actual ending account balance or expenses you paid for the period. You may use this information to compare the ongoing costs of investing in your fund and other funds. To do so, compare this 5% hypothetical example with the 5% hypothetical examples that appear in the shareholder reports of the other funds.

Please note that the expenses shown in the table are meant to highlight your ongoing costs only and do not reflect any transactional costs, such as sales charges (loads) or redemption/exchange fees. Therefore, the table is useful in comparing ongoing costs only, and will not help you determine the relative total costs of owning different funds. In addition, if these transactional costs were included, your costs would have been higher.

8


Beginning
Account Value
5/1/21
Ending
Account Value
10/31/21
Expenses Paid
During Period(1)
5/1/21 - 10/31/21
Annualized
Expense Ratio(1)
Actual
Investor Class$1,000$1,151.00$5.200.96%
I Class$1,000$1,152.30$4.120.76%
Y Class$1,000$1,152.90$3.310.61%
A Class$1,000$1,149.60$6.561.21%
C Class$1,000$1,145.30$10.601.96%
R Class$1,000$1,148.20$7.911.46%
R5 Class$1,000$1,152.30$4.120.76%
R6 Class$1,000$1,153.00$3.310.61%
Hypothetical
Investor Class$1,000$1,020.37$4.890.96%
I Class$1,000$1,021.37$3.870.76%
Y Class$1,000$1,022.13$3.110.61%
A Class$1,000$1,019.11$6.161.21%
C Class$1,000$1,015.33$9.961.96%
R Class$1,000$1,017.85$7.431.46%
R5 Class$1,000$1,021.37$3.870.76%
R6 Class$1,000$1,022.13$3.110.61%
(1)Expenses are equal to the class's annualized expense ratio listed in the table above, multiplied by the average account value over the period, multiplied by 184, the number of days in the most recent fiscal half-year, divided by 365, to reflect the one-half year period. Annualized expense ratio reflects actual expenses, including any applicable fee waivers or expense reimbursements and excluding any acquired fund fees and expenses.

9


Schedule of Investments

OCTOBER 31, 2021
SharesValue
COMMON STOCKS — 99.6%
Air Freight and Logistics — 1.8%
United Parcel Service, Inc., Class B1,109,503 $236,845,605 
Auto Components — 2.0%
Aptiv plc(1)
1,544,522 267,032,409 
Automobiles — 3.8%
Tesla, Inc.(1)
453,902 505,646,828 
Beverages — 1.7%
PepsiCo, Inc.1,448,444 234,068,550 
Biotechnology — 1.4%
Amgen, Inc.368,658 76,301,147 
CRISPR Therapeutics AG(1)
315,752 28,837,630 
Natera, Inc.(1)
271,081 31,057,750 
Vertex Pharmaceuticals, Inc.(1)
284,799 52,667,879 
188,864,406 
Building Products — 1.0%
Masco Corp.1,006,138 65,952,346 
Trex Co., Inc.(1)
655,699 69,766,374 
135,718,720 
Capital Markets — 1.6%
S&P Global, Inc.456,690 216,544,130 
Chemicals — 0.8%
Air Products and Chemicals, Inc.347,864 104,293,106 
Electrical Equipment — 2.5%
Ballard Power Systems, Inc.(1)(2)
1,968,502 35,669,256 
Generac Holdings, Inc.(1)
249,904 124,592,138 
Rockwell Automation, Inc.568,397 181,546,002 
341,807,396 
Electronic Equipment, Instruments and Components — 2.2%
CDW Corp.419,393 78,279,704 
Cognex Corp.1,180,179 103,371,879 
Keysight Technologies, Inc.(1)
662,422 119,249,208 
300,900,791 
Entertainment — 1.7%
Liberty Media Corp.-Liberty Formula One, Class C(1)
900,001 50,220,056 
Take-Two Interactive Software, Inc.(1)
348,043 62,995,783 
Walt Disney Co. (The)(1)
709,297 119,920,844 
233,136,683 
Equity Real Estate Investment Trusts (REITs) — 1.0%
SBA Communications Corp.400,851 138,425,876 
Food Products — 0.9%
Mondelez International, Inc., Class A1,749,518 106,265,723 
Vital Farms, Inc.(1)
863,807 14,183,711 
120,449,434 
Health Care Equipment and Supplies — 2.7%
DexCom, Inc.(1)
178,424 111,195,621 
Edwards Lifesciences Corp.(1)
544,820 65,280,332 
IDEXX Laboratories, Inc.(1)
92,996 61,948,356 
10


SharesValue
Intuitive Surgical, Inc.(1)
361,521 $130,556,079 
368,980,388 
Health Care Providers and Services — 1.7%
Guardant Health, Inc.(1)
163,169 19,056,507 
UnitedHealth Group, Inc.452,104 208,180,329 
227,236,836 
Hotels, Restaurants and Leisure — 1.2%
Chipotle Mexican Grill, Inc.(1)
46,360 82,475,831 
Dutch Bros, Inc., Class A(1)
305,562 23,296,047 
Expedia Group, Inc.(1)
358,770 58,985,375 
164,757,253 
Household Products — 0.7%
Procter & Gamble Co. (The)679,519 97,164,422 
Insurance — 0.2%
SelectQuote, Inc.(1)
2,119,105 28,162,906 
Interactive Media and Services — 11.4%
Alphabet, Inc., Class A(1)
385,366 1,141,037,897 
Meta Platforms, Inc., Class A(1)
903,958 292,493,690 
Snap, Inc., Class A(1)
815,202 42,863,321 
Twitter, Inc.(1)
964,424 51,635,261 
1,528,030,169 
Internet and Direct Marketing Retail — 7.9%
Amazon.com, Inc.(1)
294,237 992,293,686 
Chewy, Inc., Class A(1)(2)
920,648 69,785,118 
1,062,078,804 
IT Services — 7.5%
Okta, Inc.(1)
225,222 55,670,374 
PayPal Holdings, Inc.(1)
1,452,956 337,943,036 
Shopify, Inc., Class A(1)
25,756 37,777,098 
Twilio, Inc., Class A(1)
142,767 41,596,593 
Visa, Inc., Class A2,556,549 541,400,382 
1,014,387,483 
Life Sciences Tools and Services — 1.5%
10X Genomics, Inc., Class A(1)
207,414 33,449,656 
Agilent Technologies, Inc.790,742 124,533,957 
Repligen Corp.(1)
130,228 37,831,234 
195,814,847 
Personal Products — 0.6%
Estee Lauder Cos., Inc. (The), Class A244,542 79,312,307 
Pharmaceuticals — 1.6%
Novo Nordisk A/S, B Shares509,071 55,822,108 
Zoetis, Inc.738,824 159,733,749 
215,555,857 
Road and Rail — 1.1%
Lyft, Inc., Class A(1)
1,254,825 57,558,823 
Union Pacific Corp.384,246 92,756,984 
150,315,807 
Semiconductors and Semiconductor Equipment — 8.4%
Advanced Micro Devices, Inc.(1)
1,878,792 225,887,162 
Analog Devices, Inc.763,597 132,476,444 
ASML Holding NV(2)
269,648 219,196,752 
11


Shares/Principal
Amount
Value
NVIDIA Corp.2,143,128 $547,933,536 
1,125,493,894 
Software — 18.3%
Datadog, Inc., Class A(1)
539,262 90,083,717 
DocuSign, Inc.(1)
294,429 81,936,646 
Microsoft Corp.5,529,433 1,833,670,572 
PagerDuty, Inc.(1)
1,381,477 57,676,665 
Paycor HCM, Inc.(1)
432,050 14,015,702 
salesforce.com, Inc.(1)
341,284 102,279,402 
Splunk, Inc.(1)
501,498 82,656,900 
Workday, Inc., Class A(1)
357,466 103,657,991 
Zendesk, Inc.(1)
1,012,948 103,118,106 
2,469,095,701 
Specialty Retail — 2.3%
Home Depot, Inc. (The)814,806 302,895,982 
Technology Hardware, Storage and Peripherals — 8.3%
Apple, Inc.7,486,259 1,121,441,598 
Textiles, Apparel and Luxury Goods — 1.8%
NIKE, Inc., Class B1,404,939 235,032,245 
TOTAL COMMON STOCKS
(Cost $5,236,915,174)
13,409,490,433 
TEMPORARY CASH INVESTMENTS — 0.5%
Federal Farm Credit Discount Notes, 0.00%, 11/1/21(3)
$8,000,000 8,000,000 
Repurchase Agreement, BMO Capital Markets Corp., (collateralized by various U.S. Treasury obligations, 2.00%, 11/15/26, valued at $12,674,925), in a joint trading account at 0.01%, dated 10/29/21, due 11/1/21 (Delivery value $12,411,314)12,411,304 
Repurchase Agreement, Fixed Income Clearing Corp., (collateralized by various U.S. Treasury obligations, 4.75%, 2/15/41, valued at $42,204,636), at 0.01%, dated 10/29/21, due 11/1/21 (Delivery value $41,377,034)41,377,000 
State Street Institutional U.S. Government Money Market Fund, Premier Class1,655,708 1,655,708 
TOTAL TEMPORARY CASH INVESTMENTS
(Cost $63,444,012)
63,444,012 
TEMPORARY CASH INVESTMENTS - SECURITIES LENDING COLLATERAL(4) — 0.3%
State Street Navigator Securities Lending Government Money Market Portfolio
(Cost $45,634,735)
45,634,735 45,634,735 
TOTAL INVESTMENT SECURITIES — 100.4%
(Cost $5,345,993,921)

13,518,569,180 
OTHER ASSETS AND LIABILITIES — (0.4)%

(50,498,071)
TOTAL NET ASSETS — 100.0%

$13,468,071,109 

12


FORWARD FOREIGN CURRENCY EXCHANGE CONTRACTS
Currency
Purchased
Currency SoldCounterpartySettlement Date
Unrealized Appreciation
(Depreciation)
EUR8,713,887 USD10,200,555 Credit Suisse AG12/31/21$(111,235)
EUR12,208,888 USD14,194,541 Credit Suisse AG12/31/21(58,557)
EUR4,132,602 USD4,791,893 Credit Suisse AG12/31/21(6,985)
EUR3,589,460 USD4,177,446 Credit Suisse AG12/31/21(21,412)
EUR4,935,508 USD5,738,244 Credit Suisse AG12/31/21(23,697)
EUR6,116,251 USD7,118,479 Credit Suisse AG12/31/21(36,815)
USD203,130,201 EUR172,790,004 Credit Suisse AG12/31/213,066,380 
USD6,123,951 EUR5,218,886 Credit Suisse AG12/31/2181,296 
USD6,906,731 EUR5,974,562 Credit Suisse AG12/31/21(10,878)
USD8,030,540 EUR6,919,157 Credit Suisse AG12/31/2119,237 
USD4,627,956 EUR3,967,298 Credit Suisse AG12/31/2134,445 
USD4,767,213 EUR4,075,405 Credit Suisse AG12/31/2148,531 
$2,980,310 

FUTURES CONTRACTS PURCHASED
Reference EntityContractsExpiration DateNotional
Amount
Unrealized
Appreciation
(Depreciation)^
NASDAQ 100 E-Mini
107December 2021$33,894,390 $2,776,235 
^Amount represents value and unrealized appreciation (depreciation).

NOTES TO SCHEDULE OF INVESTMENTS
EUR-Euro
USD-United States Dollar
(1)Non-income producing.
(2)Security, or a portion thereof, is on loan. At the period end, the aggregate value of securities on loan was $257,082,522. The amount of securities on loan indicated may not correspond with the securities on loan identified because securities with pending sales are in the process of recall from the brokers.
(3)The rate indicated is the yield to maturity at purchase.
(4)Investment of cash collateral from securities on loan. At the period end, the aggregate value of the collateral held by the fund was $268,663,814, which includes securities collateral of $223,029,079.


See Notes to Financial Statements.
13


Statement of Assets and Liabilities
OCTOBER 31, 2021
Assets
Investment securities, at value (cost of $5,300,359,186) — including $257,082,522 of securities on loan$13,472,934,445 
Investment made with cash collateral received for securities on loan, at value
(cost of $45,634,735)
45,634,735 
Total investment securities, at value (cost of $5,345,993,921)13,518,569,180 
Deposits with broker for futures contracts1,819,000 
Receivable for investments sold13,345,917 
Receivable for capital shares sold2,031,249 
Receivable for variation margin on futures contracts524,871 
Unrealized appreciation on forward foreign currency exchange contracts3,249,889 
Dividends and interest receivable1,798,025 
Securities lending receivable25,071 
13,541,363,202 
Liabilities
Payable for collateral received for securities on loan45,634,735 
Payable for investments purchased13,207,889 
Payable for capital shares redeemed4,333,443 
Unrealized depreciation on forward foreign currency exchange contracts269,579 
Accrued management fees9,760,886 
Distribution and service fees payable85,561 

73,292,093 
Net Assets$13,468,071,109 
Net Assets Consist of:
Capital (par value and paid-in surplus)$4,092,023,055 
Distributable earnings9,376,048,054 
$13,468,071,109 

Net AssetsShares OutstandingNet Asset Value Per Share
Investor Class, $0.01 Par Value$10,186,486,082174,934,567$58.23
I Class, $0.01 Par Value$2,061,818,97934,539,015$59.70
Y Class, $0.01 Par Value$66,916,0371,117,819$59.86
A Class, $0.01 Par Value$144,743,1582,595,076
  $55.78*
C Class, $0.01 Par Value$12,674,358247,725$51.16
R Class, $0.01 Par Value$114,022,3652,123,597$53.69
R5 Class, $0.01 Par Value$4,949,66882,832$59.76
R6 Class, $0.01 Par Value$876,460,46214,664,386$59.77
*Maximum offering price $59.18 (net asset value divided by 0.9425).


See Notes to Financial Statements.

14


Statement of Operations
YEAR ENDED OCTOBER 31, 2021
Investment Income (Loss)
Income:
Dividends (net of foreign taxes withheld of $427,223)$72,450,100 
Securities lending, net218,354 
Interest18,465 
72,686,919 
Expenses:
Management fees109,695,122 
Distribution and service fees:
A Class313,544 
C Class122,539 
R Class533,621 
Directors' fees and expenses307,769 
Other expenses19,869 
110,992,464 
Fees waived(1)
(367,870)
110,624,594 
Net investment income (loss)(37,937,675)
Realized and Unrealized Gain (Loss)
Net realized gain (loss) on:
Investment transactions (Note 4)1,348,339,485 
Forward foreign currency exchange contract transactions2,124,750 
Futures contract transactions15,934,905 
Foreign currency translation transactions(27,709)
1,366,371,431 
Change in net unrealized appreciation (depreciation) on:
Investments2,971,421,235 
Forward foreign currency exchange contracts2,236,205 
Futures contracts2,776,235 
Translation of assets and liabilities in foreign currencies(12,903)
2,976,420,772 
Net realized and unrealized gain (loss)4,342,792,203 
Net Increase (Decrease) in Net Assets Resulting from Operations$4,304,854,528 
(1)Amount consists of $277,876, $56,936, $1,834, $3,905, $343, $3,133, $134 and $23,709 for Investor Class, I Class, Y Class, A Class, C Class, R Class, R5 Class and R6 Class, respectively.


See Notes to Financial Statements.

15


Statement of Changes in Net Assets
YEARS ENDED OCTOBER 31, 2021 AND OCTOBER 31, 2020
Increase (Decrease) in Net AssetsOctober 31, 2021October 31, 2020
Operations
Net investment income (loss)$(37,937,675)$238,951 
Net realized gain (loss)1,366,371,431 599,196,803 
Change in net unrealized appreciation (depreciation)2,976,420,772 1,536,989,906 
Net increase (decrease) in net assets resulting from operations4,304,854,528 2,136,425,660 
Distributions to Shareholders
From earnings:
Investor Class(282,536,663)(480,259,209)
I Class(62,416,300)(114,436,997)
Y Class(1,866,955)(4,514,391)
A Class(3,978,341)(7,229,137)
C Class(543,385)(744,058)
R Class(3,787,686)(7,119,319)
R5 Class(15,831)(42,460)
R6 Class(21,373,938)(41,181,311)
Decrease in net assets from distributions(376,519,099)(655,526,882)
Capital Share Transactions
Net increase (decrease) in net assets from capital share transactions (Note 5)(712,757,144)728,589,142 
Net increase (decrease) in net assets3,215,578,285 2,209,487,920 
Net Assets
Beginning of period10,252,492,824 8,043,004,904 
End of period$13,468,071,109 $10,252,492,824 


See Notes to Financial Statements.

16


Notes to Financial Statements

OCTOBER 31, 2021

1. Organization

American Century Mutual Funds, Inc. (the corporation) is registered under the Investment Company Act of 1940, as amended (the 1940 Act), as an open-end management investment company and is organized as a Maryland corporation. Growth Fund (the fund) is one fund in a series issued by the corporation. The fund's investment objective is to seek long-term capital growth.

The fund offers the Investor Class, I Class, Y Class, A Class, C Class, R Class, R5 Class and R6 Class. The A Class may incur an initial sales charge. The A Class and C Class may be subject to a contingent deferred sales charge.

2. Significant Accounting Policies

The following is a summary of significant accounting policies consistently followed by the fund in preparation of its financial statements. The fund is an investment company and follows accounting and reporting guidance in accordance with accounting principles generally accepted in the United States of America. This may require management to make certain estimates and assumptions at the date of the financial statements. Actual results could differ from these estimates. Management evaluated the impact of events or transactions occurring through the date the financial statements were issued that would merit recognition or disclosure.

Investment Valuations — The fund determines the fair value of its investments and computes its net asset value (NAV) per share at the close of regular trading (usually 4 p.m. Eastern time) on the New York Stock Exchange (NYSE) on each day the NYSE is open. The Board of Directors has adopted valuation policies and procedures to guide the investment advisor in the fund’s investment valuation process and to provide methodologies for the oversight of the fund’s pricing function.

Equity securities that are listed or traded on a domestic securities exchange are valued at the last reported sales price or at the official closing price as provided by the exchange. Equity securities traded on foreign securities exchanges are generally valued at the closing price of such securities on the exchange where primarily traded or at the close of the NYSE, if that is earlier. If no last sales price is reported, or if local convention or regulation so provides, the mean of the latest bid and asked prices may be used. Securities traded over-the-counter are valued at the mean of the latest bid and asked prices, the last sales price, or the official closing price. Equity securities initially expressed in local currencies are translated into U.S. dollars at the mean of the appropriate currency exchange rate at the close of the NYSE as provided by an independent pricing service.

Fixed income securities are valued at the evaluated mean as provided by independent pricing services or at the mean of the most recent bid and asked prices as provided by investment dealers. U.S. Treasury and Government Agency securities are valued using market models that consider trade data, quotations from dealers and active market makers, relevant yield curve and spread data, creditworthiness, trade data or market information on comparable securities, and other relevant security specific information.

Open-end management investment companies are valued at the reported NAV per share. Repurchase agreements are valued at cost, which approximates fair value. Exchange-traded futures contracts are valued at the settlement price as provided by the appropriate exchange. Forward foreign currency exchange contracts are valued at the mean of the appropriate forward exchange rate at the close of the NYSE as provided by an independent pricing service.

17


If the fund determines that the market price for an investment is not readily available or the valuation methods mentioned above do not reflect an investment’s fair value, such investment is valued as determined in good faith by the Board of Directors or its delegate, in accordance with policies and procedures adopted by the Board of Directors. In its determination of fair value, the fund may review several factors including, but not limited to, market information regarding the specific investment or comparable investments and correlation with other investment types, futures indices or general market indicators. Circumstances that may cause the fund to use these procedures to value an investment include, but are not limited to: an investment has been declared in default or is distressed; trading in a security has been suspended during the trading day or a security is not actively trading on its principal exchange; prices received from a regular pricing source are deemed unreliable; or there is a foreign market holiday and no trading occurred.

The fund monitors for significant events occurring after the close of an investment’s primary exchange but before the fund’s NAV per share is determined. Significant events may include, but are not limited to: corporate announcements and transactions; governmental action and political unrest that could impact a specific investment or an investment sector; or armed conflicts, natural disasters and similar events that could affect investments in a specific country or region. The fund also monitors for significant fluctuations between domestic and foreign markets, as evidenced by the U.S. market or such other indicators that the Board of Directors, or its delegate, deems appropriate. The fund may apply a model-derived factor to the closing price of equity securities traded on foreign securities exchanges. The factor is based on observable market data as provided by an independent pricing service.

Security Transactions — Security transactions are accounted for as of the trade date. Net realized gains and losses are determined on the identified cost basis, which is also used for federal income tax purposes.

Investment Income — Dividend income less foreign taxes withheld, if any, is recorded as of the ex-dividend date. Distributions received on securities that represent a return of capital or long-term capital gain are recorded as a reduction of cost of investments and/or as a realized gain. The fund may estimate the components of distributions received that may be considered nontaxable distributions or long-term capital gain distributions for income tax purposes. Interest income is recorded on the accrual basis and includes accretion of discounts and amortization of premiums. Securities lending income is net of fees and rebates earned by the lending agent for its services.

Foreign Currency Translations — All assets and liabilities initially expressed in foreign currencies are translated into U.S. dollars at prevailing exchange rates at period end. The fund may enter into spot foreign currency exchange contracts to facilitate transactions denominated in a foreign currency. Purchases and sales of investment securities, dividend and interest income, spot foreign currency exchange contracts, and expenses are translated at the rates of exchange prevailing on the respective dates of such transactions. Net realized and unrealized foreign currency exchange gains or losses related to investment securities are a component of net realized gain (loss) on investment transactions and change in net unrealized appreciation (depreciation) on investments, respectively.

Repurchase Agreements — The fund may enter into repurchase agreements with institutions that American Century Investment Management, Inc. (ACIM) (the investment advisor) has determined are creditworthy pursuant to criteria adopted by the Board of Directors. The fund requires that the collateral, represented by securities, received in a repurchase transaction be transferred to the custodian in a manner sufficient to enable the fund to obtain those securities in the event of a default under the repurchase agreement. ACIM monitors, on a daily basis, the securities transferred to ensure the value, including accrued interest, of the securities under each repurchase agreement is equal to or greater than amounts owed to the fund under each repurchase agreement.

Joint Trading Account — Pursuant to an Exemptive Order issued by the Securities and Exchange Commission, the fund, along with certain other funds in the American Century Investments family of funds, may transfer uninvested cash balances into a joint trading account. These balances are invested in one or more repurchase agreements that are collateralized by U.S. Treasury or Agency obligations.

Segregated Assets — In accordance with the 1940 Act, the fund segregates assets on its books and records to cover certain types of investment securities and other financial instruments. ACIM monitors, on a daily basis, the securities segregated to ensure the fund designates a sufficient amount of liquid assets, marked-to-market daily. The fund may also receive assets or be required to pledge assets at the custodian bank or with a broker for collateral requirements.

18


Income Tax Status — It is the fund’s policy to distribute substantially all net investment income and net realized gains to shareholders and to otherwise qualify as a regulated investment company under provisions of the Internal Revenue Code. Accordingly, no provision has been made for income taxes. The fund files U.S. federal, state, local and non-U.S. tax returns as applicable. The fund's tax returns are subject to examination by the relevant taxing authority until expiration of the applicable statute of limitations, which is generally three years from the date of filing but can be longer in certain jurisdictions. At this time, management believes there are no uncertain tax positions which, based on their technical merit, would not be sustained upon examination and for which it is reasonably possible that the total amounts of unrecognized tax benefits will significantly change in the next twelve months.

Multiple Class — All shares of the fund represent an equal pro rata interest in the net assets of the class to which such shares belong, and have identical voting, dividend, liquidation and other rights and the same terms and conditions, except for class specific expenses and exclusive rights to vote on matters affecting only individual classes. Income, non-class specific expenses, and realized and unrealized capital gains and losses of the fund are allocated to each class of shares based on their relative net assets.

Distributions to Shareholders — Distributions from net investment income and net realized gains, if any, are generally declared and paid annually. The fund may elect to treat a portion of its payment to a redeeming shareholder, which represents the pro rata share of undistributed net investment income and net realized gains, as a distribution for federal income tax purposes (tax equalization).

Indemnifications — Under the corporation’s organizational documents, its officers and directors are indemnified against certain liabilities arising out of the performance of their duties to the fund. In addition, in the normal course of business, the fund enters into contracts that provide general indemnifications. The maximum exposure under these arrangements is unknown as this would involve future claims that may be made against a fund. The risk of material loss from such claims is considered by management to be remote.

Securities Lending — Securities are lent to qualified financial institutions and brokers. State Street Bank & Trust Co. serves as securities lending agent to the fund pursuant to a Securities Lending Agreement. The lending of securities exposes the fund to risks such as: the borrowers may fail to return the loaned securities, the borrowers may not be able to provide additional collateral, the fund may experience delays in recovery of the loaned securities or delays in access to collateral, or the fund may experience losses related to the investment collateral. To minimize certain risks, loan counterparties pledge collateral in the form of cash and/or securities. The lending agent has agreed to indemnify the fund in the case of default of any securities borrowed. Cash collateral received is invested in the State Street Navigator Securities Lending Government Money Market Portfolio, a money market mutual fund registered under the 1940 Act. The loans may also be secured by U.S. government securities in an amount at least equal to the market value of the securities loaned, plus accrued interest and dividends, determined on a daily basis and adjusted accordingly. By lending securities, the fund seeks to increase its net investment income through the receipt of interest and fees. Such income is reflected separately within the Statement of Operations. The value of loaned securities and related collateral outstanding at period end, if any, are shown on a gross basis within the Schedule of Investments and Statement of Assets and Liabilities.

The following table reflects a breakdown of transactions accounted for as secured borrowings, the gross obligation by the type of collateral pledged, and the remaining contractual maturity of those transactions as of October 31, 2021.
Remaining Contractual Maturity of Agreements
Overnight and
Continuous
<30 days
Between
30 & 90 days
>90 days
Total
Securities Lending Transactions(1)
Common Stocks$45,634,735 — — — $45,634,735 
Gross amount of recognized liabilities for securities lending transactions$45,634,735 
(1)Amount represents the payable for cash collateral received for securities on loan. This will generally be in the Overnight and Continuous column as the securities are typically callable on demand.

19


3. Fees and Transactions with Related Parties

Certain officers and directors of the corporation are also officers and/or directors of American Century Companies, Inc. (ACC). The corporation’s investment advisor, ACIM, the corporation's distributor, American Century Investment Services, Inc. (ACIS), and the corporation’s transfer agent, American Century Services, LLC, are wholly owned, directly or indirectly, by ACC.

Management Fees — The corporation has entered into a management agreement with ACIM, under which ACIM provides the fund with investment advisory and management services in exchange for a single, unified management fee (the fee) per class. The agreement provides that ACIM will pay all expenses of managing and operating the fund, except brokerage expenses, taxes, interest, fees and expenses of the independent directors (including legal counsel fees), extraordinary expenses, and expenses incurred in connection with the provision of shareholder services and distribution services under a plan adopted pursuant to Rule 12b-1 under the 1940 Act. The fee is computed and accrued daily based on each class's daily net assets and paid monthly in arrears. The difference in the fee among the classes is a result of their separate arrangements for non-Rule 12b-1 shareholder services. It is not the result of any difference in advisory or custodial fees or other expenses related to the management of the fund’s assets, which do not vary by class. The rate of the fee is determined by applying a fee rate calculation formula. This formula takes into account the fund’s assets as well as certain assets, if any, of other clients of the investment advisor outside the American Century Investments family of funds (such as subadvised funds and separate accounts) that use very similar investment teams and strategies (strategy assets). The strategy assets of the fund also include the assets of NT Growth Fund, one fund in a series issued by the corporation. Effective August 1, 2021, the investment advisor agreed to waive a portion of the fund’s management fee such that the management fee does not exceed 0.95% for Investor Class, A Class, C Class and R Class, 0.75% for I Class and R5 Class, and 0.60% for Y Class and R6 Class. The investment advisor expects this waiver arrangement to continue until July 31, 2022 and cannot terminate it prior to such date without the approval of the Board of Directors.

The management fee schedule range and the effective annual management fee before and after waiver for each class for the period ended October 31, 2021 are as follows:
Effective Annual Management Fee
Management Fee Schedule Range
Before Waiver
After Waiver
Investor Class0.800% to 0.990%0.96%0.96%
I Class0.600% to 0.790%0.76%0.76%
Y Class0.450% to 0.640%0.61%0.61%
A Class0.800% to 0.990%0.96%0.96%
C Class0.800% to 0.990%0.96%0.96%
R Class0.800% to 0.990%0.96%0.96%
R5 Class0.600% to 0.790%0.76%0.76%
R6 Class0.450% to 0.640%0.61%0.61%

Distribution and Service Fees — The Board of Directors has adopted a separate Master Distribution and Individual Shareholder Services Plan for each of the A Class, C Class and R Class (collectively the plans), pursuant to Rule 12b-1 of the 1940 Act. The plans provide that the A Class will pay ACIS an annual distribution and service fee of 0.25%. The plans provide that the C Class will pay ACIS an annual distribution and service fee of 1.00%, of which 0.25% is paid for individual shareholder services and 0.75% is paid for distribution services. The plans provide that the R Class will pay ACIS an annual distribution and service fee of 0.50%. The fees are computed and accrued daily based on each class’s daily net assets and paid monthly in arrears. The fees are used to pay financial intermediaries for distribution and individual shareholder services. Fees incurred under the plans during the period ended October 31, 2021 are detailed in the Statement of Operations.

Directors' Fees and Expenses — The Board of Directors is responsible for overseeing the investment advisor’s management and operations of the fund. The directors receive detailed information about the fund and its investment advisor regularly throughout the year, and meet at least quarterly with management of the investment advisor to review reports about fund operations. The fund’s officers do not receive compensation from the fund.

20


Interfund Transactions — The fund may enter into security transactions with other American Century Investments funds and other client accounts of the investment advisor, in accordance with the 1940 Act rules and procedures adopted by the Board of Directors. The rules and procedures require, among other things, that these transactions be effected at the independent current market price of the security. During the period, the interfund purchases were $3,320,944 and there were no interfund sales.

4. Investment Transactions

Purchases and sales of investment securities, excluding short-term investments and in kind transactions, for the period ended October 31, 2021 were $2,470,610,649 and $3,567,997,321, respectively.

For the period ended October 31, 2021, the fund incurred net realized gains of $41,171,480 from redemptions in kind. A redemption in kind occurs when a fund delivers securities from its portfolio in lieu of cash as payment to a redeeming shareholder.


21


5. Capital Share Transactions

Transactions in shares of the fund were as follows:
Year ended
October 31, 2021
Year ended
October 31, 2020
SharesAmountSharesAmount
Investor Class/Shares Authorized2,100,000,000 2,100,000,000 
Sold5,305,769 $264,722,721 9,314,651 $343,295,401 
Issued in connection with reorganization (Note 10)— — 33,740,937 1,281,095,913 
Issued in reinvestment of distributions5,939,447 269,212,365 12,608,305 463,439,340 
Redeemed(18,886,054)(939,574,506)(38,931,327)(1,459,424,248)
(7,640,838)(405,639,420)16,732,566 628,406,406 
I Class/Shares Authorized460,000,000 460,000,000 
Sold5,030,555 253,476,557 14,389,473 554,081,579 
Issued in connection with reorganization (Note 10)— — 238,480 9,244,211 
Issued in reinvestment of distributions1,332,209 61,801,158 3,019,127 113,217,452 
Redeemed(11,938,383)(624,523,946)(15,353,587)(606,960,175)
(5,575,619)(309,246,231)2,293,493 69,583,067 
Y Class/Shares Authorized40,000,000 40,000,000 
Sold125,001 6,382,042 153,010 5,711,874 
Issued in reinvestment of distributions39,621 1,840,784 119,002 4,461,395 
Redeemed(259,242)(13,213,793)(524,867)(19,910,740)
(94,620)(4,990,967)(252,855)(9,737,471)
A Class/Shares Authorized40,000,000 40,000,000 
Sold674,956 32,255,963 683,766 24,686,474 
Issued in connection with reorganization (Note 10)— — 422,151 15,436,291 
Issued in reinvestment of distributions83,670 3,641,339 164,961 5,847,619 
Redeemed(704,720)(33,762,086)(1,436,368)(51,778,786)
53,906 2,135,216 (165,490)(5,808,402)
C Class/Shares Authorized30,000,000 30,000,000 
Sold35,432 1,582,981 74,102 2,515,992 
Issued in connection with reorganization (Note 10)— — 124,022 4,225,593 
Issued in reinvestment of distributions12,972 521,225 20,026 661,725 
Redeemed(162,645)(6,793,871)(115,923)(3,918,628)
(114,241)(4,689,665)102,227 3,484,682 
R Class/Shares Authorized40,000,000 40,000,000 
Sold242,169 11,219,666 431,377 15,135,430 
Issued in connection with reorganization (Note 10)— — 461,820 16,348,203 
Issued in reinvestment of distributions89,107 3,740,945 205,542 7,043,451 
Redeemed(675,841)(31,093,859)(1,236,289)(42,445,952)
(344,565)(16,133,248)(137,550)(3,918,868)
R5 Class/Shares Authorized30,000,000 30,000,000 
Sold75,078 3,866,385 999 38,826 
Issued in reinvestment of distributions341 15,831 1,135 42,460 
Redeemed(2,678)(146,108)(6,612)(240,109)
72,741 3,736,108 (4,478)(158,823)
R6 Class/Shares Authorized200,000,000 200,000,000 
Sold3,696,574 190,995,553 4,275,401 166,984,195 
Issued in reinvestment of distributions460,844 21,373,938 1,098,511 41,181,311 
Redeemed(3,762,407)(190,298,428)(4,210,873)(161,426,955)
395,011 22,071,063 1,163,039 46,738,551 
Net increase (decrease)(13,248,225)$(712,757,144)19,730,952 $728,589,142 
22


6. Fair Value Measurements

The fund’s investments valuation process is based on several considerations and may use multiple inputs to determine the fair value of the investments held by the fund. In conformity with accounting principles generally accepted in the United States of America, the inputs used to determine a valuation are classified into three broad levels.

Level 1 valuation inputs consist of unadjusted quoted prices in an active market for identical investments.

Level 2 valuation inputs consist of direct or indirect observable market data (including quoted prices for comparable investments, evaluations of subsequent market events, interest rates, prepayment speeds, credit risk, etc.). These inputs also consist of quoted prices for identical investments initially expressed in local currencies that are adjusted through translation into U.S. dollars.

Level 3 valuation inputs consist of unobservable data (including a fund’s own assumptions).

The level classification is based on the lowest level input that is significant to the fair valuation measurement. The valuation inputs are not necessarily an indication of the risks associated with investing in these securities or other financial instruments.

The following is a summary of the level classifications as of period end. The Schedule of Investments provides additional information on the fund’s portfolio holdings.
Level 1Level 2Level 3
Assets
Investment Securities
Common Stocks$13,134,471,573 $275,018,860 — 
Temporary Cash Investments1,655,708 61,788,304 — 
Temporary Cash Investments - Securities Lending Collateral45,634,735 — — 
$13,181,762,016 $336,807,164 — 
Other Financial Instruments
Futures Contracts$2,776,235 — — 
Forward Foreign Currency Exchange Contracts— $3,249,889 — 
$2,776,235 $3,249,889 — 
Liabilities
Other Financial Instruments
Forward Foreign Currency Exchange Contracts— $269,579 — 

7. Derivative Instruments

Equity Price Risk — The fund is subject to equity price risk in the normal course of pursuing its investment objectives. A fund may enter into futures contracts based on an equity index in order to manage its exposure to changes in market conditions. A fund may purchase futures contracts to gain exposure to increases in market value or sell futures contracts to protect against a decline in market value. Upon entering into a futures contract, a fund is required to deposit either cash or securities in an amount equal to a certain percentage of the contract value (initial margin). Subsequent payments (variation margin) are made or received daily, in cash, by a fund. The variation margin is equal to the daily change in the contract value and is recorded as unrealized gains and losses. A fund recognizes a realized gain or loss when the contract is closed or expires. Net realized and unrealized gains or losses occurring during the holding period of futures contracts are a component of net realized gain (loss) on futures contract transactions and change in net unrealized appreciation (depreciation) on futures contracts, respectively. One of the risks of entering into futures contracts is the possibility that the change in value of the contract may not correlate with the changes in value of the underlying securities. The fund's average notional exposure to equity price risk derivative instruments held during the period was $39,652,153 futures contracts purchased.


23


Foreign Currency Risk — The fund is subject to foreign currency exchange rate risk in the normal course of pursuing its investment objectives. The value of foreign investments held by a fund may be significantly affected by changes in foreign currency exchange rates. The dollar value of a foreign security generally decreases when the value of the dollar rises against the foreign currency in which the security is denominated and tends to increase when the value of the dollar declines against such foreign currency. A fund may enter into forward foreign currency exchange contracts to reduce a fund's exposure to foreign currency exchange rate fluctuations. The net U.S. dollar value of foreign currency underlying all contractual commitments held by a fund and the resulting unrealized appreciation or depreciation are determined daily. Realized gain or loss is recorded upon settlement of the contract. Net realized and unrealized gains or losses occurring during the holding period of forward foreign currency exchange contracts are a component of net realized gain (loss) on forward foreign currency exchange contract transactions and change in net unrealized appreciation (depreciation) on forward foreign currency exchange contracts, respectively. A fund bears the risk of an unfavorable change in the foreign currency exchange rate underlying the forward contract. Additionally, losses, up to the fair value, may arise if the counterparties do not perform under the contract terms. The fund's average U.S. dollar exposure to foreign currency risk derivative instruments held during the period was $232,100,649.

Value of Derivative Instruments as of October 31, 2021
Asset Derivatives
Liability Derivatives
Type of Risk ExposureLocation on Statement of Assets and Liabilities
Value
Location on Statement of Assets and Liabilities
Value
Equity Price RiskReceivable for variation margin on futures contracts*$524,871 Payable for variation margin on futures contracts*— 
Foreign Currency RiskUnrealized appreciation on forward foreign currency exchange contracts3,249,889 Unrealized depreciation on forward foreign currency exchange contracts$269,579 
$3,774,760 $269,579 
*Included in the unrealized appreciation (depreciation) on futures contracts, as reported in the Schedule of Investments.

Effect of Derivative Instruments on the Statement of Operations for the Year Ended October 31, 2021
Net Realized Gain (Loss)Change in Net Unrealized Appreciation (Depreciation)
Type of Risk ExposureLocation on Statement of OperationsValueLocation on Statement of OperationsValue
Equity Price Risk
Net realized gain (loss) on futures contract transactions
$15,934,905 Change in net unrealized appreciation (depreciation) on futures contracts$2,776,235
Foreign Currency Risk
Net realized gain (loss) on forward foreign currency exchange contract transactions
2,124,750 Change in net unrealized appreciation (depreciation) on forward foreign currency exchange contracts2,236,205
$18,059,655 $5,012,440

8. Risk Factors

The value of the fund’s shares will go up and down, sometimes rapidly or unpredictably, based on the performance of the securities owned by the fund and other factors generally affecting the securities market. Market risks, including political, regulatory, economic and social developments, can affect the value of the fund’s investments. Natural disasters, public health emergencies, terrorism and other unforeseeable events may lead to increased market volatility and may have adverse long-term effects on world economies and markets generally.


24


9. Federal Tax Information

On December 7, 2021, the fund declared and paid a per-share distribution from net realized gains to shareholders of record on December 6, 2021 of $5.3078 for the Investor Class, I Class, Y Class, A Class, C Class, R Class, R5 Class and R6 Class.

The tax character of distributions paid during the years ended October 31, 2021 and October 31, 2020 were as follows:
20212020
Distributions Paid From
Ordinary income— $24,642,374 
Long-term capital gains$376,519,099 $630,884,508 

The book-basis character of distributions made during the year from net investment income or net realized gains may differ from their ultimate characterization for federal income tax purposes. These differences reflect the differing character of certain income items and net realized gains and losses for financial statement and tax purposes, and may result in reclassification among certain capital accounts on the financial statements.

As of period end, the federal tax cost of investments and the components of distributable earnings on a tax-basis were as follows:

Federal tax cost of investments$5,359,919,929 
Gross tax appreciation of investments$8,213,286,476 
Gross tax depreciation of investments(54,637,225)
Net tax appreciation (depreciation) of investments8,158,649,251 
Net tax appreciation (depreciation) on derivatives and translation of assets and
liabilities in foreign currencies
8,681 
Net tax appreciation (depreciation) $8,158,657,932 
Undistributed ordinary income$79,614,038 
Accumulated long-term gains$1,137,776,084 

The difference between book-basis and tax-basis unrealized appreciation (depreciation) is attributable primarily to the realization to ordinary income for tax purposes of unrealized gains on investments in passive foreign investment companies.

10. Reorganization

On September 11, 2019, the Board of Directors approved an agreement and plan of reorganization (the reorganization), whereby the net assets of All Cap Growth Fund, one fund in a series issued by the corporation, were transferred to Growth Fund in exchange for shares of Growth Fund. The purpose of the transaction was to combine two funds with substantially similar investment objectives and strategies. The financial statements and performance history of Growth Fund survived after the reorganization. The reorganization was effective at the close of the NYSE on February 21, 2020.

The reorganization was accomplished by a tax-free exchange of shares. On February 21, 2020, All Cap Growth Fund exchanged its shares for shares of Growth Fund as follows:

Original Fund/Class
Shares Exchanged
New Fund/Class
Shares Received
All Cap Growth Fund – Investor Class36,344,493 Growth Fund – Investor Class33,740,937 
All Cap Growth Fund – I Class256,052 Growth Fund – I Class238,480 
All Cap Growth Fund – A Class451,934 Growth Fund – A Class422,151 
All Cap Growth Fund – C Class137,457 Growth Fund – C Class124,022 
All Cap Growth Fund – R Class495,557 Growth Fund – R Class461,820 




25


The net assets of All Cap Growth Fund and Growth Fund immediately before the reorganization were $1,326,350,211 and $8,778,658,792, respectively. All Cap Growth Fund's unrealized appreciation of $530,451,716 was combined with that of Growth Fund. Immediately after the reorganization, the combined net assets were $10,105,009,003.

Assuming the reorganization had been completed on November 1, 2019, the beginning of the annual reporting period, the pro forma results of operations for the period ended October 31, 2020 are as follows:
Net investment income (loss)$1,186,943 
Net realized and unrealized gain (loss)2,308,332,754 
Net increase (decrease) in net assets resulting from operations$2,309,519,697 

Because the combined investment portfolios have been managed as a single integrated portfolio since the reorganization was completed, it is not practicable to separate the amounts of revenue and earnings of All Cap Growth Fund that have been included in the fund’s Statement of Operations since February 21, 2020.
26


Financial Highlights
For a Share Outstanding Throughout the Years Ended October 31 (except as noted)
Per-Share DataRatios and Supplemental Data
Income From Investment Operations:Distributions From:Ratio to Average Net Assets of:
Net Asset
Value,
Beginning
of Period
Net
Investment
Income
(Loss)(1)
Net
Realized
and
Unrealized
Gain (Loss)
Total From
Investment
Operations
Net
Investment
Income
Net
Realized
Gains
Total
Distributions
Net Asset
Value,
End
of Period
Total
Return(2)
Operating
Expenses
Operating
Expenses
(before
expense
waiver)
Net
Investment
Income
(Loss)
Net
Investment
Income
(Loss)
(before expense waiver)
Portfolio
Turnover
Rate
Net
Assets,
End of
Period
(in thousands)
Investor Class
2021$41.94(0.18)18.0317.85(1.56)(1.56)$58.2343.66%0.96%0.96%(0.36)%(0.36)%21%$10,186,486 
2020$35.80(0.02)9.129.10(0.15)(2.81)(2.96)$41.9426.70%0.97%0.97%(0.04)%(0.04)%33%$7,656,430 
2019$34.940.084.704.78(0.08)(3.84)(3.92)$35.8016.35%0.98%0.98%0.24%0.24%30%$5,937,959 
2018$34.930.043.353.39(0.06)(3.32)(3.38)$34.9410.22%0.97%0.97%0.13%0.13%38%$5,627,171 
2017$28.640.087.677.75(0.17)(1.29)(1.46)$34.9328.26%0.98%0.98%0.26%0.26%48%$5,648,965 
I Class
2021$42.87(0.08)18.4718.39(1.56)(1.56)$59.7043.95%0.76%0.76%(0.16)%(0.16)%21%$2,061,819 
2020$36.560.069.299.35(0.23)(2.81)(3.04)$42.8726.93%0.77%0.77%0.16%0.16%33%$1,719,814 
2019$35.590.154.814.96(0.15)(3.84)(3.99)$36.5616.62%0.78%0.78%0.44%0.44%30%$1,382,618 
2018$35.520.123.403.52(0.13)(3.32)(3.45)$35.5910.46%0.77%0.77%0.33%0.33%38%$1,230,065 
2017$29.110.157.787.93(0.23)(1.29)(1.52)$35.5228.48%0.78%0.78%0.46%0.46%48%$1,271,821 



For a Share Outstanding Throughout the Years Ended October 31 (except as noted)
Per-Share DataRatios and Supplemental Data
Income From Investment Operations:Distributions From:Ratio to Average Net Assets of:
Net Asset
Value,
Beginning
of Period
Net
Investment
Income
(Loss)(1)
Net
Realized
and
Unrealized
Gain (Loss)
Total From
Investment
Operations
Net
Investment
Income
Net
Realized
Gains
Total
Distributions
Net Asset
Value,
End
of Period
Total
Return(2)
Operating
Expenses
Operating
Expenses
(before
expense
waiver)
Net
Investment
Income
(Loss)
Net
Investment
Income
(Loss)
(before expense waiver)
Portfolio
Turnover
Rate
Net
Assets,
End of
Period
(in thousands)
Y Class
2021$42.93(0.01)18.5018.49(1.56)(1.56)$59.8644.13%0.61%0.61%(0.01)%(0.01)%21%$66,916 
2020$36.610.139.309.43(0.30)(2.81)(3.11)$42.9327.15%0.62%0.62%0.31%0.31%33%$52,046 
2019$35.640.204.815.01(0.20)(3.84)(4.04)$36.6116.78%0.63%0.63%0.59%0.59%30%$53,641 
2018$35.540.173.403.57(0.15)(3.32)(3.47)$35.6410.61%0.62%0.62%0.48%0.48%38%$52,601 
2017(3)
$30.930.084.534.61$35.5414.90%
0.63%(4)
0.63%(4)
0.43%(4)
0.43%(4)
48%(5)
$56,218 
A Class
2021$40.32(0.30)17.3217.02(1.56)(1.56)$55.7843.31%1.21%1.21%(0.61)%(0.61)%21%$144,743 
2020$34.52(0.10)8.758.65(0.04)(2.81)(2.85)$40.3226.38%1.22%1.22%(0.29)%(0.29)%33%$102,472 
2019$33.82
(6)
4.544.54(3.84)(3.84)$34.5216.06%1.23%1.23%(0.01)%(0.01)%30%$93,422 
2018$33.94(0.04)3.243.20(3.32)(3.32)$33.829.94%1.22%1.22%(0.12)%(0.12)%38%$103,115 
2017$27.860.017.467.47(0.10)(1.29)(1.39)$33.9427.95%1.23%1.23%0.01%0.01%48%$113,348 
C Class
2021$37.37(0.59)15.9415.35(1.56)(1.56)$51.1642.23%1.96%1.96%(1.36)%(1.36)%21%$12,674 
2020$32.37(0.37)8.187.81(2.81)(2.81)$37.3725.43%1.97%1.97%(1.04)%(1.04)%33%$13,527 
2019$32.18(0.23)4.264.03(3.84)(3.84)$32.3715.23%1.98%1.98%(0.76)%(0.76)%30%$8,408 
2018$32.67(0.29)3.122.83(3.32)(3.32)$32.189.12%1.97%1.97%(0.87)%(0.87)%38%$9,871 
2017$26.97(0.21)7.206.99(1.29)(1.29)$32.6726.99%1.98%1.98%(0.74)%(0.74)%48%$9,962 



For a Share Outstanding Throughout the Years Ended October 31 (except as noted)
Per-Share DataRatios and Supplemental Data
Income From Investment Operations:Distributions From:Ratio to Average Net Assets of:
Net Asset
Value,
Beginning
of Period
Net
Investment
Income
(Loss)(1)
Net
Realized
and
Unrealized
Gain (Loss)
Total From
Investment
Operations
Net
Investment
Income
Net
Realized
Gains
Total
Distributions
Net Asset
Value,
End
of Period
Total
Return(2)
Operating
Expenses
Operating
Expenses
(before
expense
waiver)
Net
Investment
Income
(Loss)
Net
Investment
Income
(Loss)
(before expense waiver)
Portfolio
Turnover
Rate
Net
Assets,
End of
Period
(in thousands)
R Class
2021$38.96(0.40)16.6916.29(1.56)(1.56)$53.6942.94%1.46%1.46%(0.86)%(0.86)%21%$114,022 
2020$33.50(0.19)8.498.30(0.03)(2.81)(2.84)$38.9626.07%1.47%1.47%(0.54)%(0.54)%33%$96,170 
2019$33.02(0.08)4.404.32(3.84)(3.84)$33.5015.78%1.48%1.48%(0.26)%(0.26)%30%$87,302 
2018$33.29(0.13)3.183.05(3.32)(3.32)$33.029.66%1.47%1.47%(0.37)%(0.37)%38%$100,915 
2017$27.35(0.07)7.327.25(0.02)(1.29)(1.31)$33.2927.62%1.48%1.48%(0.24)%(0.24)%48%$104,368 
R5 Class
2021$42.91(0.09)18.5018.41(1.56)(1.56)$59.7643.96%0.76%0.76%(0.16)%(0.16)%21%$4,950 
2020$36.590.089.289.36(0.23)(2.81)(3.04)$42.9126.94%0.77%0.77%0.16%0.16%33%$433 
2019$35.620.154.814.96(0.15)(3.84)(3.99)$36.5916.61%0.78%0.78%0.44%0.44%30%$533 
2018$35.530.123.403.52(0.11)(3.32)(3.43)$35.6210.45%0.77%0.77%0.33%0.33%38%$404 
2017(3)
$30.950.054.534.58$35.5314.80%
0.78%(4)
0.78%(4)
0.27%(4)
0.27%(4)
48%(5)
$6 
R6 Class
2021$42.86(0.01)18.4818.47(1.56)(1.56)$59.7744.15%0.61%0.61%(0.01)%(0.01)%21%$876,460 
2020$36.560.129.299.41(0.30)(2.81)(3.11)$42.8627.13%0.62%0.62%0.31%0.31%33%$611,600 
2019$35.590.214.805.01(0.20)(3.84)(4.04)$36.5616.81%0.63%0.63%0.59%0.59%30%$479,123 
2018$35.530.173.403.57(0.19)(3.32)(3.51)$35.5910.60%0.62%0.62%0.48%0.48%38%$834,003 
2017$29.110.187.807.98(0.27)(1.29)(1.56)$35.5328.71%0.63%0.63%0.61%0.61%48%$963,039 




Notes to Financial Highlights
(1)Computed using average shares outstanding throughout the period.
(2)Total returns are calculated based on the net asset value of the last business day and do not reflect applicable sales charges, if any. Total returns for periods less than one year are not annualized.
(3)April 10, 2017 (commencement of sale) through October 31, 2017.
(4)Annualized.
(5)Portfolio turnover is calculated at the fund level. Percentage indicated was calculated for the year ended October 31, 2017.
(6)Per-share amount was less than $0.005.


See Notes to Financial Statements.



Report of Independent Registered Public Accounting Firm

To the Shareholders and the Board of Directors of American Century Mutual Funds, Inc.:

Opinion on the Financial Statements and Financial Highlights

We have audited the accompanying statement of assets and liabilities, including the schedule of investments, of Growth Fund (the “Fund”), one of the funds constituting the American Century Mutual Funds, Inc., as of October 31, 2021, the related statement of operations for the year then ended, the statements of changes in net assets for each of the two years in the period then ended, the financial highlights for each of the five years in the period then ended, and the related notes. In our opinion, the financial statements and financial highlights present fairly, in all material respects, the financial position of Growth Fund of the American Century Mutual Funds, Inc. as of October 31, 2021, and the results of its operations for the year then ended, the changes in its net assets for each of the two years in the period then ended, and the financial highlights for each of the five years in the period then ended, in conformity with accounting principles generally accepted in the United States of America.

Basis for Opinion

These financial statements and financial highlights are the responsibility of the Fund's management. Our responsibility is to express an opinion on the Fund’s financial statements and financial highlights based on our audits. We are a public accounting firm registered with the Public Company Accounting Oversight Board (United States) (PCAOB) and are required to be independent with respect to the Fund in accordance with the U.S. federal securities laws and the applicable rules and regulations of the Securities and Exchange Commission and the PCAOB.

We conducted our audits in accordance with the standards of the PCAOB. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements and financial highlights are free of material misstatement, whether due to error or fraud. The Fund is not required to have, nor were we engaged to perform, an audit of its internal control over financial reporting. As part of our audits we are required to obtain an understanding of internal control over financial reporting but not for the purpose of expressing an opinion on the effectiveness of the Fund’s internal control over financial reporting. Accordingly, we express no such opinion.

Our audits included performing procedures to assess the risks of material misstatement of the financial statements and financial highlights, whether due to error or fraud, and performing procedures that respond to those risks. Such procedures included examining, on a test basis, evidence regarding the amounts and disclosures in the financial statements and financial highlights. Our audits also included evaluating the accounting principles used and significant estimates made by management, as well as evaluating the overall presentation of the financial statements and financial highlights. Our procedures included confirmation of securities owned as of October 31, 2021, by correspondence with the custodian and brokers; when replies were not received from brokers, we performed other auditing procedures. We believe that our audits provide a reasonable basis for our opinion.

/s/ Deloitte & Touche LLP

Kansas City, Missouri
December 15, 2021

We have served as the auditor of one or more American Century investment companies since 1997.
31


Management

The Board of Directors

The individuals listed below serve as directors of the funds. Each director will continue to serve in this capacity until death, retirement, resignation or removal from office. The board has adopted a mandatory retirement age for directors who are not “interested persons,” as that term is defined in the Investment Company Act (independent directors). Independent directors shall retire by December 31 of the year in which they reach their 75th birthday.
Jonathan S.Thomas is an “interested person” because he currently serves as President and Chief Executive Officer of American Century Companies, Inc. (ACC), the parent company of American Century Investment Management, Inc. (ACIM or the advisor). The other directors (more than three-fourths of the total number) are independent. They are not employees, directors or officers of, and have no financial interest in, ACC or any of its wholly owned, direct or indirect, subsidiaries, including ACIM, American Century Investment Services, Inc. (ACIS) and American Century Services, LLC (ACS), and they do not have any other affiliations, positions or relationships that would cause them to be considered “interested persons” under the Investment Company Act. The directors serve in this capacity for seven (in the case of Jonathan S. Thomas, 16; and Stephen E. Yates, 8) registered investment companies in the American Century Investments family of funds.
The following table presents additional information about the directors. The mailing address for each director is 4500 Main Street, Kansas City, Missouri 64111.
Name
(Year of Birth)
Position(s) Held with FundsLength of Time ServedPrincipal Occupation(s) During Past 5 YearsNumber of American Century Portfolios Overseen by DirectorOther Directorships Held During Past 5 Years
Independent Directors
Thomas W. Bunn (1953)DirectorSince 2017Retired72SquareTwo Financial; Barings (formerly Babson Capital Funds Trust) (2013 to 2016)
Chris H. Cheesman
(1962)
DirectorSince 2019
Retired. Senior Vice President & Chief Audit Executive, AllianceBernstein (1999 to 2018)72Alleghany Corporation
Barry Fink
(1955)
DirectorSince 2012 (independent since 2016)Retired72None
Rajesh K. Gupta
(1960)
DirectorSince 2019
Partner Emeritus, SeaCrest Investment Management and SeaCrest Wealth Management (2019 to Present); Chief Executive Officer and Chief Investment Officer, SeaCrest Investment Management (2006 to 2019); Chief Executive Officer and Chief Investment Officer, SeaCrest Wealth Management (2008 to 2019)72None
32


Name
(Year of Birth)
Position(s) Held with FundsLength of Time ServedPrincipal Occupation(s) During Past 5 YearsNumber of American Century Portfolios Overseen by DirectorOther Directorships Held During Past 5 Years
Independent Directors
Lynn Jenkins
(1963)
DirectorSince 2019
Consultant, LJ Strategies (2019 to present); United States Representative, U.S. House of Representatives (2009 to 2018)72MGP Ingredients, Inc. (2019 to 2021)
Jan M. Lewis
(1957)
DirectorSince 2011Retired72None
John R. Whitten
(1946)
DirectorSince 2008Retired72Onto Innovation Inc. (2019 to 2020); Rudolph Technologies, Inc. (2006 to 2019)
Stephen E. Yates
(1948)
Director and Chairman of the BoardSince 2012 (Chairman since 2018)Retired107None
Interested Director
Jonathan S. Thomas
(1963)
DirectorSince 2007President and Chief Executive Officer, ACC (2007 to present). Also serves as Chief Executive Officer, ACS; Director, ACC and other ACC subsidiaries145None
The Statement of Additional Information has additional information about the fund's directors and is available without charge, upon request, by calling 1-800-345-2021.
33


Officers

The following table presents certain information about the executive officers of the funds. Each officer serves as an officer for 16 (in the case of Robert J. Leach, 15) investment companies in the American Century family of funds. No officer is compensated for his or her service as an officer of the funds. The listed officers are interested persons of the funds and are appointed or re-appointed on an annual basis. The mailing address for each officer listed below is 4500 Main Street, Kansas City, Missouri 64111.
Name
(Year of Birth)
Offices with the FundsPrincipal Occupation(s) During the Past Five Years
Patrick Bannigan
(1965)
President since 2019Executive Vice President and Director, ACC (2012 to present); Chief Financial Officer, Chief Accounting Officer and Treasurer, ACC (2015 to present). Also serves as President, ACS; Vice President, ACIM; Chief Financial Officer, Chief Accounting Officer and/or Director, ACIM, ACS and other ACC subsidiaries
R. Wes Campbell
(1974)
Chief Financial Officer and Treasurer since 2018Vice President, ACS, (2020 to present); Investment Operations and Investment Accounting, ACS (2000 to present)
Amy D. Shelton
(1964)
Chief Compliance Officer and Vice President since 2014Chief Compliance Officer, American Century funds, (2014 to present); Chief Compliance Officer, ACIM (2014 to present); Chief Compliance Officer, ACIS (2009 to present). Also serves as Vice President, ACIS
John Pak
(1968)
General Counsel and
Senior Vice President since 2021
General Counsel and Senior Vice President, ACC (2021 to present). Also serves as General Counsel and Senior Vice President, ACIM, ACS and ACIS. Chief Legal Officer of Investment and Wealth Management, The Bank of New York Mellon (2014 to 2021)
C. Jean Wade
(1964)
Vice President since 2012Senior Vice President, ACS (2017 to present); Vice President, ACS (2000 to 2017)
Robert J. Leach
(1966)
Vice President since 2006 Vice President, ACS (2000 to present)
David H. Reinmiller
(1963)
Vice President since 2000Attorney, ACC (1994 to present). Also serves as Vice President, ACIM and ACS
Ward D. Stauffer
(1960)
Secretary since 2005Attorney, ACC (2003 to present)





34


Approval of Management Agreement

At a meeting held on June 30, 2021, the Fund’s Board of Directors (the "Board") unanimously approved the renewal of the management agreement pursuant to which American Century Investment Management, Inc. (the “Advisor”) acts as the investment advisor for the Fund. Under Section 15(c) of the Investment Company Act, contracts for investment advisory services are required to be reviewed, evaluated, and approved by a majority of a fund’s directors (the “Directors”), including a majority of the independent Directors, each year.

Prior to its consideration of the renewal of the management agreement, the Directors requested and reviewed extensive data and information compiled by the Advisor and certain independent providers of evaluation data concerning the Fund and the services provided to the Fund by the Advisor. This review was in addition to the oversight and evaluation undertaken by the Board and its committees on a continual basis and the information received was supplemental to the extensive information that the Board and its committees receive and consider throughout the year.

In connection with its consideration of the renewal of the management agreement, the Board’s review and evaluation of the services provided by the Advisor and its affiliates included, but was not limited to, the following:

the nature, extent, and quality of investment management, shareholder services, and other services provided and to be provided to the Fund including without limitation portfolio management and trading services, shareholder and intermediary services, compliance and legal services, fund accounting and financial reporting, and fund share distribution;
the wide range of other programs and services provided and to be provided to the Fund and its shareholders on a routine and non-routine basis;
the Fund’s investment performance, including data comparing the Fund's performance to appropriate benchmarks and/or a peer group of other mutual funds with similar investment objectives and strategies;
the cost of owning the Fund compared to the cost of owning similar funds;
the compliance policies, procedures, and regulatory experience of the Advisor and the Fund's service providers;
the Advisor’s strategic plans, COVID-19 pandemic response, vendor management practices, and social justice initiatives;
the Advisor’s business continuity plans and cyber security practices;
financial data showing the cost of services provided to the Fund, the profitability of the Fund to the Advisor, and the overall profitability of the Advisor;
possible economies of scale associated with the Advisor’s management of the Fund and other accounts;
services provided and charges to the Advisor's other investment management clients;
acquired fund fees and expenses;
payments and practices in connection with financial intermediaries holding shares of the Fund and the services provided by intermediaries in connection therewith; and
possible collateral benefits to the Advisor from the management of the Fund.

The Board held two meetings to consider the renewal and formed a subcommittee to evaluate the Fund’s competitive market. The independent Directors also met in private session three times to review and discuss the information provided in response to their request. The independent Directors held active discussions with the Advisor regarding the renewal of the management agreement, requesting supplemental information, and reviewing information provided by the Advisor in response thereto. The independent Directors had the benefit of the advice of their independent counsel throughout the process.


35


Factors Considered

The Directors considered all of the information provided by the Advisor, the independent data providers, and independent counsel in connection with the approval. They determined that the information was sufficient for them to evaluate the management agreement for the Fund. In connection with their review, the Directors did not identify any single factor as being all-important or controlling, and each Director may have attributed different levels of importance to different factors. In deciding to renew the management agreement, the Board based its decision on a number of factors, including without limitation the following:

Nature, Extent and Quality of Services — Generally. Under the management agreement, the Advisor is responsible for providing or arranging for all services necessary for the operation of the Fund. The Board noted that the Advisor provides or arranges at its own expense a wide variety of services which include the following:

constructing and designing the Fund
portfolio research and security selection
initial capitalization/funding
securities trading
Fund administration
custody of Fund assets
daily valuation of the Fund’s portfolio
liquidity monitoring and management
risk management, including cyber security
shareholder servicing and transfer agency, including shareholder confirmations, recordkeeping, and communications
legal services (except the independent Directors’ counsel)
regulatory and portfolio compliance
financial reporting
marketing and distribution (except amounts paid by the Fund under Rule 12b-1 plans)

The Board noted that many of these services have expanded over time in terms of both quantity and complexity in response to shareholder demands, competition in the industry, changing distribution channels, and the changing regulatory environment.

Investment Management Services. The nature of the investment management services provided to the Fund is quite complex and allows Fund shareholders access to professional money management, instant diversification of their investments within an asset class, the opportunity to easily diversify among asset classes by investing in or exchanging among various American Century Investments funds, and liquidity. In evaluating investment performance, the Board expects the Advisor to manage the Fund in accordance with its investment objectives and approved strategies. Further, the Directors recognize that the Advisor has an obligation to monitor trading activities, and in particular to seek the best execution of fund trades, and to evaluate the use of and payment for research. In providing these services, the Advisor utilizes teams of investment professionals (portfolio managers, analysts, research assistants, and securities traders) who require extensive information technology, research, training, compliance, and other systems to conduct their business. The Board, directly and through its Fund Performance Review Committee, provides oversight of the investment performance process. It regularly reviews investment performance information for the Fund, together with comparative information for appropriate benchmarks and/or peer groups of similarly-managed funds, over different time horizons. The Directors also review investment performance information during the management agreement renewal process. If performance concerns are identified, the Fund receives special reviews until performance improves, during which the Board discusses with the Advisor the reasons for such results (e.g., market conditions, security selection) and any efforts being undertaken to improve performance. The Fund’s performance was below its benchmark for the one-, three-, five-, and ten-year periods reviewed by the Board. The Board found the investment management services provided by the Advisor to the Fund to be satisfactory and consistent with the management agreement.
36


Shareholder and Other Services. Under the management agreement, the Advisor provides the Fund with a comprehensive package of transfer agency, shareholder, and other services. The Board, directly and through its various committees, regularly reviews reports and evaluations of such services at its regular meetings. These reports include, but are not limited to, information regarding the operational efficiency and accuracy of the shareholder and transfer agency services provided, staffing levels, shareholder satisfaction, technology support (including cyber security), new products and services offered to Fund shareholders, securities trading activities, portfolio valuation services, auditing services, and legal and operational compliance activities. The Board found the services provided by the Advisor to the Fund under the management agreement to be competitive and of high quality.

Costs of Services and Profitability. The Advisor provides detailed information concerning its cost of providing various services to the Fund, its profitability in managing the Fund (pre- and post-distribution), its overall profitability, and its financial condition. The Directors have reviewed with the Advisor the methodology used to prepare this financial information. This information is considered in evaluating the Advisor’s financial condition, its ability to continue to provide services under the management agreement, and the reasonableness of the current management fee. The Board concluded that the Advisor’s profits were reasonable in light of the services provided to the Fund.

Ethics. The Board generally considers the Advisor’s commitment to providing quality services to shareholders and to conducting its business ethically. They noted that the Advisor’s practices generally meet or exceed industry best practices.

Economies of Scale. The Board also reviewed information provided by the Advisor regarding the possible existence of economies of scale in connection with the management of the Fund. The Board concluded that economies of scale are difficult to measure and predict with precision, especially on a fund-by-fund basis. The Board concluded that the Advisor is sharing economies of scale, to the extent they exist, through its competitive fee structure, offering competitive fees from fund inception, and through reinvestment in its business, infrastructure, investment capabilities and initiatives to provide shareholders additional content and services.

Comparison to Other Funds’ Fees. The management agreement provides that the Fund pays the Advisor a single, all-inclusive (or unified) management fee for providing all services necessary for the management and operation of the Fund, other than brokerage expenses, expenses attributable to short sales, taxes, interest, extraordinary expenses, fees and expenses of the Fund’s independent Directors (including their independent legal counsel), and expenses incurred in connection with the provision of shareholder services and distribution services under a plan adopted pursuant to Rule 12b-1 under the Investment Company Act. Under the unified fee structure, the Advisor is responsible for providing all investment advisory, custody, audit, administrative, compliance, recordkeeping, marketing and shareholder services, or arranging and supervising third parties to provide such services. By contrast, most other funds are charged a variety of fees, including an investment advisory fee, a transfer agency fee, an administrative fee, distribution charges, and other expenses. Other than their investment advisory fees and any applicable Rule 12b-1 distribution fees, all other components of the total fees charged by these other funds may be increased without shareholder approval. The Board believes the unified fee structure is a benefit to Fund shareholders because it clearly discloses to shareholders the cost of owning Fund shares, and, since the unified fee cannot be increased without a vote of Fund shareholders, it shifts to the Advisor the risk of increased costs of operating the Fund and provides a direct incentive to minimize administrative inefficiencies. Part of the Board’s analysis of fee levels involves reviewing certain evaluative data compiled by an independent provider comparing the Fund’s unified fee to the total expense ratios of its peers. The unified fee charged to shareholders of the Fund was above the median of the total expense ratios of the Fund’s peer expense universe. In addition, the Board reviewed the Fund’s position relative to the narrower set of its expense group peers. The Board and the Advisor agreed to a temporary reduction of the Fund's fee schedule that should have the effect of lowering the Fund's annual unified management fee by approximately 0.02% (e.g., the Investor Class unified fee will be reduced from 0.97% to 0.95%), for at least one year, beginning August 1, 2021. The Board concluded that the management fee paid by the Fund to the Advisor under the management agreement is reasonable in light of the services provided to the Fund.

37


Comparison to Fees and Services Provided to Other Clients of the Advisor. The Board also requested and received information from the Advisor concerning the nature of the services, fees, costs, and profitability of its advisory services to advisory clients other than the Fund. They observed that these varying types of client accounts require different services and involve different regulatory and entrepreneurial risks than the management of the Fund. The Board analyzed this information and concluded that the fees charged and services provided to the Fund were reasonable by comparison.

Payments to Intermediaries. The Directors also requested and received a description of payments made to intermediaries by the Fund and the Advisor and services provided in response thereto. These payments include various payments made by the Fund or the Advisor to different types of intermediaries and recordkeepers for distribution and service activities provided for the Fund. The Directors reviewed such information and received representations from the Advisor that all such payments by the Fund were made pursuant to the Fund's Rule 12b-1 Plan and that all such payments by the Advisor were made from the Advisor’s resources and reasonable profits. The Board found such payments to be reasonable in scope and purpose.

Collateral or “Fall-Out” Benefits Derived by the Advisor. The Board considered the possible existence of collateral benefits the Advisor may receive as a result of its relationship with the Fund. They concluded that the Advisor’s primary business is managing funds and it generally does not use fund or shareholder information to generate profits in other lines of business, and therefore does not derive any significant collateral benefits from them. To the extent there are potential collateral benefits, the Board has been advised and has taken this into consideration in its review of the management contract with the Fund. The Board noted that additional assets from other clients may offer the Advisor some benefit from increased leverage with service providers and counterparties. Additionally, the Advisor may receive proprietary research from broker-dealers that execute fund portfolio transactions, which the Board concluded is likely to benefit other clients of the Advisor, as well as Fund shareholders. The Board also determined that the Advisor is able to provide investment management services to certain clients other than the Fund, at least in part, due to its existing infrastructure built to serve the fund complex. The Board concluded that appropriate allocation methodologies had been employed to assign resources and the cost of those resources to these other clients.

Existing Relationship. The Board also considered whether there was any reason for not continuing the existing arrangement with the Advisor. In this regard, the Board was mindful of the potential disruptions of the Fund’s operations and various risks, uncertainties, and other effects that could occur as a result of a decision not to continue such relationship. In particular, the Board recognized that most shareholders have invested in the Fund on the strength of the Advisor’s industry standing and reputation and in the expectation that the Advisor will have a continuing role in providing advisory services to the Fund.

Conclusion of the Directors. As a result of this process, the Board, including all of the independent Directors, taking into account all of the factors discussed above and the information provided by the Advisor and others in connection with its review and throughout the year, determined that the management fee is fair and reasonable in light of the services provided and that the investment management agreement between the Fund and the Advisor should be renewed.
38


Additional Information

Retirement Account Information

As required by law, distributions you receive from certain retirement accounts are subject to federal income tax withholding, unless you elect not to have withholding apply*. Tax will be withheld on the total amount withdrawn even though you may be receiving amounts that are not subject to withholding, such as nondeductible contributions. In such case, excess amounts of withholding could occur. You may adjust your withholding election so that a greater or lesser amount will be withheld.
If you don’t want us to withhold on this amount, you must notify us to not withhold the federal income tax. You may notify us in writing or in certain situations by telephone or through other electronic means. For systematic withdrawals, your withholding election will remain in effect until revoked or changed by filing a new election. You have the right to revoke your election at any time and change your withholding percentage for future distributions.
Remember, even if you elect not to have income tax withheld, you are liable for paying income tax on the taxable portion of your withdrawal. If you elect not to have income tax withheld or you don’t have enough income tax withheld, you may be responsible for payment of estimated tax. You may incur penalties under the estimated tax rules if your withholding and estimated tax payments are not sufficient. You can reduce or defer the income tax on a distribution by directly or indirectly rolling such distribution over to another IRA or eligible plan. You should consult your tax advisor for additional information.
State tax will be withheld if, at the time of your distribution, your address is within one of the mandatory withholding states and you have federal income tax withheld (or as otherwise required by state law). State taxes will be withheld from your distribution in accordance with the respective state rules.
*Some 403(b), 457 and qualified retirement plan distributions may be subject to 20% mandatory withholding, as they are subject to special tax and withholding rules.  Your plan administrator or plan sponsor is required to provide you with a special tax notice explaining those rules at the time you request a distribution.  If applicable, federal and/or state taxes may be withheld from your distribution amount.


Proxy Voting Policies

A description of the policies that the fund's investment advisor uses in exercising the voting rights associated with the securities purchased and/or held by the fund is available without charge, upon request, by calling 1-800-345-2021. It is also available on American Century Investments’ website at americancentury.com/proxy and on the Securities and Exchange Commission’s website at sec.gov. Information regarding how the investment advisor voted proxies relating to portfolio securities during the most recent 12-month period ended June 30 is available on americancentury.com/proxy. It is also available at sec.gov.


Quarterly Portfolio Disclosure

The fund files its complete schedule of portfolio holdings with the Securities and Exchange Commission (SEC) for the first and third quarters of each fiscal year as an exhibit to its reports on Form N-PORT. These portfolio holdings are available on the fund's website at americancentury.com and, upon request, by calling 1-800-345-2021. The fund’s Form N-PORT reports are available on the SEC’s website at sec.gov.



39


Other Tax Information

The following information is provided pursuant to provisions of the Internal Revenue Code.

The fund hereby designates $448,038,724, or up to the maximum amount allowable, as long-term capital gain distributions (20% rate gain distributions) for the fiscal year ended October 31, 2021.

The fund hereby designates $5,826,912 as qualified short-term capital gain distributions for purposes of Internal Revenue Code Section 871 for the fiscal year ended October 31, 2021.

The fund utilized earnings and profits of $77,346,537 distributed to shareholders on redemption of shares as part of the dividends paid deduction (tax equalization).
40






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Contact Usamericancentury.com
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Investor Services Representative1-800-345-2021
or 816-531-5575
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American Century Mutual Funds, Inc.
Investment Advisor:
American Century Investment Management, Inc.
Kansas City, Missouri
This report and the statements it contains are submitted for the general information of our shareholders. The report is not authorized for distribution to prospective investors unless preceded or accompanied by an effective prospectus.
©2021 American Century Proprietary Holdings, Inc. All rights reserved.
CL-ANN-90970 2112





    


image8.jpg
Annual Report
October 31, 2021
Heritage Fund
Investor Class (TWHIX)
I Class (ATHIX)
Y Class (ATHYX)
A Class (ATHAX)
C Class (AHGCX)
R Class (ATHWX)
R5 Class (ATHGX)
R6 Class (ATHDX)


















Table of Contents
 
President’s Letter
Performance
Portfolio Commentary
Fund Characteristics
Shareholder Fee Example
Schedule of Investments
Statement of Assets and Liabilities
Statement of Operations
Statement of Changes in Net Assets
Notes to Financial Statements
Financial Highlights
Report of Independent Registered Public Accounting Firm
Management
Approval of Management Agreement
Additional Information


















Any opinions expressed in this report reflect those of the author as of the date of the report, and do not necessarily represent the opinions of American Century Investments® or any other person in the American Century Investments organization. Any such opinions are subject to change at any time based upon market or other conditions and American Century Investments disclaims any responsibility to update such opinions. These opinions may not be relied upon as investment advice and, because investment decisions made by American Century Investments funds are based on numerous factors, may not be relied upon as an indication of trading intent on behalf of any American Century Investments fund. Security examples are used for representational purposes only and are not intended as recommendations to purchase or sell securities. Performance information for comparative indices and securities is provided to American Century Investments by third party vendors. To the best of American Century Investments’ knowledge, such information is accurate at the time of printing.



President’s Letter
image30.jpg Jonathan Thomas

Dear Investor:

Thank you for reviewing this annual report for the period ended October 31, 2021. Annual reports help convey important information about fund returns, including market factors that affected performance. For additional investment insights, please visit americancentury.com.
Economic, Earnings Gains Fueled Rally Among Risk-On Assets

Stocks and other risk-on assets rallied for the 12-month period, despite lingering pandemic-related challenges. Upbeat data on U.S. manufacturing, employment and housing, along with central bank and federal government support and positive vaccine developments, helped boost corporate earnings and promote investor optimism. Outside the U.S., most economies recovered, but generally at a slower pace. Virus outbreaks and slower vaccine rollouts, particularly in emerging markets, led to lingering lockdowns in some regions.

As the period progressed, steady economic gains combined with ongoing monetary and fiscal support, rising energy prices and severe supply chain disruptions pushed global interest rates and inflation higher. In the U.S., year-over-year headline inflation climbed to 6.2% in October 2021, the largest 12-month increase in nearly 31 years.
Late in the period, the Federal Reserve (Fed) confirmed it would start tapering its bond buying in November. Yet despite inflation’s surge, the Fed left short-term interest rates unchanged. Central banks in Europe and the U.K. maintained their supportive interest rate and bond-buying programs as inflation ticked higher.

Overall, stocks delivered stellar performance for the 12-month period, highlighted by the S&P 500 Index’s gain of nearly 43%. Assets offering inflation-fighting potential, including real estate investment trusts, fared even better. Meanwhile, global bonds retreated as interest rates rose. However, emerging markets bonds largely advanced, benefiting from risk-on sentiment.
Several Factors Shaping Market Dynamics

The return to pre-pandemic life is progressing, albeit somewhat cautiously due to COVID-19’s lingering effects. As the economy and markets respond to this fluid backdrop, investors will face opportunities and ongoing challenges. Economic growth, inflation, the virus’s trajectory, supply chain normalization and fiscal and monetary policy likely will sway market dynamics.

We appreciate your confidence in us during these extraordinary times. Our firm has a long history of helping clients weather unpredictable markets, and we’re confident we will continue to meet today’s challenges.

Sincerely,
image19.jpg
Jonathan Thomas
President and Chief Executive Officer
American Century Investments
2


Performance
Total Returns as of October 31, 2021
Average Annual Returns
Ticker
Symbol
1 year5 years10 yearsSince
Inception
Inception
Date
Investor ClassTWHIX40.54%21.64%15.64%11/10/87
Russell Midcap Growth Index39.43%21.89%16.84%
I ClassATHIX40.78%21.89%15.87%6/16/97
Y ClassATHYX40.98%21.90%4/10/17
A ClassATHAX7/11/97
No sales charge40.12%21.34%15.34%
With sales charge32.07%19.91%14.66%
C ClassAHGCX39.13%20.44%14.48%6/26/01
R ClassATHWX39.80%21.03%15.06%9/28/07
R5 ClassATHGX40.78%21.71%4/10/17
R6 ClassATHDX40.98%22.07%15.70%7/26/13
Average annual returns since inception are presented when ten years of performance history is not available.
Extraordinary performance is attributable in part to unusually favorable market conditions and may not be repeated or consistently achieved in the future.

C Class shares will automatically convert to A Class shares after being held for approximately eight years. C Class average annual returns do not reflect this conversion.

Sales charges include initial sales charges and contingent deferred sales charges (CDSCs), as applicable. A Class shares have a 5.75% maximum initial sales charge and may be subject to a maximum CDSC of 1.00%. C Class shares redeemed within 12 months of purchase are subject to a maximum CDSC of 1.00%. The SEC requires that mutual funds provide performance information net of maximum sales charges in all cases where charges could be applied.















Data presented reflect past performance. Past performance is no guarantee of future results. Current performance may be higher or lower than the performance shown. Total returns for periods less than one year are not annualized. Investment return and principal value will fluctuate, and redemption value may be more or less than original cost. Data assumes reinvestment of dividends and capital gains, and none of the charts reflect the deduction of taxes that a shareholder would pay on fund distributions or the redemption of fund shares. To obtain performance data current to the most recent month end, please call 1-800-345-2021 or visit americancentury.com. For additional information about the fund, please consult the prospectus.
3


Growth of $10,000 Over 10 Years
$10,000 investment made October 31, 2011
Performance for other share classes will vary due to differences in fee structure.
chart-7ba25f99767941cc8f7a.jpg
Value on October 31, 2021
Investor Class — $42,800
Russell Midcap Growth Index — $47,478
Total Annual Fund Operating Expenses
Investor ClassI ClassY ClassA ClassC ClassR ClassR5 ClassR6 Class
1.01%0.81%0.66%1.26%2.01%1.51%0.81%0.66%
The total annual fund operating expenses shown is as stated in the fund’s prospectus current as of the date of this report. The prospectus may vary from the expense ratio shown elsewhere in this report because it is based on a different time period, includes acquired fund fees and expenses, and, if applicable, does not include fee waivers or expense reimbursements.



















Data presented reflect past performance. Past performance is no guarantee of future results. Current performance may be higher or lower than the performance shown. Total returns for periods less than one year are not annualized. Investment return and principal value will fluctuate, and redemption value may be more or less than original cost. Data assumes reinvestment of dividends and capital gains, and none of the charts reflect the deduction of taxes that a shareholder would pay on fund distributions or the redemption of fund shares. To obtain performance data current to the most recent month end, please call 1-800-345-2021 or visit americancentury.com. For additional information about the fund, please consult the prospectus.
4


Portfolio Commentary

Portfolio Managers: Rob Brookby and Nalin Yogasundram

Performance Summary

Heritage returned 40.54%* for the 12 months ended October 31, 2021, outpacing the 39.43% return of the fund’s benchmark, the Russell Midcap Growth Index.

U.S. stocks posted strong returns during the reporting period, supported by federal government stimulus and low interest rates. The rollout of COVID-19 vaccines allowed the economy to reopen, and despite concerns about the delta variant, inflationary pressures and supply chain constraints, several market indices ended the 12-month period at record highs. Within the Russell Midcap Growth Index, energy was the top-performing sector, benefiting from increased demand as global economies began to return to more-normal conditions amid limited supplies. Consumer staples was the only sector to decline.

The information technology and materials sectors led outperformance relative to the benchmark, due primarily to stock selection. Stock decisions in the health care sector detracted.

Information Technology Led Performance

Stock selection in the software industry helped drive the information technology sector and portfolio outperformance relative to the benchmark. HubSpot provides software that allows small businesses to efficiently run and grow their businesses. It offers innovative solutions, and HubSpot benefited from growth in small business formation coming out of the recession, providing a tailwind of new customer acquisition. Atlassian was a top contributor. This software company provides collaborative tools used by small and midsize companies and increasingly larger companies. As pandemic restrictions eased and workers started returning to the office, Atlassian saw renewed growth for its software, driving strong revenue and earnings. Manhattan Associates provides cloud-based supply chain management software. The company reported better-than-expected quarterly earnings throughout the year. Manhattan Associates benefited from the restrictions due to the pandemic, and we believe the transition to online buying and curbside pickup are secular trends that fit with the company’s strengths.

Cybersecurity firm Palo Alto Networks outperformed as companies beefed up their vigilance because of increasing ransomware and other attacks. Demand for Palo Alto’s firewalls and other cloud-based offerings led to strong earnings, and management raised guidance for next year. In IT services, Square was a significant contributor. The payments company outperformed as its main businesses—small retailers and peer to peer—both benefited from the stay-at-home restrictions. Coffee shops and restaurants have had to adjust to new business models, and individuals are increasingly using digital payments. We see these as secular trends that have been accelerated by the pandemic.

Stock selection in the materials sector aided performance. Materials in general benefited from greater demand and firmer pricing due to global supply chain disruptions. Stock decisions in the chemicals industry helped drive outperformance in the sector. Albemarle was a top contributor on demand for lithium, a key ingredient of batteries for electric vehicles.

Health Care Stocks Detracted

Stock choices in the health care sector weighed on performance. Biotechnology company Moderna outperformed after it reported that its COVID-19 vaccine worked well against the virus’s more contagious delta variant. Moderna’s messenger RNA technology is also seen as having potentially



*All fund returns referenced in this commentary are for Investor Class shares. Performance for other share classes will vary due to differences in fee structure; when Investor Class performance exceeds that of the fund’s benchmark, other share classes may not. See page 3 for returns for all share classes.
5


wider applications. Our lack of exposure detracted from relative results. Home health and hospice care provider Amedisys lagged after it offered disappointing forward guidance as the pandemic hurt its ability to hire and retain staff.

Other key detractors included The Boston Beer Co. The beverage company’s stock declined after management reported quarterly earnings that fell short of expectations. Much of the weakness was attributed to greater competition and lower demand in the hard seltzer market, impacting the company’s Truly brand. We eliminated our position. The stock of Las Vegas Sands, an operator of casino resorts in Macau and Singapore, was pressured by possible new dividend regulations in Macau that would be harmful to shareholders and concerns about China’s increasing interference in certain sectors. We eliminated our holding because of these uncertainties.

Splunk also hampered performance. We eliminated this security software stock because the company has had execution problems as it moves from an on-premises to a cloud-based subscription service. Additionally, its sales force experienced some leadership changes. SelectQuote offers consumers a platform to compare insurance policies. SelectQuote and the industry in general have struggled with plan persistency, the percentage of policyholders that continue paying premiums. As a result, SelectQuote offered disappointing guidance for next year. We sold our holding.

Outlook

Our process uses a combined top-down, bottom-up fundamental framework aimed at identifying mid-cap companies producing attractive, sustainable growth. We seek to reduce unintended, nonfundamental risks and align the portfolio with fundamental, company-specific risks that we believe will be rewarded over time. As a result of this approach, our sector and industry allocations reflect where we are finding opportunities at a given time.

As more normal activities resume, we see opportunities in infrastructure build-out, e-commerce, entertainment and other industries. Our key investment themes cross sector boundaries. For example, cybersecurity issues can affect everything from supply chains to meatpacking. Data analytics is important for any enterprise to help control spending and better understand customers.
6


Fund Characteristics 
OCTOBER 31, 2021
Types of Investments in Portfolio% of net assets
Common Stocks98.6%
Temporary Cash Investments1.5%
Other Assets and Liabilities(0.1)%
Top Five Industries% of net assets
Software19.1%
Life Sciences Tools and Services5.8%
Health Care Equipment and Supplies5.5%
IT Services5.5%
Electrical Equipment5.3%
7


Shareholder Fee Example 

Fund shareholders may incur two types of costs: (1) transaction costs, including sales charges (loads) on purchase payments and redemption/exchange fees; and (2) ongoing costs, including management fees; distribution and service (12b-1) fees; and other fund expenses. This example is intended to help you understand your ongoing costs (in dollars) of investing in your fund and to compare these costs with the ongoing cost of investing in other mutual funds.

The example is based on an investment of $1,000 made at the beginning of the period and held for the entire period from May 1, 2021 to October 31, 2021.

Actual Expenses

The table provides information about actual account values and actual expenses for each class. You may use the information, together with the amount you invested, to estimate the expenses that you paid over the period. First, identify the share class you own. Then simply divide your account value by $1,000 (for example, an $8,600 account value divided by $1,000 = 8.6), then multiply the result by the number under the heading “Expenses Paid During Period” to estimate the expenses you paid on your account during this period.

If you hold Investor Class shares of any American Century Investments fund, or I Class shares of the American Century Diversified Bond Fund, in an American Century Investments account (i.e., not through a financial intermediary or employer-sponsored retirement plan account), American Century Investments may charge you a $25.00 annual account maintenance fee if the value of those shares is less than $10,000. We will redeem shares automatically in one of your accounts to pay the $25.00 fee. In determining your total eligible investment amount, we will include your investments in all personal accounts (including American Century Investments brokerage accounts) registered under your Social Security number. Personal accounts include individual accounts, joint accounts, UGMA/UTMA accounts, personal trusts, Coverdell Education Savings Accounts and IRAs (including traditional, Roth, Rollover, SEP-, SARSEP- and SIMPLE-IRAs), and certain other retirement accounts. If you have only business, business retirement, employer-sponsored or American Century Investments brokerage accounts, you are currently not subject to this fee. If you are subject to the account maintenance fee, your account value could be reduced by the fee amount.

Hypothetical Example for Comparison Purposes

The table also provides information about hypothetical account values and hypothetical expenses based on the actual expense ratio of each class of your fund and an assumed rate of return of 5% per year before expenses, which is not the actual return of a fund’s share class. The hypothetical account values and expenses may not be used to estimate the actual ending account balance or expenses you paid for the period. You may use this information to compare the ongoing costs of investing in your fund and other funds. To do so, compare this 5% hypothetical example with the 5% hypothetical examples that appear in the shareholder reports of the other funds.

Please note that the expenses shown in the table are meant to highlight your ongoing costs only and do not reflect any transactional costs, such as sales charges (loads) or redemption/exchange fees. Therefore, the table is useful in comparing ongoing costs only, and will not help you determine the relative total costs of owning different funds. In addition, if these transactional costs were included, your costs would have been higher.

8


Beginning
Account Value
5/1/21
Ending
Account Value
10/31/21
Expenses Paid
During Period(1)
5/1/21 - 10/31/21
Annualized
Expense Ratio(1)
Actual
Investor Class$1,000$1,098.10$5.291.00%
I Class$1,000$1,099.10$4.230.80%
Y Class$1,000$1,099.80$3.440.65%
A Class$1,000$1,096.10$6.601.25%
C Class$1,000$1,092.10$10.552.00%
R Class$1,000$1,095.10$7.921.50%
R5 Class$1,000$1,098.80$4.230.80%
R6 Class$1,000$1,099.80$3.440.65%
Hypothetical
Investor Class$1,000$1,020.16$5.091.00%
I Class$1,000$1,021.17$4.080.80%
Y Class$1,000$1,021.93$3.310.65%
A Class$1,000$1,018.90$6.361.25%
C Class$1,000$1,015.12$10.162.00%
R Class$1,000$1,017.64$7.631.50%
R5 Class$1,000$1,021.17$4.080.80%
R6 Class$1,000$1,021.93$3.310.65%
(1)Expenses are equal to the class's annualized expense ratio listed in the table above, multiplied by the average account value over the period, multiplied by 184, the number of days in the most recent fiscal half-year, divided by 365, to reflect the one-half year period. Annualized expense ratio reflects actual expenses, including any applicable fee waivers or expense reimbursements and excluding any acquired fund fees and expenses.
9


Schedule of Investments

OCTOBER 31, 2021
SharesValue
COMMON STOCKS — 98.6%


Aerospace and Defense — 0.8%
HEICO Corp.391,532 $54,575,645 
Auto Components — 1.8%
Aptiv plc(1)
656,675 113,532,541 
Beverages — 0.6%
Celsius Holdings, Inc.(1)
412,988 39,861,602 
Biotechnology — 3.2%
Alnylam Pharmaceuticals, Inc.(1)
366,100 58,414,916 
Horizon Therapeutics plc(1)
711,406 85,304,693 
Natera, Inc.(1)
424,340 48,616,634 
Turning Point Therapeutics, Inc.(1)
403,943 16,795,950 
209,132,193 
Building Products — 2.3%
Trane Technologies plc558,498 101,049,043 
Zurn Water Solutions Corp.1,346,505 48,851,202 
149,900,245 
Capital Markets — 4.7%
LPL Financial Holdings, Inc.913,480 149,828,990 
MarketAxess Holdings, Inc.76,065 31,085,483 
MSCI, Inc.180,245 119,841,296 
300,755,769 
Chemicals — 1.6%
Albemarle Corp.186,710 46,765,254 
Element Solutions, Inc.2,465,678 55,995,547 
102,760,801 
Communications Equipment — 3.6%
Arista Networks, Inc.(1)
302,307 123,852,155 
F5 Networks, Inc.(1)
502,191 106,037,629 
229,889,784 
Containers and Packaging — 2.6%
Avery Dennison Corp.526,866 114,709,266 
Ball Corp.594,223 54,359,520 
169,068,786 
Electrical Equipment — 5.3%
AMETEK, Inc.682,362 90,344,729 
Generac Holdings, Inc.(1)
123,705 61,674,365 
nVent Electric plc1,711,449 60,670,867 
Plug Power, Inc.(1)
771,927 29,541,646 
Regal Rexnord Corp.358,416 54,597,509 
Rockwell Automation, Inc.145,260 46,396,044 
343,225,160 
Electronic Equipment, Instruments and Components — 3.8%
Cognex Corp.1,150,241 100,749,609 
Keysight Technologies, Inc.(1)
788,291 141,908,146 
242,657,755 
Entertainment — 2.5%
Live Nation Entertainment, Inc.(1)
476,670 48,215,170 
10


SharesValue
ROBLOX Corp., Class A(1)
241,928 $20,326,791 
Roku, Inc.(1)
253,024 77,147,018 
Zynga, Inc., Class A(1)
2,390,455 17,641,558 
163,330,537 
Health Care Equipment and Supplies — 5.5%
Align Technology, Inc.(1)
77,891 48,632,804 
DexCom, Inc.(1)
190,354 118,630,516 
IDEXX Laboratories, Inc.(1)
191,045 127,262,716 
Teleflex, Inc.164,052 58,556,721 
353,082,757 
Health Care Providers and Services — 1.5%
Amedisys, Inc.(1)
249,667 42,278,610 
Encompass Health Corp.402,444 25,579,341 
R1 RCM, Inc.(1)
1,242,466 26,961,512 
94,819,463 
Health Care Technology — 1.8%
Veeva Systems, Inc., Class A(1)
357,647 113,377,675 
Hotels, Restaurants and Leisure — 3.4%
Chipotle Mexican Grill, Inc.(1)
46,780 83,223,023 
Hilton Worldwide Holdings, Inc.(1)
928,609 133,673,266 
216,896,289 
Interactive Media and Services — 2.3%
Match Group, Inc.(1)
603,522 90,999,047 
Pinterest, Inc., Class A(1)
1,208,067 53,928,111 
144,927,158 
Internet and Direct Marketing Retail — 2.1%
Chewy, Inc., Class A(1)
627,111 47,535,014 
Etsy, Inc.(1)
337,146 84,519,131 
132,054,145 
IT Services — 5.5%
Cloudflare, Inc., Class A(1)
370,663 72,175,499 
EPAM Systems, Inc.(1)
147,354 99,204,607 
Okta, Inc.(1)
366,709 90,643,131 
Square, Inc., Class A(1)
239,423 60,933,153 
Twilio, Inc., Class A(1)
95,757 27,899,760 
350,856,150 
Leisure Products — 0.6%
Peloton Interactive, Inc., Class A(1)
419,584 38,366,761 
Life Sciences Tools and Services — 5.8%
10X Genomics, Inc., Class A(1)
271,809 43,834,638 
Agilent Technologies, Inc.445,680 70,190,143 
Bio-Techne Corp.164,989 86,396,490 
Mettler-Toledo International, Inc.(1)
76,558 113,373,211 
Repligen Corp.(1)
208,864 60,674,992 
374,469,474 
Machinery — 2.5%
Graco, Inc.674,083 50,677,560 
Parker-Hannifin Corp.361,056 107,085,599 
157,763,159 
Professional Services — 3.9%
CoStar Group, Inc.(1)
650,250 55,954,013 
Jacobs Engineering Group, Inc.667,506 93,731,193 
11


Shares/Principal AmountValue
TransUnion338,715 $39,050,452 
Verisk Analytics, Inc.308,331 64,832,759 
253,568,417 
Semiconductors and Semiconductor Equipment — 4.6%
Enphase Energy, Inc.(1)
392,694 90,959,711 
Marvell Technology, Inc.1,575,267 107,905,789 
Monolithic Power Systems, Inc.65,217 34,268,925 
Skyworks Solutions, Inc.381,368 63,738,034 
296,872,459 
Software — 19.1%
Atlassian Corp. plc, Class A(1)
257,082 117,776,977 
Autodesk, Inc.(1)
209,830 66,644,106 
Cadence Design Systems, Inc.(1)
1,178,447 204,000,960 
Coupa Software, Inc.(1)
160,039 36,440,880 
Datadog, Inc., Class A(1)
401,145 67,011,272 
DocuSign, Inc.(1)
456,881 127,145,414 
HubSpot, Inc.(1)
190,570 154,405,531 
Manhattan Associates, Inc.(1)
798,653 144,987,466 
Palantir Technologies, Inc., Class A(1)
3,680,157 95,242,463 
Palo Alto Networks, Inc.(1)
418,478 213,042,965 
1,226,698,034 
Specialty Retail — 4.1%
Burlington Stores, Inc.(1)
351,347 97,073,662 
Carvana Co.(1)
186,576 56,566,112 
Five Below, Inc.(1)
175,917 34,708,424 
Floor & Decor Holdings, Inc., Class A(1)
576,100 78,303,512 
266,651,710 
Textiles, Apparel and Luxury Goods — 1.9%
lululemon athletica, Inc.(1)
269,090 125,398,631 
Trading Companies and Distributors — 1.2%
W.W. Grainger, Inc.160,602 74,376,392 
TOTAL COMMON STOCKS
(Cost $3,948,476,073)
6,338,869,492 
TEMPORARY CASH INVESTMENTS — 1.5%


Federal Farm Credit Discount Notes, 0.00%, 11/1/21(2)
$40,000,000 40,000,000 
Repurchase Agreement, BMO Capital Markets Corp., (collateralized by various U.S. Treasury obligations, 2.00%, 11/15/26, valued at $12,062,274), in a joint trading account at 0.01%, dated 10/29/21, due 11/1/21 (Delivery value $11,811,404)11,811,395 
Repurchase Agreement, Fixed Income Clearing Corp., (collateralized by various U.S. Treasury obligations, 2.25%, 5/15/41, valued at $40,164,623), at 0.01%, dated 10/29/21, due 11/1/21 (Delivery value $39,377,033)39,377,000 
State Street Institutional U.S. Government Money Market Fund, Premier Class1,575,705 1,575,705 
TOTAL TEMPORARY CASH INVESTMENTS
(Cost $92,764,100)
92,764,100 
TOTAL INVESTMENT SECURITIES — 100.1%
(Cost $4,041,240,173)

6,431,633,592 
OTHER ASSETS AND LIABILITIES — (0.1)%

(4,898,910)
TOTAL NET ASSETS — 100.0%

$6,426,734,682 

12


NOTES TO SCHEDULE OF INVESTMENTS
(1)Non-income producing.
(2)The rate indicated is the yield to maturity at purchase.


See Notes to Financial Statements.

13


Statement of Assets and Liabilities
OCTOBER 31, 2021
Assets
Investment securities, at value (cost of $4,041,240,173)$6,431,633,592 
Receivable for investments sold741,076 
Receivable for capital shares sold815,597 
Dividends and interest receivable452,471 
Securities lending receivable542 
6,433,643,278 
Liabilities
Payable for capital shares redeemed1,704,031 
Accrued management fees5,096,412 
Distribution and service fees payable108,153 
6,908,596 
Net Assets$6,426,734,682 
Net Assets Consist of:
Capital (par value and paid-in surplus)$3,409,221,228 
Distributable earnings3,017,513,454 
$6,426,734,682 

Net AssetsShares OutstandingNet Asset Value Per Share
Investor Class, $0.01 Par Value
$5,307,248,829176,937,673$30.00
I Class, $0.01 Par Value
$413,523,19312,434,258$33.26
Y Class, $0.01 Par Value
$85,720,1892,526,403$33.93
A Class, $0.01 Par Value
$364,851,57413,971,624
$26.11*
C Class, $0.01 Par Value
$21,836,1721,288,400$16.95
R Class, $0.01 Par Value
$37,752,8271,457,026$25.91
R5 Class, $0.01 Par Value
$972,66629,245$33.26
R6 Class, $0.01 Par Value
$194,829,2325,742,586$33.93
*Maximum offering price $27.70 (net asset value divided by 0.9425).


See Notes to Financial Statements.
14


Statement of Operations
YEAR ENDED OCTOBER 31, 2021
Investment Income (Loss)
Income:
Dividends (net of foreign taxes withheld of $38,213)$20,595,876 
Securities lending, net14,290 
Interest10,746 
20,620,912 
Expenses:
Management fees58,171,858 
Distribution and service fees:
A Class857,049 
C Class268,390 
R Class178,970 
Directors' fees and expenses152,532 
Other expenses327 
59,629,126 
Net investment income (loss)(39,008,214)
Realized and Unrealized Gain (Loss)
Net realized gain (loss) on:
Investment transactions726,738,007 
Forward foreign currency exchange contract transactions3,774,930 
Foreign currency translation transactions(44,237)
730,468,700 
Change in net unrealized appreciation (depreciation) on:
Investments1,254,683,296 
Forward foreign currency exchange contracts206,369 
Translation of assets and liabilities in foreign currencies(583)
1,254,889,082 
Net realized and unrealized gain (loss)1,985,357,782 
Net Increase (Decrease) in Net Assets Resulting from Operations$1,946,349,568 


See Notes to Financial Statements.
15


Statement of Changes in Net Assets
YEARS ENDED OCTOBER 31, 2021 AND OCTOBER 31, 2020
Increase (Decrease) in Net Assets
October 31, 2021October 31, 2020
Operations
Net investment income (loss)$(39,008,214)$(21,722,245)
Net realized gain (loss)730,468,700 742,646,637 
Change in net unrealized appreciation (depreciation)1,254,889,082 309,937,844 
Net increase (decrease) in net assets resulting from operations1,946,349,568 1,030,862,236 
Distributions to Shareholders
From earnings:
Investor Class(586,342,385)(393,425,552)
I Class(43,469,882)(30,338,935)
Y Class(7,086,626)(5,616,329)
A Class(45,691,761)(31,178,565)
C Class(7,188,612)(6,010,954)
R Class(5,053,233)(3,890,228)
R5 Class(94,815)(409,601)
R6 Class(19,890,507)(13,008,625)
Decrease in net assets from distributions(714,817,821)(483,878,789)
Capital Share Transactions
Net increase (decrease) in net assets from capital share transactions (Note 5)234,696,206 (129,879,890)
Net increase (decrease) in net assets1,466,227,953 417,103,557 
Net Assets
Beginning of period4,960,506,729 4,543,403,172 
End of period$6,426,734,682 $4,960,506,729 


See Notes to Financial Statements.
16


Notes to Financial Statements

OCTOBER 31, 2021

1. Organization

American Century Mutual Funds, Inc. (the corporation) is registered under the Investment Company Act of 1940, as amended (the 1940 Act), as an open-end management investment company and is organized as a Maryland corporation. Heritage Fund (the fund) is one fund in a series issued by the corporation. The fund's investment objective is to seek long-term capital growth.

The fund offers the Investor Class, I Class, Y Class, A Class, C Class, R Class, R5 Class and R6 Class. The A Class may incur an initial sales charge. The A Class and C Class may be subject to a contingent deferred sales charge.
2. Significant Accounting Policies

The following is a summary of significant accounting policies consistently followed by the fund in preparation of its financial statements. The fund is an investment company and follows accounting and reporting guidance in accordance with accounting principles generally accepted in the United States of America. This may require management to make certain estimates and assumptions at the date of the financial statements. Actual results could differ from these estimates. Management evaluated the impact of events or transactions occurring through the date the financial statements were issued that would merit recognition or disclosure.

Investment Valuations — The fund determines the fair value of its investments and computes its net asset value (NAV) per share at the close of regular trading (usually 4 p.m. Eastern time) on the New York Stock Exchange (NYSE) on each day the NYSE is open. The Board of Directors has adopted valuation policies and procedures to guide the investment advisor in the fund’s investment valuation process and to provide methodologies for the oversight of the fund’s pricing function.
Equity securities that are listed or traded on a domestic securities exchange are valued at the last reported sales price or at the official closing price as provided by the exchange. Equity securities traded on foreign securities exchanges are generally valued at the closing price of such securities on the exchange where primarily traded or at the close of the NYSE, if that is earlier. If no last sales price is reported, or if local convention or regulation so provides, the mean of the latest bid and asked prices may be used. Securities traded over-the-counter are valued at the mean of the latest bid and asked prices, the last sales price, or the official closing price. Equity securities initially expressed in local currencies are translated into U.S. dollars at the mean of the appropriate currency exchange rate at the close of the NYSE as provided by an independent pricing service.
Fixed income securities are valued at the evaluated mean as provided by independent pricing services or at the mean of the most recent bid and asked prices as provided by investment dealers. U.S. Treasury and Government Agency securities are valued using market models that consider trade data, quotations from dealers and active market makers, relevant yield curve and spread data, creditworthiness, trade data or market information on comparable securities, and other relevant security specific information.
Open-end management investment companies are valued at the reported NAV per share. Repurchase agreements are valued at cost, which approximates fair value. Forward foreign currency exchange contracts are valued at the mean of the appropriate forward exchange rate at the close of the NYSE as provided by an independent pricing service.
If the fund determines that the market price for an investment is not readily available or the valuation methods mentioned above do not reflect an investment’s fair value, such investment is valued as determined in good faith by the Board of Directors or its delegate, in accordance with policies and procedures adopted by the Board of Directors. In its determination of fair value, the fund may review several factors including, but not limited to, market information regarding the specific investment or comparable investments and correlation with other investment types, futures indices or general market indicators. Circumstances that may cause the fund to use these procedures to value an investment include, but are not limited to: an investment has been declared in default or is distressed; trading in a security has been suspended during the trading day or a security is not actively trading on its principal exchange; prices received from a regular pricing source are deemed unreliable; or there is a foreign market holiday and no trading occurred.
17


The fund monitors for significant events occurring after the close of an investment’s primary exchange but before the fund’s NAV per share is determined. Significant events may include, but are not limited to: corporate announcements and transactions; governmental action and political unrest that could impact a specific investment or an investment sector; or armed conflicts, natural disasters and similar events that could affect investments in a specific country or region. The fund also monitors for significant fluctuations between domestic and foreign markets, as evidenced by the U.S. market or such other indicators that the Board of Directors, or its delegate, deems appropriate. The fund may apply a model-derived factor to the closing price of equity securities traded on foreign securities exchanges. The factor is based on observable market data as provided by an independent pricing service.

Security Transactions — Security transactions are accounted for as of the trade date. Net realized gains and losses are determined on the identified cost basis, which is also used for federal income tax purposes.
Investment Income — Dividend income less foreign taxes withheld, if any, is recorded as of the ex-dividend date. Distributions received on securities that represent a return of capital or long-term capital gain are recorded as a reduction of cost of investments and/or as a realized gain. The fund may estimate the components of distributions received that may be considered nontaxable distributions or long-term capital gain distributions for income tax purposes. Interest income is recorded on the accrual basis and includes accretion of discounts and amortization of premiums. Securities lending income is net of fees and rebates earned by the lending agent for its services.
Foreign Currency Translations — All assets and liabilities initially expressed in foreign currencies are translated into U.S. dollars at prevailing exchange rates at period end. The fund may enter into spot foreign currency exchange contracts to facilitate transactions denominated in a foreign currency. Purchases and sales of investment securities, dividend and interest income, spot foreign currency exchange contracts, and expenses are translated at the rates of exchange prevailing on the respective dates of such transactions. Net realized and unrealized foreign currency exchange gains or losses related to investment securities are a component of net realized gain (loss) on investment transactions and change in net unrealized appreciation (depreciation) on investments, respectively.
Repurchase Agreements — The fund may enter into repurchase agreements with institutions that American Century Investment Management, Inc. (ACIM) (the investment advisor) has determined are creditworthy pursuant to criteria adopted by the Board of Directors. The fund requires that the collateral, represented by securities, received in a repurchase transaction be transferred to the custodian in a manner sufficient to enable the fund to obtain those securities in the event of a default under the repurchase agreement. ACIM monitors, on a daily basis, the securities transferred to ensure the value, including accrued interest, of the securities under each repurchase agreement is equal to or greater than amounts owed to the fund under each repurchase agreement.
Joint Trading Account — Pursuant to an Exemptive Order issued by the Securities and Exchange Commission, the fund, along with certain other funds in the American Century Investments family of funds, may transfer uninvested cash balances into a joint trading account. These balances are invested in one or more repurchase agreements that are collateralized by U.S. Treasury or Agency obligations.
Segregated Assets — In accordance with the 1940 Act, the fund segregates assets on its books and records to cover certain types of investment securities and other financial instruments. ACIM monitors, on a daily basis, the securities segregated to ensure the fund designates a sufficient amount of liquid assets, marked-to-market daily. The fund may also receive assets or be required to pledge assets at the custodian bank or with a broker for collateral requirements.
Income Tax Status — It is the fund’s policy to distribute substantially all net investment income and net realized gains to shareholders and to otherwise qualify as a regulated investment company under provisions of the Internal Revenue Code. Accordingly, no provision has been made for income taxes. The fund files U.S. federal, state, local and non-U.S. tax returns as applicable. The fund's tax returns are subject to examination by the relevant taxing authority until expiration of the applicable statute of limitations, which is generally three years from the date of filing but can be longer in certain jurisdictions. At this time, management believes there are no uncertain tax positions which, based on their technical merit, would not be sustained upon examination and for which it is reasonably possible that the total amounts of unrecognized tax benefits will significantly change in the next twelve months.

18


Multiple Class — All shares of the fund represent an equal pro rata interest in the net assets of the class to which such shares belong, and have identical voting, dividend, liquidation and other rights and the same terms and conditions, except for class specific expenses and exclusive rights to vote on matters affecting only individual classes. Income, non-class specific expenses, and realized and unrealized capital gains and losses of the fund are allocated to each class of shares based on their relative net assets.
Distributions to Shareholders — Distributions from net investment income and net realized gains, if any, are generally declared and paid annually. The fund may elect to treat a portion of its payment to a redeeming shareholder, which represents the pro rata share of undistributed net investment income and net realized gains, as a distribution for federal income tax purposes (tax equalization).
Indemnifications — Under the corporation’s organizational documents, its officers and directors are indemnified against certain liabilities arising out of the performance of their duties to the fund. In addition, in the normal course of business, the fund enters into contracts that provide general indemnifications. The maximum exposure under these arrangements is unknown as this would involve future claims that may be made against a fund. The risk of material loss from such claims is considered by management to be remote.
Securities Lending — Securities are lent to qualified financial institutions and brokers. State Street Bank & Trust Co. serves as securities lending agent to the fund pursuant to a Securities Lending Agreement. The lending of securities exposes the fund to risks such as: the borrowers may fail to return the loaned securities, the borrowers may not be able to provide additional collateral, the fund may experience delays in recovery of the loaned securities or delays in access to collateral, or the fund may experience losses related to the investment collateral. To minimize certain risks, loan counterparties pledge collateral in the form of cash and/or securities. The lending agent has agreed to indemnify the fund in the case of default of any securities borrowed. Cash collateral received is invested in the State Street Navigator Securities Lending Government Money Market Portfolio, a money market mutual fund registered under the 1940 Act. The loans may also be secured by U.S. government securities in an amount at least equal to the market value of the securities loaned, plus accrued interest and dividends, determined on a daily basis and adjusted accordingly. By lending securities, the fund seeks to increase its net investment income through the receipt of interest and fees. Such income is reflected separately within the Statement of Operations. The value of loaned securities and related collateral outstanding at period end, if any, are shown on a gross basis within the Schedule of Investments and Statement of Assets and Liabilities.
3. Fees and Transactions with Related Parties

Certain officers and directors of the corporation are also officers and/or directors of American Century Companies, Inc. (ACC). The corporation’s investment advisor, ACIM, the corporation's distributor, American Century Investment Services, Inc. (ACIS), and the corporation’s transfer agent, American Century Services, LLC, are wholly owned, directly or indirectly, by ACC.
Management Fees — The corporation has entered into a management agreement with ACIM, under which ACIM provides the fund with investment advisory and management services in exchange for a single, unified management fee (the fee) per class. The agreement provides that ACIM will pay all expenses of managing and operating the fund, except brokerage expenses, taxes, interest, fees and expenses of the independent directors (including legal counsel fees), extraordinary expenses, and expenses incurred in connection with the provision of shareholder services and distribution services under a plan adopted pursuant to Rule 12b-1 under the 1940 Act. The fee is computed and accrued daily based on each class's daily net assets and paid monthly in arrears. The difference in the fee among the classes is a result of their separate arrangements for non-Rule 12b-1 shareholder services. It is not the result of any difference in advisory or custodial fees or other expenses related to the management of the fund’s assets, which do not vary by class.
The annual management fee for each class is as follows:
Investor Class
I Class
Y Class
A Class
C Class
R Class
R5 Class
R6 Class
1.000%0.800%0.650%1.000%1.000%1.000%0.800%0.650%

19


Distribution and Service Fees — The Board of Directors has adopted a separate Master Distribution and Individual Shareholder Services Plan for each of the A Class, C Class and R Class (collectively the plans), pursuant to Rule 12b-1 of the 1940 Act. The plans provide that the A Class will pay ACIS an annual distribution and service fee of 0.25%. The plans provide that the C Class will pay ACIS an annual distribution and service fee of 1.00%, of which 0.25% is paid for individual shareholder services and 0.75% is paid for distribution services. The plans provide that the R Class will pay ACIS an annual distribution and service fee of 0.50%. The fees are computed and accrued daily based on each class’s daily net assets and paid monthly in arrears. The fees are used to pay financial intermediaries for distribution and individual shareholder services. Fees incurred under the plans during the period ended October 31, 2021 are detailed in the Statement of Operations.
Directors' Fees and Expenses — The Board of Directors is responsible for overseeing the investment advisor’s management and operations of the fund. The directors receive detailed information about the fund and its investment advisor regularly throughout the year, and meet at least quarterly with management of the investment advisor to review reports about fund operations. The fund’s officers do not receive compensation from the fund.
Interfund Transactions — The fund may enter into security transactions with other American Century Investments funds and other client accounts of the investment advisor, in accordance with the 1940 Act rules and procedures adopted by the Board of Directors. The rules and procedures require, among other things, that these transactions be effected at the independent current market price of the security. During the period, the interfund purchases and sales were $414,003 and $2,367,237, respectively. The effect of interfund transactions on the Statement of Operations was $306,935 in net realized gain (loss) on investment transactions.
4. Investment Transactions

Purchases and sales of investment securities, excluding short-term investments, for the period ended October 31, 2021 were $2,593,202,441 and $3,176,544,249, respectively.

20


5. Capital Share Transactions

Transactions in shares of the fund were as follows:
Year ended
October 31, 2021
Year ended
October 31, 2020
SharesAmountSharesAmount
Investor Class/Shares Authorized2,100,000,000 2,100,000,000 
Sold7,069,672 $190,536,048 8,318,301 $170,505,402 
Issued in reinvestment of distributions22,643,103 564,891,390 18,572,102 380,170,938 
Redeemed(20,262,521)(549,716,482)(29,696,397)(623,476,372)
9,450,254 205,710,956 (2,805,994)(72,800,032)
I Class/Shares Authorized175,000,000 175,000,000 
Sold2,723,934 82,538,821 3,026,131 72,188,642 
Issued in reinvestment of distributions1,510,846 41,729,561 1,292,245 28,868,755 
Redeemed(4,129,476)(124,200,919)(6,286,808)(144,634,896)
105,304 67,463 (1,968,432)(43,577,499)
Y Class/Shares Authorized30,000,000 30,000,000 
Sold718,287 21,940,985 2,100,087 50,592,554 
Issued in reinvestment of distributions246,029 6,923,247 242,850 5,507,845 
Redeemed(392,997)(12,068,109)(1,637,996)(41,380,807)
571,319 16,796,123 704,941 14,719,592 
A Class/Shares Authorized170,000,000 170,000,000 
Sold2,270,649 53,457,609 2,133,477 40,359,264 
Issued in reinvestment of distributions1,995,138 43,434,155 1,643,351 29,958,297 
Redeemed(3,292,227)(78,227,401)(4,216,962)(78,996,914)
973,560 18,664,363 (440,134)(8,679,353)
C Class/Shares Authorized70,000,000 70,000,000 
Sold77,895 1,237,207 102,610 1,363,953 
Issued in reinvestment of distributions503,874 7,170,128 435,672 5,615,807 
Redeemed(1,374,461)(20,969,404)(1,194,272)(16,177,174)
(792,692)(12,562,069)(655,990)(9,197,414)
R Class/Shares Authorized40,000,000 40,000,000 
Sold267,540 6,273,040 308,951 5,835,185 
Issued in reinvestment of distributions233,252 5,049,747 212,437 3,864,234 
Redeemed(520,917)(12,173,944)(719,551)(13,655,328)
(20,125)(851,157)(198,163)(3,955,909)
R5 Class/Shares Authorized30,000,000 30,000,000 
Sold1,618 48,767 45,219 1,091,389 
Issued in reinvestment of distributions3,433 94,815 18,335 409,601 
Redeemed(26,019)(795,308)(169,115)(3,123,113)
(20,968)(651,726)(105,561)(1,622,123)
R6 Class/Shares Authorized70,000,000 70,000,000 
Sold1,744,294 53,635,470 1,630,358 37,972,288 
Issued in reinvestment of distributions705,357 19,848,742 573,408 13,004,903 
Redeemed(2,188,698)(65,961,959)(2,378,050)(55,744,343)
260,953 7,522,253 (174,284)(4,767,152)
Net increase (decrease)10,527,605 $234,696,206 (5,643,617)$(129,879,890)

21


6. Fair Value Measurements

The fund’s investments valuation process is based on several considerations and may use multiple inputs to determine the fair value of the investments held by the fund. In conformity with accounting principles generally accepted in the United States of America, the inputs used to determine a valuation are classified into three broad levels.

Level 1 valuation inputs consist of unadjusted quoted prices in an active market for identical investments.

Level 2 valuation inputs consist of direct or indirect observable market data (including quoted prices for comparable investments, evaluations of subsequent market events, interest rates, prepayment speeds, credit risk, etc.). These inputs also consist of quoted prices for identical investments initially expressed in local currencies that are adjusted through translation into U.S. dollars.

Level 3 valuation inputs consist of unobservable data (including a fund’s own assumptions).

The level classification is based on the lowest level input that is significant to the fair valuation measurement. The valuation inputs are not necessarily an indication of the risks associated with investing in these securities or other financial instruments.
The following is a summary of the level classifications as of period end. The Schedule of Investments provides additional information on the fund’s portfolio holdings.
Level 1Level 2Level 3
Assets
Investment Securities
Common Stocks$6,338,869,492 — — 
Temporary Cash Investments1,575,705 $91,188,395 — 
$6,340,445,197 $91,188,395 — 

7. Derivative Instruments

Foreign Currency Risk — The fund is subject to foreign currency exchange rate risk in the normal course of pursuing its investment objectives. The value of foreign investments held by a fund may be significantly affected by changes in foreign currency exchange rates. The dollar value of a foreign security generally decreases when the value of the dollar rises against the foreign currency in which the security is denominated and tends to increase when the value of the dollar declines against such foreign currency. A fund may enter into forward foreign currency exchange contracts to reduce a fund's exposure to foreign currency exchange rate fluctuations. The net U.S. dollar value of foreign currency underlying all contractual commitments held by a fund and the resulting unrealized appreciation or depreciation are determined daily. Realized gain or loss is recorded upon settlement of the contract. Net realized and unrealized gains or losses occurring during the holding period of forward foreign currency exchange contracts are a component of net realized gain (loss) on forward foreign currency exchange contract transactions and change in net unrealized appreciation (depreciation) on forward foreign currency exchange contracts, respectively. A fund bears the risk of an unfavorable change in the foreign currency exchange rate underlying the forward contract. Additionally, losses, up to the fair value, may arise if the counterparties do not perform under the contract terms. The fund's average U.S. dollar exposure to foreign currency risk derivative instruments held during the period was $100,441,541.
At period end, the fund did not have any derivative instruments disclosed on the Statement of Assets and Liabilities. For the year ended October 31, 2021, the effect of foreign currency risk derivative instruments on the Statement of Operations was $3,774,930 in net realized gain (loss) on forward foreign currency exchange contract transactions and $206,369 in change in net unrealized appreciation (depreciation) on forward foreign currency exchange contracts.

22


8. Risk Factors

The value of the fund’s shares will go up and down, sometimes rapidly or unpredictably, based on the performance of the securities owned by the fund and other factors generally affecting the securities market. Market risks, including political, regulatory, economic and social developments, can affect the value of the fund’s investments. Natural disasters, public health emergencies, terrorism and other unforeseeable events may lead to increased market volatility and may have adverse long-term effects on world economies and markets generally.
The fund invests in common stocks of small companies. Because of this, the fund may be subject to greater risk and market fluctuations than a fund investing in larger, more established companies.
9. Federal Tax Information

On December 7, 2021, the fund declared and paid a per-share distribution from net realized gains to shareholders of record on December 6, 2021 of $3.0780 for the Investor Class, I Class, Y Class, A Class, C Class, R Class, R5 Class and R6 Class.

The tax character of distributions paid during the years ended October 31, 2021 and October 31, 2020 were as follows:
20212020
Distributions Paid From
Ordinary income— — 
Long-term capital gains$714,817,821 $483,878,789 

The book-basis character of distributions made during the year from net investment income or net realized gains may differ from their ultimate characterization for federal income tax purposes. These differences reflect the differing character of certain income items and net realized gains and losses for financial statement and tax purposes, and may result in reclassification among certain capital accounts on the financial statements.

As of period end, the federal tax cost of investments and the components of distributable earnings on a tax-basis were as follows:

Federal tax cost of investments$4,046,358,221 
Gross tax appreciation of investments$2,457,448,994 
Gross tax depreciation of investments(72,173,623)
Net tax appreciation (depreciation) of investments2,385,275,371 
Net tax appreciation (depreciation) on derivatives and translation of assets and liabilities in foreign currencies (388)
Net tax appreciation (depreciation)$2,385,274,983 
Undistributed ordinary income$137,016,912 
Accumulated long-term gains$495,221,559 

The difference between book-basis and tax-basis unrealized appreciation (depreciation) is attributable primarily to the tax deferral of losses on wash sales.


23


Financial Highlights
For a Share Outstanding Throughout the Years Ended October 31 (except as noted)
Per-Share DataRatios and Supplemental Data
Income From Investment Operations:Ratio to Average Net Assets of:
Net Asset
Value,
Beginning
of Period
Net
Investment
Income
(Loss)
(1)
Net
Realized
and
Unrealized
Gain (Loss)
Total From
Investment
Operations
Distributions From Net
Realized
Gains
Net Asset
Value,
End
of Period
Total
Return
(2)
Operating
Expenses
Net
Investment
Income
(Loss)
Portfolio
Turnover
Rate
Net
Assets,
End of
Period
(in thousands)
Investor Class
2021$24.38(0.18)9.359.17(3.55)$30.0040.54%1.00%(0.66)%44%$5,307,249 
2020$21.74(0.10)5.094.99(2.35)$24.3825.00%1.00%(0.47)%85%$4,083,843 
2019$23.19(0.08)2.952.87(4.32)$21.7417.22%1.00%(0.38)%82%$3,702,699 
2018$23.67(0.07)1.701.63(2.11)$23.197.16%1.00%(0.30)%85%$3,787,202 
2017$21.28(0.03)4.184.15(1.76)$23.6720.77%1.01%(0.15)%56%$4,083,669 
I Class
2021$26.66(0.14)10.2910.15(3.55)$33.2640.78%0.80%(0.46)%44%$413,523 
2020$23.52(0.06)5.555.49(2.35)$26.6625.25%0.80%(0.27)%85%$328,636 
2019$24.66(0.04)3.223.18(4.32)$23.5217.50%0.80%(0.18)%82%$336,242 
2018$25.00(0.03)1.801.77(2.11)$24.667.35%0.80%(0.10)%85%$247,267 
2017$22.34
(3)
4.424.42(1.76)$25.0021.01%0.81%0.05%56%$262,095 
Y Class
2021$27.10(0.10)10.4810.38(3.55)$33.9340.98%0.65%(0.31)%44%$85,720 
2020$23.84(0.03)5.645.61(2.35)$27.1025.43%0.65%(0.12)%85%$52,978 
2019$24.90(0.01)3.273.26(4.32)$23.8417.68%0.65%(0.03)%82%$29,803 
2018$25.19
(3)
1.821.82(2.11)$24.907.51%0.65%0.05%85%$9,694 
2017(4)
$22.840.022.332.35$25.1910.29%
0.66%(5)
0.12%(5)
56%(6)
$6 



For a Share Outstanding Throughout the Years Ended October 31 (except as noted)
Per-Share DataRatios and Supplemental Data
Income From Investment Operations:Ratio to Average Net Assets of:
Net Asset
Value,
Beginning
of Period
Net
Investment
Income
(Loss)
(1)
Net
Realized
and
Unrealized
Gain (Loss)
Total From
Investment
Operations
Distributions From Net
Realized
Gains
Net Asset
Value,
End
of Period
Total
Return
(2)
Operating
Expenses
Net
Investment
Income
(Loss)
Portfolio
Turnover
Rate
Net
Assets,
End of
Period
(in thousands)
A Class
2021$21.67(0.22)8.217.99(3.55)$26.1140.12%1.25%(0.91)%44%$364,852 
2020$19.61(0.14)4.554.41(2.35)$21.6724.73%1.25%(0.72)%85%$281,637 
2019$21.42(0.12)2.632.51(4.32)$19.6116.91%1.25%(0.63)%82%$263,578 
2018$22.07(0.12)1.581.46(2.11)$21.426.89%1.25%(0.55)%85%$276,813 
2017$20.00(0.08)3.913.83(1.76)$22.0720.48%1.26%(0.40)%56%$353,039 
C Class
2021$15.22(0.25)5.535.28(3.55)$16.9539.13%2.00%(1.66)%44%$21,836 
2020$14.54(0.20)3.233.03(2.35)$15.2223.73%2.00%(1.47)%85%$31,677 
2019$17.18(0.19)1.871.68(4.32)$14.5416.06%2.00%(1.38)%82%$39,794 
2018$18.22(0.23)1.301.07(2.11)$17.186.13%2.00%(1.30)%85%$57,552 
2017$16.92(0.19)3.253.06(1.76)$18.2219.58%2.01%(1.15)%56%$88,629 
R Class
2021$21.57(0.27)8.167.89(3.55)$25.9139.80%1.50%(1.16)%44%$37,753 
2020$19.58(0.18)4.524.34(2.35)$21.5724.37%1.50%(0.97)%85%$31,862 
2019$21.43(0.17)2.642.47(4.32)$19.5816.66%1.50%(0.88)%82%$32,803 
2018$22.13(0.18)1.591.41(2.11)$21.436.62%1.50%(0.80)%85%$32,464 
2017$20.10(0.13)3.923.79(1.76)$22.1320.16%1.51%(0.65)%56%$39,033 



For a Share Outstanding Throughout the Years Ended October 31 (except as noted)
Per-Share DataRatios and Supplemental Data
Income From Investment Operations:Ratio to Average Net Assets of:
Net Asset
Value,
Beginning
of Period
Net
Investment
Income
(Loss)
(1)
Net
Realized
and
Unrealized
Gain (Loss)
Total From
Investment
Operations
Distributions From Net
Realized
Gains
Net Asset
Value,
End
of Period
Total
Return
(2)
Operating
Expenses
Net
Investment
Income
(Loss)
Portfolio
Turnover
Rate
Net
Assets,
End of
Period
(in thousands)
R5 Class
2021$26.66(0.14)10.2910.15(3.55)$33.2640.78%0.80%(0.46)%44%$973 
2020$23.52(0.04)5.535.49(2.35)$26.6625.25%0.80%(0.27)%85%$1,339 
2019$24.66(0.04)3.223.18(4.32)$23.5217.50%0.80%(0.18)%82%$3,663 
2018$25.00(0.04)1.811.77(2.11)$24.667.35%0.80%(0.10)%85%$3,053 
2017(4)
$22.69
(3)
2.312.31$25.0010.18%
0.81%(5)
(0.03)%(5)
56%(6)
$114 
R6 Class
2021$27.10(0.09)10.4710.38(3.55)$33.9340.98%0.65%(0.31)%44%$194,829 
2020$23.84(0.03)5.645.61(2.35)$27.1025.43%0.65%(0.12)%85%$148,536 
2019$24.90(0.01)3.273.26(4.32)$23.8417.68%0.65%(0.03)%82%$134,822 
2018$25.190.021.801.82(2.11)$24.907.51%0.65%0.05%85%$132,651 
2017$22.460.044.454.49(1.76)$25.1921.22%0.66%0.20%56%$186,335 




Notes to Financial Highlights
(1)Computed using average shares outstanding throughout the period.
(2)Total returns are calculated based on the net asset value of the last business day and do not reflect applicable sales charges, if any. Total returns for periods less than one year are not annualized.
(3)Per-share amount was less than $0.005.
(4)April 10, 2017 (commencement of sale) through October 31, 2017.
(5)Annualized.
(6)Portfolio turnover is calculated at the fund level. Percentage indicated was calculated for the year ended October 31, 2017.


See Notes to Financial Statements.



Report of Independent Registered Public Accounting Firm

To the Shareholders and the Board of Directors of American Century Mutual Funds, Inc.:

Opinion on the Financial Statements and Financial Highlights

We have audited the accompanying statement of assets and liabilities, including the schedule of investments, of Heritage Fund (the “Fund”), one of the funds constituting the American Century Mutual Funds, Inc., as of October 31, 2021, the related statement of operations for the year then ended, the statements of changes in net assets for each of the two years in the period then ended, the financial highlights for each of the five years in the period then ended, and the related notes. In our opinion, the financial statements and financial highlights present fairly, in all material respects, the financial position of Heritage Fund of the American Century Mutual Funds, Inc. as of October 31, 2021, and the results of its operations for the year then ended, the changes in its net assets for each of the two years in the period then ended, and the financial highlights for each of the five years in the period then ended, in conformity with accounting principles generally accepted in the United States of America.

Basis for Opinion

These financial statements and financial highlights are the responsibility of the Fund's management. Our responsibility is to express an opinion on the Fund’s financial statements and financial highlights based on our audits. We are a public accounting firm registered with the Public Company Accounting Oversight Board (United States) (PCAOB) and are required to be independent with respect to the Fund in accordance with the U.S. federal securities laws and the applicable rules and regulations of the Securities and Exchange Commission and the PCAOB.

We conducted our audits in accordance with the standards of the PCAOB. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements and financial highlights are free of material misstatement, whether due to error or fraud. The Fund is not required to have, nor were we engaged to perform, an audit of its internal control over financial reporting. As part of our audits we are required to obtain an understanding of internal control over financial reporting but not for the purpose of expressing an opinion on the effectiveness of the Fund’s internal control over financial reporting. Accordingly, we express no such opinion.

Our audits included performing procedures to assess the risks of material misstatement of the financial statements and financial highlights, whether due to error or fraud, and performing procedures that respond to those risks. Such procedures included examining, on a test basis, evidence regarding the amounts and disclosures in the financial statements and financial highlights. Our audits also included evaluating the accounting principles used and significant estimates made by management, as well as evaluating the overall presentation of the financial statements and financial highlights. Our procedures included confirmation of securities owned as of October 31, 2021, by correspondence with the custodian and brokers; when replies were not received from brokers, we performed other auditing procedures. We believe that our audits provide a reasonable basis for our opinion.

/s/ Deloitte & Touche LLP

Kansas City, Missouri
December 15, 2021

We have served as the auditor of one or more American Century investment companies since 1997.
28


Management

The Board of Directors

The individuals listed below serve as directors of the funds. Each director will continue to serve in this capacity until death, retirement, resignation or removal from office. The board has adopted a mandatory retirement age for directors who are not “interested persons,” as that term is defined in the Investment Company Act (independent directors). Independent directors shall retire by December 31 of the year in which they reach their 75th birthday.
Jonathan S.Thomas is an “interested person” because he currently serves as President and Chief Executive Officer of American Century Companies, Inc. (ACC), the parent company of American Century Investment Management, Inc. (ACIM or the advisor). The other directors (more than three-fourths of the total number) are independent. They are not employees, directors or officers of, and have no financial interest in, ACC or any of its wholly owned, direct or indirect, subsidiaries, including ACIM, American Century Investment Services, Inc. (ACIS) and American Century Services, LLC (ACS), and they do not have any other affiliations, positions or relationships that would cause them to be considered “interested persons” under the Investment Company Act. The directors serve in this capacity for seven (in the case of Jonathan S. Thomas, 16; and Stephen E. Yates, 8) registered investment companies in the American Century Investments family of funds.
The following table presents additional information about the directors. The mailing address for each director is 4500 Main Street, Kansas City, Missouri 64111.
Name
(Year of Birth)
Position(s) Held with FundsLength of Time ServedPrincipal Occupation(s) During Past 5 YearsNumber of American Century Portfolios Overseen by DirectorOther Directorships Held During Past 5 Years
Independent Directors
Thomas W. Bunn (1953)DirectorSince 2017Retired72SquareTwo Financial; Barings (formerly Babson Capital Funds Trust) (2013 to 2016)
Chris H. Cheesman
(1962)
DirectorSince 2019
Retired. Senior Vice President & Chief Audit Executive, AllianceBernstein (1999 to 2018)72Alleghany Corporation
Barry Fink
(1955)
DirectorSince 2012 (independent since 2016)Retired72None
Rajesh K. Gupta
(1960)
DirectorSince 2019
Partner Emeritus, SeaCrest Investment Management and SeaCrest Wealth Management (2019 to Present); Chief Executive Officer and Chief Investment Officer, SeaCrest Investment Management (2006 to 2019); Chief Executive Officer and Chief Investment Officer, SeaCrest Wealth Management (2008 to 2019)72None
29


Name
(Year of Birth)
Position(s) Held with FundsLength of Time ServedPrincipal Occupation(s) During Past 5 YearsNumber of American Century Portfolios Overseen by DirectorOther Directorships Held During Past 5 Years
Independent Directors
Lynn Jenkins
(1963)
DirectorSince 2019
Consultant, LJ Strategies (2019 to present); United States Representative, U.S. House of Representatives (2009 to 2018)72MGP Ingredients, Inc. (2019 to 2021)
Jan M. Lewis
(1957)
DirectorSince 2011Retired72None
John R. Whitten
(1946)
DirectorSince 2008Retired72Onto Innovation Inc. (2019 to 2020); Rudolph Technologies, Inc. (2006 to 2019)
Stephen E. Yates
(1948)
Director and Chairman of the BoardSince 2012 (Chairman since 2018)Retired107None
Interested Director
Jonathan S. Thomas
(1963)
DirectorSince 2007President and Chief Executive Officer, ACC (2007 to present). Also serves as Chief Executive Officer, ACS; Director, ACC and other ACC subsidiaries145None
The Statement of Additional Information has additional information about the fund's directors and is available without charge, upon request, by calling 1-800-345-2021.
30


Officers

The following table presents certain information about the executive officers of the funds. Each officer serves as an officer for 16 (in the case of Robert J. Leach, 15) investment companies in the American Century family of funds. No officer is compensated for his or her service as an officer of the funds. The listed officers are interested persons of the funds and are appointed or re-appointed on an annual basis. The mailing address for each officer listed below is 4500 Main Street, Kansas City, Missouri 64111.
Name
(Year of Birth)
Offices with the FundsPrincipal Occupation(s) During the Past Five Years
Patrick Bannigan
(1965)
President since 2019Executive Vice President and Director, ACC (2012 to present); Chief Financial Officer, Chief Accounting Officer and Treasurer, ACC (2015 to present). Also serves as President, ACS; Vice President, ACIM; Chief Financial Officer, Chief Accounting Officer and/or Director, ACIM, ACS and other ACC subsidiaries
R. Wes Campbell
(1974)
Chief Financial Officer and Treasurer since 2018Vice President, ACS, (2020 to present); Investment Operations and Investment Accounting, ACS (2000 to present)
Amy D. Shelton
(1964)
Chief Compliance Officer and Vice President since 2014Chief Compliance Officer, American Century funds, (2014 to present); Chief Compliance Officer, ACIM (2014 to present); Chief Compliance Officer, ACIS (2009 to present). Also serves as Vice President, ACIS
John Pak
(1968)
General Counsel and
Senior Vice President since 2021
General Counsel and Senior Vice President, ACC (2021 to present). Also serves as General Counsel and Senior Vice President, ACIM, ACS and ACIS. Chief Legal Officer of Investment and Wealth Management, The Bank of New York Mellon (2014 to 2021)
C. Jean Wade
(1964)
Vice President since 2012Senior Vice President, ACS (2017 to present); Vice President, ACS (2000 to 2017)
Robert J. Leach
(1966)
Vice President since 2006 Vice President, ACS (2000 to present)
David H. Reinmiller
(1963)
Vice President since 2000Attorney, ACC (1994 to present). Also serves as Vice President, ACIM and ACS
Ward D. Stauffer
(1960)
Secretary since 2005Attorney, ACC (2003 to present)





31


Approval of Management Agreement

At a meeting held on June 30, 2021, the Fund’s Board of Directors (the "Board") unanimously approved the renewal of the management agreement pursuant to which American Century Investment Management, Inc. (the “Advisor”) acts as the investment advisor for the Fund. Under Section 15(c) of the Investment Company Act, contracts for investment advisory services are required to be reviewed, evaluated, and approved by a majority of a fund’s directors (the “Directors”), including a majority of the independent Directors, each year.

Prior to its consideration of the renewal of the management agreement, the Directors requested and reviewed extensive data and information compiled by the Advisor and certain independent providers of evaluation data concerning the Fund and the services provided to the Fund by the Advisor. This review was in addition to the oversight and evaluation undertaken by the Board and its committees on a continual basis and the information received was supplemental to the extensive information that the Board and its committees receive and consider throughout the year.

In connection with its consideration of the renewal of the management agreement, the Board’s review and evaluation of the services provided by the Advisor and its affiliates included, but was not limited to, the following:

the nature, extent, and quality of investment management, shareholder services, and other services provided and to be provided to the Fund including without limitation portfolio management and trading services, shareholder and intermediary services, compliance and legal services, fund accounting and financial reporting, and fund share distribution;
the wide range of other programs and services provided and to be provided to the Fund and its shareholders on a routine and non-routine basis;
the Fund’s investment performance, including data comparing the Fund's performance to appropriate benchmarks and/or a peer group of other mutual funds with similar investment objectives and strategies;
the cost of owning the Fund compared to the cost of owning similar funds;
the compliance policies, procedures, and regulatory experience of the Advisor and the Fund's service providers;
the Advisor’s strategic plans, COVID-19 pandemic response, vendor management practices, and social justice initiatives;
the Advisor’s business continuity plans and cyber security practices;
financial data showing the cost of services provided to the Fund, the profitability of the Fund to the Advisor, and the overall profitability of the Advisor;
possible economies of scale associated with the Advisor’s management of the Fund and other accounts;
services provided and charges to the Advisor's other investment management clients;
acquired fund fees and expenses;
payments and practices in connection with financial intermediaries holding shares of the Fund and the services provided by intermediaries in connection therewith; and
possible collateral benefits to the Advisor from the management of the Fund.

The Board held two meetings to consider the renewal. The independent Directors also met in private session three times to review and discuss the information provided in response to their request. The independent Directors held active discussions with the Advisor regarding the renewal of the management agreement, requesting supplemental information, and reviewing information provided by the Advisor in response thereto. The independent Directors had the benefit of the advice of their independent counsel throughout the process.



32


Factors Considered

The Directors considered all of the information provided by the Advisor, the independent data providers, and independent counsel in connection with the approval. They determined that the information was sufficient for them to evaluate the management agreement for the Fund. In connection with their review, the Directors did not identify any single factor as being all-important or controlling, and each Director may have attributed different levels of importance to different factors. In deciding to renew the management agreement, the Board based its decision on a number of factors, including without limitation the following:

Nature, Extent and Quality of Services — Generally. Under the management agreement, the Advisor is responsible for providing or arranging for all services necessary for the operation of the Fund. The Board noted that the Advisor provides or arranges at its own expense a wide variety of services which include the following:

constructing and designing the Fund
portfolio research and security selection
initial capitalization/funding
securities trading
Fund administration
custody of Fund assets
daily valuation of the Fund’s portfolio
liquidity monitoring and management
risk management, including cyber security
shareholder servicing and transfer agency, including shareholder confirmations, recordkeeping, and communications
legal services (except the independent Directors’ counsel)
regulatory and portfolio compliance
financial reporting
marketing and distribution (except amounts paid by the Fund under Rule 12b-1 plans)

The Board noted that many of these services have expanded over time in terms of both quantity and complexity in response to shareholder demands, competition in the industry, changing distribution channels, and the changing regulatory environment.

Investment Management Services. The nature of the investment management services provided to the Fund is quite complex and allows Fund shareholders access to professional money management, instant diversification of their investments within an asset class, the opportunity to easily diversify among asset classes by investing in or exchanging among various American Century Investments funds, and liquidity. In evaluating investment performance, the Board expects the Advisor to manage the Fund in accordance with its investment objectives and approved strategies. Further, the Directors recognize that the Advisor has an obligation to monitor trading activities, and in particular to seek the best execution of fund trades, and to evaluate the use of and payment for research. In providing these services, the Advisor utilizes teams of investment professionals (portfolio managers, analysts, research assistants, and securities traders) who require extensive information technology, research, training, compliance, and other systems to conduct their business. The Board, directly and through its Fund Performance Review Committee, provides oversight of the investment performance process. It regularly reviews investment performance information for the Fund, together with comparative information for appropriate benchmarks and/or peer groups of similarly-managed funds, over different time horizons. The Directors also review investment performance information during the management agreement renewal process. If performance concerns are identified, the Fund receives special reviews until performance improves, during which the Board discusses with the Advisor the reasons for such results (e.g., market conditions, security selection) and any efforts being undertaken to improve performance. The Fund’s performance was above its benchmark for the one-, three-, and five-year periods and below its benchmark for the ten-year period reviewed by the Board. The Board found the investment management services provided by the Advisor to the Fund to be satisfactory and consistent with the management agreement.
33


Shareholder and Other Services. Under the management agreement, the Advisor provides the Fund with a comprehensive package of transfer agency, shareholder, and other services. The Board, directly and through its various committees, regularly reviews reports and evaluations of such services at its regular meetings. These reports include, but are not limited to, information regarding the operational efficiency and accuracy of the shareholder and transfer agency services provided, staffing levels, shareholder satisfaction, technology support (including cyber security), new products and services offered to Fund shareholders, securities trading activities, portfolio valuation services, auditing services, and legal and operational compliance activities. The Board found the services provided by the Advisor to the Fund under the management agreement to be competitive and of high quality.

Costs of Services and Profitability. The Advisor provides detailed information concerning its cost of providing various services to the Fund, its profitability in managing the Fund (pre- and post-distribution), its overall profitability, and its financial condition. The Directors have reviewed with the Advisor the methodology used to prepare this financial information. This information is considered in evaluating the Advisor’s financial condition, its ability to continue to provide services under the management agreement, and the reasonableness of the current management fee. The Board concluded that the Advisor’s profits were reasonable in light of the services provided to the Fund.

Ethics. The Board generally considers the Advisor’s commitment to providing quality services to shareholders and to conducting its business ethically. They noted that the Advisor’s practices generally meet or exceed industry best practices.

Economies of Scale. The Board also reviewed information provided by the Advisor regarding the possible existence of economies of scale in connection with the management of the Fund. The Board concluded that economies of scale are difficult to measure and predict with precision, especially on a fund-by-fund basis. The Board concluded that the Advisor is sharing economies of scale, to the extent they exist, through its competitive fee structure, offering competitive fees from fund inception, and through reinvestment in its business, infrastructure, investment capabilities and initiatives to provide shareholders additional content and services.

Comparison to Other Funds’ Fees. The management agreement provides that the Fund pays the Advisor a single, all-inclusive (or unified) management fee for providing all services necessary for the management and operation of the Fund, other than brokerage expenses, expenses attributable to short sales, taxes, interest, extraordinary expenses, fees and expenses of the Fund’s independent Directors (including their independent legal counsel), and expenses incurred in connection with the provision of shareholder services and distribution services under a plan adopted pursuant to Rule 12b-1 under the Investment Company Act. Under the unified fee structure, the Advisor is responsible for providing all investment advisory, custody, audit, administrative, compliance, recordkeeping, marketing and shareholder services, or arranging and supervising third parties to provide such services. By contrast, most other funds are charged a variety of fees, including an investment advisory fee, a transfer agency fee, an administrative fee, distribution charges, and other expenses. Other than their investment advisory fees and any applicable Rule 12b-1 distribution fees, all other components of the total fees charged by these other funds may be increased without shareholder approval. The Board believes the unified fee structure is a benefit to Fund shareholders because it clearly discloses to shareholders the cost of owning Fund shares, and, since the unified fee cannot be increased without a vote of Fund shareholders, it shifts to the Advisor the risk of increased costs of operating the Fund and provides a direct incentive to minimize administrative inefficiencies. Part of the Board’s analysis of fee levels involves reviewing certain evaluative data compiled by an independent provider comparing the Fund’s unified fee to the total expense ratios of its peers. The unified fee charged to shareholders of the Fund was below the median of the total expense ratios of the Fund’s peer expense universe. In addition, the Board reviewed the Fund’s position relative to the narrower set of its expense group peers. The Board concluded that the management fee paid by the Fund to the Advisor under the management agreement is reasonable in light of the services provided to the Fund.

Comparison to Fees and Services Provided to Other Clients of the Advisor. The Board also requested and received information from the Advisor concerning the nature of the services, fees, costs, and profitability of its advisory services to advisory clients other than the Fund. They
34


observed that these varying types of client accounts require different services and involve different regulatory and entrepreneurial risks than the management of the Fund. The Board analyzed this information and concluded that the fees charged and services provided to the Fund were reasonable by comparison.

Payments to Intermediaries. The Directors also requested and received a description of payments made to intermediaries by the Fund and the Advisor and services provided in response thereto. These payments include various payments made by the Fund or the Advisor to different types of intermediaries and recordkeepers for distribution and service activities provided for the Fund. The Directors reviewed such information and received representations from the Advisor that all such payments by the Fund were made pursuant to the Fund's Rule 12b-1 Plan and that all such payments by the Advisor were made from the Advisor’s resources and reasonable profits. The Board found such payments to be reasonable in scope and purpose.

Collateral or “Fall-Out” Benefits Derived by the Advisor. The Board considered the possible existence of collateral benefits the Advisor may receive as a result of its relationship with the Fund. They concluded that the Advisor’s primary business is managing funds and it generally does not use fund or shareholder information to generate profits in other lines of business, and therefore does not derive any significant collateral benefits from them. To the extent there are potential collateral benefits, the Board has been advised and has taken this into consideration in its review of the management contract with the Fund. The Board noted that additional assets from other clients may offer the Advisor some benefit from increased leverage with service providers and counterparties. Additionally, the Advisor may receive proprietary research from broker-dealers that execute fund portfolio transactions, which the Board concluded is likely to benefit other clients of the Advisor, as well as Fund shareholders. The Board also determined that the Advisor is able to provide investment management services to certain clients other than the Fund, at least in part, due to its existing infrastructure built to serve the fund complex. The Board concluded that appropriate allocation methodologies had been employed to assign resources and the cost of those resources to these other clients.

Existing Relationship. The Board also considered whether there was any reason for not continuing the existing arrangement with the Advisor. In this regard, the Board was mindful of the potential disruptions of the Fund’s operations and various risks, uncertainties, and other effects that could occur as a result of a decision not to continue such relationship. In particular, the Board recognized that most shareholders have invested in the Fund on the strength of the Advisor’s industry standing and reputation and in the expectation that the Advisor will have a continuing role in providing advisory services to the Fund.

Conclusion of the Directors. As a result of this process, the Board, including all of the independent Directors, taking into account all of the factors discussed above and the information provided by the Advisor and others in connection with its review and throughout the year, determined that the management fee is fair and reasonable in light of the services provided and that the investment management agreement between the Fund and the Advisor should be renewed.
35


Additional Information

Retirement Account Information

As required by law, distributions you receive from certain retirement accounts are subject to federal income tax withholding, unless you elect not to have withholding apply*. Tax will be withheld on the total amount withdrawn even though you may be receiving amounts that are not subject to withholding, such as nondeductible contributions. In such case, excess amounts of withholding could occur. You may adjust your withholding election so that a greater or lesser amount will be withheld.
If you don’t want us to withhold on this amount, you must notify us to not withhold the federal income tax. You may notify us in writing or in certain situations by telephone or through other electronic means. For systematic withdrawals, your withholding election will remain in effect until revoked or changed by filing a new election. You have the right to revoke your election at any time and change your withholding percentage for future distributions.
Remember, even if you elect not to have income tax withheld, you are liable for paying income tax on the taxable portion of your withdrawal. If you elect not to have income tax withheld or you don’t have enough income tax withheld, you may be responsible for payment of estimated tax. You may incur penalties under the estimated tax rules if your withholding and estimated tax payments are not sufficient. You can reduce or defer the income tax on a distribution by directly or indirectly rolling such distribution over to another IRA or eligible plan. You should consult your tax advisor for additional information.
State tax will be withheld if, at the time of your distribution, your address is within one of the mandatory withholding states and you have federal income tax withheld (or as otherwise required by state law). State taxes will be withheld from your distribution in accordance with the respective state rules.
*Some 403(b), 457 and qualified retirement plan distributions may be subject to 20% mandatory withholding, as they are subject to special tax and withholding rules.  Your plan administrator or plan sponsor is required to provide you with a special tax notice explaining those rules at the time you request a distribution.  If applicable, federal and/or state taxes may be withheld from your distribution amount.


Proxy Voting Policies

A description of the policies that the fund's investment advisor uses in exercising the voting rights associated with the securities purchased and/or held by the fund is available without charge, upon request, by calling 1-800-345-2021. It is also available on American Century Investments’ website at americancentury.com/proxy and on the Securities and Exchange Commission’s website at sec.gov. Information regarding how the investment advisor voted proxies relating to portfolio securities during the most recent 12-month period ended June 30 is available on americancentury.com/proxy. It is also available at sec.gov.


Quarterly Portfolio Disclosure

The fund files its complete schedule of portfolio holdings with the Securities and Exchange Commission (SEC) for the first and third quarters of each fiscal year as an exhibit to its reports on Form N-PORT. These portfolio holdings are available on the fund's website at americancentury.com and, upon request, by calling 1-800-345-2021. The fund’s Form N-PORT reports are available on the SEC’s website at sec.gov.

36


Other Tax Information

The following information is provided pursuant to provisions of the Internal Revenue Code.

The fund hereby designates $743,683,554, or up to the maximum amount allowable, as long-term capital gain distributions (20% rate gain distributions) for the fiscal year ended October 31, 2021.

The fund hereby designates $7,986,414 as qualified short-term capital gain distributions for purposes of Internal Revenue Code Section 871 for the fiscal year ended October 31, 2021.

The fund utilized earnings and profits of $36,852,147 distributed to shareholders on redemption of shares as part of the dividends paid deduction (tax equalization).

37


Notes
38


Notes
39


Notes
40






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Contact Usamericancentury.com
Automated Information Line1-800-345-8765
Investor Services Representative1-800-345-2021
or 816-531-5575
Investors Using Advisors1-800-378-9878
Business, Not-For-Profit, Employer-Sponsored Retirement Plans1-800-345-3533
Banks and Trust Companies, Broker-Dealers, Financial Professionals, Insurance Companies1-800-345-6488
Telecommunications Relay Service for the Deaf711
American Century Mutual Funds, Inc.
Investment Advisor:
American Century Investment Management, Inc.
Kansas City, Missouri
This report and the statements it contains are submitted for the general information of our shareholders. The report is not authorized for distribution to prospective investors unless preceded or accompanied by an effective prospectus.
©2021 American Century Proprietary Holdings, Inc. All rights reserved.
CL-ANN-90977 2112




    


image8.jpg
Annual Report
October 31, 2021
NT Growth Fund
G Class (ACLTX)





























Table of Contents
Performance
Portfolio Commentary
Fund Characteristics
Shareholder Fee Example
Schedule of Investments
Statement of Assets and Liabilities
Statement of Operations
Statement of Changes in Net Assets
Notes to Financial Statements
Financial Highlights
Report of Independent Registered Public Accounting Firm
Management
Approval of Management Agreement
Additional Information





















Any opinions expressed in this report reflect those of the author as of the date of the report, and do not necessarily represent the opinions of American Century Investments® or any other person in the American Century Investments organization. Any such opinions are subject to change at any time based upon market or other conditions and American Century Investments disclaims any responsibility to update such opinions. These opinions may not be relied upon as investment advice and, because investment decisions made by American Century Investments funds are based on numerous factors, may not be relied upon as an indication of trading intent on behalf of any American Century Investments fund. Security examples are used for representational purposes only and are not intended as recommendations to purchase or sell securities. Performance information for comparative indices and securities is provided to American Century Investments by third party vendors. To the best of American Century Investments’ knowledge, such information is accurate at the time of printing.



Performance
Total Returns as of October 31, 2021
  Average Annual Returns
 Ticker
Symbol
1 year5 years10 yearsInception
Date
G ClassACLTX44.81%25.60%18.44%5/12/06
Russell 1000 Growth Index43.21%25.47%19.41%
Fund returns would have been lower if a portion of the fees had not been waived. Extraordinary performance is attributable in part to unusually favorable market conditions and may not be repeated or consistently achieved in the future.

Growth of $10,000 Over 10 Years
$10,000 investment made October 31, 2011
 chart-cb9609326e8845158c8a.jpg
Value on October 31, 2021
G Class — $54,380
Russell 1000 Growth Index — $59,008
Ending value of G Class would have been lower if a portion of the fees had not been waived.

Total Annual Fund Operating Expenses
G Class0.63%
The total annual fund operating expenses shown is as stated in the fund’s prospectus current as of the date of this report. The prospectus may vary from the expense ratio shown elsewhere in this report because it is based on a different time period, includes acquired fund fees and expenses, and, if applicable, does not include fee waivers or expense reimbursements.



Data presented reflect past performance. Past performance is no guarantee of future results. Current performance may be higher or lower than the performance shown. Total returns for periods less than one year are not annualized. Investment return and principal value will fluctuate, and redemption value may be more or less than original cost. Data assumes reinvestment of dividends and capital gains, and none of the charts reflect the deduction of taxes that a shareholder would pay on fund distributions or the redemption of fund shares. To obtain performance data current to the most recent month end, please call 1-800-345-2021 or visit americancentury.com. For additional information about the fund, please consult the prospectus.
2


Portfolio Commentary

Portfolio Managers: Joe Reiland, Justin Brown and Scott Marolf

Greg Woodhams left the portfolio management team September 1, 2021. He is retiring, effective December 31, 2021. Joe Reiland was named portfolio manager.

Performance Summary

NT Growth returned 44.81%* for the 12 months ended October 31, 2021, versus the 43.21% return of the fund’s benchmark, the Russell 1000 Growth Index.

U.S. stocks posted strong returns during the reporting period, supported by federal government stimulus and low interest rates. The rollout of COVID-19 vaccines allowed the economy to reopen, and despite concerns about the delta variant, inflationary pressures and supply chain constraints, several market indices ended the 12-month period at record highs. Within the Russell 1000 Growth Index, all sectors posted double-digit gains, led by energy, which surged on demand and limited supply as the economy began to reopen. Materials was the weakest sector.

Stock selection in the communication services and industrials sectors helped drive outperformance relative to the benchmark. Stock decisions in the financials and consumer staples sectors weighed on performance.

Communication Services Stocks Were Top Contributors

Interactive media and services stocks led outperformance in the communication services sector. Alphabet was a major industry contributor. Digital advertising remained a strength for Google’s parent company, driven by sustained e-commerce and reopening activity. Its YouTube business, in particular, was strong as new advertising products across both brand and direct response have been favorably received.

Other top contributors included ASML Holding. This Netherlands-based semiconductor equipment manufacturer outperformed due to strong demand for its extreme ultraviolet lithography technology that allows semiconductor manufacturers to make smaller and more efficient chips. Demand for semiconductors has been strong and manufacturers need new equipment to increase production. NVIDIA, a gaming and artificial intelligence chipmaker, benefited relative performance. NVIDIA reported better-than-expected earnings and offered positive forward guidance based on strength in data center and gaming CPUs.

Microsoft reported strong revenue and earnings growth, and the stock also received a tailwind from large-capitalization software returning to favor. The messaging software company Slack Technologies rose sharply following the announcement that it would be acquired by salesforce.com. As a result of the deal, Slack was eliminated from the portfolio. Not owning Zoom Video Communications helped performance. After benefiting from the pandemic in 2020, investors reallocated capital in 2021 to stocks expected to benefit from the reopening of the economy. Zoom was a victim of the market’s swing, and our lack of exposure was helpful.

Financials Hampered Performance

Stock choices in the insurance industry weighed on relative performance in the financials sector. SelectQuote offers consumers a platform to compare insurance policies. The company and the industry in general have struggled with plan persistency, the percentage of policyholders that continue paying premiums. As a result, SelectQuote offered disappointing guidance for next year.






*Fund returns would have been lower if a portion of the fees had not been waived.
3


Elsewhere, underweighting Tesla detracted. The electric carmaker continued to benefit from solid fundamental reports and strong demand for its vehicles. The stock also got a boost when it was added to the S&P 500 Index. Visa underperformed. The digital payments company’s stock lagged on concerns about potential renewed restrictions due to the COVID-19 delta variant, which could reduce travel and cross-border transaction volumes. Splunk offers cloud-based data analysis software that helps companies understand how efficiently their internal operations are running. Investors appeared concerned about increasing competition, and Splunk experienced some leadership changes.

Not owning Moderna detracted. The biotechnology company’s stock surged on excitement around its successful COVID-19 vaccine, booster shots and the potential for annual boosters beyond 2021. While we are impressed by the speed of development and effectiveness of Moderna’s messenger RNA drug development technology, the market seemed to be ascribing quite a bit of long-term value to COVID-19 vaccine revenue, which is highly uncertain. Zendesk, a cloud-based customer support software company, missed revenue and earnings forecasts due to lower revenue from one of its consumption-based products and a greater mix shift to enterprise deals, which have larger, longer-term contracts over time, but recognize less revenue up front. We view this as a positive long-term sign for the business despite the impact to revenue in the near term.

Outlook

We believe stock selection—rather than sector allocation or market timing via the use of cash—is the most efficient means of generating superior risk-adjusted returns. As a result of this approach, the portfolio’s sector and industry selection, as well as capitalization range allocations, are primarily due to identifying what we believe to be superior individual securities.

At period-end, our largest sector allocation relative to the benchmark was communication services. The largest underweight was financials.




4


Fund Characteristics 
OCTOBER 31, 2021
Types of Investments in Portfolio% of net assets
Common Stocks97.7%
Temporary Cash Investments2.3%
Temporary Cash Investments - Securities Lending Collateral0.5%
Other Assets and Liabilities(0.5)%
Top Five Industries% of net assets
Software17.9%
Interactive Media and Services11.1%
Semiconductors and Semiconductor Equipment8.2%
Technology Hardware, Storage and Peripherals8.1%
Internet and Direct Marketing Retail7.6%
5


Shareholder Fee Example

Fund shareholders may incur two types of costs: (1) transaction costs, including sales charges (loads) on purchase payments and redemption/exchange fees; and (2) ongoing costs, including management fees; distribution and service (12b-1) fees; and other fund expenses. This example is intended to help you understand your ongoing costs (in dollars) of investing in your fund and to compare these costs with the ongoing cost of investing in other mutual funds.

The example is based on an investment of $1,000 made at the beginning of the period and held for the entire period from May 1, 2021 to October 31, 2021.

Actual Expenses

The table provides information about actual account values and actual expenses for each class. You may use the information, together with the amount you invested, to estimate the expenses that you paid over the period. First, identify the share class you own. Then simply divide your account value by $1,000 (for example, an $8,600 account value divided by $1,000 = 8.6), then multiply the result by the number under the heading “Expenses Paid During Period” to estimate the expenses you paid on your account during this period.

Hypothetical Example for Comparison Purposes

The table also provides information about hypothetical account values and hypothetical expenses based on the actual expense ratio of each class of your fund and an assumed rate of return of 5% per year before expenses, which is not the actual return of a fund’s share class. The hypothetical account values and expenses may not be used to estimate the actual ending account balance or expenses you paid for the period. You may use this information to compare the ongoing costs of investing in your fund and other funds. To do so, compare this 5% hypothetical example with the 5% hypothetical examples that appear in the shareholder reports of the other funds.

Please note that the expenses shown in the table are meant to highlight your ongoing costs only and do not reflect any transactional costs, such as sales charges (loads) or redemption/exchange fees. Therefore, the table is useful in comparing ongoing costs only, and will not help you determine the relative total costs of owning different funds. In addition, if these transactional costs were included, your costs would have been higher.
Beginning
Account Value
5/1/21
Ending
Account Value
10/31/21
Expenses Paid
During Period(1)
5/1/21 - 10/31/21
Annualized
Expense Ratio(1)
Actual
G Class$1,000$1,155.70$0.050.01%
Hypothetical
G Class$1,000$1,025.16$0.050.01%
(1)Expenses are equal to the class's annualized expense ratio listed in the table above, multiplied by the average account value over the period, multiplied by 184, the number of days in the most recent fiscal half-year, divided by 365, to reflect the one-half year period. Annualized expense ratio reflects actual expenses, including any applicable fee waivers or expense reimbursements and excluding any acquired fund fees and expenses.
6


Schedule of Investments

OCTOBER 31, 2021
SharesValue
COMMON STOCKS — 97.7%


Air Freight and Logistics — 1.8%
United Parcel Service, Inc., Class B138,861 $29,642,658 
Auto Components — 1.9%
Aptiv plc(1)
189,166 32,704,910 
Automobiles — 3.8%
Tesla, Inc.(1)
57,143 63,657,302 
Beverages — 1.7%
PepsiCo, Inc.182,318 29,462,589 
Biotechnology — 1.4%
Amgen, Inc.47,724 9,877,436 
CRISPR Therapeutics AG(1)
40,951 3,740,055 
Natera, Inc.(1)
28,671 3,284,836 
Vertex Pharmaceuticals, Inc.(1)
37,418 6,919,711 
23,822,038 
Building Products — 1.0%
Masco Corp.123,243 8,078,579 
Trex Co., Inc.(1)
82,389 8,766,189 
16,844,768 
Capital Markets — 1.6%
S&P Global, Inc.58,222 27,606,543 
Chemicals — 0.8%
Air Products and Chemicals, Inc.43,584 13,066,919 
Electrical Equipment — 2.5%
Ballard Power Systems, Inc.(1)(2)
264,369 4,790,366 
Generac Holdings, Inc.(1)
30,966 15,438,409 
Rockwell Automation, Inc.68,969 22,028,699 
42,257,474 
Electronic Equipment, Instruments and Components — 2.2%
CDW Corp.51,906 9,688,255 
Cognex Corp.145,083 12,707,820 
Keysight Technologies, Inc.(1)
82,769 14,900,075 
37,296,150 
Entertainment — 1.7%
Liberty Media Corp.-Liberty Formula One, Class C(1)
109,785 6,126,003 
Take-Two Interactive Software, Inc.(1)
42,718 7,731,958 
Walt Disney Co. (The)(1)
86,238 14,580,259 
28,438,220 
Equity Real Estate Investment Trusts (REITs) — 1.0%
SBA Communications Corp.50,267 17,358,703 
Food Products — 0.9%
Mondelez International, Inc., Class A219,423 13,327,753 
Vital Farms, Inc.(1)
111,836 1,836,347 
15,164,100 
Health Care Equipment and Supplies — 2.7%
DexCom, Inc.(1)
22,010 13,716,852 
Edwards Lifesciences Corp.(1)
68,379 8,193,172 
IDEXX Laboratories, Inc.(1)
11,662 7,768,525 
7


SharesValue
Intuitive Surgical, Inc.(1)
45,201 $16,323,437 
46,001,986 
Health Care Providers and Services — 1.6%
Guardant Health, Inc.(1)
21,377 2,496,620 
UnitedHealth Group, Inc.54,582 25,133,373 
27,629,993 
Hotels, Restaurants and Leisure — 1.2%
Chipotle Mexican Grill, Inc.(1)
5,689 10,120,902 
Dutch Bros, Inc., Class A(1)
37,204 2,836,433 
Expedia Group, Inc.(1)
43,915 7,220,065 
20,177,400 
Household Products — 0.7%
Procter & Gamble Co. (The)85,285 12,194,902 
Insurance — 0.2%
SelectQuote, Inc.(1)
274,626 3,649,779 
Interactive Media and Services — 11.1%
Alphabet, Inc., Class A(1)
47,167 139,657,714 
Meta Platforms, Inc., Class A(1)
113,383 36,687,337 
Snap, Inc., Class A(1)
102,342 5,381,143 
Twitter, Inc.(1)
119,806 6,414,413 
188,140,607 
Internet and Direct Marketing Retail — 7.6%
Amazon.com, Inc.(1)
35,538 119,849,417 
Chewy, Inc., Class A(1)(2)
115,373 8,745,274 
128,594,691 
IT Services — 7.4%
Okta, Inc.(1)
27,870 6,888,906 
PayPal Holdings, Inc.(1)
182,218 42,382,085 
Shopify, Inc., Class A(1)
3,224 4,728,737 
Twilio, Inc., Class A(1)
17,338 5,051,600 
Visa, Inc., Class A311,048 65,870,635 
124,921,963 
Life Sciences Tools and Services — 1.5%
10X Genomics, Inc., Class A(1)
25,968 4,187,859 
Agilent Technologies, Inc.99,000 15,591,510 
Repligen Corp.(1)
16,900 4,909,450 
24,688,819 
Personal Products — 0.6%
Estee Lauder Cos., Inc. (The), Class A30,317 9,832,713 
Pharmaceuticals — 1.6%
Novo Nordisk A/S, B Shares62,849 6,891,698 
Zoetis, Inc.88,953 19,231,639 
26,123,337 
Road and Rail — 1.1%
Lyft, Inc., Class A(1)
148,551 6,814,034 
Union Pacific Corp.46,642 11,259,379 
18,073,413 
Semiconductors and Semiconductor Equipment — 8.2%
Advanced Micro Devices, Inc.(1)
229,105 27,545,294 
Analog Devices, Inc.95,043 16,489,010 
ASML Holding NV34,355 27,927,166 
NVIDIA Corp.262,785 67,186,241 
139,147,711 
8


SharesValue
Software — 17.9%
Datadog, Inc., Class A(1)
67,267 $11,236,952 
DocuSign, Inc.(1)
36,040 10,029,572 
Microsoft Corp.675,757 224,094,536 
PagerDuty, Inc.(1)
169,449 7,074,496 
Paycor HCM, Inc.(1)
54,169 1,757,242 
salesforce.com, Inc.(1)
41,801 12,527,342 
Splunk, Inc.(1)
61,251 10,095,390 
Workday, Inc., Class A(1)
43,846 12,714,463 
Zendesk, Inc.(1)
124,159 12,639,386 
302,169,379 
Specialty Retail — 2.2%
Home Depot, Inc. (The)98,993 36,799,658 
Technology Hardware, Storage and Peripherals — 8.1%
Apple, Inc.910,362 136,372,228 
Textiles, Apparel and Luxury Goods — 1.7%
NIKE, Inc., Class B175,837 29,415,772 
TOTAL COMMON STOCKS
(Cost $768,734,350)
1,651,256,725 
TEMPORARY CASH INVESTMENTS — 2.3%


Repurchase Agreement, BMO Capital Markets Corp., (collateralized by various U.S. Treasury obligations, 2.00%, 11/15/26, valued at $8,747,593), in a joint trading account at 0.01%, dated 10/29/21, due 11/1/21 (Delivery value $8,565,662)8,565,655 
Repurchase Agreement, Fixed Income Clearing Corp., (collateralized by various U.S. Treasury obligations, 4.75%, 2/15/41, valued at $29,125,190), at 0.01%, dated 10/29/21, due 11/1/21 (Delivery value $28,554,024)28,554,000 
State Street Institutional U.S. Government Money Market Fund, Premier Class817,998 817,998 
TOTAL TEMPORARY CASH INVESTMENTS
(Cost $37,937,653)
37,937,653 
TEMPORARY CASH INVESTMENTS - SECURITIES LENDING COLLATERAL(3) — 0.5%
State Street Navigator Securities Lending Government Money Market Portfolio
(Cost $8,962,020)
8,962,020 8,962,020 
TOTAL INVESTMENT SECURITIES — 100.5%
(Cost $815,634,023)

1,698,156,398 
OTHER ASSETS AND LIABILITIES — (0.5)%

(9,136,393)
TOTAL NET ASSETS — 100.0%

$1,689,020,005 

9


FORWARD FOREIGN CURRENCY EXCHANGE CONTRACTS
Currency PurchasedCurrency SoldCounterpartySettlement DateUnrealized Appreciation
(Depreciation)
EUR1,077,545 USD1,261,383 Credit Suisse AG12/31/21$(13,755)
EUR1,509,730 USD1,755,273 Credit Suisse AG12/31/21(7,241)
EUR511,031 USD592,557 Credit Suisse AG12/31/21(864)
EUR443,867 USD516,576 Credit Suisse AG12/31/21(2,648)
EUR610,317 USD709,582 Credit Suisse AG12/31/21(2,930)
EUR756,325 USD880,259 Credit Suisse AG12/31/21(4,552)
USD25,118,738 EUR21,366,920 Credit Suisse AG12/31/21379,183 
USD757,277 EUR645,359 Credit Suisse AG12/31/2110,053 
USD854,075 EUR738,804 Credit Suisse AG12/31/21(1,345)
USD993,043 EUR855,611 Credit Suisse AG12/31/212,379 
USD572,285 EUR490,589 Credit Suisse AG12/31/214,259 
USD1,133,108 EUR975,338 Credit Suisse AG12/31/213,819 
$366,358 

FUTURES CONTRACTS PURCHASED
Reference EntityContractsExpiration DateNotional
Amount
Unrealized Appreciation
(Depreciation)^
NASDAQ 100 E-Mini112December 2021$35,478,240 $1,340,123 
^Amount represents value and unrealized appreciation (depreciation).

NOTES TO SCHEDULE OF INVESTMENTS
EUR-Euro
USD-United States Dollar
(1)Non-income producing.
(2)Security, or a portion thereof, is on loan. At the period end, the aggregate value of securities on loan was $12,361,090. The amount of securities on loan indicated may not correspond with the securities on loan identified because securities with pending sales are in the process of recall from the brokers.
(3)Investment of cash collateral from securities on loan. At the period end, the aggregate value of the collateral held by the fund was $12,552,826, which includes securities collateral of $3,590,806.


See Notes to Financial Statements.
10


Statement of Assets and Liabilities
OCTOBER 31, 2021
Assets
Investment securities, at value (cost of $806,672,003) — including $12,361,090 of securities on loan$1,689,194,378 
Investment made with cash collateral received for securities on loan, at value (cost of $8,962,020)
8,962,020 
Total investment securities, at value (cost of $815,634,023)1,698,156,398 
Cash426,000 
Deposits with broker for futures contracts1,904,000 
Receivable for investments sold1,667,987 
Receivable for capital shares sold268,625 
Receivable for variation margin on futures contracts305,027 
Unrealized appreciation on forward foreign currency exchange contracts399,693 
Dividends and interest receivable238,209 
Securities lending receivable3,074 
1,703,369,013 
Liabilities
Payable for collateral received for securities on loan8,962,020 
Payable for investments purchased2,512,566 
Payable for capital shares redeemed2,841,087 
Unrealized depreciation on forward foreign currency exchange contracts33,335 
14,349,008 
Net Assets$1,689,020,005 
G Class Capital Shares, $0.01 Par Value
Shares authorized780,000,000 
Shares outstanding65,397,130 
Net Asset Value Per Share$25.83 
Net Assets Consist of:
Capital (par value and paid-in surplus)$685,548,155 
Distributable earnings1,003,471,850 
$1,689,020,005 


See Notes to Financial Statements.
11


Statement of Operations
YEAR ENDED OCTOBER 31, 2021
Investment Income (Loss)
Income:
Dividends (net of foreign taxes withheld of $54,368)$9,216,871 
Securities lending, net49,557 
Interest2,572 
9,269,000 
Expenses:
Management fees9,425,042 
Directors' fees and expenses39,136 
Other expenses30,657 
9,494,835 
Fees waived(9,425,042)
69,793 
Net investment income (loss)9,199,207 
Realized and Unrealized Gain (Loss)
Net realized gain (loss) on:
Investment transactions112,800,049 
Forward foreign currency exchange contract transactions268,276 
Futures contract transactions1,598,437 
Foreign currency translation transactions3,542 
114,670,304 
Change in net unrealized appreciation (depreciation) on:
Investments440,238,459 
Forward foreign currency exchange contracts267,900 
Futures contracts1,340,123 
Translation of assets and liabilities in foreign currencies(977)
441,845,505 
Net realized and unrealized gain (loss)556,515,809 
Net Increase (Decrease) in Net Assets Resulting from Operations$565,715,016 


See Notes to Financial Statements.
12


Statement of Changes in Net Assets
YEARS ENDED OCTOBER 31, 2021 AND OCTOBER 31, 2020
Increase (Decrease) in Net AssetsOctober 31, 2021October 31, 2020
Operations
Net investment income (loss)$9,199,207 $8,913,201 
Net realized gain (loss)114,670,304 194,190,011 
Change in net unrealized appreciation (depreciation)441,845,505 10,632,746 
Net increase (decrease) in net assets resulting from operations565,715,016 213,735,958 
Distributions to Shareholders
From earnings(156,222,533)(121,765,935)
Capital Share Transactions
Proceeds from shares sold195,330,153 642,945,523 
Proceeds from reinvestment of distributions156,222,533 121,765,935 
Payments for shares redeemed(354,741,301)(651,200,701)
Net increase (decrease) in net assets from capital share transactions(3,188,615)113,510,757 
Net increase (decrease) in net assets406,303,868 205,480,780 
Net Assets
Beginning of period1,282,716,137 1,077,235,357 
End of period$1,689,020,005 $1,282,716,137 
Transactions in Shares of the Fund
Sold8,950,142 32,808,941 
Issued in reinvestment of distributions7,826,780 7,300,116 
Redeemed(15,527,464)(35,290,362)
Net increase (decrease) in shares of the fund1,249,458 4,818,695 


See Notes to Financial Statements.
13


Notes to Financial Statements

OCTOBER 31, 2021

1. Organization

American Century Mutual Funds, Inc. (the corporation) is registered under the Investment Company Act of 1940, as amended (the 1940 Act), as an open-end management investment company and is organized as a Maryland corporation. NT Growth Fund (the fund) is one fund in a series issued by the corporation. The fund's investment objective is to seek long-term capital growth. The fund offers the G Class.

2. Significant Accounting Policies

The following is a summary of significant accounting policies consistently followed by the fund in preparation of its financial statements. The fund is an investment company and follows accounting and reporting guidance in accordance with accounting principles generally accepted in the United States of America. This may require management to make certain estimates and assumptions at the date of the financial statements. Actual results could differ from these estimates. Management evaluated the impact of events or transactions occurring through the date the financial statements were issued that would merit recognition or disclosure.

Investment Valuations — The fund determines the fair value of its investments and computes its net asset value (NAV) per share at the close of regular trading (usually 4 p.m. Eastern time) on the New York Stock Exchange (NYSE) on each day the NYSE is open. The Board of Directors has adopted valuation policies and procedures to guide the investment advisor in the fund’s investment valuation process and to provide methodologies for the oversight of the fund’s pricing function.

Equity securities that are listed or traded on a domestic securities exchange are valued at the last reported sales price or at the official closing price as provided by the exchange. Equity securities traded on foreign securities exchanges are generally valued at the closing price of such securities on the exchange where primarily traded or at the close of the NYSE, if that is earlier. If no last sales price is reported, or if local convention or regulation so provides, the mean of the latest bid and asked prices may be used. Securities traded over-the-counter are valued at the mean of the latest bid and asked prices, the last sales price, or the official closing price. Equity securities initially expressed in local currencies are translated into U.S. dollars at the mean of the appropriate currency exchange rate at the close of the NYSE as provided by an independent pricing service.

Open-end management investment companies are valued at the reported NAV per share. Repurchase agreements are valued at cost, which approximates fair value. Exchange-traded futures contracts are valued at the settlement price as provided by the appropriate exchange. Forward foreign currency exchange contracts are valued at the mean of the appropriate forward exchange rate at the close of the NYSE as provided by an independent pricing service.

If the fund determines that the market price for an investment is not readily available or the valuation methods mentioned above do not reflect an investment’s fair value, such investment is valued as determined in good faith by the Board of Directors or its delegate, in accordance with policies and procedures adopted by the Board of Directors. In its determination of fair value, the fund may review several factors including, but not limited to, market information regarding the specific investment or comparable investments and correlation with other investment types, futures indices or general market indicators. Circumstances that may cause the fund to use these procedures to value an investment include, but are not limited to: an investment has been declared in default or is distressed; trading in a security has been suspended during the trading day or a security is not actively trading on its principal exchange; prices received from a regular pricing source are deemed unreliable; or there is a foreign market holiday and no trading occurred.

14


The fund monitors for significant events occurring after the close of an investment’s primary exchange but before the fund’s NAV per share is determined. Significant events may include, but are not limited to: corporate announcements and transactions; governmental action and political unrest that could impact a specific investment or an investment sector; or armed conflicts, natural disasters and similar events that could affect investments in a specific country or region. The fund also monitors for significant fluctuations between domestic and foreign markets, as evidenced by the U.S. market or such other indicators that the Board of Directors, or its delegate, deems appropriate. The fund may apply a model-derived factor to the closing price of equity securities traded on foreign securities exchanges. The factor is based on observable market data as provided by an independent pricing service.

Security Transactions — Security transactions are accounted for as of the trade date. Net realized gains and losses are determined on the identified cost basis, which is also used for federal income tax purposes.

Investment Income — Dividend income less foreign taxes withheld, if any, is recorded as of the ex-dividend date. Distributions received on securities that represent a return of capital or long-term capital gain are recorded as a reduction of cost of investments and/or as a realized gain. The fund may estimate the components of distributions received that may be considered nontaxable distributions or long-term capital gain distributions for income tax purposes. Interest income is recorded on the accrual basis and includes accretion of discounts and amortization of premiums. Securities lending income is net of fees and rebates earned by the lending agent for its services.

Foreign Currency Translations — All assets and liabilities initially expressed in foreign currencies are translated into U.S. dollars at prevailing exchange rates at period end. The fund may enter into spot foreign currency exchange contracts to facilitate transactions denominated in a foreign currency. Purchases and sales of investment securities, dividend and interest income, spot foreign currency exchange contracts, and expenses are translated at the rates of exchange prevailing on the respective dates of such transactions. Net realized and unrealized foreign currency exchange gains or losses related to investment securities are a component of net realized gain (loss) on investment transactions and change in net unrealized appreciation (depreciation) on investments, respectively.

Repurchase Agreements — The fund may enter into repurchase agreements with institutions that American Century Investment Management, Inc. (ACIM) (the investment advisor) has determined are creditworthy pursuant to criteria adopted by the Board of Directors. The fund requires that the collateral, represented by securities, received in a repurchase transaction be transferred to the custodian in a manner sufficient to enable the fund to obtain those securities in the event of a default under the repurchase agreement. ACIM monitors, on a daily basis, the securities transferred to ensure the value, including accrued interest, of the securities under each repurchase agreement is equal to or greater than amounts owed to the fund under each repurchase agreement.

Joint Trading Account — Pursuant to an Exemptive Order issued by the Securities and Exchange Commission, the fund, along with certain other funds in the American Century Investments family of funds, may transfer uninvested cash balances into a joint trading account. These balances are invested in one or more repurchase agreements that are collateralized by U.S. Treasury or Agency obligations.

Segregated Assets — In accordance with the 1940 Act, the fund segregates assets on its books and records to cover certain types of investment securities and other financial instruments. ACIM monitors, on a daily basis, the securities segregated to ensure the fund designates a sufficient amount of liquid assets, marked-to-market daily. The fund may also receive assets or be required to pledge assets at the custodian bank or with a broker for collateral requirements.

Income Tax Status — It is the fund’s policy to distribute substantially all net investment income and net realized gains to shareholders and to otherwise qualify as a regulated investment company under provisions of the Internal Revenue Code. Accordingly, no provision has been made for income taxes. The fund files U.S. federal, state, local and non-U.S. tax returns as applicable. The fund's tax returns are subject to examination by the relevant taxing authority until expiration of the applicable statute of limitations, which is generally three years from the date of filing but can be longer in certain jurisdictions. At this time, management believes there are no uncertain tax positions which, based on their technical merit, would not be sustained upon examination and for which it is reasonably possible that the total amounts of unrecognized tax benefits will significantly change in the next twelve months.

15


Distributions to Shareholders — Distributions from net investment income and net realized gains, if any, are generally declared and paid annually.

Indemnifications — Under the corporation’s organizational documents, its officers and directors are indemnified against certain liabilities arising out of the performance of their duties to the fund. In addition, in the normal course of business, the fund enters into contracts that provide general indemnifications. The maximum exposure under these arrangements is unknown as this would involve future claims that may be made against a fund. The risk of material loss from such claims is considered by management to be remote.

Securities Lending — Securities are lent to qualified financial institutions and brokers. State Street Bank & Trust Co. serves as securities lending agent to the fund pursuant to a Securities Lending Agreement. The lending of securities exposes the fund to risks such as: the borrowers may fail to return the loaned securities, the borrowers may not be able to provide additional collateral, the fund may experience delays in recovery of the loaned securities or delays in access to collateral, or the fund may experience losses related to the investment collateral. To minimize certain risks, loan counterparties pledge collateral in the form of cash and/or securities. The lending agent has agreed to indemnify the fund in the case of default of any securities borrowed. Cash collateral received is invested in the State Street Navigator Securities Lending Government Money Market Portfolio, a money market mutual fund registered under the 1940 Act. The loans may also be secured by U.S. government securities in an amount at least equal to the market value of the securities loaned, plus accrued interest and dividends, determined on a daily basis and adjusted accordingly. By lending securities, the fund seeks to increase its net investment income through the receipt of interest and fees. Such income is reflected separately within the Statement of Operations. The value of loaned securities and related collateral outstanding at period end, if any, are shown on a gross basis within the Schedule of Investments and Statement of Assets and Liabilities.

The following table reflects a breakdown of transactions accounted for as secured borrowings, the gross obligation by the type of collateral pledged, and the remaining contractual maturity of those transactions as of October 31, 2021.
Remaining Contractual Maturity of Agreements
Overnight and
Continuous
<30 days
Between
30 & 90 days
>90 days
Total
Securities Lending Transactions(1)
Common Stocks$8,962,020 — — — $8,962,020 
Gross amount of recognized liabilities for securities lending transactions$8,962,020 
(1)Amount represents the payable for cash collateral received for securities on loan. This will generally be in the Overnight and Continuous column as the securities are typically callable on demand.

3. Fees and Transactions with Related Parties

Certain officers and directors of the corporation are also officers and/or directors of American Century Companies, Inc. (ACC). The corporation’s investment advisor, ACIM, the corporation's distributor, American Century Investment Services, Inc., and the corporation’s transfer agent, American Century Services, LLC, are wholly owned, directly or indirectly, by ACC. Various funds issued by American Century Asset Allocation Portfolios, Inc. own, in aggregate, 53% of the shares of the fund. Related parties do not invest in the fund for the purpose of exercising management or control.

Management Fees — The corporation has entered into a management agreement with ACIM, under which ACIM provides the fund with investment advisory and management services in exchange for a single, unified management fee (the fee). The agreement provides that ACIM will pay all expenses of managing and operating the fund, except brokerage expenses, taxes, interest, fees and expenses of the independent directors (including legal counsel fees), and extraordinary expenses. The fee is computed and accrued daily based on the daily net assets of the fund and paid monthly in arrears. The rate of the fee is determined by applying a fee rate calculation formula. This formula takes into account the fund’s assets as well as certain assets, if any, of other clients of the investment advisor outside the American Century Investments family of funds (such as subadvised funds and separate accounts) that use very similar investment teams and strategies (strategy assets). The strategy assets of the fund also include the assets of Growth Fund, one fund in a series issued by the corporation. The management fee schedule ranges from 0.450% to 0.640%. The investment advisor agreed to waive the fund's management fee in its entirety. The investment advisor expects this waiver to remain in effect permanently and cannot terminate it without the approval of the Board of Directors. The effective annual management fee for the period ended October 31, 2021 was 0.61% before waiver and 0.00% after waiver.
16


Directors' Fees and Expenses — The Board of Directors is responsible for overseeing the investment advisor’s management and operations of the fund. The directors receive detailed information about the fund and its investment advisor regularly throughout the year, and meet at least quarterly with management of the investment advisor to review reports about fund operations. The fund’s officers do not receive compensation from the fund.

Interfund Transactions — The fund may enter into security transactions with other American Century Investments funds and other client accounts of the investment advisor, in accordance with the 1940 Act rules and procedures adopted by the Board of Directors. The rules and procedures require, among other things, that these transactions be effected at the independent current market price of the security. During the period, the interfund purchases were $527,190 and there were no interfund sales.

4. Investment Transactions

Purchases and sales of investment securities, excluding short-term investments, for the period ended October 31, 2021 were $448,919,987 and $630,343,037, respectively.

5. Fair Value Measurements

The fund’s investments valuation process is based on several considerations and may use multiple inputs to determine the fair value of the investments held by the fund. In conformity with accounting principles generally accepted in the United States of America, the inputs used to determine a valuation are classified into three broad levels.

Level 1 valuation inputs consist of unadjusted quoted prices in an active market for identical investments.

Level 2 valuation inputs consist of direct or indirect observable market data (including quoted prices for comparable investments, evaluations of subsequent market events, interest rates, prepayment speeds, credit risk, etc.). These inputs also consist of quoted prices for identical investments initially expressed in local currencies that are adjusted through translation into U.S. dollars.

Level 3 valuation inputs consist of unobservable data (including a fund’s own assumptions).

The level classification is based on the lowest level input that is significant to the fair valuation measurement. The valuation inputs are not necessarily an indication of the risks associated with investing in these securities or other financial instruments.
The following is a summary of the level classifications as of period end. The Schedule of Investments provides additional information on the fund’s portfolio holdings.
Level 1Level 2Level 3
Assets
Investment Securities
Common Stocks$1,616,437,861 $34,818,864 — 
Temporary Cash Investments817,998 37,119,655 — 
Temporary Cash Investments - Securities Lending Collateral8,962,020 — — 
$1,626,217,879 $71,938,519 — 
Other Financial Instruments
Futures Contracts$1,340,123 — — 
Forward Foreign Currency Exchange Contracts— $399,693 — 
$1,340,123 $399,693 — 
Liabilities
Other Financial Instruments
Forward Foreign Currency Exchange Contracts— $33,335 — 




17


6. Derivative Instruments

Equity Price Risk — The fund is subject to equity price risk in the normal course of pursuing its investment objectives. A fund may enter into futures contracts based on an equity index in order to manage its exposure to changes in market conditions. A fund may purchase futures contracts to gain exposure to increases in market value or sell futures contracts to protect against a decline in market value. Upon entering into a futures contract, a fund is required to deposit either cash or securities in an amount equal to a certain percentage of the contract value (initial margin). Subsequent payments (variation margin) are made or received daily, in cash, by a fund. The variation margin is equal to the daily change in the contract value and is recorded as unrealized gains and losses. A fund recognizes a realized gain or loss when the contract is closed or expires. Net realized and unrealized gains or losses occurring during the holding period of futures contracts are a component of net realized gain (loss) on futures contract transactions and change in net unrealized appreciation (depreciation) on futures contracts, respectively. One of the risks of entering into futures contracts is the possibility that the change in value of the contract may not correlate with the changes in value of the underlying securities. The fund's average notional exposure to equity price risk derivative instruments held during the period was $14,191,742 futures contracts purchased.

Foreign Currency Risk — The fund is subject to foreign currency exchange rate risk in the normal course of pursuing its investment objectives. The value of foreign investments held by a fund may be significantly affected by changes in foreign currency exchange rates. The dollar value of a foreign security generally decreases when the value of the dollar rises against the foreign currency in which the security is denominated and tends to increase when the value of the dollar declines against such foreign currency. A fund may enter into forward foreign currency exchange contracts to reduce a fund's exposure to foreign currency exchange rate fluctuations. The net U.S. dollar value of foreign currency underlying all contractual commitments held by a fund and the resulting unrealized appreciation or depreciation are determined daily. Realized gain or loss is recorded upon settlement of the contract. Net realized and unrealized gains or losses occurring during the holding period of forward foreign currency exchange contracts are a component of net realized gain (loss) on forward foreign currency exchange contract transactions and change in net unrealized appreciation (depreciation) on forward foreign currency exchange contracts, respectively. A fund bears the risk of an unfavorable change in the foreign currency exchange rate underlying the forward contract. Additionally, losses, up to the fair value, may arise if the counterparties do not perform under the contract terms. The fund's average U.S. dollar exposure to foreign currency risk derivative instruments held during the period was $30,039,280.

Value of Derivative Instruments as of October 31, 2021
Asset Derivatives
Liability Derivatives
Type of Risk ExposureLocation on Statement of Assets and Liabilities
Value
Location on Statement of Assets and Liabilities
Value
Equity Price RiskReceivable for variation margin on futures contracts*$305,027 Payable for variation margin on futures contracts*— 
Foreign Currency RiskUnrealized appreciation on forward foreign currency exchange contracts399,693 Unrealized depreciation on forward foreign currency exchange contracts$33,335 
$704,720 $33,335 
*Included in the unrealized appreciation (depreciation) on futures contracts, as reported in the Schedule of Investments.

Effect of Derivative Instruments on the Statement of Operations for the Year Ended October 31, 2021
Net Realized Gain (Loss)
Change in Net Unrealized
Appreciation (Depreciation)
Type of Risk ExposureLocation on Statement of Operations
Value
Location on Statement of Operations
Value
Equity Price RiskNet realized gain (loss) on futures contract transactions$1,598,437 Change in net unrealized appreciation (depreciation) on futures contracts$1,340,123 
Foreign Currency RiskNet realized gain (loss) on forward foreign currency exchange contract transactions268,276 Change in net unrealized appreciation (depreciation) on forward foreign currency exchange contracts267,900 
$1,866,713 $1,608,023 

18


7. Risk Factors

The value of the fund’s shares will go up and down, sometimes rapidly or unpredictably, based on the performance of the securities owned by the fund and other factors generally affecting the securities market. Market risks, including political, regulatory, economic and social developments, can affect the value of the fund’s investments. Natural disasters, public health emergencies, terrorism and other unforeseeable events may lead to increased market volatility and may have adverse long-term effects on world economies and markets generally.

The fund is owned by a relatively small number of shareholders, and in the event such shareholders redeem, the ongoing operations of the fund may be at risk.

8. Federal Tax Information

On December 7, 2021, the fund declared and paid per-share distributions of $1.8393 and $0.2001 from net realized gains and net investment income, respectively, to shareholders of record on December 6, 2021.

The tax character of distributions paid during the years ended October 31, 2021 and October 31, 2020 were as follows:
20212020
Distributions Paid From
Ordinary income$9,439,077 $16,872,974 
Long-term capital gains$146,783,456 $104,892,961 

The book-basis character of distributions made during the year from net investment income or net realized gains may differ from their ultimate characterization for federal income tax purposes. These differences reflect the differing character of certain income items and net realized gains and losses for financial statement and tax purposes, and may result in reclassification among certain capital accounts on the financial statements.

As of period end, the federal tax cost of investments and the components of distributable earnings on a tax-basis were as follows:

Federal tax cost of investments$819,757,297 
Gross tax appreciation of investments$886,372,509 
Gross tax depreciation of investments(7,973,408)
Net tax appreciation (depreciation) of investments878,399,101 
Net tax appreciation (depreciation) on derivatives and translation of assets and
liabilities in foreign currencies
1,306 
Net tax appreciation (depreciation) $878,400,407 
Undistributed ordinary income$53,926,673 
Accumulated long-term gains$71,144,770 

The difference between book-basis and tax-basis unrealized appreciation (depreciation) is attributable primarily to the tax deferral of losses on wash sales.

9. Corporate Event

On December 2, 2021, the Board of Directors approved an agreement and plan of reorganization (the reorganization), whereby the net assets of the fund will be transferred to Growth Fund, one fund in a series issued by the corporation, in exchange for shares of Growth Fund. The financial statements and performance history of Growth Fund will survive after the reorganization. The reorganization is expected to be completed in 2022.
19


Financial Highlights
For a Share Outstanding Throughout the Years Ended October 31 (except as noted)
Per-Share DataRatios and Supplemental Data
Income From Investment Operations:Distributions From:Ratio to Average Net Assets of:
Net Asset Value, Beginning of Period
Net
Investment
Income
(Loss)(1)
Net Realized and Unrealized Gain (Loss)Total From
Investment
Operations
Net
Investment
Income
Net
Realized
Gains
Total
Distributions
Net Asset
Value,
End
of Period
Total
Return(2)
Operating
Expenses
Operating
Expenses
(before
expense
waiver)
Net
Investment
Income
(Loss)
Net
Investment
Income
(Loss)
(before
expense
waiver)
Portfolio
Turnover
Rate
Net
Assets,
End of
Period
(in thousands)
G Class
2021$20.000.138.128.25(0.10)(2.32)(2.42)$25.8344.81%
0.00%(3)
0.61%0.60%(0.01)%30%$1,689,020 
2020$18.160.174.294.46(0.27)(2.35)(2.62)$20.0027.44%0.01%0.63%0.92%0.30%40%$1,282,716 
2019$18.590.202.412.61(0.22)(2.82)(3.04)$18.1618.16%
0.00%(3)
0.63%1.20%0.57%43%$1,077,235 
2018$18.380.201.802.00(0.13)(1.66)(1.79)$18.5911.50%
0.00%(3)
0.62%1.09%0.47%53%$1,159,387 
2017$14.620.114.004.11(0.12)(0.23)(0.35)$18.3828.64%0.56%0.74%0.67%0.49%64%$1,364,741 
Notes to Financial Highlights
(1)Computed using average shares outstanding throughout the period.
(2)Total returns are calculated based on the net asset value of the last business day. Total returns for periods less than one year are not annualized.
(3)Ratio was less than 0.005%.


See Notes to Financial Statements.



Report of Independent Registered Public Accounting Firm

To the Shareholders and the Board of Directors of American Century Mutual Funds, Inc.:

Opinion on the Financial Statements and Financial Highlights

We have audited the accompanying statement of assets and liabilities, including the schedule of investments, of NT Growth Fund (the “Fund”), one of the funds constituting the American Century Mutual Funds, Inc., as of October 31, 2021, the related statement of operations for the year then ended, the statements of changes in net assets for each of the two years in the period then ended, the financial highlights for each of the five years in the period then ended, and the related notes. In our opinion, the financial statements and financial highlights present fairly, in all material respects, the financial position of NT Growth Fund of the American Century Mutual Funds, Inc. as of October 31, 2021, and the results of its operations for the year then ended, the changes in its net assets for each of the two years in the period then ended, and the financial highlights for each of the five years in the period then ended, in conformity with accounting principles generally accepted in the United States of America.

Basis for Opinion

These financial statements and financial highlights are the responsibility of the Fund's management. Our responsibility is to express an opinion on the Fund’s financial statements and financial highlights based on our audits. We are a public accounting firm registered with the Public Company Accounting Oversight Board (United States) (PCAOB) and are required to be independent with respect to the Fund in accordance with the U.S. federal securities laws and the applicable rules and regulations of the Securities and Exchange Commission and the PCAOB.

We conducted our audits in accordance with the standards of the PCAOB. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements and financial highlights are free of material misstatement, whether due to error or fraud. The Fund is not required to have, nor were we engaged to perform, an audit of its internal control over financial reporting. As part of our audits we are required to obtain an understanding of internal control over financial reporting but not for the purpose of expressing an opinion on the effectiveness of the Fund’s internal control over financial reporting. Accordingly, we express no such opinion.

Our audits included performing procedures to assess the risks of material misstatement of the financial statements and financial highlights, whether due to error or fraud, and performing procedures that respond to those risks. Such procedures included examining, on a test basis, evidence regarding the amounts and disclosures in the financial statements and financial highlights. Our audits also included evaluating the accounting principles used and significant estimates made by management, as well as evaluating the overall presentation of the financial statements and financial highlights. Our procedures included confirmation of securities owned as of October 31, 2021, by correspondence with the custodian and brokers; when replies were not received from brokers, we performed other auditing procedures. We believe that our audits provide a reasonable basis for our opinion.

/s/ Deloitte & Touche LLP

Kansas City, Missouri
December 15, 2021

We have served as the auditor of one or more American Century investment companies since 1997.
21


Management

The Board of Directors

The individuals listed below serve as directors of the funds. Each director will continue to serve in this capacity until death, retirement, resignation or removal from office. The board has adopted a mandatory retirement age for directors who are not “interested persons,” as that term is defined in the Investment Company Act (independent directors). Independent directors shall retire by December 31 of the year in which they reach their 75th birthday.
Jonathan S.Thomas is an “interested person” because he currently serves as President and Chief Executive Officer of American Century Companies, Inc. (ACC), the parent company of American Century Investment Management, Inc. (ACIM or the advisor). The other directors (more than three-fourths of the total number) are independent. They are not employees, directors or officers of, and have no financial interest in, ACC or any of its wholly owned, direct or indirect, subsidiaries, including ACIM, American Century Investment Services, Inc. (ACIS) and American Century Services, LLC (ACS), and they do not have any other affiliations, positions or relationships that would cause them to be considered “interested persons” under the Investment Company Act. The directors serve in this capacity for seven (in the case of Jonathan S. Thomas, 16; and Stephen E. Yates, 8) registered investment companies in the American Century Investments family of funds.
The following table presents additional information about the directors. The mailing address for each director is 4500 Main Street, Kansas City, Missouri 64111.
Name
(Year of Birth)
Position(s) Held with FundsLength of Time ServedPrincipal Occupation(s) During Past 5 YearsNumber of American Century Portfolios Overseen by DirectorOther Directorships Held During Past 5 Years
Independent Directors
Thomas W. Bunn (1953)DirectorSince 2017Retired72SquareTwo Financial; Barings (formerly Babson Capital Funds Trust) (2013 to 2016)
Chris H. Cheesman
(1962)
DirectorSince 2019
Retired. Senior Vice President & Chief Audit Executive, AllianceBernstein (1999 to 2018)72Alleghany Corporation
Barry Fink
(1955)
DirectorSince 2012 (independent since 2016)Retired72None
Rajesh K. Gupta
(1960)
DirectorSince 2019
Partner Emeritus, SeaCrest Investment Management and SeaCrest Wealth Management (2019 to Present); Chief Executive Officer and Chief Investment Officer, SeaCrest Investment Management (2006 to 2019); Chief Executive Officer and Chief Investment Officer, SeaCrest Wealth Management (2008 to 2019)72None
22


Name
(Year of Birth)
Position(s) Held with FundsLength of Time ServedPrincipal Occupation(s) During Past 5 YearsNumber of American Century Portfolios Overseen by DirectorOther Directorships Held During Past 5 Years
Independent Directors
Lynn Jenkins
(1963)
DirectorSince 2019
Consultant, LJ Strategies (2019 to present); United States Representative, U.S. House of Representatives (2009 to 2018)72MGP Ingredients, Inc. (2019 to 2021)
Jan M. Lewis
(1957)
DirectorSince 2011Retired72None
John R. Whitten
(1946)
DirectorSince 2008Retired72Onto Innovation Inc. (2019 to 2020); Rudolph Technologies, Inc. (2006 to 2019)
Stephen E. Yates
(1948)
Director and Chairman of the BoardSince 2012 (Chairman since 2018)Retired107None
Interested Director
Jonathan S. Thomas
(1963)
DirectorSince 2007President and Chief Executive Officer, ACC (2007 to present). Also serves as Chief Executive Officer, ACS; Director, ACC and other ACC subsidiaries145None
The Statement of Additional Information has additional information about the fund's directors and is available without charge, upon request, by calling 1-800-345-2021.
23


Officers

The following table presents certain information about the executive officers of the funds. Each officer serves as an officer for 16 (in the case of Robert J. Leach, 15) investment companies in the American Century family of funds. No officer is compensated for his or her service as an officer of the funds. The listed officers are interested persons of the funds and are appointed or re-appointed on an annual basis. The mailing address for each officer listed below is 4500 Main Street, Kansas City, Missouri 64111.
Name
(Year of Birth)
Offices with the FundsPrincipal Occupation(s) During the Past Five Years
Patrick Bannigan
(1965)
President since 2019Executive Vice President and Director, ACC (2012 to present); Chief Financial Officer, Chief Accounting Officer and Treasurer, ACC (2015 to present). Also serves as President, ACS; Vice President, ACIM; Chief Financial Officer, Chief Accounting Officer and/or Director, ACIM, ACS and other ACC subsidiaries
R. Wes Campbell
(1974)
Chief Financial Officer and Treasurer since 2018Vice President, ACS, (2020 to present); Investment Operations and Investment Accounting, ACS (2000 to present)
Amy D. Shelton
(1964)
Chief Compliance Officer and Vice President since 2014Chief Compliance Officer, American Century funds, (2014 to present); Chief Compliance Officer, ACIM (2014 to present); Chief Compliance Officer, ACIS (2009 to present). Also serves as Vice President, ACIS
John Pak
(1968)
General Counsel and
Senior Vice President since 2021
General Counsel and Senior Vice President, ACC (2021 to present). Also serves as General Counsel and Senior Vice President, ACIM, ACS and ACIS. Chief Legal Officer of Investment and Wealth Management, The Bank of New York Mellon (2014 to 2021)
C. Jean Wade
(1964)
Vice President since 2012Senior Vice President, ACS (2017 to present); Vice President, ACS (2000 to 2017)
Robert J. Leach
(1966)
Vice President since 2006 Vice President, ACS (2000 to present)
David H. Reinmiller
(1963)
Vice President since 2000Attorney, ACC (1994 to present). Also serves as Vice President, ACIM and ACS
Ward D. Stauffer
(1960)
Secretary since 2005Attorney, ACC (2003 to present)





24


Approval of Management Agreement

At a meeting held on June 30, 2021, the Fund’s Board of Directors (the "Board") unanimously approved the renewal of the management agreement pursuant to which American Century Investment Management, Inc. (the “Advisor”) acts as the investment advisor for the Fund. Under Section 15(c) of the Investment Company Act, contracts for investment advisory services are required to be reviewed, evaluated, and approved by a majority of a fund’s directors (the “Directors”), including a majority of the independent Directors, each year.

Prior to its consideration of the renewal of the management agreement, the Directors requested and reviewed extensive data and information compiled by the Advisor and certain independent providers of evaluation data concerning the Fund and the services provided to the Fund by the Advisor. This review was in addition to the oversight and evaluation undertaken by the Board and its committees on a continual basis and the information received was supplemental to the extensive information that the Board and its committees receive and consider throughout the year.

In connection with its consideration of the renewal of the management agreement, the Board’s review and evaluation of the services provided by the Advisor and its affiliates included, but was not limited to, the following:

the nature, extent, and quality of investment management, shareholder services, and other services provided and to be provided to the Fund including without limitation portfolio management and trading services, shareholder and intermediary services, compliance and legal services, fund accounting and financial reporting, and fund share distribution;
the wide range of other programs and services provided and to be provided to the Fund and its shareholders on a routine and non-routine basis;
the Fund’s investment performance, including data comparing the Fund's performance to appropriate benchmarks and/or a peer group of other mutual funds with similar investment objectives and strategies;
the cost of owning the Fund compared to the cost of owning similar funds;
the compliance policies, procedures, and regulatory experience of the Advisor and the Fund's service providers;
the Advisor’s strategic plans, COVID-19 pandemic response, vendor management practices, and social justice initiatives;
the Advisor’s business continuity plans and cyber security practices;
financial data showing the cost of services provided to the Fund, the profitability of the Fund to the Advisor, and the overall profitability of the Advisor;
possible economies of scale associated with the Advisor’s management of the Fund and other accounts;
services provided and charges to the Advisor's other investment management clients;
acquired fund fees and expenses;
payments and practices in connection with financial intermediaries holding shares of the Fund and the services provided by intermediaries in connection therewith; and
possible collateral benefits to the Advisor from the management of the Fund.

The Board held two meetings to consider the renewal and formed a subcommittee to evaluate the Fund’s competitive market. The independent Directors also met in private session three times to review and discuss the information provided in response to their request. The independent Directors held active discussions with the Advisor regarding the renewal of the management agreement, requesting supplemental information, and reviewing information provided by the Advisor in response thereto. The independent Directors had the benefit of the advice of their independent counsel throughout the process.


25


Factors Considered

The Directors considered all of the information provided by the Advisor, the independent data providers, and independent counsel in connection with the approval. They determined that the information was sufficient for them to evaluate the management agreement for the Fund. In connection with their review, the Directors did not identify any single factor as being all-important or controlling, and each Director may have attributed different levels of importance to different factors. In deciding to renew the management agreement, the Board based its decision on a number of factors, including without limitation the following:

Nature, Extent and Quality of Services — Generally. Under the management agreement, the Advisor is responsible for providing or arranging for all services necessary for the operation of the Fund. The Board noted that the Advisor provides or arranges at its own expense a wide variety of services which include the following:

constructing and designing the Fund
portfolio research and security selection
initial capitalization/funding
securities trading
Fund administration
custody of Fund assets
daily valuation of the Fund’s portfolio
liquidity monitoring and management
risk management, including cyber security
shareholder servicing and transfer agency, including shareholder confirmations, recordkeeping, and communications
legal services (except the independent Directors’ counsel)
regulatory and portfolio compliance
financial reporting
marketing and distribution (except amounts paid by the Fund under Rule 12b-1 plans)

The Board noted that many of these services have expanded over time in terms of both quantity and complexity in response to shareholder demands, competition in the industry, changing distribution channels, and the changing regulatory environment.

Investment Management Services. The nature of the investment management services provided to the Fund is quite complex and allows Fund shareholders access to professional money management, instant diversification of their investments within an asset class, the opportunity to easily diversify among asset classes by investing in or exchanging among various American Century Investments funds, and liquidity. In evaluating investment performance, the Board expects the Advisor to manage the Fund in accordance with its investment objectives and approved strategies. Further, the Directors recognize that the Advisor has an obligation to monitor trading activities, and in particular to seek the best execution of fund trades, and to evaluate the use of and payment for research. In providing these services, the Advisor utilizes teams of investment professionals (portfolio managers, analysts, research assistants, and securities traders) who require extensive information technology, research, training, compliance, and other systems to conduct their business. The Board, directly and through its Fund Performance Review Committee, provides oversight of the investment performance process. It regularly reviews investment performance information for the Fund, together with comparative information for appropriate benchmarks and/or peer groups of similarly-managed funds, over different time horizons. The Directors also review investment performance information during the management agreement renewal process. If performance concerns are identified, the Fund receives special reviews until performance improves, during which the Board discusses with the Advisor the reasons for such results (e.g., market conditions, security selection) and any efforts being undertaken to improve performance. The Fund’s performance was below its benchmark for the one-, three-, five-, and ten-year periods reviewed by the Board. The Board found the investment management services provided by the Advisor to the Fund to be satisfactory and consistent with the management agreement.
26


Shareholder and Other Services. Under the management agreement, the Advisor provides the Fund with a comprehensive package of transfer agency, shareholder, and other services. The Board, directly and through its various committees, regularly reviews reports and evaluations of such services at its regular meetings. These reports include, but are not limited to, information regarding the operational efficiency and accuracy of the shareholder and transfer agency services provided, staffing levels, shareholder satisfaction, technology support (including cyber security), new products and services offered to Fund shareholders, securities trading activities, portfolio valuation services, auditing services, and legal and operational compliance activities. The Board found the services provided by the Advisor to the Fund under the management agreement to be competitive and of high quality.

Costs of Services and Profitability. The Advisor provides detailed information concerning its cost of providing various services to the Fund, its profitability in managing the Fund (pre- and post-distribution), its overall profitability, and its financial condition. The Directors have reviewed with the Advisor the methodology used to prepare this financial information. This information is considered in evaluating the Advisor’s financial condition, its ability to continue to provide services under the management agreement, and the reasonableness of the current management fee. The Board concluded that the Advisor’s profits were reasonable in light of the services provided to the Fund.

Ethics. The Board generally considers the Advisor’s commitment to providing quality services to shareholders and to conducting its business ethically. They noted that the Advisor’s practices generally meet or exceed industry best practices.

Economies of Scale. The Board also reviewed information provided by the Advisor regarding the possible existence of economies of scale in connection with the management of the Fund. The Board concluded that economies of scale are difficult to measure and predict with precision, especially on a fund-by-fund basis. The Board concluded that the Advisor is sharing economies of scale, to the extent they exist, through its competitive fee structure, offering competitive fees from fund inception, and through reinvestment in its business, infrastructure, investment capabilities and initiatives to provide shareholders additional content and services.

Comparison to Other Funds’ Fees. The management agreement provides that the Fund pays the Advisor a single, all-inclusive (or unified) management fee for providing all services necessary for the management and operation of the Fund, other than brokerage expenses, expenses attributable to short sales, taxes, interest, extraordinary expenses, fees and expenses of the Fund’s independent Directors (including their independent legal counsel), and expenses incurred in connection with the provision of shareholder services and distribution services under a plan adopted pursuant to Rule 12b-1 under the Investment Company Act. Under the unified fee structure, the Advisor is responsible for providing all investment advisory, custody, audit, administrative, compliance, recordkeeping, marketing and shareholder services, or arranging and supervising third parties to provide such services. By contrast, most other funds are charged a variety of fees, including an investment advisory fee, a transfer agency fee, an administrative fee, distribution charges, and other expenses. Other than their investment advisory fees and any applicable Rule 12b-1 distribution fees, all other components of the total fees charged by these other funds may be increased without shareholder approval. The Board believes the unified fee structure is a benefit to Fund shareholders because it clearly discloses to shareholders the cost of owning Fund shares, and, since the unified fee cannot be increased without a vote of Fund shareholders, it shifts to the Advisor the risk of increased costs of operating the Fund and provides a direct incentive to minimize administrative inefficiencies. Part of the Board’s analysis of fee levels involves reviewing certain evaluative data compiled by an independent provider comparing the Fund’s unified fee to the total expense ratios of its peers. The unified fee charged to shareholders of the Fund was above the median of the total expense ratios of the Fund’s peer expense universe. In addition, the Board reviewed the Fund’s position relative to the narrower set of its expense group peers. The Board and the Advisor agreed to a temporary reduction of the Fund's fee schedule that should have the effect of lowering the Fund's annual unified management fee by approximately 0.02% (e.g., the G Class unified fee will be reduced from 0.62% to 0.60%), for at least one year, beginning August 1, 2021. The Board concluded that the management fee paid by the Fund to the Advisor under the management agreement is reasonable in light of the services provided to the Fund.

27


Comparison to Fees and Services Provided to Other Clients of the Advisor. The Board also requested and received information from the Advisor concerning the nature of the services, fees, costs, and profitability of its advisory services to advisory clients other than the Fund. They observed that these varying types of client accounts require different services and involve different regulatory and entrepreneurial risks than the management of the Fund. The Board analyzed this information and concluded that the fees charged and services provided to the Fund were reasonable by comparison.

Payments to Intermediaries. The Directors also requested and received a description of payments made to intermediaries by the Fund and the Advisor and services provided in response thereto. These payments include various payments made by the Fund or the Advisor to different types of intermediaries and recordkeepers for distribution and service activities provided for the Fund. The Directors reviewed such information and received representations from the Advisor that all such payments by the Fund were made pursuant to the Fund's Rule 12b-1 Plan and that all such payments by the Advisor were made from the Advisor’s resources and reasonable profits. The Board found such payments to be reasonable in scope and purpose.

Collateral or “Fall-Out” Benefits Derived by the Advisor. The Board considered the possible existence of collateral benefits the Advisor may receive as a result of its relationship with the Fund. They concluded that the Advisor’s primary business is managing funds and it generally does not use fund or shareholder information to generate profits in other lines of business, and therefore does not derive any significant collateral benefits from them. To the extent there are potential collateral benefits, the Board has been advised and has taken this into consideration in its review of the management contract with the Fund. The Board noted that additional assets from other clients may offer the Advisor some benefit from increased leverage with service providers and counterparties. Additionally, the Advisor may receive proprietary research from broker-dealers that execute fund portfolio transactions, which the Board concluded is likely to benefit other clients of the Advisor, as well as Fund shareholders. The Board also determined that the Advisor is able to provide investment management services to certain clients other than the Fund, at least in part, due to its existing infrastructure built to serve the fund complex. The Board concluded that appropriate allocation methodologies had been employed to assign resources and the cost of those resources to these other clients.

Existing Relationship. The Board also considered whether there was any reason for not continuing the existing arrangement with the Advisor. In this regard, the Board was mindful of the potential disruptions of the Fund’s operations and various risks, uncertainties, and other effects that could occur as a result of a decision not to continue such relationship. In particular, the Board recognized that most shareholders have invested in the Fund on the strength of the Advisor’s industry standing and reputation and in the expectation that the Advisor will have a continuing role in providing advisory services to the Fund.

Conclusion of the Directors. As a result of this process, the Board, including all of the independent Directors, taking into account all of the factors discussed above and the information provided by the Advisor and others in connection with its review and throughout the year, determined that the management fee is fair and reasonable in light of the services provided and that the investment management agreement between the Fund and the Advisor should be renewed.
28


Additional Information

Retirement Account Information

As required by law, distributions you receive from certain retirement accounts are subject to federal income tax withholding, unless you elect not to have withholding apply*. Tax will be withheld on the total amount withdrawn even though you may be receiving amounts that are not subject to withholding, such as nondeductible contributions. In such case, excess amounts of withholding could occur. You may adjust your withholding election so that a greater or lesser amount will be withheld.
If you don’t want us to withhold on this amount, you must notify us to not withhold the federal income tax. You may notify us in writing or in certain situations by telephone or through other electronic means. For systematic withdrawals, your withholding election will remain in effect until revoked or changed by filing a new election. You have the right to revoke your election at any time and change your withholding percentage for future distributions.
Remember, even if you elect not to have income tax withheld, you are liable for paying income tax on the taxable portion of your withdrawal. If you elect not to have income tax withheld or you don’t have enough income tax withheld, you may be responsible for payment of estimated tax. You may incur penalties under the estimated tax rules if your withholding and estimated tax payments are not sufficient. You can reduce or defer the income tax on a distribution by directly or indirectly rolling such distribution over to another IRA or eligible plan. You should consult your tax advisor for additional information.
State tax will be withheld if, at the time of your distribution, your address is within one of the mandatory withholding states and you have federal income tax withheld (or as otherwise required by state law). State taxes will be withheld from your distribution in accordance with the respective state rules.
*Some 403(b), 457 and qualified retirement plan distributions may be subject to 20% mandatory withholding, as they are subject to special tax and withholding rules.  Your plan administrator or plan sponsor is required to provide you with a special tax notice explaining those rules at the time you request a distribution.  If applicable, federal and/or state taxes may be withheld from your distribution amount.


Proxy Voting Policies

A description of the policies that the fund's investment advisor uses in exercising the voting rights associated with the securities purchased and/or held by the fund is available without charge, upon request, by calling 1-800-345-2021. It is also available on American Century Investments’ website at americancentury.com/proxy and on the Securities and Exchange Commission’s website at sec.gov. Information regarding how the investment advisor voted proxies relating to portfolio securities during the most recent 12-month period ended June 30 is available on americancentury.com/proxy. It is also available at sec.gov.


Quarterly Portfolio Disclosure

The fund files its complete schedule of portfolio holdings with the Securities and Exchange Commission (SEC) for the first and third quarters of each fiscal year as an exhibit to its reports on Form N-PORT. These portfolio holdings are available on the fund's website at americancentury.com and, upon request, by calling 1-800-345-2021. The fund’s Form N-PORT reports are available on the SEC’s website at sec.gov.




29


Other Tax Information

The following information is provided pursuant to provisions of the Internal Revenue Code.

The fund hereby designates up to the maximum amount allowable as qualified dividend income for the fiscal year ended October 31, 2021.

For corporate taxpayers, the fund hereby designates $6,889,771, or up to the maximum amount allowable, of ordinary income distributions paid during the fiscal year ended October 31, 2021 as qualified for the corporate dividends received deduction.

The fund hereby designates $146,783,456 or up to the maximum amount allowable, as long-term capital gain distributions (20% rate gain distributions) for the fiscal year ended October 31, 2021.

The fund hereby designates $2,750,374 as qualified short-term capital gain distributions for purposes of Internal Revenue Code Section 871 for the fiscal year ended October 31, 2021.
30


Notes


31


Notes
32






image8.jpg
Contact Usamericancentury.com
Automated Information Line1-800-345-8765
Investor Services Representative1-800-345-2021
or 816-531-5575
Investors Using Advisors1-800-378-9878
Business, Not-For-Profit, Employer-Sponsored Retirement Plans1-800-345-3533
Banks and Trust Companies, Broker-Dealers, Financial Professionals, Insurance Companies1-800-345-6488
Telecommunications Relay Service for the Deaf711
American Century Mutual Funds, Inc.
Investment Advisor:
American Century Investment Management, Inc.
Kansas City, Missouri
This report and the statements it contains are submitted for the general information of our shareholders. The report is not authorized for distribution to prospective investors unless preceded or accompanied by an effective prospectus.
©2021 American Century Proprietary Holdings, Inc. All rights reserved.
CL-ANN-90986 2112




    


image8.jpg
Annual Report
October 31, 2021
NT Heritage Fund
G Class (ACLWX)






























Table of Contents

Performance
Portfolio Commentary
Fund Characteristics
Shareholder Fee Example
Schedule of Investments
Statement of Assets and Liabilities
Statement of Operations
Statement of Changes in Net Assets
Notes to Financial Statements
Financial Highlights
Report of Independent Registered Public Accounting Firm
Management
Approval of Management Agreement
Additional Information




















Any opinions expressed in this report reflect those of the author as of the date of the report, and do not necessarily represent the opinions of American Century Investments® or any other person in the American Century Investments organization. Any such opinions are subject to change at any time based upon market or other conditions and American Century Investments disclaims any responsibility to update such opinions. These opinions may not be relied upon as investment advice and, because investment decisions made by American Century Investments funds are based on numerous factors, may not be relied upon as an indication of trading intent on behalf of any American Century Investments fund. Security examples are used for representational purposes only and are not intended as recommendations to purchase or sell securities. Performance information for comparative indices and securities is provided to American Century Investments by third party vendors. To the best of American Century Investments’ knowledge, such information is accurate at the time of printing.



Performance
Total Returns as of October 31, 2021
Average Annual Returns
 Ticker
Symbol
1 year5 years10 yearsInception
Date
G ClassACLWX41.75%22.54%16.01%5/12/06
Russell Midcap Growth Index39.43%21.89%16.84%
Fund returns would have been lower if a portion of the fees had not been waived.

Extraordinary performance is attributable in part to unusually favorable market conditions and may not be repeated or consistently achieved in the future.

Growth of $10,000 Over 10 Years
$10,000 investment made October 31, 2011
 chart-63ddaaa6d72445d6a06a.jpg
Value on October 31, 2021
G Class — $44,206
Russell Midcap Growth Index — $47,478
Ending value of G Class would have been lower if a portion of the fees had not been waived.

Total Annual Fund Operating Expenses
G Class0.66%
The total annual fund operating expenses shown is as stated in the fund’s prospectus current as of the date of this report. The prospectus may vary from the expense ratio shown elsewhere in this report because it is based on a different time period, includes acquired fund fees and expenses, and, if applicable, does not include fee waivers or expense reimbursements.




Data presented reflect past performance. Past performance is no guarantee of future results. Current performance may be higher or lower than the performance shown. Total returns for periods less than one year are not annualized. Investment return and principal value will fluctuate, and redemption value may be more or less than original cost. Data assumes reinvestment of dividends and capital gains, and none of the charts reflect the deduction of taxes that a shareholder would pay on fund distributions or the redemption of fund shares. To obtain performance data current to the most recent month end, please call 1-800-345-2021 or visit americancentury.com. For additional information about the fund, please consult the prospectus.
2


Portfolio Commentary
 
Portfolio Managers: Rob Brookby and Nalin Yogasundram

Performance Summary

NT Heritage returned 41.75%* for the 12 months ended October 31, 2021, outpacing the 39.43% return of the fund’s benchmark, the Russell Midcap Growth Index.

U.S. stocks posted strong returns during the reporting period, supported by federal government stimulus and low interest rates. The rollout of COVID-19 vaccines allowed the economy to reopen, and despite concerns about the delta variant, inflationary pressures and supply chain constraints, several market indices ended the 12-month period at record highs. Within the Russell Midcap Growth Index, energy was the top-performing sector, benefiting from increased demand as global economies began to return to more-normal conditions amid limited supplies. Consumer staples was the only sector to decline.

The information technology and materials sectors led outperformance relative to the benchmark, due primarily to stock selection. Stock decisions in the health care sector detracted.

Information Technology Led Performance

Stock selection in the software industry helped drive the information technology sector and portfolio outperformance relative to the benchmark. HubSpot provides software that allows small businesses to efficiently run and grow their businesses. It offers innovative solutions, and HubSpot benefited from growth in small business formation coming out of the recession, providing a tailwind of new customer acquisition. Atlassian was a top contributor. This software company provides collaborative tools used by small and midsize companies and increasingly larger companies. As pandemic restrictions eased and workers started returning to the office, Atlassian saw renewed growth for its software, driving strong revenue and earnings. Manhattan Associates provides cloud-based supply chain management software. The company reported better-than-expected quarterly earnings throughout the year. Manhattan Associates benefited from the restrictions due to the pandemic, and we believe the transition to online buying and curbside pickup are secular trends that fit with the company’s strengths.

Cybersecurity firm Palo Alto Networks outperformed as companies beefed up their vigilance because of increasing ransomware and other attacks. Demand for Palo Alto’s firewalls and other cloud-based offerings led to strong earnings, and management raised guidance for next year. In IT services, Square was a significant contributor. The payments company outperformed as its main businesses—small retailers and peer to peer—both benefited from the stay-at-home restrictions. Coffee shops and restaurants have had to adjust to new business models, and individuals are increasingly using digital payments. We see these as secular trends that have been accelerated by the pandemic.

Stock selection in the materials sector aided performance. Materials in general benefited from greater demand and firmer pricing due to global supply chain disruptions. Stock decisions in the chemicals industry helped drive outperformance in the sector. Albemarle was a top contributor on demand for lithium, a key ingredient of batteries for electric vehicles.

Health Care Stocks Detracted

Stock choices in the health care sector weighed on performance. Biotechnology company Moderna outperformed after it reported that its COVID-19 vaccine worked well against the virus’s more contagious delta variant. Moderna’s messenger RNA technology is also seen as having potentially




*Fund returns would have been lower if a portion of the fees had not been waived.
3


wider applications. Our lack of exposure detracted from relative results. Home health and hospice care provider Amedisys lagged after it offered disappointing forward guidance as the pandemic hurt its ability to hire and retain staff.

Other key detractors included The Boston Beer Co. The beverage company’s stock declined after management reported quarterly earnings that fell short of expectations. Much of the weakness was attributed to greater competition and lower demand in the hard seltzer market, impacting the company’s Truly brand. We eliminated our position. The stock of Las Vegas Sands, an operator of casino resorts in Macau and Singapore, was pressured by possible new dividend regulations in Macau that would be harmful to shareholders and concerns about China’s increasing interference in certain sectors. We eliminated our holding because of these uncertainties.

Splunk also hampered performance. We eliminated this security software stock because the company has had execution problems as it moves from an on-premises to a cloud-based subscription service. Additionally, its sales force experienced some leadership changes. SelectQuote offers consumers a platform to compare insurance policies. SelectQuote and the industry in general have struggled with plan persistency, the percentage of policyholders that continue paying premiums. As a result, SelectQuote offered disappointing guidance for next year. We sold our holding.

Outlook

Our process uses a combined top-down, bottom-up fundamental framework aimed at identifying mid-cap companies producing attractive, sustainable growth. We seek to reduce unintended, nonfundamental risks and align the portfolio with fundamental, company-specific risks that we believe will be rewarded over time. As a result of this approach, our sector and industry allocations reflect where we are finding opportunities at a given time.

As more normal activities resume, we see opportunities in infrastructure build-out, e-commerce, entertainment and other industries. Our key investment themes cross sector boundaries. For example, cybersecurity issues can affect everything from supply chains to meatpacking. Data analytics is important for any enterprise to help control spending and better understand customers.



4


Fund Characteristics
OCTOBER 31, 2021
Types of Investments in Portfolio% of net assets
Common Stocks98.5%
Temporary Cash Investments1.5%
Temporary Cash Investments - Securities Lending Collateral0.5%
Other Assets and Liabilities(0.5)%
Top Five Industries% of net assets
Software19.0%
Life Sciences Tools and Services5.8%
Health Care Equipment and Supplies5.5%
IT Services5.5%
Electrical Equipment5.3%

5


Shareholder Fee Example 

Fund shareholders may incur two types of costs: (1) transaction costs, including sales charges (loads) on purchase payments and redemption/exchange fees; and (2) ongoing costs, including management fees; distribution and service (12b-1) fees; and other fund expenses. This example is intended to help you understand your ongoing costs (in dollars) of investing in your fund and to compare these costs with the ongoing cost of investing in other mutual funds.

The example is based on an investment of $1,000 made at the beginning of the period and held for the entire period from May 1, 2021 to October 31, 2021.

Actual Expenses

The table provides information about actual account values and actual expenses for each class. You may use the information, together with the amount you invested, to estimate the expenses that you paid over the period. First, identify the share class you own. Then simply divide your account value by $1,000 (for example, an $8,600 account value divided by $1,000 = 8.6), then multiply the result by the number under the heading “Expenses Paid During Period” to estimate the expenses you paid on your account during this period.

Hypothetical Example for Comparison Purposes

The table also provides information about hypothetical account values and hypothetical expenses based on the actual expense ratio of each class of your fund and an assumed rate of return of 5% per year before expenses, which is not the actual return of a fund’s share class. The hypothetical account values and expenses may not be used to estimate the actual ending account balance or expenses you paid for the period. You may use this information to compare the ongoing costs of investing in your fund and other funds. To do so, compare this 5% hypothetical example with the 5% hypothetical examples that appear in the shareholder reports of the other funds.

Please note that the expenses shown in the table are meant to highlight your ongoing costs only and do not reflect any transactional costs, such as sales charges (loads) or redemption/exchange fees. Therefore, the table is useful in comparing ongoing costs only, and will not help you determine the relative total costs of owning different funds. In addition, if these transactional costs were included, your costs would have been higher.

Beginning
Account Value
5/1/21
Ending
Account Value
10/31/21
Expenses Paid
During Period(1)
5/1/21 - 10/31/21
Annualized
Expense Ratio(1)(2)
Actual
G Class$1,000$1,103.30$0.000.00%
Hypothetical
G Class$1,000$1,025.21$0.000.00%
(1)Expenses are equal to the class's annualized expense ratio listed in the table above, multiplied by the average account value over the period, multiplied by 184, the number of days in the most recent fiscal half-year, divided by 365, to reflect the one-half year period. Annualized expense ratio reflects actual expenses, including any applicable fee waivers or expense reimbursements and excluding any acquired fund fees and expenses.
(2)Other expenses, which include directors' fees and expenses, did not exceed 0.005%.
6


Schedule of Investments

OCTOBER 31, 2021
SharesValue
COMMON STOCKS — 98.5%


Aerospace and Defense — 0.8%
HEICO Corp.74,559 $10,392,779 
Auto Components — 1.8%
Aptiv plc(1)
126,506 21,871,622 
Beverages — 0.6%
Celsius Holdings, Inc.(1)
78,138 7,541,880 
Biotechnology — 3.3%
Alnylam Pharmaceuticals, Inc.(1)
69,674 11,117,183 
Horizon Therapeutics plc(1)
139,181 16,689,194 
Natera, Inc.(1)
83,431 9,558,690 
Turning Point Therapeutics, Inc.(1)
76,427 3,177,835 
40,542,902 
Building Products — 2.3%
Trane Technologies plc107,228 19,400,762 
Zurn Water Solutions Corp.256,488 9,305,385 
28,706,147 
Capital Markets — 4.7%
LPL Financial Holdings, Inc.175,304 28,753,362 
MarketAxess Holdings, Inc.14,597 5,965,356 
MSCI, Inc.34,357 22,843,282 
57,562,000 
Chemicals — 1.6%
Albemarle Corp.36,839 9,227,065 
Element Solutions, Inc.478,992 10,877,908 
20,104,973 
Communications Equipment — 3.6%
Arista Networks, Inc.(1)
58,758 24,072,565 
F5 Networks, Inc.(1)
95,627 20,191,641 
44,264,206 
Containers and Packaging — 2.6%
Avery Dennison Corp.101,538 22,106,853 
Ball Corp.116,514 10,658,701 
32,765,554 
Electrical Equipment — 5.3%
AMETEK, Inc.131,116 17,359,758 
Generac Holdings, Inc.(1)
24,286 12,108,028 
nVent Electric plc329,586 11,683,824 
Plug Power, Inc.(1)
148,639 5,688,415 
Regal Rexnord Corp.69,025 10,514,578 
Rockwell Automation, Inc.27,276 8,711,954 
66,066,557 
Electronic Equipment, Instruments and Components — 3.7%
Cognex Corp.219,028 19,184,663 
Keysight Technologies, Inc.(1)
150,106 27,022,082 
46,206,745 
Entertainment — 2.5%
Live Nation Entertainment, Inc.(1)
93,520 9,459,548 
7


SharesValue
ROBLOX Corp., Class A(1)
46,298 $3,889,958 
Roku, Inc.(1)
48,365 14,746,488 
Zynga, Inc., Class A(1)
457,460 3,376,055 
31,472,049 
Health Care Equipment and Supplies — 5.5%
Align Technology, Inc.(1)
14,952 9,335,580 
DexCom, Inc.(1)
37,157 23,156,614 
IDEXX Laboratories, Inc.(1)
36,535 24,337,425 
Teleflex, Inc.32,450 11,582,703 
68,412,322 
Health Care Providers and Services — 1.5%
Amedisys, Inc.(1)
49,579 8,395,708 
Encompass Health Corp.76,176 4,841,746 
R1 RCM, Inc.(1)
243,291 5,279,415 
18,516,869 
Health Care Technology — 1.8%
Veeva Systems, Inc., Class A(1)
69,410 22,003,664 
Hotels, Restaurants and Leisure — 3.4%
Chipotle Mexican Grill, Inc.(1)
8,857 15,756,869 
Hilton Worldwide Holdings, Inc.(1)
178,827 25,742,146 
41,499,015 
Interactive Media and Services — 2.2%
Match Group, Inc.(1)
114,696 17,293,863 
Pinterest, Inc., Class A(1)
229,913 10,263,316 
27,557,179 
Internet and Direct Marketing Retail — 2.1%
Chewy, Inc., Class A(1)(2)
119,368 9,048,094 
Etsy, Inc.(1)
65,508 16,422,201 
25,470,295 
IT Services — 5.5%
Cloudflare, Inc., Class A(1)
70,191 13,667,592 
EPAM Systems, Inc.(1)
28,781 19,376,520 
Okta, Inc.(1)
69,829 17,260,332 
Square, Inc., Class A(1)
47,042 11,972,189 
Twilio, Inc., Class A(1)
18,234 5,312,658 
67,589,291 
Leisure Products — 0.6%
Peloton Interactive, Inc., Class A(1)
80,801 7,388,443 
Life Sciences Tools and Services — 5.8%
10X Genomics, Inc., Class A(1)
52,635 8,488,446 
Agilent Technologies, Inc.86,991 13,700,213 
Bio-Techne Corp.31,400 16,442,610 
Mettler-Toledo International, Inc.(1)
14,560 21,561,613 
Repligen Corp.(1)
40,601 11,794,590 
71,987,472 
Machinery — 2.4%
Graco, Inc.126,443 9,505,985 
Parker-Hannifin Corp.69,986 20,757,148 
30,263,133 
Professional Services — 3.9%
CoStar Group, Inc.(1)
122,710 10,559,196 
Jacobs Engineering Group, Inc.130,196 18,282,122 
8


SharesValue
TransUnion63,136 $7,278,949 
Verisk Analytics, Inc.60,335 12,686,641 
48,806,908 
Semiconductors and Semiconductor Equipment — 4.7%
Enphase Energy, Inc.(1)
76,884 17,808,641 
Marvell Technology, Inc.306,282 20,980,317 
Monolithic Power Systems, Inc.12,512 6,574,556 
Skyworks Solutions, Inc.73,165 12,228,066 
57,591,580 
Software — 19.0%
Atlassian Corp. plc, Class A(1)
48,953 22,426,838 
Autodesk, Inc.(1)
41,370 13,139,526 
Cadence Design Systems, Inc.(1)
227,136 39,319,513 
Coupa Software, Inc.(1)
30,132 6,861,056 
Datadog, Inc., Class A(1)
76,386 12,760,281 
DocuSign, Inc.(1)
86,999 24,210,952 
HubSpot, Inc.(1)
36,847 29,854,545 
Manhattan Associates, Inc.(1)
152,079 27,608,422 
Palantir Technologies, Inc., Class A(1)
700,774 18,136,031 
Palo Alto Networks, Inc.(1)
80,829 41,149,235 
235,466,399 
Specialty Retail — 4.1%
Burlington Stores, Inc.(1)
66,715 18,432,688 
Carvana Co.(1)
35,672 10,815,037 
Five Below, Inc.(1)
33,877 6,683,932 
Floor & Decor Holdings, Inc., Class A(1)
112,048 15,229,564 
51,161,221 
Textiles, Apparel and Luxury Goods — 2.0%
lululemon athletica, Inc.(1)
52,015 24,239,510 
Trading Companies and Distributors — 1.2%
W.W. Grainger, Inc.30,861 14,292,038 
TOTAL COMMON STOCKS
(Cost $795,831,714)
1,219,742,753 
TEMPORARY CASH INVESTMENTS — 1.5%


Repurchase Agreement, BMO Capital Markets Corp., (collateralized by various U.S. Treasury obligations, 2.00%, 11/15/26, valued at $4,087,026), in a joint trading account at 0.01%, dated 10/29/21, due 11/1/21 (Delivery value $4,002,024)4,002,021 
Repurchase Agreement, Fixed Income Clearing Corp., (collateralized by various U.S. Treasury obligations, 1.875%, 2/15/41, valued at $13,606,876), at 0.01%, dated 10/29/21, due 11/1/21 (Delivery value $13,340,011)13,340,000 
State Street Institutional U.S. Government Money Market Fund, Premier Class533,842 533,842 
TOTAL TEMPORARY CASH INVESTMENTS
(Cost $17,875,863)
17,875,863 
TEMPORARY CASH INVESTMENTS - SECURITIES LENDING COLLATERAL(3) — 0.5%
State Street Navigator Securities Lending Government Money Market Portfolio
(Cost $6,498,918)
6,498,918 6,498,918 
TOTAL INVESTMENT SECURITIES — 100.5%
(Cost $820,206,495)

1,244,117,534 
OTHER ASSETS AND LIABILITIES — (0.5)%

(6,218,688)
TOTAL NET ASSETS — 100.0%

$1,237,898,846 

9


NOTES TO SCHEDULE OF INVESTMENTS
(1)Non-income producing.
(2)Security, or a portion thereof, is on loan. At the period end, the aggregate value of securities on loan was $9,048,094. The amount of securities on loan indicated may not correspond with the securities on loan identified because securities with pending sales are in the process of recall from the brokers.
(3)Investment of cash collateral from securities on loan. At the period end, the aggregate value of the collateral held by the fund was $9,192,481, which includes securities collateral of $2,693,563.


See Notes to Financial Statements.

10


Statement of Assets and Liabilities
OCTOBER 31, 2021
Assets
Investment securities, at value (cost of $813,707,577) — including $9,048,094 of securities on loan$1,237,618,616 
Investment made with cash collateral received for securities on loan, at value
(cost of $6,498,918)
6,498,918 
Total investment securities, at value (cost of $820,206,495)1,244,117,534 
Receivable for investments sold173,201 
Receivable for capital shares sold18,808 
Dividends and interest receivable86,856 
Securities lending receivable1,365 
1,244,397,764 
Liabilities
Payable for collateral received for securities on loan6,498,918 
Net Assets$1,237,898,846 
G Class Capital Shares, $0.01 Par Value
Shares authorized600,000,000 
Shares outstanding68,173,788 
Net Asset Value Per Share$18.16 
Net Assets Consist of:
Capital (par value and paid-in surplus)$704,576,442 
Distributable earnings533,322,404 
$1,237,898,846 


See Notes to Financial Statements.
11


Statement of Operations
YEAR ENDED OCTOBER 31, 2021
Investment Income (Loss)
Income:
Dividends (net of foreign taxes withheld of $6,207)$3,823,589 
Securities lending, net10,179 
Interest2,297 
3,836,065 
Expenses:
Management fees7,276,777 
Directors' fees and expenses28,575 
Other expenses25,303 
7,330,655 
Fees waived(7,276,777)
53,878 
Net investment income (loss)3,782,187 
Realized and Unrealized Gain (Loss)
Net realized gain (loss) on:
Investment transactions121,919,892 
Forward foreign currency exchange contract transactions667,486 
Foreign currency translation transactions(4,359)
122,583,019 
Change in net unrealized appreciation (depreciation) on:
Investments257,036,673 
Forward foreign currency exchange contracts39,152 
Translation of assets and liabilities in foreign currencies(69)
257,075,756 
Net realized and unrealized gain (loss)379,658,775 
Net Increase (Decrease) in Net Assets Resulting from Operations$383,440,962 


See Notes to Financial Statements.
12


Statement of Changes in Net Assets
YEARS ENDED OCTOBER 31, 2021 AND OCTOBER 31, 2020
Increase (Decrease) in Net AssetsOctober 31, 2021October 31, 2020
Operations
Net investment income (loss)$3,782,187 $3,400,615 
Net realized gain (loss)122,583,019 101,553,526 
Change in net unrealized appreciation (depreciation)257,075,756 52,011,363 
Net increase (decrease) in net assets resulting from operations383,440,962 156,965,504 
Distributions to Shareholders
From earnings(96,345,623)(81,790,080)
Capital Share Transactions
Proceeds from shares sold191,957,895 470,785,649 
Proceeds from reinvestment of distributions96,345,623 81,790,080 
Payments for shares redeemed(272,817,844)(294,257,396)
Net increase (decrease) in net assets from capital share transactions15,485,674 258,318,333 
Net increase (decrease) in net assets302,581,013 333,493,757 
Net Assets
Beginning of period935,317,833 601,824,076 
End of period$1,237,898,846 $935,317,833 
Transactions in Shares of the Fund
Sold11,937,903 35,788,482 
Issued in reinvestment of distributions6,431,617 6,931,363 
Redeemed(16,368,826)(22,986,369)
Net increase (decrease) in shares of the fund2,000,694 19,733,476 


See Notes to Financial Statements.

13


Notes to Financial Statements

OCTOBER 31, 2021

1. Organization

American Century Mutual Funds, Inc. (the corporation) is registered under the Investment Company Act of 1940, as amended (the 1940 Act), as an open-end management investment company and is organized as a Maryland corporation. NT Heritage Fund (the fund) is one fund in a series issued by the corporation. The fund's investment objective is to seek long-term capital growth. The fund offers the G Class.

2. Significant Accounting Policies

The following is a summary of significant accounting policies consistently followed by the fund in preparation of its financial statements. The fund is an investment company and follows accounting and reporting guidance in accordance with accounting principles generally accepted in the United States of America. This may require management to make certain estimates and assumptions at the date of the financial statements. Actual results could differ from these estimates. Management evaluated the impact of events or transactions occurring through the date the financial statements were issued that would merit recognition or disclosure.

Investment Valuations — The fund determines the fair value of its investments and computes its net asset value (NAV) per share at the close of regular trading (usually 4 p.m. Eastern time) on the New York Stock Exchange (NYSE) on each day the NYSE is open. The Board of Directors has adopted valuation policies and procedures to guide the investment advisor in the fund’s investment valuation process and to provide methodologies for the oversight of the fund’s pricing function.

Equity securities that are listed or traded on a domestic securities exchange are valued at the last reported sales price or at the official closing price as provided by the exchange. Equity securities traded on foreign securities exchanges are generally valued at the closing price of such securities on the exchange where primarily traded or at the close of the NYSE, if that is earlier. If no last sales price is reported, or if local convention or regulation so provides, the mean of the latest bid and asked prices may be used. Securities traded over-the-counter are valued at the mean of the latest bid and asked prices, the last sales price, or the official closing price. Equity securities initially expressed in local currencies are translated into U.S. dollars at the mean of the appropriate currency exchange rate at the close of the NYSE as provided by an independent pricing service.

Open-end management investment companies are valued at the reported NAV per share. Repurchase agreements are valued at cost, which approximates fair value. Forward foreign currency exchange contracts are valued at the mean of the appropriate forward exchange rate at the close of the NYSE as provided by an independent pricing service.
If the fund determines that the market price for an investment is not readily available or the valuation methods mentioned above do not reflect an investment’s fair value, such investment is valued as determined in good faith by the Board of Directors or its delegate, in accordance with policies and procedures adopted by the Board of Directors. In its determination of fair value, the fund may review several factors including, but not limited to, market information regarding the specific investment or comparable investments and correlation with other investment types, futures indices or general market indicators. Circumstances that may cause the fund to use these procedures to value an investment include, but are not limited to: an investment has been declared in default or is distressed; trading in a security has been suspended during the trading day or a security is not actively trading on its principal exchange; prices received from a regular pricing source are deemed unreliable; or there is a foreign market holiday and no trading occurred.
The fund monitors for significant events occurring after the close of an investment’s primary exchange but before the fund’s NAV per share is determined. Significant events may include, but are not limited to: corporate announcements and transactions; governmental action and political unrest that could impact a specific investment or an investment sector; or armed conflicts, natural disasters and similar events that could affect investments in a specific country or region. The fund also monitors for significant fluctuations between domestic and foreign markets, as evidenced by the U.S. market or such other indicators that the Board of Directors, or its delegate, deems appropriate. The fund may apply a model-derived factor to the closing price of equity securities traded on foreign securities exchanges. The factor is based on observable market data as provided by an independent pricing service.
14


Security Transactions — Security transactions are accounted for as of the trade date. Net realized gains and losses are determined on the identified cost basis, which is also used for federal income tax purposes.
Investment Income — Dividend income less foreign taxes withheld, if any, is recorded as of the ex-dividend date. Distributions received on securities that represent a return of capital or long-term capital gain are recorded as a reduction of cost of investments and/or as a realized gain. The fund may estimate the components of distributions received that may be considered nontaxable distributions or long-term capital gain distributions for income tax purposes. Interest income is recorded on the accrual basis and includes accretion of discounts and amortization of premiums. Securities lending income is net of fees and rebates earned by the lending agent for its services.
Foreign Currency Translations — All assets and liabilities initially expressed in foreign currencies are translated into U.S. dollars at prevailing exchange rates at period end. The fund may enter into spot foreign currency exchange contracts to facilitate transactions denominated in a foreign currency. Purchases and sales of investment securities, dividend and interest income, spot foreign currency exchange contracts, and expenses are translated at the rates of exchange prevailing on the respective dates of such transactions. Net realized and unrealized foreign currency exchange gains or losses related to investment securities are a component of net realized gain (loss) on investment transactions and change in net unrealized appreciation (depreciation) on investments, respectively.
Repurchase Agreements — The fund may enter into repurchase agreements with institutions that American Century Investment Management, Inc. (ACIM) (the investment advisor) has determined are creditworthy pursuant to criteria adopted by the Board of Directors. The fund requires that the collateral, represented by securities, received in a repurchase transaction be transferred to the custodian in a manner sufficient to enable the fund to obtain those securities in the event of a default under the repurchase agreement. ACIM monitors, on a daily basis, the securities transferred to ensure the value, including accrued interest, of the securities under each repurchase agreement is equal to or greater than amounts owed to the fund under each repurchase agreement.
Joint Trading Account — Pursuant to an Exemptive Order issued by the Securities and Exchange Commission, the fund, along with certain other funds in the American Century Investments family of funds, may transfer uninvested cash balances into a joint trading account. These balances are invested in one or more repurchase agreements that are collateralized by U.S. Treasury or Agency obligations.
Segregated Assets — In accordance with the 1940 Act, the fund segregates assets on its books and records to cover certain types of investment securities and other financial instruments. ACIM monitors, on a daily basis, the securities segregated to ensure the fund designates a sufficient amount of liquid assets, marked-to-market daily. The fund may also receive assets or be required to pledge assets at the custodian bank or with a broker for collateral requirements.
Income Tax Status — It is the fund’s policy to distribute substantially all net investment income and net realized gains to shareholders and to otherwise qualify as a regulated investment company under provisions of the Internal Revenue Code. Accordingly, no provision has been made for income taxes. The fund files U.S. federal, state, local and non-U.S. tax returns as applicable. The fund's tax returns are subject to examination by the relevant taxing authority until expiration of the applicable statute of limitations, which is generally three years from the date of filing but can be longer in certain jurisdictions. At this time, management believes there are no uncertain tax positions which, based on their technical merit, would not be sustained upon examination and for which it is reasonably possible that the total amounts of unrecognized tax benefits will significantly change in the next twelve months.
Distributions to Shareholders — Distributions from net investment income and net realized gains, if any, are generally declared and paid annually. The fund may elect to treat a portion of its payment to a redeeming shareholder, which represents the pro rata share of undistributed net investment income and net realized gains, as a distribution for federal income tax purposes (tax equalization).
Indemnifications — Under the corporation’s organizational documents, its officers and directors are indemnified against certain liabilities arising out of the performance of their duties to the fund. In addition, in the normal course of business, the fund enters into contracts that provide general indemnifications. The maximum exposure under these arrangements is unknown as this would involve future claims that may be made against a fund. The risk of material loss from such claims is considered by management to be remote.

15


Securities Lending — Securities are lent to qualified financial institutions and brokers. State Street Bank & Trust Co. serves as securities lending agent to the fund pursuant to a Securities Lending Agreement. The lending of securities exposes the fund to risks such as: the borrowers may fail to return the loaned securities, the borrowers may not be able to provide additional collateral, the fund may experience delays in recovery of the loaned securities or delays in access to collateral, or the fund may experience losses related to the investment collateral. To minimize certain risks, loan counterparties pledge collateral in the form of cash and/or securities. The lending agent has agreed to indemnify the fund in the case of default of any securities borrowed. Cash collateral received is invested in the State Street Navigator Securities Lending Government Money Market Portfolio, a money market mutual fund registered under the 1940 Act. The loans may also be secured by U.S. government securities in an amount at least equal to the market value of the securities loaned, plus accrued interest and dividends, determined on a daily basis and adjusted accordingly. By lending securities, the fund seeks to increase its net investment income through the receipt of interest and fees. Such income is reflected separately within the Statement of Operations. The value of loaned securities and related collateral outstanding at period end, if any, are shown on a gross basis within the Schedule of Investments and Statement of Assets and Liabilities.

The following table reflects a breakdown of transactions accounted for as secured borrowings, the gross obligation by the type of collateral pledged, and the remaining contractual maturity of those transactions as of October 31, 2021.
Remaining Contractual Maturity of Agreements
Overnight and
Continuous
<30 daysBetween
30 & 90 days
>90 daysTotal
Securities Lending Transactions(1)
Common Stocks$6,498,918 — — — $6,498,918 
Gross amount of recognized liabilities for securities lending transactions$6,498,918 
(1)Amount represents the payable for cash collateral received for securities on loan. This will generally be in the Overnight and Continuous column as the securities are typically callable on demand.

3. Fees and Transactions with Related Parties

Certain officers and directors of the corporation are also officers and/or directors of American Century Companies, Inc. (ACC). The corporation’s investment advisor, ACIM, the corporation's distributor, American Century Investment Services, Inc., and the corporation’s transfer agent, American Century Services, LLC, are wholly owned, directly or indirectly, by ACC. Various funds issued by American Century Asset Allocation Portfolios, Inc. own, in aggregate, 50% of the shares of the fund. Related parties do not invest in the fund for the purpose of exercising management or control.
Management Fees —The corporation has entered into a management agreement with ACIM, under which ACIM provides the fund with investment advisory and management services in exchange for a single, unified management fee (the fee). The agreement provides that ACIM will pay all expenses of managing and operating the fund, except brokerage expenses, taxes, interest, fees and expenses of the independent directors (including legal counsel fees), and extraordinary expenses. The fee is computed and accrued daily based on the daily net assets of the fund and paid monthly in arrears. The annual management fee is 0.650%. The investment advisor agreed to waive the fund's management fee in its entirety. The investment advisor expects this waiver to remain in effect permanently and cannot terminate it without the approval of the Board of Directors. The annual management fee for the period ended October 31, 2021 was 0.000% after waiver.
Directors' Fees and Expenses — The Board of Directors is responsible for overseeing the investment advisor’s management and operations of the fund. The directors receive detailed information about the fund and its investment advisor regularly throughout the year, and meet at least quarterly with management of the investment advisor to review reports about fund operations. The fund’s officers do not receive compensation from the fund.
Interfund Transactions — The fund may enter into security transactions with other American Century Investments funds and other client accounts of the investment advisor, in accordance with the 1940 Act rules and procedures adopted by the Board of Directors. The rules and procedures require, among other things, that these transactions be effected at the independent current market price of the security. During the period, the interfund purchases and sales were $168,730 and $563,061, respectively. The effect of interfund transactions on the Statement of Operations was $1,019 in net realized gain (loss) on investment transactions.

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4. Investment Transactions

Purchases and sales of investment securities, excluding short-term investments, for the period ended October 31, 2021 were $699,385,278 and $788,944,752, respectively.

5. Fair Value Measurements

The fund’s investments valuation process is based on several considerations and may use multiple inputs to determine the fair value of the investments held by the fund. In conformity with accounting principles generally accepted in the United States of America, the inputs used to determine a valuation are classified into three broad levels.

Level 1 valuation inputs consist of unadjusted quoted prices in an active market for identical investments.

Level 2 valuation inputs consist of direct or indirect observable market data (including quoted prices for comparable investments, evaluations of subsequent market events, interest rates, prepayment speeds, credit risk, etc.). These inputs also consist of quoted prices for identical investments initially expressed in local currencies that are adjusted through translation into U.S. dollars.

Level 3 valuation inputs consist of unobservable data (including a fund’s own assumptions).

The level classification is based on the lowest level input that is significant to the fair valuation measurement. The valuation inputs are not necessarily an indication of the risks associated with investing in these securities or other financial instruments.
The following is a summary of the level classifications as of period end. The Schedule of Investments provides additional information on the fund’s portfolio holdings.
Level 1Level 2Level 3
Assets
Investment Securities
Common Stocks$1,219,742,753 — — 
Temporary Cash Investments533,842 $17,342,021 — 
Temporary Cash Investments - Securities Lending Collateral6,498,918 — — 
$1,226,775,513 $17,342,021 — 

6. Derivative Instruments

Foreign Currency Risk — The fund is subject to foreign currency exchange rate risk in the normal course of pursuing its investment objectives. The value of foreign investments held by a fund may be significantly affected by changes in foreign currency exchange rates. The dollar value of a foreign security generally decreases when the value of the dollar rises against the foreign currency in which the security is denominated and tends to increase when the value of the dollar declines against such foreign currency. A fund may enter into forward foreign currency exchange contracts to reduce a fund's exposure to foreign currency exchange rate fluctuations. The net U.S. dollar value of foreign currency underlying all contractual commitments held by a fund and the resulting unrealized appreciation or depreciation are determined daily. Realized gain or loss is recorded upon settlement of the contract. Net realized and unrealized gains or losses occurring during the holding period of forward foreign currency exchange contracts are a component of net realized gain (loss) on forward foreign currency exchange contract transactions and change in net unrealized appreciation (depreciation) on forward foreign currency exchange contracts, respectively. A fund bears the risk of an unfavorable change in the foreign currency exchange rate underlying the forward contract. Additionally, losses, up to the fair value, may arise if the counterparties do not perform under the contract terms. The fund's average U.S. dollar exposure to foreign currency risk derivative instruments held during the period was $18,849,631.
At period end, the fund did not have any derivative instruments disclosed on the Statement of Assets and Liabilities. For the year ended October 31, 2021, the effect of foreign currency risk derivative instruments on the Statement of Operations was $667,486 in net realized gain (loss) on forward foreign currency exchange contract transactions and $39,152 in change in net unrealized appreciation (depreciation) on forward foreign currency exchange contracts.

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7. Risk Factors

The value of the fund’s shares will go up and down, sometimes rapidly or unpredictably, based on the performance of the securities owned by the fund and other factors generally affecting the securities market. Market risks, including political, regulatory, economic and social developments, can affect the value of the fund’s investments. Natural disasters, public health emergencies, terrorism and other unforeseeable events may lead to increased market volatility and may have adverse long-term effects on world economies and markets generally.
The fund is owned by a relatively small number of shareholders, and in the event such shareholders redeem, the ongoing operations of the fund may be at risk.
The fund invests in common stocks of small companies. Because of this, the fund may be subject to greater risk and market fluctuations than a fund investing in larger, more established companies.
8. Federal Tax Information
On December 7, 2021, the fund declared and paid per-share distributions of $1.6482 and $0.0639 from net
realized gains and net investment income, respectively, to shareholders of record on December 6, 2021.

The tax character of distributions paid during the years ended October 31, 2021 and October 31, 2020 were as follows:
20212020
Distributions Paid From
Ordinary income$4,956,025 $2,988,466 
Long-term capital gains$91,389,598 $78,801,614 

The book-basis character of distributions made during the year from net investment income or net realized gains may differ from their ultimate characterization for federal income tax purposes. These differences reflect the differing character of certain income items and net realized gains and losses for financial statement and tax purposes, and may result in reclassification among certain capital accounts on the financial statements.

As of period end, the federal tax cost of investments and the components of distributable earnings on a tax-basis were as follows:

Federal tax cost of investments$825,390,603 
Gross tax appreciation of investments$433,113,201 
Gross tax depreciation of investments(14,386,270)
Net tax appreciation (depreciation) of investments418,726,931 
Net tax appreciation (depreciation) on derivatives and translation of assets and liabilities in foreign currencies (46)
Net tax appreciation (depreciation)$418,726,885 
Undistributed ordinary income$52,561,300 
Accumulated long-term gains$62,034,219 

The difference between book-basis and tax-basis unrealized appreciation (depreciation) is attributable primarily to the tax deferral of losses on wash sales.

9. Corporate Event

On December 2, 2021, the Board of Directors approved an agreement and plan of reorganization (the reorganization), whereby the net assets of the fund will be transferred to Heritage Fund, one fund in a series issued by the corporation, in exchange for shares of Heritage Fund. The financial statements and performance history of Heritage Fund will survive after the reorganization. The reorganization is expected to be completed in 2022.
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Financial Highlights
For a Share Outstanding Throughout the Years Ended October 31 (except as noted)
Per-Share DataRatios and Supplemental Data
Income From Investment Operations:Distributions From:Ratio to Average Net Assets of:
Net Asset
Value,
Beginning
of Period
Net
Investment
Income
(Loss)(1)
Net
Realized
and
Unrealized
Gain (Loss)
Total From
Investment
Operations
Net
Investment
Income
Net
Realized
Gains
Total
Distributions
Net Asset
Value,
End
of Period
Total
Return(2)
Operating
Expenses
Operating
Expenses
(before
expense
waiver)
Net
Investment
Income
(Loss)
Net
Investment
Income
(Loss)
(before
expense
waiver)
Portfolio
Turnover
Rate
Net
Assets,
End of
Period
(in thousands)
G Class
2021$14.130.065.515.57(0.05)(1.49)(1.54)$18.1641.75%
0.00%(3)
0.65%0.34%(0.31)%64%$1,237,899 
2020$12.960.062.932.99(0.07)(1.75)(1.82)$14.1325.77%0.01%0.66%0.50%(0.15)%91%$935,318 
2019$14.530.081.661.74(0.12)(3.19)(3.31)$12.9618.18%0.01%0.66%0.62%(0.03)%92%$601,824 
2018$14.410.101.051.15(0.05)(0.98)(1.03)$14.538.19%
0.00%(3)
0.65%0.71%0.06%90%$691,805 
2017$12.310.042.502.54(0.44)(0.44)$14.4121.29%0.58%0.76%0.27%0.09%67%$822,910 
Notes to Financial Highlights
(1)Computed using average shares outstanding throughout the period.
(2)Total returns are calculated based on the net asset value of the last business day. Total returns for periods less than one year are not annualized.
(3)Ratio was less than 0.005%.


See Notes to Financial Statements.



Report of Independent Registered Public Accounting Firm

To the Shareholders and the Board of Directors of American Century Mutual Funds, Inc.:

Opinion on the Financial Statements and Financial Highlights

We have audited the accompanying statement of assets and liabilities, including the schedule of investments, of NT Heritage Fund (the “Fund”), one of the funds constituting the American Century Mutual Funds, Inc., as of October 31, 2021, the related statement of operations for the year then ended, the statements of changes in net assets for each of the two years in the period then ended, the financial highlights for each of the five years in the period then ended, and the related notes. In our opinion, the financial statements and financial highlights present fairly, in all material respects, the financial position of NT Heritage Fund of the American Century Mutual Funds, Inc. as of October 31, 2021, and the results of its operations for the year then ended, the changes in its net assets for each of the two years in the period then ended, and the financial highlights for each of the five years in the period then ended, in conformity with accounting principles generally accepted in the United States of America.

Basis for Opinion

These financial statements and financial highlights are the responsibility of the Fund's management. Our responsibility is to express an opinion on the Fund’s financial statements and financial highlights based on our audits. We are a public accounting firm registered with the Public Company Accounting Oversight Board (United States) (PCAOB) and are required to be independent with respect to the Fund in accordance with the U.S. federal securities laws and the applicable rules and regulations of the Securities and Exchange Commission and the PCAOB.

We conducted our audits in accordance with the standards of the PCAOB. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements and financial highlights are free of material misstatement, whether due to error or fraud. The Fund is not required to have, nor were we engaged to perform, an audit of its internal control over financial reporting. As part of our audits we are required to obtain an understanding of internal control over financial reporting but not for the purpose of expressing an opinion on the effectiveness of the Fund’s internal control over financial reporting. Accordingly, we express no such opinion.

Our audits included performing procedures to assess the risks of material misstatement of the financial statements and financial highlights, whether due to error or fraud, and performing procedures that respond to those risks. Such procedures included examining, on a test basis, evidence regarding the amounts and disclosures in the financial statements and financial highlights. Our audits also included evaluating the accounting principles used and significant estimates made by management, as well as evaluating the overall presentation of the financial statements and financial highlights. Our procedures included confirmation of securities owned as of October 31, 2021, by correspondence with the custodian and brokers; when replies were not received from brokers, we performed other auditing procedures. We believe that our audits provide a reasonable basis for our opinion.

/s/ Deloitte & Touche LLP

Kansas City, Missouri
December 15, 2021

We have served as the auditor of one or more American Century investment companies since 1997.
20


Management

The Board of Directors

The individuals listed below serve as directors of the funds. Each director will continue to serve in this capacity until death, retirement, resignation or removal from office. The board has adopted a mandatory retirement age for directors who are not “interested persons,” as that term is defined in the Investment Company Act (independent directors). Independent directors shall retire by December 31 of the year in which they reach their 75th birthday.
Jonathan S.Thomas is an “interested person” because he currently serves as President and Chief Executive Officer of American Century Companies, Inc. (ACC), the parent company of American Century Investment Management, Inc. (ACIM or the advisor). The other directors (more than three-fourths of the total number) are independent. They are not employees, directors or officers of, and have no financial interest in, ACC or any of its wholly owned, direct or indirect, subsidiaries, including ACIM, American Century Investment Services, Inc. (ACIS) and American Century Services, LLC (ACS), and they do not have any other affiliations, positions or relationships that would cause them to be considered “interested persons” under the Investment Company Act. The directors serve in this capacity for seven (in the case of Jonathan S. Thomas, 16; and Stephen E. Yates, 8) registered investment companies in the American Century Investments family of funds.
The following table presents additional information about the directors. The mailing address for each director is 4500 Main Street, Kansas City, Missouri 64111.
Name
(Year of Birth)
Position(s) Held with FundsLength of Time ServedPrincipal Occupation(s) During Past 5 YearsNumber of American Century Portfolios Overseen by DirectorOther Directorships Held During Past 5 Years
Independent Directors
Thomas W. Bunn (1953)DirectorSince 2017Retired72SquareTwo Financial; Barings (formerly Babson Capital Funds Trust) (2013 to 2016)
Chris H. Cheesman
(1962)
DirectorSince 2019
Retired. Senior Vice President & Chief Audit Executive, AllianceBernstein (1999 to 2018)72Alleghany Corporation
Barry Fink
(1955)
DirectorSince 2012 (independent since 2016)Retired72None
Rajesh K. Gupta
(1960)
DirectorSince 2019
Partner Emeritus, SeaCrest Investment Management and SeaCrest Wealth Management (2019 to Present); Chief Executive Officer and Chief Investment Officer, SeaCrest Investment Management (2006 to 2019); Chief Executive Officer and Chief Investment Officer, SeaCrest Wealth Management (2008 to 2019)72None
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Name
(Year of Birth)
Position(s) Held with FundsLength of Time ServedPrincipal Occupation(s) During Past 5 YearsNumber of American Century Portfolios Overseen by DirectorOther Directorships Held During Past 5 Years
Independent Directors
Lynn Jenkins
(1963)
DirectorSince 2019
Consultant, LJ Strategies (2019 to present); United States Representative, U.S. House of Representatives (2009 to 2018)72MGP Ingredients, Inc. (2019 to 2021)
Jan M. Lewis
(1957)
DirectorSince 2011Retired72None
John R. Whitten
(1946)
DirectorSince 2008Retired72Onto Innovation Inc. (2019 to 2020); Rudolph Technologies, Inc. (2006 to 2019)
Stephen E. Yates
(1948)
Director and Chairman of the BoardSince 2012 (Chairman since 2018)Retired107None
Interested Director
Jonathan S. Thomas
(1963)
DirectorSince 2007President and Chief Executive Officer, ACC (2007 to present). Also serves as Chief Executive Officer, ACS; Director, ACC and other ACC subsidiaries145None
The Statement of Additional Information has additional information about the fund's directors and is available without charge, upon request, by calling 1-800-345-2021.
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Officers

The following table presents certain information about the executive officers of the funds. Each officer serves as an officer for 16 (in the case of Robert J. Leach, 15) investment companies in the American Century family of funds. No officer is compensated for his or her service as an officer of the funds. The listed officers are interested persons of the funds and are appointed or re-appointed on an annual basis. The mailing address for each officer listed below is 4500 Main Street, Kansas City, Missouri 64111.
Name
(Year of Birth)
Offices with the FundsPrincipal Occupation(s) During the Past Five Years
Patrick Bannigan
(1965)
President since 2019Executive Vice President and Director, ACC (2012 to present); Chief Financial Officer, Chief Accounting Officer and Treasurer, ACC (2015 to present). Also serves as President, ACS; Vice President, ACIM; Chief Financial Officer, Chief Accounting Officer and/or Director, ACIM, ACS and other ACC subsidiaries
R. Wes Campbell
(1974)
Chief Financial Officer and Treasurer since 2018Vice President, ACS, (2020 to present); Investment Operations and Investment Accounting, ACS (2000 to present)
Amy D. Shelton
(1964)
Chief Compliance Officer and Vice President since 2014Chief Compliance Officer, American Century funds, (2014 to present); Chief Compliance Officer, ACIM (2014 to present); Chief Compliance Officer, ACIS (2009 to present). Also serves as Vice President, ACIS
John Pak
(1968)
General Counsel and
Senior Vice President since 2021
General Counsel and Senior Vice President, ACC (2021 to present). Also serves as General Counsel and Senior Vice President, ACIM, ACS and ACIS. Chief Legal Officer of Investment and Wealth Management, The Bank of New York Mellon (2014 to 2021)
C. Jean Wade
(1964)
Vice President since 2012Senior Vice President, ACS (2017 to present); Vice President, ACS (2000 to 2017)
Robert J. Leach
(1966)
Vice President since 2006 Vice President, ACS (2000 to present)
David H. Reinmiller
(1963)
Vice President since 2000Attorney, ACC (1994 to present). Also serves as Vice President, ACIM and ACS
Ward D. Stauffer
(1960)
Secretary since 2005Attorney, ACC (2003 to present)





23


Approval of Management Agreement

At a meeting held on June 30, 2021, the Fund’s Board of Directors (the "Board") unanimously approved the renewal of the management agreement pursuant to which American Century Investment Management, Inc. (the “Advisor”) acts as the investment advisor for the Fund. Under Section 15(c) of the Investment Company Act, contracts for investment advisory services are required to be reviewed, evaluated, and approved by a majority of a fund’s directors (the “Directors”), including a majority of the independent Directors, each year.

Prior to its consideration of the renewal of the management agreement, the Directors requested and reviewed extensive data and information compiled by the Advisor and certain independent providers of evaluation data concerning the Fund and the services provided to the Fund by the Advisor. This review was in addition to the oversight and evaluation undertaken by the Board and its committees on a continual basis and the information received was supplemental to the extensive information that the Board and its committees receive and consider throughout the year.

In connection with its consideration of the renewal of the management agreement, the Board’s review and evaluation of the services provided by the Advisor and its affiliates included, but was not limited to, the following:

the nature, extent, and quality of investment management, shareholder services, and other services provided and to be provided to the Fund including without limitation portfolio management and trading services, shareholder and intermediary services, compliance and legal services, fund accounting and financial reporting, and fund share distribution;
the wide range of other programs and services provided and to be provided to the Fund and its shareholders on a routine and non-routine basis;
the Fund’s investment performance, including data comparing the Fund's performance to appropriate benchmarks and/or a peer group of other mutual funds with similar investment objectives and strategies;
the cost of owning the Fund compared to the cost of owning similar funds;
the compliance policies, procedures, and regulatory experience of the Advisor and the Fund's service providers;
the Advisor’s strategic plans, COVID-19 pandemic response, vendor management practices, and social justice initiatives;
the Advisor’s business continuity plans and cyber security practices;
financial data showing the cost of services provided to the Fund, the profitability of the Fund to the Advisor, and the overall profitability of the Advisor;
possible economies of scale associated with the Advisor’s management of the Fund and other accounts;
services provided and charges to the Advisor's other investment management clients;
acquired fund fees and expenses;
payments and practices in connection with financial intermediaries holding shares of the Fund and the services provided by intermediaries in connection therewith; and
possible collateral benefits to the Advisor from the management of the Fund.

The Board held two meetings to consider the renewal. The independent Directors also met in private session three times to review and discuss the information provided in response to their request. The independent Directors held active discussions with the Advisor regarding the renewal of the management agreement, requesting supplemental information, and reviewing information provided by the Advisor in response thereto. The independent Directors had the benefit of the advice of their independent counsel throughout the process.



24


Factors Considered

The Directors considered all of the information provided by the Advisor, the independent data providers, and independent counsel in connection with the approval. They determined that the information was sufficient for them to evaluate the management agreement for the Fund. In connection with their review, the Directors did not identify any single factor as being all-important or controlling, and each Director may have attributed different levels of importance to different factors. In deciding to renew the management agreement, the Board based its decision on a number of factors, including without limitation the following:

Nature, Extent and Quality of Services — Generally. Under the management agreement, the Advisor is responsible for providing or arranging for all services necessary for the operation of the Fund. The Board noted that the Advisor provides or arranges at its own expense a wide variety of services which include the following:

constructing and designing the Fund
portfolio research and security selection
initial capitalization/funding
securities trading
Fund administration
custody of Fund assets
daily valuation of the Fund’s portfolio
liquidity monitoring and management
risk management, including cyber security
shareholder servicing and transfer agency, including shareholder confirmations, recordkeeping, and communications
legal services (except the independent Directors’ counsel)
regulatory and portfolio compliance
financial reporting
marketing and distribution (except amounts paid by the Fund under Rule 12b-1 plans)

The Board noted that many of these services have expanded over time in terms of both quantity and complexity in response to shareholder demands, competition in the industry, changing distribution channels, and the changing regulatory environment.

Investment Management Services. The nature of the investment management services provided to the Fund is quite complex and allows Fund shareholders access to professional money management, instant diversification of their investments within an asset class, the opportunity to easily diversify among asset classes by investing in or exchanging among various American Century Investments funds, and liquidity. In evaluating investment performance, the Board expects the Advisor to manage the Fund in accordance with its investment objectives and approved strategies. Further, the Directors recognize that the Advisor has an obligation to monitor trading activities, and in particular to seek the best execution of fund trades, and to evaluate the use of and payment for research. In providing these services, the Advisor utilizes teams of investment professionals (portfolio managers, analysts, research assistants, and securities traders) who require extensive information technology, research, training, compliance, and other systems to conduct their business. The Board, directly and through its Fund Performance Review Committee, provides oversight of the investment performance process. It regularly reviews investment performance information for the Fund, together with comparative information for appropriate benchmarks and/or peer groups of similarly-managed funds, over different time horizons. The Directors also review investment performance information during the management agreement renewal process. If performance concerns are identified, the Fund receives special reviews until performance improves, during which the Board discusses with the Advisor the reasons for such results (e.g., market conditions, security selection) and any efforts being undertaken to improve performance. The Fund’s performance was above its benchmark for the one-, three-, and five-year periods and below its benchmark for the ten-year period reviewed by the Board. The Board found the investment management services provided by the Advisor to the Fund to be satisfactory and consistent with the management agreement.
25


Shareholder and Other Services. Under the management agreement, the Advisor provides the Fund with a comprehensive package of transfer agency, shareholder, and other services. The Board, directly and through its various committees, regularly reviews reports and evaluations of such services at its regular meetings. These reports include, but are not limited to, information regarding the operational efficiency and accuracy of the shareholder and transfer agency services provided, staffing levels, shareholder satisfaction, technology support (including cyber security), new products and services offered to Fund shareholders, securities trading activities, portfolio valuation services, auditing services, and legal and operational compliance activities. The Board found the services provided by the Advisor to the Fund under the management agreement to be competitive and of high quality.

Costs of Services and Profitability. The Advisor provides detailed information concerning its cost of providing various services to the Fund, its profitability in managing the Fund (pre- and post-distribution), its overall profitability, and its financial condition. The Directors have reviewed with the Advisor the methodology used to prepare this financial information. This information is considered in evaluating the Advisor’s financial condition, its ability to continue to provide services under the management agreement, and the reasonableness of the current management fee. The Board concluded that the Advisor’s profits were reasonable in light of the services provided to the Fund.

Ethics. The Board generally considers the Advisor’s commitment to providing quality services to shareholders and to conducting its business ethically. They noted that the Advisor’s practices generally meet or exceed industry best practices.

Economies of Scale. The Board also reviewed information provided by the Advisor regarding the possible existence of economies of scale in connection with the management of the Fund. The Board concluded that economies of scale are difficult to measure and predict with precision, especially on a fund-by-fund basis. The Board concluded that the Advisor is sharing economies of scale, to the extent they exist, through its competitive fee structure, offering competitive fees from fund inception, and through reinvestment in its business, infrastructure, investment capabilities and initiatives to provide shareholders additional content and services.

Comparison to Other Funds’ Fees. The management agreement provides that the Fund pays the Advisor a single, all-inclusive (or unified) management fee for providing all services necessary for the management and operation of the Fund, other than brokerage expenses, expenses attributable to short sales, taxes, interest, extraordinary expenses, fees and expenses of the Fund’s independent Directors (including their independent legal counsel), and expenses incurred in connection with the provision of shareholder services and distribution services under a plan adopted pursuant to Rule 12b-1 under the Investment Company Act. Under the unified fee structure, the Advisor is responsible for providing all investment advisory, custody, audit, administrative, compliance, recordkeeping, marketing and shareholder services, or arranging and supervising third parties to provide such services. By contrast, most other funds are charged a variety of fees, including an investment advisory fee, a transfer agency fee, an administrative fee, distribution charges, and other expenses. Other than their investment advisory fees and any applicable Rule 12b-1 distribution fees, all other components of the total fees charged by these other funds may be increased without shareholder approval. The Board believes the unified fee structure is a benefit to Fund shareholders because it clearly discloses to shareholders the cost of owning Fund shares, and, since the unified fee cannot be increased without a vote of Fund shareholders, it shifts to the Advisor the risk of increased costs of operating the Fund and provides a direct incentive to minimize administrative inefficiencies. Part of the Board’s analysis of fee levels involves reviewing certain evaluative data compiled by an independent provider comparing the Fund’s unified fee to the total expense ratios of its peers. The unified fee charged to shareholders of the Fund was below the median of the total expense ratios of the Fund’s peer expense universe. In addition, the Board reviewed the Fund’s position relative to the narrower set of its expense group peers. The Board concluded that the management fee paid by the Fund to the Advisor under the management agreement is reasonable in light of the services provided to the Fund.

Comparison to Fees and Services Provided to Other Clients of the Advisor. The Board also requested and received information from the Advisor concerning the nature of the services, fees, costs, and profitability of its advisory services to advisory clients other than the Fund. They
26


observed that these varying types of client accounts require different services and involve different regulatory and entrepreneurial risks than the management of the Fund. The Board analyzed this information and concluded that the fees charged and services provided to the Fund were reasonable by comparison.

Payments to Intermediaries. The Directors also requested and received a description of payments made to intermediaries by the Fund and the Advisor and services provided in response thereto. These payments include various payments made by the Fund or the Advisor to different types of intermediaries and recordkeepers for distribution and service activities provided for the Fund. The Directors reviewed such information and received representations from the Advisor that all such payments by the Fund were made pursuant to the Fund's Rule 12b-1 Plan and that all such payments by the Advisor were made from the Advisor’s resources and reasonable profits. The Board found such payments to be reasonable in scope and purpose.

Collateral or “Fall-Out” Benefits Derived by the Advisor. The Board considered the possible existence of collateral benefits the Advisor may receive as a result of its relationship with the Fund. They concluded that the Advisor’s primary business is managing funds and it generally does not use fund or shareholder information to generate profits in other lines of business, and therefore does not derive any significant collateral benefits from them. To the extent there are potential collateral benefits, the Board has been advised and has taken this into consideration in its review of the management contract with the Fund. The Board noted that additional assets from other clients may offer the Advisor some benefit from increased leverage with service providers and counterparties. Additionally, the Advisor may receive proprietary research from broker-dealers that execute fund portfolio transactions, which the Board concluded is likely to benefit other clients of the Advisor, as well as Fund shareholders. The Board also determined that the Advisor is able to provide investment management services to certain clients other than the Fund, at least in part, due to its existing infrastructure built to serve the fund complex. The Board concluded that appropriate allocation methodologies had been employed to assign resources and the cost of those resources to these other clients.

Existing Relationship. The Board also considered whether there was any reason for not continuing the existing arrangement with the Advisor. In this regard, the Board was mindful of the potential disruptions of the Fund’s operations and various risks, uncertainties, and other effects that could occur as a result of a decision not to continue such relationship. In particular, the Board recognized that most shareholders have invested in the Fund on the strength of the Advisor’s industry standing and reputation and in the expectation that the Advisor will have a continuing role in providing advisory services to the Fund.

Conclusion of the Directors. As a result of this process, the Board, including all of the independent Directors, taking into account all of the factors discussed above and the information provided by the Advisor and others in connection with its review and throughout the year, determined that the management fee is fair and reasonable in light of the services provided and that the investment management agreement between the Fund and the Advisor should be renewed.
27


Additional Information

Retirement Account Information

As required by law, distributions you receive from certain retirement accounts are subject to federal income tax withholding, unless you elect not to have withholding apply*. Tax will be withheld on the total amount withdrawn even though you may be receiving amounts that are not subject to withholding, such as nondeductible contributions. In such case, excess amounts of withholding could occur. You may adjust your withholding election so that a greater or lesser amount will be withheld.
If you don’t want us to withhold on this amount, you must notify us to not withhold the federal income tax. You may notify us in writing or in certain situations by telephone or through other electronic means. For systematic withdrawals, your withholding election will remain in effect until revoked or changed by filing a new election. You have the right to revoke your election at any time and change your withholding percentage for future distributions.
Remember, even if you elect not to have income tax withheld, you are liable for paying income tax on the taxable portion of your withdrawal. If you elect not to have income tax withheld or you don’t have enough income tax withheld, you may be responsible for payment of estimated tax. You may incur penalties under the estimated tax rules if your withholding and estimated tax payments are not sufficient. You can reduce or defer the income tax on a distribution by directly or indirectly rolling such distribution over to another IRA or eligible plan. You should consult your tax advisor for additional information.
State tax will be withheld if, at the time of your distribution, your address is within one of the mandatory withholding states and you have federal income tax withheld (or as otherwise required by state law). State taxes will be withheld from your distribution in accordance with the respective state rules.
*Some 403(b), 457 and qualified retirement plan distributions may be subject to 20% mandatory withholding, as they are subject to special tax and withholding rules.  Your plan administrator or plan sponsor is required to provide you with a special tax notice explaining those rules at the time you request a distribution.  If applicable, federal and/or state taxes may be withheld from your distribution amount.


Proxy Voting Policies

A description of the policies that the fund's investment advisor uses in exercising the voting rights associated with the securities purchased and/or held by the fund is available without charge, upon request, by calling 1-800-345-2021. It is also available on American Century Investments’ website at americancentury.com/proxy and on the Securities and Exchange Commission’s website at sec.gov. Information regarding how the investment advisor voted proxies relating to portfolio securities during the most recent 12-month period ended June 30 is available on americancentury.com/proxy. It is also available at sec.gov.


Quarterly Portfolio Disclosure

The fund files its complete schedule of portfolio holdings with the Securities and Exchange Commission (SEC) for the first and third quarters of each fiscal year as an exhibit to its reports on Form N-PORT. These portfolio holdings are available on the fund's website at americancentury.com and, upon request, by calling 1-800-345-2021. The fund’s Form N-PORT reports are available on the SEC’s website at sec.gov.



28


Other Tax Information

The following information is provided pursuant to provisions of the Internal Revenue Code.

The fund hereby designates up to the maximum amount allowable as qualified dividend income for the fiscal year ended October 31, 2021.

For corporate taxpayers, the fund hereby designates $2,757,538, or up to the maximum amount allowable, of ordinary income distributions paid during the fiscal year ended October 31, 2021 as qualified for the corporate dividends received deduction.

The fund hereby designates $96,311,885, or up to the maximum amount allowable, as long-term capital gain distributions (20% rate gain distributions) for the fiscal year ended October 31, 2021.

The fund hereby designates $5,648,481 as qualified short-term capital gain distributions for purposes of Internal Revenue Code Section 871 for the fiscal year ended October 31, 2021.

The fund utilized earnings and profits of $9,131,746 distributed to shareholders on redemption of shares as part of the dividends paid deduction (tax equalization).

29


Notes
30


Notes
31


Notes
32






image8.jpg
Contact Usamericancentury.com
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Investor Services Representative1-800-345-2021
or 816-531-5575
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Telecommunications Relay Service for the Deaf711
American Century Mutual Funds, Inc.
Investment Advisor:
American Century Investment Management, Inc.
Kansas City, Missouri
This report and the statements it contains are submitted for the general information of our shareholders. The report is not authorized for distribution to prospective investors unless preceded or accompanied by an effective prospectus.
©2021 American Century Proprietary Holdings, Inc. All rights reserved.
CL-ANN-90987 2112




    


image8.jpg
Annual Report
October 31, 2021
Select Fund
Investor Class (TWCIX)
I Class (TWSIX)
Y Class (ASLWX)
A Class (TWCAX)
C Class (ACSLX)
R Class (ASERX)
R5 Class (ASLGX)
R6 Class (ASDEX)






















Table of Contents
 
President’s Letter
Performance
Portfolio Commentary
Fund Characteristics
Shareholder Fee Example
Schedule of Investments
Statement of Assets and Liabilities
Statement of Operations
Statement of Changes in Net Assets
Notes to Financial Statements
Financial Highlights
Report of Independent Registered Public Accounting Firm
Management
Approval of Management Agreement
Additional Information

















Any opinions expressed in this report reflect those of the author as of the date of the report, and do not necessarily represent the opinions of American Century Investments® or any other person in the American Century Investments organization. Any such opinions are subject to change at any time based upon market or other conditions and American Century Investments disclaims any responsibility to update such opinions. These opinions may not be relied upon as investment advice and, because investment decisions made by American Century Investments funds are based on numerous factors, may not be relied upon as an indication of trading intent on behalf of any American Century Investments fund. Security examples are used for representational purposes only and are not intended as recommendations to purchase or sell securities. Performance information for comparative indices and securities is provided to American Century Investments by third party vendors. To the best of American Century Investments’ knowledge, such information is accurate at the time of printing.



President’s Letter
image30.jpg Jonathan Thomas

Dear Investor:

Thank you for reviewing this annual report for the period ended October 31, 2021. Annual reports help convey important information about fund returns, including market factors that affected performance. For additional investment insights, please visit americancentury.com.
Economic, Earnings Gains Fueled Rally Among Risk-On Assets

Stocks and other risk-on assets rallied for the 12-month period, despite lingering pandemic-related challenges. Upbeat data on U.S. manufacturing, employment and housing, along with central bank and federal government support and positive vaccine developments, helped boost corporate earnings and promote investor optimism. Outside the U.S., most economies recovered, but generally at a slower pace. Virus outbreaks and slower vaccine rollouts, particularly in emerging markets, led to lingering lockdowns in some regions.

As the period progressed, steady economic gains combined with ongoing monetary and fiscal support, rising energy prices and severe supply chain disruptions pushed global interest rates and inflation higher. In the U.S., year-over-year headline inflation climbed to 6.2% in October 2021, the largest 12-month increase in nearly 31 years.
Late in the period, the Federal Reserve (Fed) confirmed it would start tapering its bond buying in November. Yet despite inflation’s surge, the Fed left short-term interest rates unchanged. Central banks in Europe and the U.K. maintained their supportive interest rate and bond-buying programs as inflation ticked higher.

Overall, stocks delivered stellar performance for the 12-month period, highlighted by the S&P 500 Index’s gain of nearly 43%. Assets offering inflation-fighting potential, including real estate investment trusts, fared even better. Meanwhile, global bonds retreated as interest rates rose. However, emerging markets bonds largely advanced, benefiting from risk-on sentiment.
Several Factors Shaping Market Dynamics

The return to pre-pandemic life is progressing, albeit somewhat cautiously due to COVID-19’s lingering effects. As the economy and markets respond to this fluid backdrop, investors will face opportunities and ongoing challenges. Economic growth, inflation, the virus’s trajectory, supply chain normalization and fiscal and monetary policy likely will sway market dynamics.

We appreciate your confidence in us during these extraordinary times. Our firm has a long history of helping clients weather unpredictable markets, and we’re confident we will continue to meet today’s challenges.

Sincerely,
image19.jpg
Jonathan Thomas
President and Chief Executive Officer
American Century Investments
2


Performance
Total Returns as of October 31, 2021
Average Annual Returns
Ticker
Symbol
1 year5 years10 yearsSince
Inception
Inception
Date
Investor ClassTWCIX40.63%23.43%17.73%6/30/71
Russell 1000 Growth Index43.21%25.47%19.41%
I ClassTWSIX40.90%23.68%17.97%3/13/97
Y ClassASLWX41.11%23.35%4/10/17
A ClassTWCAX8/8/97
No sales charge40.26%23.12%17.44%
With sales charge32.20%21.67%16.74%
C ClassACSLX39.23%22.20%16.56%1/31/03
R ClassASERX39.92%22.82%17.14%7/29/05
R5 ClassASLGX40.91%23.15%4/10/17
R6 ClassASDEX41.11%23.86%18.76%7/26/13
Average annual returns since inception are presented when ten years of performance history is not available.
Although the fund’s actual inception date was October 31, 1958, this inception date corresponds with the investment advisor’s implementation of its current investment philosophy and practices. Fund returns would have been lower if a portion of the fees had not been waived. Extraordinary performance is attributable in part to unusually favorable market conditions and may not be repeated or consistently achieved in the future.

C Class shares will automatically convert to A Class shares after being held for approximately eight years. C Class average annual returns do not reflect this conversion.

Sales charges include initial sales charges and contingent deferred sales charges (CDSCs), as applicable. A Class shares have a 5.75% maximum initial sales charge and may be subject to a maximum CDSC of 1.00%. C Class shares redeemed within 12 months of purchase are subject to a maximum CDSC of 1.00%. The SEC requires that mutual funds provide performance information net of maximum sales charges in all cases where charges could be applied.













Data presented reflect past performance. Past performance is no guarantee of future results. Current performance may be higher or lower than the performance shown. Total returns for periods less than one year are not annualized. Investment return and principal value will fluctuate, and redemption value may be more or less than original cost. Data assumes reinvestment of dividends and capital gains, and none of the charts reflect the deduction of taxes that a shareholder would pay on fund distributions or the redemption of fund shares. To obtain performance data current to the most recent month end, please call 1-800-345-2021 or visit americancentury.com. For additional information about the fund, please consult the prospectus.
3


Growth of $10,000 Over 10 Years
$10,000 investment made October 31, 2011
Performance for other share classes will vary due to differences in fee structure.
 chart-b11c78ed8def43d0b36a.jpg
Value on October 31, 2021
Investor Class — $51,223
Russell 1000 Growth Index — $59,008
Ending value of Investor Class would have been lower if a portion of the fees had not been waived.

Total Annual Fund Operating Expenses
Investor ClassI ClassY ClassA ClassC ClassR ClassR5 ClassR6 Class
0.99%0.79%0.64%1.24%1.99%1.49%0.79%0.64%
The total annual fund operating expenses shown is as stated in the fund’s prospectus current as of the date of this report. The prospectus may vary from the expense ratio shown elsewhere in this report because it is based on a different time period, includes acquired fund fees and expenses, and, if applicable, does not include fee waivers or expense reimbursements.
















Data presented reflect past performance. Past performance is no guarantee of future results. Current performance may be higher or lower than the performance shown. Total returns for periods less than one year are not annualized. Investment return and principal value will fluctuate, and redemption value may be more or less than original cost. Data assumes reinvestment of dividends and capital gains, and none of the charts reflect the deduction of taxes that a shareholder would pay on fund distributions or the redemption of fund shares. To obtain performance data current to the most recent month end, please call 1-800-345-2021 or visit americancentury.com. For additional information about the fund, please consult the prospectus.
4


Portfolio Commentary

Portfolio Managers: Keith Lee, Michael Li and Chris Krantz

Performance Summary

Select returned 40.63%* for the 12 months ended October 31, 2021, lagging the 43.21% return of the fund’s benchmark, the Russell 1000 Growth Index.

U.S. stocks posted strong returns during the reporting period, supported by federal government stimulus and low interest rates. The rollout of COVID-19 vaccines allowed the economy to reopen, and despite concerns about the delta variant, inflationary pressures and supply chain constraints, several market indices ended the 12-month period at record highs. Within the Russell 1000 Growth Index, all sectors posted double-digit gains, led by energy, which surged on demand and limited supply as the economy began to reopen. Materials was the weakest sector.

Stock selection in the information technology and health care sectors detracted from performance relative to the benchmark. Stock choices in the communication services and consumer staples sectors benefited performance.

Information Technology Stocks Led Detractors

IT services holdings helped drive underperformance in the information technology sector, led by Mastercard. The digital payments company’s stock lagged on concerns that the delta variant of COVID-19 might lead to renewed lockdowns that would slow economic growth, impacting consumer spending and travel. Elsewhere in information technology, our lack of exposure to NVIDIA detracted from performance compared with the benchmark. We don’t dispute that NVIDIA has a very strong position in certain chips and applications. But from our perspective, we see greater opportunity in the users of the company’s technology that have exceptionally large addressable markets, such as Alphabet, Meta Platforms (formerly Facebook) and Amazon, among others. Underweighting Microsoft relative to the benchmark also detracted. The software giant reported better-than-expected revenue and earnings, aided by the strong performance of its Azure cloud segment.

Other significant detractors included underweighting Tesla relative to the benchmark. The electric carmaker continued to benefit from solid fundamental reports and strong demand for its vehicles. The stock also got a boost when it was added to the S&P 500 Index. Bristol-Myers Squibb’s stock price fell late in the period along with other large-cap pharmaceutical stocks, largely on concerns about proposed legislation that would lower drug prices. Investors also worried about biosimilar drugs expected to come to market next year.

Communication Services Stocks Aided Relative Performance

Alphabet led contributors in the communication services sector. Digital advertising remained strong for Google’s parent company, driven by sustained e-commerce and reopening activity. Its YouTube business, in particular, produced strong results as new advertising products across both brand and direct response were favorably received.

Other top contributors included Atlassian. This software company provides collaborative tools used by small and midsize companies and increasingly larger companies. As pandemic restrictions eased and workers started returning to the office, Atlassian saw renewed growth for its software, driving strong revenue and earnings. Crowdstrike Holdings, a cloud-based cybersecurity firm, outperformed, helped by a tailwind caused by recent high-profile ransomware attacks. Not owning



*All fund returns referenced in this commentary are for Investor Class shares. Fund returns would have been lower if a portion of the fees had not been waived. Performance for other share classes will vary due to differences in fee structure; when Investor Class performance exceeds that of the fund’s benchmark, other share classes may not. See page 3 for returns for all share classes.
5


Zoom Video Communications helped performance compared with the benchmark. After benefiting from the pandemic in 2020, investors reallocated capital in 2021 to stocks that were expected to benefit from the reopening of the economy. Zoom was a victim of the market’s swing, and our lack of exposure was helpful. MSCI, a leading provider of global financial market indices and software, outperformed after posting better-than-expected revenue and earnings. The company has enjoyed high recurring revenue and operating margins, and we think it is positioned for long-term growth thanks to its analytics business and role as a key provider of environment, sustainability and governance data.

Outlook

We remain confident in our belief that high-quality companies with a capability for sustained long-term growth can outperform over time. Our portfolio positioning reflects where we are finding attractive, well-run mature growth companies as a result of the application of that philosophy and process.

At the end of the reporting period, our largest sector overweight relative to the benchmark was communication services. The sector encompasses entertainment and communication stocks, including large portfolio holdings Google parent Alphabet and Meta Platforms, the new name for Facebook. Information technology also ended the period overweight, reflecting what we view as an abundance of high-quality, well-run companies benefiting from powerful secular trends. Industrials was the largest sector underweight.















6


Fund Characteristics
OCTOBER 31, 2021
Types of Investments in Portfolio% of net assets
Common Stocks99.5%
Convertible Bonds0.4%
Temporary Cash Investments0.1%
Other Assets and Liabilities
—*
*Category is less than 0.05% of total net assets.
Top Five Industries% of net assets
Software15.7%
Interactive Media and Services14.0%
Technology Hardware, Storage and Peripherals13.2%
IT Services10.1%
Semiconductors and Semiconductor Equipment7.5%

7


Shareholder Fee Example 

Fund shareholders may incur two types of costs: (1) transaction costs, including sales charges (loads) on purchase payments and redemption/exchange fees; and (2) ongoing costs, including management fees; distribution and service (12b-1) fees; and other fund expenses. This example is intended to help you understand your ongoing costs (in dollars) of investing in your fund and to compare these costs with the ongoing cost of investing in other mutual funds.

The example is based on an investment of $1,000 made at the beginning of the period and held for the entire period from May 1, 2021 to October 31, 2021.

Actual Expenses

The table provides information about actual account values and actual expenses for each class. You may use the information, together with the amount you invested, to estimate the expenses that you paid over the period. First, identify the share class you own. Then simply divide your account value by $1,000 (for example, an $8,600 account value divided by $1,000 = 8.6), then multiply the result by the number under the heading “Expenses Paid During Period” to estimate the expenses you paid on your account during this period.

If you hold Investor Class shares of any American Century Investments fund, or I Class shares of the American Century Diversified Bond Fund, in an American Century Investments account (i.e., not through a financial intermediary or employer-sponsored retirement plan account), American Century Investments may charge you a $25.00 annual account maintenance fee if the value of those shares is less than $10,000. We will redeem shares automatically in one of your accounts to pay the $25.00 fee. In determining your total eligible investment amount, we will include your investments in all personal accounts (including American Century Investments brokerage accounts) registered under your Social Security number. Personal accounts include individual accounts, joint accounts, UGMA/UTMA accounts, personal trusts, Coverdell Education Savings Accounts and IRAs (including traditional, Roth, Rollover, SEP-, SARSEP- and SIMPLE-IRAs), and certain other retirement accounts. If you have only business, business retirement, employer-sponsored or American Century Investments brokerage accounts, you are currently not subject to this fee. If you are subject to the account maintenance fee, your account value could be reduced by the fee amount.

Hypothetical Example for Comparison Purposes

The table also provides information about hypothetical account values and hypothetical expenses based on the actual expense ratio of each class of your fund and an assumed rate of return of 5% per year before expenses, which is not the actual return of a fund’s share class. The hypothetical account values and expenses may not be used to estimate the actual ending account balance or expenses you paid for the period. You may use this information to compare the ongoing costs of investing in your fund and other funds. To do so, compare this 5% hypothetical example with the 5% hypothetical examples that appear in the shareholder reports of the other funds.

Please note that the expenses shown in the table are meant to highlight your ongoing costs only and do not reflect any transactional costs, such as sales charges (loads) or redemption/exchange fees. Therefore, the table is useful in comparing ongoing costs only, and will not help you determine the relative total costs of owning different funds. In addition, if these transactional costs were included, your costs would have been higher.
8


Beginning
Account Value
5/1/21
Ending
Account Value
10/31/21
Expenses Paid
During Period(1)
5/1/21 - 10/31/21
Annualized
Expense Ratio(1)
Actual
Investor Class$1,000$1,133.20$5.160.96%
I Class$1,000$1,134.30$4.090.76%
Y Class$1,000$1,135.20$3.280.61%
A Class$1,000$1,131.80$6.501.21%
C Class$1,000$1,127.50$10.511.96%
R Class$1,000$1,130.40$7.841.46%
R5 Class$1,000$1,134.40$4.090.76%
R6 Class$1,000$1,135.20$3.280.61%
Hypothetical
Investor Class$1,000$1,020.37$4.890.96%
I Class$1,000$1,021.37$3.870.76%
Y Class$1,000$1,022.13$3.110.61%
A Class$1,000$1,019.11$6.161.21%
C Class$1,000$1,015.33$9.961.96%
R Class$1,000$1,017.85$7.431.46%
R5 Class$1,000$1,021.37$3.870.76%
R6 Class$1,000$1,022.13$3.110.61%
(1)Expenses are equal to the class's annualized expense ratio listed in the table above, multiplied by the average account value over the period, multiplied by 184, the number of days in the most recent fiscal half-year, divided by 365, to reflect the one-half year period. Annualized expense ratio reflects actual expenses, including any applicable fee waivers or expense reimbursements and excluding any acquired fund fees and expenses.
9


Schedule of Investments

OCTOBER 31, 2021
SharesValue
COMMON STOCKS — 99.5%


Auto Components — 0.5%
Aptiv plc(1)
155,600 $26,901,683 
Automobiles — 3.8%
Tesla, Inc.(1)
174,100 193,947,400 
Beverages — 1.1%
Constellation Brands, Inc., Class A194,700 42,212,907 
Diageo plc330,500 16,442,933 
58,655,840 
Biotechnology — 2.8%
Biogen, Inc.(1)
201,600 53,762,688 
Regeneron Pharmaceuticals, Inc.(1)
139,800 89,463,612 
143,226,300 
Capital Markets — 1.9%
Moody's Corp.71,100 28,735,065 
MSCI, Inc.106,400 70,743,232 
99,478,297 
Containers and Packaging — 0.6%
Ball Corp.314,600 28,779,608 
Energy Equipment and Services — 0.4%
ChampionX Corp.(1)
781,400 20,496,122 
Entertainment — 1.5%
Electronic Arts, Inc.253,100 35,497,275 
Walt Disney Co. (The)(1)
235,700 39,849,799 
75,347,074 
Equity Real Estate Investment Trusts (REITs) — 1.3%
American Tower Corp.111,800 31,524,246 
Equinix, Inc.41,700 34,905,819 
66,430,065 
Food and Staples Retailing — 1.3%
Costco Wholesale Corp.130,200 63,998,508 
Health Care Equipment and Supplies — 2.3%
Danaher Corp.132,500 41,309,525 
Penumbra, Inc.(1)
102,200 28,263,410 
Stryker Corp.177,300 47,174,211 
116,747,146 
Health Care Providers and Services — 3.3%
UnitedHealth Group, Inc.362,400 166,874,328 
Hotels, Restaurants and Leisure — 0.8%
Airbnb, Inc., Class A(1)
249,500 42,579,670 
Industrial Conglomerates — 0.2%
Roper Technologies, Inc.26,000 12,684,620 
Interactive Media and Services — 14.0%
Alphabet, Inc., Class A(1)
90,600 268,259,352 
Alphabet, Inc., Class C(1)
84,900 251,763,309 
Meta Platforms, Inc., Class A(1)
609,400 197,183,558 
717,206,219 
Internet and Direct Marketing Retail — 7.0%
Amazon.com, Inc.(1)
106,300 358,489,309 
10


Shares/
Principal Amount
Value
IT Services — 9.7%
Mastercard, Inc., Class A624,100 $209,398,032 
PayPal Holdings, Inc.(1)
806,800 187,653,612 
Visa, Inc., Class A471,300 99,807,201 
496,858,845 
Machinery — 0.5%
FANUC Corp.129,200 25,532,645 
Personal Products — 0.7%
Estee Lauder Cos., Inc. (The), Class A111,100 36,033,063 
Pharmaceuticals — 1.2%
Bristol-Myers Squibb Co.1,077,000 62,896,800 
Professional Services — 0.8%
IHS Markit Ltd.122,700 16,039,344 
Verisk Analytics, Inc.122,000 25,652,940 
41,692,284 
Road and Rail — 0.4%
Canadian Pacific Railway Ltd.272,000 21,052,747 
Semiconductors and Semiconductor Equipment — 7.5%
Analog Devices, Inc.960,449 166,628,297 
KLA Corp.162,100 60,424,396 
Texas Instruments, Inc.551,200 103,338,976 
Xilinx, Inc.291,200 52,416,000 
382,807,669 
Software — 15.7%
Adobe, Inc.(1)
62,500 40,647,500 
Atlassian Corp. plc, Class A(1)
309,000 141,562,170 
Crowdstrike Holdings, Inc., Class A(1)
272,900 76,903,220 
Microsoft Corp.1,181,100 391,676,382 
salesforce.com, Inc.(1)
188,000 56,341,720 
Zendesk, Inc.(1)
190,100 19,352,180 
Zscaler, Inc.(1)
236,200 75,314,732 
801,797,904 
Specialty Retail — 5.4%
Home Depot, Inc. (The)249,600 92,786,304 
Lowe's Cos., Inc.419,200 98,017,344 
Tractor Supply Co.389,400 84,565,998 
275,369,646 
Technology Hardware, Storage and Peripherals — 13.2%
Apple, Inc.4,509,000 675,448,200 
Textiles, Apparel and Luxury Goods — 1.6%
NIKE, Inc., Class B498,200 83,343,878 
TOTAL COMMON STOCKS
(Cost $1,557,479,285)
5,094,675,870 
CONVERTIBLE BONDS — 0.4%


IT Services — 0.4%
Square, Inc., 0.50%, 5/15/23
(Cost $5,358,969)
$5,601,000 18,318,771 
TEMPORARY CASH INVESTMENTS — 0.1%


Repurchase Agreement, BMO Capital Markets Corp., (collateralized by various U.S. Treasury obligations, 2.00%, 11/15/26, valued at $1,327,848), in a joint trading account at 0.01%, dated 10/29/21, due 11/1/21 (Delivery value $1,300,231)1,300,230 
11


SharesValue
Repurchase Agreement, Fixed Income Clearing Corp., (collateralized by various U.S. Treasury obligations, 2.25%, 5/15/41, valued at $4,417,718), at 0.01%, dated 10/29/21, due 11/1/21 (Delivery value $4,331,004)$4,331,000 
State Street Institutional U.S. Government Money Market Fund, Premier Class173,793 173,793 
TOTAL TEMPORARY CASH INVESTMENTS
(Cost $5,805,023)
5,805,023 
TOTAL INVESTMENT SECURITIES — 100.0%
(Cost $1,568,643,277)

5,118,799,664 
OTHER ASSETS AND LIABILITIES

(7,463)
TOTAL NET ASSETS — 100.0%

$5,118,792,201 

FORWARD FOREIGN CURRENCY EXCHANGE CONTRACTS
Currency PurchasedCurrency SoldCounterpartySettlement DateUnrealized Appreciation
(Depreciation)
USD12,554,405 CAD15,984,080 Morgan Stanley12/31/21$(363,116)
USD421,077 CAD521,696 Morgan Stanley12/31/21(531)
USD539,885 CAD668,304 Morgan Stanley12/31/21(204)
USD609,841 CAD753,984 Morgan Stanley12/31/21510 
$(363,341)

NOTES TO SCHEDULE OF INVESTMENTS
CAD-Canadian Dollar
USD-United States Dollar
Category is less than 0.05% of total net assets.
(1)Non-income producing.


See Notes to Financial Statements.
12


Statement of Assets and Liabilities
OCTOBER 31, 2021
Assets
Investment securities, at value (cost of $1,568,643,277)$5,118,799,664 
Receivable for investments sold2,131,759 
Receivable for capital shares sold785,045 
Unrealized appreciation on forward foreign currency exchange contracts510 
Dividends and interest receivable2,223,452 
Securities lending receivable815 
5,123,941,245 
Liabilities
Payable for capital shares redeemed829,215 
Unrealized depreciation on forward foreign currency exchange contracts363,851 
Accrued management fees3,935,950 
Distribution and service fees payable20,028 
5,149,044 
Net Assets$5,118,792,201 
Net Assets Consist of:
Capital (par value and paid-in surplus)$1,189,986,924 
Distributable earnings3,928,805,277 
$5,118,792,201 

Net AssetsShares OutstandingNet Asset Value Per Share
Investor Class, $0.01 Par Value$4,770,671,57338,435,773$124.12
I Class, $0.01 Par Value$156,502,4121,229,702$127.27
Y Class, $0.01 Par Value$103,668,547810,730$127.87
A Class, $0.01 Par Value$72,805,566607,027
$119.94*
C Class, $0.01 Par Value$4,151,37540,540$102.40
R Class, $0.01 Par Value$4,452,34137,796$117.80
R5 Class, $0.01 Par Value$12,983102$127.28
R6 Class, $0.01 Par Value$6,527,40451,114$127.70
*Maximum offering price $127.26 (net asset value divided by 0.9425).


See Notes to Financial Statements.
13


Statement of Operations
YEAR ENDED OCTOBER 31, 2021
Investment Income (Loss)
Income:
Dividends (net of foreign taxes withheld of $77,219)$27,063,585 
Interest193,585 
Securities lending, net14,171 
27,271,341 
Expenses:
Management fees44,430,106 
Distribution and service fees:
A Class162,608 
C Class44,125 
R Class19,784 
Directors' fees and expenses115,977 
Other expenses4,278 
44,776,878 
Fees waived(1)
(1,054,000)
43,722,878 
Net investment income (loss)(16,451,537)
Realized and Unrealized Gain (Loss)
Net realized gain (loss) on:
Investment transactions394,273,975 
Forward foreign currency exchange contract transactions(584,387)
Written options contract transactions375,041 
Foreign currency translation transactions(1,875)
394,062,754 
Change in net unrealized appreciation (depreciation) on:
Investments1,143,394,927 
Forward foreign currency exchange contracts(351,694)
Translation of assets and liabilities in foreign currencies(6,256)
1,143,036,977 
Net realized and unrealized gain (loss)1,537,099,731 
Net Increase (Decrease) in Net Assets Resulting from Operations$1,520,648,194 
(1)Amount consists of $983,414, $32,543, $19,804, $15,009, $995, $913, $4 and $1,318 for Investor Class, I Class, Y Class, A Class, C Class, R Class, R5 Class and R6 Class, respectively.


See Notes to Financial Statements.
14


Statement of Changes in Net Assets
YEARS ENDED OCTOBER 31, 2021 AND OCTOBER 31, 2020
Increase (Decrease) in Net AssetsOctober 31, 2021October 31, 2020
Operations
Net investment income (loss)
$(16,451,537)$(5,118,930)
Net realized gain (loss)
394,062,754 268,341,969 
Change in net unrealized appreciation (depreciation)
1,143,036,977 557,360,313 
Net increase (decrease) in net assets resulting from operations
1,520,648,194 820,583,352 
Distributions to Shareholders
From earnings:
Investor Class(240,030,213)(167,944,066)
I Class(7,922,820)(5,704,618)
Y Class(4,985,113)(2,611,966)
A Class(3,739,458)(2,383,411)
C Class(416,002)(346,331)
R Class(245,807)(178,475)
R5 Class(604)(394)
R6 Class(271,184)(158,543)
Decrease in net assets from distributions(257,611,201)(179,327,804)
Capital Share Transactions
Net increase (decrease) in net assets from capital share transactions (Note 5)(1,114,068)(42,842,237)
Net increase (decrease) in net assets1,261,922,925 598,413,311 
Net Assets
Beginning of period3,856,869,276 3,258,455,965 
End of period$5,118,792,201 $3,856,869,276 


See Notes to Financial Statements.
15


Notes to Financial Statements

OCTOBER 31, 2021

1. Organization

American Century Mutual Funds, Inc. (the corporation) is registered under the Investment Company Act of 1940, as amended (the 1940 Act), as an open-end management investment company and is organized as a Maryland corporation. Select Fund (the fund) is one fund in a series issued by the corporation. The fund’s investment objective is to seek long-term capital growth.

The fund offers the Investor Class, I Class, Y Class, A Class, C Class, R Class, R5 Class and R6 Class. The A Class may incur an initial sales charge. The A Class and C Class may be subject to a contingent deferred sales charge.

2. Significant Accounting Policies

The following is a summary of significant accounting policies consistently followed by the fund in preparation of its financial statements. The fund is an investment company and follows accounting and reporting guidance in accordance with accounting principles generally accepted in the United States of America. This may require management to make certain estimates and assumptions at the date of the financial statements. Actual results could differ from these estimates. Management evaluated the impact of events or transactions occurring through the date the financial statements were issued that would merit recognition or disclosure.

Investment Valuations — The fund determines the fair value of its investments and computes its net asset value (NAV) per share at the close of regular trading (usually 4 p.m. Eastern time) on the New York Stock Exchange (NYSE) on each day the NYSE is open. The Board of Directors has adopted valuation policies and procedures to guide the investment advisor in the fund’s investment valuation process and to provide methodologies for the oversight of the fund’s pricing function.

Equity securities that are listed or traded on a domestic securities exchange are valued at the last reported sales price or at the official closing price as provided by the exchange. Equity securities traded on foreign securities exchanges are generally valued at the closing price of such securities on the exchange where primarily traded or at the close of the NYSE, if that is earlier. If no last sales price is reported, or if local convention or regulation so provides, the mean of the latest bid and asked prices may be used. Securities traded over-the-counter are valued at the mean of the latest bid and asked prices, the last sales price, or the official closing price. Equity securities initially expressed in local currencies are translated into U.S. dollars at the mean of the appropriate currency exchange rate at the close of the NYSE as provided by an independent pricing service.

Fixed income securities are valued at the evaluated mean as provided by independent pricing services or at the mean of the most recent bid and asked prices as provided by investment dealers. Convertible bonds are valued using market models that consider trade data, quotations from dealers and active market makers, relevant yield curve and spread data, creditworthiness, trade data or market information on comparable securities, and other relevant security specific information.

Open-end management investment companies are valued at the reported NAV per share. Exchange-traded options contracts are valued at a mean as provided by independent pricing services. Repurchase agreements are valued at cost, which approximates fair value. Forward foreign currency exchange contracts are valued at the mean of the appropriate forward exchange rate at the close of the NYSE as provided by an independent pricing service.

If the fund determines that the market price for an investment is not readily available or the valuation methods mentioned above do not reflect an investment’s fair value, such investment is valued as determined in good faith by the Board of Directors or its delegate, in accordance with policies and procedures adopted by the Board of Directors. In its determination of fair value, the fund may review several factors including, but not limited to, market information regarding the specific investment or comparable investments and correlation with other investment types, futures indices or general market indicators. Circumstances that may cause the fund to use these procedures to value an investment include, but are not limited to: an investment has been declared in default or is distressed; trading in a security has been suspended during the trading day or a
16


security is not actively trading on its principal exchange; prices received from a regular pricing source are deemed unreliable; or there is a foreign market holiday and no trading occurred.
The fund monitors for significant events occurring after the close of an investment’s primary exchange but before the fund’s NAV per share is determined. Significant events may include, but are not limited to: corporate announcements and transactions; governmental action and political unrest that could impact a specific investment or an investment sector; or armed conflicts, natural disasters and similar events that could affect investments in a specific country or region. The fund also monitors for significant fluctuations between domestic and foreign markets, as evidenced by the U.S. market or such other indicators that the Board of Directors, or its delegate, deems appropriate. The fund may apply a model-derived factor to the closing price of equity securities traded on foreign securities exchanges. The factor is based on observable market data as provided by an independent pricing service.
Security Transactions — Security transactions are accounted for as of the trade date. Net realized gains and losses are determined on the identified cost basis, which is also used for federal income tax purposes.
Investment Income — Dividend income less foreign taxes withheld, if any, is recorded as of the ex-dividend date. Distributions received on securities that represent a return of capital or long-term capital gain are recorded as a reduction of cost of investments and/or as a realized gain. The fund may estimate the components of distributions received that may be considered nontaxable distributions or long-term capital gain distributions for income tax purposes. Interest income is recorded on the accrual basis and includes accretion of discounts and amortization of premiums. For convertible bonds, the premiums attributable only to the debt instrument are amortized. Securities lending income is net of fees and rebates earned by the lending agent for its services.
Foreign Currency Translations — All assets and liabilities initially expressed in foreign currencies are translated into U.S. dollars at prevailing exchange rates at period end. The fund may enter into spot foreign currency exchange contracts to facilitate transactions denominated in a foreign currency. Purchases and sales of investment securities, dividend and interest income, spot foreign currency exchange contracts, and expenses are translated at the rates of exchange prevailing on the respective dates of such transactions. Net realized and unrealized foreign currency exchange gains or losses related to investment securities are a component of net realized gain (loss) on investment transactions and change in net unrealized appreciation (depreciation) on investments, respectively.
Repurchase Agreements — The fund may enter into repurchase agreements with institutions that American Century Investment Management, Inc. (ACIM) (the investment advisor) has determined are creditworthy pursuant to criteria adopted by the Board of Directors. The fund requires that the collateral, represented by securities, received in a repurchase transaction be transferred to the custodian in a manner sufficient to enable the fund to obtain those securities in the event of a default under the repurchase agreement. ACIM monitors, on a daily basis, the securities transferred to ensure the value, including accrued interest, of the securities under each repurchase agreement is equal to or greater than amounts owed to the fund under each repurchase agreement.
Joint Trading Account — Pursuant to an Exemptive Order issued by the Securities and Exchange Commission, the fund, along with certain other funds in the American Century Investments family of funds, may transfer uninvested cash balances into a joint trading account. These balances are invested in one or more repurchase agreements that are collateralized by U.S. Treasury or Agency obligations.
Segregated Assets — In accordance with the 1940 Act, the fund segregates assets on its books and records to cover certain types of investment securities and other financial instruments. ACIM monitors, on a daily basis, the securities segregated to ensure the fund designates a sufficient amount of liquid assets, marked-to-market daily. The fund may also receive assets or be required to pledge assets at the custodian bank or with a broker for collateral requirements.

Income Tax Status — It is the fund’s policy to distribute substantially all net investment income and net realized gains to shareholders and to otherwise qualify as a regulated investment company under provisions of the Internal Revenue Code. Accordingly, no provision has been made for income taxes. The fund files U.S. federal, state, local and non-U.S. tax returns as applicable. The fund's tax returns are subject to examination by the relevant taxing authority until expiration of the applicable statute of limitations, which is generally three years from the date of filing but can be longer in certain jurisdictions. At this time, management believes there are no uncertain tax positions which, based on their technical merit, would not be sustained upon examination and for which it is reasonably possible that the total amounts of unrecognized tax benefits will significantly change in the next twelve months.
17


Multiple Class — All shares of the fund represent an equal pro rata interest in the net assets of the class to which such shares belong, and have identical voting, dividend, liquidation and other rights and the same terms and conditions, except for class specific expenses and exclusive rights to vote on matters affecting only individual classes. Income, non-class specific expenses, and realized and unrealized capital gains and losses of the fund are allocated to each class of shares based on their relative net assets.
Distributions to Shareholders — Distributions from net investment income and net realized gains, if any, are generally declared and paid annually.
Indemnifications — Under the corporation’s organizational documents, its officers and directors are indemnified against certain liabilities arising out of the performance of their duties to the fund. In addition, in the normal course of business, the fund enters into contracts that provide general indemnifications. The maximum exposure under these arrangements is unknown as this would involve future claims that may be made against a fund. The risk of material loss from such claims is considered by management to be remote.
Securities Lending — Securities are lent to qualified financial institutions and brokers. State Street Bank & Trust Co. serves as securities lending agent to the fund pursuant to a Securities Lending Agreement. The lending of securities exposes the fund to risks such as: the borrowers may fail to return the loaned securities, the borrowers may not be able to provide additional collateral, the fund may experience delays in recovery of the loaned securities or delays in access to collateral, or the fund may experience losses related to the investment collateral. To minimize certain risks, loan counterparties pledge collateral in the form of cash and/or securities. The lending agent has agreed to indemnify the fund in the case of default of any securities borrowed. Cash collateral received is invested in the State Street Navigator Securities Lending Government Money Market Portfolio, a money market mutual fund registered under the 1940 Act. The loans may also be secured by U.S. government securities in an amount at least equal to the market value of the securities loaned, plus accrued interest and dividends, determined on a daily basis and adjusted accordingly. By lending securities, the fund seeks to increase its net investment income through the receipt of interest and fees. Such income is reflected separately within the Statement of Operations. The value of loaned securities and related collateral outstanding at period end, if any, are shown on a gross basis within the Schedule of Investments and Statement of Assets and Liabilities.
3. Fees and Transactions with Related Parties

Certain officers and directors of the corporation are also officers and/or directors of American Century Companies, Inc. (ACC). The corporation’s investment advisor, ACIM, the corporation's distributor, American Century Investment Services, Inc. (ACIS), and the corporation’s transfer agent, American Century Services, LLC, are wholly owned, directly or indirectly, by ACC.

Management Fees — The corporation has entered into a management agreement with ACIM, under which ACIM provides the fund with investment advisory and management services in exchange for a single, unified management fee (the fee) per class. The agreement provides that ACIM will pay all expenses of managing and operating the fund, except brokerage expenses, taxes, interest, fees and expenses of the independent directors (including legal counsel fees), extraordinary expenses, and expenses incurred in connection with the provision of shareholder services and distribution services under a plan adopted pursuant to Rule 12b-1 under the 1940 Act. The fee is computed and accrued daily based on each class's daily net assets and paid monthly in arrears. The difference in the fee among the classes is a result of their separate arrangements for non-Rule 12b-1 shareholder services. It is not the result of any difference in advisory or custodial fees or other expenses related to the management of the fund’s assets, which do not vary by class. The rate of the fee is determined by applying a fee rate calculation formula. This formula takes into account the fund’s assets as well as certain assets, if any, of other clients of the investment advisor outside the American Century Investments family of funds (such as subadvised funds and separate accounts) that use very similar investment teams and strategies (strategy assets). From November 1, 2020 through July 31, 2021, the investment advisor agreed to waive 0.02% of the fund’s management fee. Effective August 1, 2021, the investment advisor terminated the waiver and agreed to waive a portion of the fund’s management fee such that the management fee does not exceed 0.954% for Investor Class, A Class, C Class and R Class, 0.754% for I Class and R5 Class, and 0.604% for Y Class and R6 Class. The investment advisor expects this waiver arrangement to continue until July 31, 2022 and cannot terminate it prior to such date without the approval of the Board of Directors.
18


The management fee schedule range and the effective annual management fee before and after waiver for each class for the period ended October 31, 2021 are as follows:
Management Fee
Schedule Range
Effective Annual Management Fee
Before WaiverAfter Waiver
Investor Class0.800% to 0.990%0.99%0.97%
I Class0.600% to 0.790%0.79%0.77%
Y Class0.450% to 0.640%0.64%0.62%
A Class0.800% to 0.990%0.99%0.97%
C Class0.800% to 0.990%0.99%0.97%
R Class0.800% to 0.990%0.99%0.97%
R5 Class0.600% to 0.790%0.79%0.77%
R6 Class0.450% to 0.640%0.64%0.62%

Distribution and Service Fees — The Board of Directors has adopted a separate Master Distribution and Individual Shareholder Services Plan for each of the A Class, C Class and R Class (collectively the plans), pursuant to Rule 12b-1 of the 1940 Act. The plans provide that the A Class will pay ACIS an annual distribution and service fee of 0.25%. The plans provide that the C Class will pay ACIS an annual distribution and service fee of 1.00%, of which 0.25% is paid for individual shareholder services and 0.75% is paid for distribution services. The plans provide that the R Class will pay ACIS an annual distribution and service fee of 0.50%. The fees are computed and accrued daily based on each class’s daily net assets and paid monthly in arrears. The fees are used to pay financial intermediaries for distribution and individual shareholder services. Fees incurred under the plans during the period ended October 31, 2021 are detailed in the Statement of Operations.

Directors' Fees and Expenses — The Board of Directors is responsible for overseeing the investment advisor’s management and operations of the fund. The directors receive detailed information about the fund and its investment advisor regularly throughout the year, and meet at least quarterly with management of the investment advisor to review reports about fund operations. The fund’s officers do not receive compensation from the fund.
Interfund Transactions — The fund may enter into security transactions with other American Century Investments funds and other client accounts of the investment advisor, in accordance with the 1940 Act rules and procedures adopted by the Board of Directors. The rules and procedures require, among other things, that these transactions be effected at the independent current market price of the security. During the period, the interfund sales were $1,599,640 and there were no interfund purchases. The effect of interfund transactions on the Statement of Operations was $1,487,559 in net realized gain (loss) on investment transactions.

4. Investment Transactions

Purchases and sales of investment securities, excluding short-term investments, for the period ended October 31, 2021 were $511,054,061 and $790,457,214, respectively.
19


5. Capital Share Transactions

Transactions in shares of the fund were as follows:
Year ended
October 31, 2021
Year ended
October 31, 2020
SharesAmountSharesAmount
Investor Class/Shares Authorized475,000,000 475,000,000 
Sold
892,572 $96,405,055 1,243,588 $102,506,141 
Issued in reinvestment of distributions
2,304,332 226,851,440 2,018,516 159,826,128 
Redeemed
(3,050,748)(327,630,332)(3,836,882)(319,224,605)
146,156 (4,373,837)(574,778)(56,892,336)
I Class/Shares Authorized40,000,000 40,000,000 
Sold241,612 26,516,887 263,810 22,646,467 
Issued in reinvestment of distributions75,030 7,559,973 67,528 5,454,233 
Redeemed(336,569)(36,292,186)(397,122)(32,507,442)
(19,927)(2,215,326)(65,784)(4,406,742)
Y Class/Shares Authorized30,000,000 30,000,000 
Sold539,904 62,766,563 372,810 32,358,265 
Issued in reinvestment of distributions48,856 4,939,354 31,872 2,578,781 
Redeemed(532,009)(61,052,630)(224,881)(20,117,689)
56,751 6,653,287 179,801 14,819,357 
A Class/Shares Authorized40,000,000 40,000,000 
Sold64,313 6,610,145 150,187 12,354,119 
Issued in reinvestment of distributions38,481 3,669,198 30,503 2,349,653 
Redeemed(94,091)(9,834,703)(130,967)(10,805,132)
8,703 444,640 49,723 3,898,640 
C Class/Shares Authorized30,000,000 30,000,000 
Sold6,208 568,197 3,306 218,808 
Issued in reinvestment of distributions5,050 413,834 4,778 321,908 
Redeemed(38,754)(3,272,318)(21,797)(1,593,266)
(27,496)(2,290,287)(13,713)(1,052,550)
R Class/Shares Authorized30,000,000 30,000,000 
Sold9,167 939,879 13,166 1,067,191 
Issued in reinvestment of distributions2,207 206,867 2,346 178,475 
Redeemed(11,240)(1,143,785)(17,732)(1,462,813)
134 2,961 (2,220)(217,147)
R5 Class/Shares Authorized30,000,000 30,000,000 
Issued in reinvestment of distributions604 394 
R6 Class/Shares Authorized40,000,000 40,000,000 
Sold13,479 1,430,105 24,479 2,048,036 
Issued in reinvestment of distributions2,671 269,645 1,952 157,710 
Redeemed(9,294)(1,035,860)(13,941)(1,197,599)
6,856 663,890 12,490 1,008,147 
Net increase (decrease)171,183 $(1,114,068)(414,476)$(42,842,237)

20


6. Fair Value Measurements

The fund’s investments valuation process is based on several considerations and may use multiple inputs to determine the fair value of the investments held by the fund. In conformity with accounting principles generally accepted in the United States of America, the inputs used to determine a valuation are classified into three broad levels.

Level 1 valuation inputs consist of unadjusted quoted prices in an active market for identical investments.

Level 2 valuation inputs consist of direct or indirect observable market data (including quoted prices for comparable investments, evaluations of subsequent market events, interest rates, prepayment speeds, credit risk, etc.). These inputs also consist of quoted prices for identical investments initially expressed in local currencies that are adjusted through translation into U.S. dollars.

Level 3 valuation inputs consist of unobservable data (including a fund’s own assumptions).

The level classification is based on the lowest level input that is significant to the fair valuation measurement. The valuation inputs are not necessarily an indication of the risks associated with investing in these securities or other financial instruments.
The following is a summary of the level classifications as of period end. The Schedule of Investments provides additional information on the fund’s portfolio holdings.
Level 1Level 2Level 3
Assets
Investment Securities
Common Stocks$5,031,647,545 $63,028,325 — 
Convertible Bonds— 18,318,771 — 
Temporary Cash Investments173,793 5,631,230 — 
$5,031,821,338 $86,978,326 — 
Other Financial Instruments
Forward Foreign Currency Exchange Contracts— $510 — 
Liabilities
Other Financial Instruments
Forward Foreign Currency Exchange Contracts— $363,851 — 

7. Derivative Instruments

Equity Price Risk — The fund is subject to equity price risk in the normal course of pursuing its investment objectives. A fund may enter into options contracts based on an equity index or specific security in order to manage its exposure to changes in market conditions. The risks of entering into equity price risk derivative instruments include the possible lack of liquidity, failure of the counterparty to meet its obligations, and that there may be unfavorable changes in the underlying investments or instruments. A fund may purchase or write an option contract to protect against declines in market value on the underlying index or security. A purchased option contract provides the fund a right, but not an obligation, to buy (call) or sell (put) an equity-related asset at a specified exercise price within a certain period or on a specific date. A written option contract holds the corresponding obligation to sell (call writing) or buy (put writing) the underlying equity-related asset if the purchaser exercises the option contract. The buyer pays the seller an initial purchase price (premium) for this right. Option contracts purchased by a fund are accounted for in the same manner as marketable portfolio securities. The premium received by a fund for option contracts written is recorded as a liability and valued daily. The proceeds from securities sold through the exercise of option contracts are decreased by the premium paid to purchase the option contracts. A fund may recognize a realized gain or loss when the option contract is closed, exercised or expires. Net realized and unrealized gains or losses occurring during the holding period of purchased options contracts are a component of net realized gain (loss) on investment transactions and change in net unrealized appreciation (depreciation) on investments, respectively. Net realized and unrealized gains or losses occurring during the holding period of written options contracts are a component of net realized gain (loss) on written options contract transactions and change in net unrealized appreciation (depreciation) on written options contracts, respectively. The fund’s average exposure to equity price risk derivative instruments held during the period was 1,622 written options contracts.

21


Foreign Currency Risk — The fund is subject to foreign currency exchange rate risk in the normal course of pursuing its investment objectives. The value of foreign investments held by a fund may be significantly affected by changes in foreign currency exchange rates. The dollar value of a foreign security generally decreases when the value of the dollar rises against the foreign currency in which the security is denominated and tends to increase when the value of the dollar declines against such foreign currency. A fund may enter into forward foreign currency exchange contracts to reduce a fund's exposure to foreign currency exchange rate fluctuations. The net U.S. dollar value of foreign currency underlying all contractual commitments held by a fund and the resulting unrealized appreciation or depreciation are determined daily. Realized gain or loss is recorded upon settlement of the contract. Net realized and unrealized gains or losses occurring during the holding period of forward foreign currency exchange contracts are a component of net realized gain (loss) on forward foreign currency exchange contract transactions and change in net unrealized appreciation (depreciation) on forward foreign currency exchange contracts, respectively. A fund bears the risk of an unfavorable change in the foreign currency exchange rate underlying the forward contract. Additionally, losses, up to the fair value, may arise if the counterparties do not perform under the contract terms. The fund's average U.S. dollar exposure to foreign currency risk derivative instruments held during the period was $15,888,489.

Value of Derivative Instruments as of October 31, 2021
Asset DerivativesLiability Derivatives
Type of Risk ExposureLocation on Statement of Assets and LiabilitiesValueLocation on Statement of Assets and LiabilitiesValue
Foreign Currency RiskUnrealized appreciation on forward foreign currency exchange contracts$510 Unrealized depreciation on forward foreign currency exchange contracts$363,851 

Effect of Derivative Instruments on the Statement of Operations for the Year Ended October 31, 2021
Net Realized Gain (Loss)Change in Net Unrealized Appreciation (Depreciation)
Type of Risk ExposureLocation on Statement of OperationsValueLocation on Statement of OperationsValue
Equity Price RiskNet realized gain (loss) on written options contract transactions$375,041 Change in net unrealized appreciation (depreciation) on written options contracts— 
Foreign Currency RiskNet realized gain (loss) on forward foreign currency exchange contract transactions(584,387)Change in net unrealized appreciation (depreciation) on forward foreign currency exchange contracts$(351,694)
$(209,346)$(351,694)

8. Risk Factors

The value of the fund’s shares will go up and down, sometimes rapidly or unpredictably, based on the performance of the securities owned by the fund and other factors generally affecting the securities market. Market risks, including political, regulatory, economic and social developments, can affect the value of the fund’s investments. Natural disasters, public health emergencies, terrorism and other unforeseeable events may lead to increased market volatility and may have adverse long-term effects on world economies and markets generally.
9. Federal Tax Information
On December 7, 2021, the fund declared and paid a per-share distribution from net realized gains to shareholders of record on December 6, 2021 of $9.6280 for the Investor Class, I Class, Y Class, A Class, C Class, R Class, R5 Class and R6 Class.

The tax character of distributions paid during the years ended October 31, 2021 and October 31, 2020 were as follows:
20212020
Distributions Paid From
Ordinary income— $28,200 
Long-term capital gains$257,611,201 $179,299,604 
22


The book-basis character of distributions made during the year from net investment income or net realized gains may differ from their ultimate characterization for federal income tax purposes. These differences reflect the differing character of certain income items and net realized gains and losses for financial statement and tax purposes, and may result in reclassification among certain capital accounts on the financial statements.

As of period end, the federal tax cost of investments and the components of distributable earnings on a tax-basis were as follows:
Federal tax cost of investments$1,568,678,719 
Gross tax appreciation of investments$3,551,463,515 
Gross tax depreciation of investments(1,342,570)
Net tax appreciation (depreciation) of investments3,550,120,945 
Net tax appreciation (depreciation) on derivatives and translation of assets and liabilities in foreign currencies(5,120)
Net tax appreciation (depreciation)$3,550,115,825 
Undistributed ordinary income$— 
Accumulated long-term gains$394,628,218 
Late-year ordinary loss deferral$(15,938,766)
The difference between book-basis and tax-basis unrealized appreciation (depreciation) is attributable primarily to the realization for tax purposes of unrealized gains( losses) on certain foreign currency exchange contracts.

Loss deferrals represent certain qualified losses that the fund has elected to treat as having been incurred in the following fiscal year for federal income tax purposes.
23


Financial Highlights
For a Share Outstanding Throughout the Years Ended October 31 (except as noted)
Per-Share DataRatios and Supplemental Data
Income From Investment Operations:Distributions From:Ratio to Average Net Assets of:
Net Asset
Value,
Beginning
of Period
Net
Investment
Income
(Loss)(1)
Net
Realized
and
Unrealized
Gain (Loss)
Total From
Investment
Operations
Net
Investment
Income
Net
Realized
Gains
Total
Distributions
Net Asset
Value,
End
of Period
Total
Return
(2)
Operating
Expenses
Operating
Expenses
(before
expense
waiver)
Net
Investment
Income
(Loss)
Net
Investment
Income
(Loss)
(before
expense
waiver)
Portfolio
Turnover
Rate
Net
Assets,
End of
Period
(in thousands)
Investor Class
2021$93.93(0.40)36.9136.51(6.32)(6.32)$124.1240.63%0.97%0.99%(0.37)%(0.39)%11%$4,770,672 
2020$78.58(0.13)19.8319.70(4.35)(4.35)$93.9326.10%0.97%0.99%(0.15)%(0.17)%16%$3,596,722 
2019$73.74
(3)
10.4210.42(0.03)(5.55)(5.58)$78.5815.98%0.97%0.99%
0.00%(4)
(0.02)%17%$3,054,007 
2018$71.920.046.206.24(0.21)(4.21)(4.42)$73.748.94%0.97%0.99%0.06%0.04%22%$2,835,970 
2017$58.320.2115.5915.80(0.22)(1.98)(2.20)$71.9227.93%0.99%1.00%0.33%0.32%19%$2,753,729 
I Class
2021$95.99(0.19)37.7937.60(6.32)(6.32)$127.2740.90%0.77%0.79%(0.17)%(0.19)%11%$156,502 
2020$80.060.0520.2320.28(4.35)(4.35)$95.9926.35%0.77%0.79%0.05%0.03%16%$119,954 
2019$75.020.1310.6310.76(0.17)(5.55)(5.72)$80.0616.22%0.77%0.79%0.20%0.18%17%$105,310 
2018$73.110.196.296.48(0.36)(4.21)(4.57)$75.029.15%0.77%0.79%0.26%0.24%22%$70,986 
2017$59.250.3115.8716.18(0.34)(1.98)(2.32)$73.1128.20%0.79%0.80%0.53%0.52%19%$60,895 



For a Share Outstanding Throughout the Years Ended October 31 (except as noted)
Per-Share DataRatios and Supplemental Data
Income From Investment Operations:Distributions From:Ratio to Average Net Assets of:
Net Asset
Value,
Beginning
of Period
Net
Investment
Income
(Loss)(1)
Net
Realized
and
Unrealized
Gain (Loss)
Total From
Investment
Operations
Net
Investment
Income
Net
Realized
Gains
Total
Distributions
Net Asset
Value,
End
of Period
Total
Return
(2)
Operating
Expenses
Operating
Expenses
(before
expense
waiver)
Net
Investment
Income
(Loss)
Net
Investment
Income
(Loss)
(before
expense
waiver)
Portfolio
Turnover
Rate
Net
Assets,
End of
Period
(in thousands)
Y Class
2021$96.28(0.03)37.9437.91(6.32)(6.32)$127.8741.11%0.62%0.64%(0.02)%(0.04)%11%$103,669 
2020$80.170.1620.3020.46(4.35)(4.35)$96.2826.55%0.62%0.64%0.20%0.18%16%$72,595 
2019$75.130.2210.6410.86(0.27)(5.55)(5.82)$80.1716.38%0.62%0.64%0.35%0.33%17%$46,034 
2018$73.130.286.336.61(0.40)(4.21)(4.61)$75.139.34%0.62%0.64%0.41%0.39%22%$14,529 
2017(5)
$63.800.229.119.33$73.1314.62%
0.64%(6)
0.65%(6)
0.59%(6)
0.58%(6)
19%(7)
$6 
A Class
2021$91.18(0.65)35.7335.08(6.32)(6.32)$119.9440.26%1.22%1.24%(0.62)%(0.64)%11%$72,806 
2020$76.58(0.33)19.2818.95(4.35)(4.35)$91.1825.79%1.22%1.24%(0.40)%(0.42)%16%$54,558 
2019$72.15(0.18)10.169.98(5.55)(5.55)$76.5815.69%1.22%1.24%(0.25)%(0.27)%17%$42,013 
2018$70.45(0.14)6.075.93(0.02)(4.21)(4.23)$72.158.67%1.22%1.24%(0.19)%(0.21)%22%$39,459 
2017$57.160.0515.2915.34(0.07)(1.98)(2.05)$70.4527.63%1.24%1.25%0.08%0.07%19%$40,345 
C Class
2021$79.23(1.21)30.7029.49(6.32)(6.32)$102.4039.23%1.97%1.99%(1.37)%(1.39)%11%$4,151 
2020$67.55(0.82)16.8516.03(4.35)(4.35)$79.2324.85%1.97%1.99%(1.15)%(1.17)%16%$5,390 
2019$64.79(0.63)8.948.31(5.55)(5.55)$67.5514.82%1.97%1.99%(1.00)%(1.02)%17%$5,523 
2018$64.11(0.62)5.514.89(4.21)(4.21)$64.797.86%1.97%1.99%(0.94)%(0.96)%22%$5,700 
2017$52.51(0.39)13.9713.58(1.98)(1.98)$64.1126.66%1.99%2.00%(0.67)%(0.68)%19%$5,668 



For a Share Outstanding Throughout the Years Ended October 31 (except as noted)
Per-Share DataRatios and Supplemental Data
Income From Investment Operations:Distributions From:Ratio to Average Net Assets of:
Net Asset
Value,
Beginning
of Period
Net
Investment
Income
(Loss)(1)
Net
Realized
and
Unrealized
Gain (Loss)
Total From
Investment
Operations
Net
Investment
Income
Net
Realized
Gains
Total
Distributions
Net Asset
Value,
End
of Period
Total
Return
(2)
Operating
Expenses
Operating
Expenses
(before
expense
waiver)
Net
Investment
Income
(Loss)
Net
Investment
Income
(Loss)
(before
expense
waiver)
Portfolio
Turnover
Rate
Net
Assets,
End of
Period
(in thousands)
R Class
2021$89.86(0.90)35.1634.26(6.32)(6.32)$117.8039.92%1.47%1.49%(0.87)%(0.89)%11%$4,452 
2020$75.71(0.53)19.0318.50(4.35)(4.35)$89.8625.48%1.47%1.49%(0.65)%(0.67)%16%$3,384 
2019$71.56(0.36)10.069.70(5.55)(5.55)$75.7115.40%1.47%1.49%(0.50)%(0.52)%17%$3,019 
2018$70.05(0.30)6.025.72(4.21)(4.21)$71.568.41%1.47%1.49%(0.44)%(0.46)%22%$2,259 
2017$56.92(0.11)15.2215.11(1.98)(1.98)$70.0527.30%1.49%1.50%(0.17)%(0.18)%19%$3,518 
R5 Class
2021$95.99(0.18)37.7937.61(6.32)(6.32)$127.2840.91%0.77%0.79%(0.17)%(0.19)%11%$13 
2020$80.070.0320.2420.27(4.35)(4.35)$95.9926.34%0.77%0.79%0.05%0.03%16%$9 
2019$75.040.1310.6210.75(0.17)(5.55)(5.72)$80.0716.20%0.77%0.79%0.20%0.18%17%$7 
2018$73.100.186.286.46(0.31)(4.21)(4.52)$75.049.13%0.77%0.79%0.26%0.24%22%$6 
2017(5)
$63.830.179.109.27$73.1014.52%
0.79%(6)
0.80%(6)
0.44%(6)
0.43%(6)
19%(7)
$6 
R6 Class
2021$96.16(0.02)37.8837.86(6.32)(6.32)$127.7041.11%0.62%0.64%(0.02)%(0.04)%11%$6,527 
2020$80.080.1620.2720.43(4.35)(4.35)$96.1626.54%0.62%0.64%0.20%0.18%16%$4,256 
2019$75.050.2510.6010.85(0.27)(5.55)(5.82)$80.0816.39%0.62%0.64%0.35%0.33%17%$2,544 
2018$73.130.316.296.60(0.47)(4.21)(4.68)$75.059.33%0.62%0.64%0.41%0.39%22%$1,708 
2017$59.270.5115.7616.27(0.43)(1.98)(2.41)$73.1328.38%0.64%0.65%0.68%0.67%19%$1,519 




Notes to Financial Highlights
(1)Computed using average shares outstanding throughout the period.
(2)Total returns are calculated based on the net asset value of the last business day and do not reflect applicable sales charges, if any. Total returns for periods less than one year are not annualized.
(3)Amount is less than $0.005.
(4)Ratio was less than 0.005%.
(5)April 10, 2017 (commencement of sale) through October 31, 2017.
(6)Annualized.
(7)Portfolio turnover is calculated at the fund level. Percentage indicated was calculated for the year ended October 31, 2017.


See Notes to Financial Statements.



Report of Independent Registered Public Accounting Firm

To the Shareholders and the Board of Directors of American Century Mutual Funds, Inc.:

Opinion on the Financial Statements and Financial Highlights

We have audited the accompanying statement of assets and liabilities, including the schedule of investments, of Select Fund (the “Fund”), one of the funds constituting the American Century Mutual Funds, Inc., as of October 31, 2021, the related statement of operations for the year then ended, the statements of changes in net assets for each of the two years in the period then ended, the financial highlights for each of the five years in the period then ended, and the related notes. In our opinion, the financial statements and financial highlights present fairly, in all material respects, the financial position of Select Fund of the American Century Mutual Funds, Inc. as of October 31, 2021, and the results of its operations for the year then ended, the changes in its net assets for each of the two years in the period then ended, and the financial highlights for each of the five years in the period then ended, in conformity with accounting principles generally accepted in the United States of America.

Basis for Opinion

These financial statements and financial highlights are the responsibility of the Fund's management. Our responsibility is to express an opinion on the Fund’s financial statements and financial highlights based on our audits. We are a public accounting firm registered with the Public Company Accounting Oversight Board (United States) (PCAOB) and are required to be independent with respect to the Fund in accordance with the U.S. federal securities laws and the applicable rules and regulations of the Securities and Exchange Commission and the PCAOB.

We conducted our audits in accordance with the standards of the PCAOB. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements and financial highlights are free of material misstatement, whether due to error or fraud. The Fund is not required to have, nor were we engaged to perform, an audit of its internal control over financial reporting. As part of our audits we are required to obtain an understanding of internal control over financial reporting but not for the purpose of expressing an opinion on the effectiveness of the Fund’s internal control over financial reporting. Accordingly, we express no such opinion.

Our audits included performing procedures to assess the risks of material misstatement of the financial statements and financial highlights, whether due to error or fraud, and performing procedures that respond to those risks. Such procedures included examining, on a test basis, evidence regarding the amounts and disclosures in the financial statements and financial highlights. Our audits also included evaluating the accounting principles used and significant estimates made by management, as well as evaluating the overall presentation of the financial statements and financial highlights. Our procedures included confirmation of securities owned as of October 31, 2021, by correspondence with the custodian and brokers; when replies were not received from brokers, we performed other auditing procedures. We believe that our audits provide a reasonable basis for our opinion.

/s/ Deloitte & Touche LLP

Kansas City, Missouri
December 15, 2021

We have served as the auditor of one or more American Century investment companies since 1997.
28


Management

The Board of Directors

The individuals listed below serve as directors of the funds. Each director will continue to serve in this capacity until death, retirement, resignation or removal from office. The board has adopted a mandatory retirement age for directors who are not “interested persons,” as that term is defined in the Investment Company Act (independent directors). Independent directors shall retire by December 31 of the year in which they reach their 75th birthday.
Jonathan S.Thomas is an “interested person” because he currently serves as President and Chief Executive Officer of American Century Companies, Inc. (ACC), the parent company of American Century Investment Management, Inc. (ACIM or the advisor). The other directors (more than three-fourths of the total number) are independent. They are not employees, directors or officers of, and have no financial interest in, ACC or any of its wholly owned, direct or indirect, subsidiaries, including ACIM, American Century Investment Services, Inc. (ACIS) and American Century Services, LLC (ACS), and they do not have any other affiliations, positions or relationships that would cause them to be considered “interested persons” under the Investment Company Act. The directors serve in this capacity for seven (in the case of Jonathan S. Thomas, 16; and Stephen E. Yates, 8) registered investment companies in the American Century Investments family of funds.
The following table presents additional information about the directors. The mailing address for each director is 4500 Main Street, Kansas City, Missouri 64111.
Name
(Year of Birth)
Position(s) Held with FundsLength of Time ServedPrincipal Occupation(s) During Past 5 YearsNumber of American Century Portfolios Overseen by DirectorOther Directorships Held During Past 5 Years
Independent Directors
Thomas W. Bunn (1953)DirectorSince 2017Retired72SquareTwo Financial; Barings (formerly Babson Capital Funds Trust) (2013 to 2016)
Chris H. Cheesman
(1962)
DirectorSince 2019
Retired. Senior Vice President & Chief Audit Executive, AllianceBernstein (1999 to 2018)72Alleghany Corporation
Barry Fink
(1955)
DirectorSince 2012 (independent since 2016)Retired72None
Rajesh K. Gupta
(1960)
DirectorSince 2019
Partner Emeritus, SeaCrest Investment Management and SeaCrest Wealth Management (2019 to Present); Chief Executive Officer and Chief Investment Officer, SeaCrest Investment Management (2006 to 2019); Chief Executive Officer and Chief Investment Officer, SeaCrest Wealth Management (2008 to 2019)72None
29


Name
(Year of Birth)
Position(s) Held with FundsLength of Time ServedPrincipal Occupation(s) During Past 5 YearsNumber of American Century Portfolios Overseen by DirectorOther Directorships Held During Past 5 Years
Independent Directors
Lynn Jenkins
(1963)
DirectorSince 2019
Consultant, LJ Strategies (2019 to present); United States Representative, U.S. House of Representatives (2009 to 2018)72MGP Ingredients, Inc. (2019 to 2021)
Jan M. Lewis
(1957)
DirectorSince 2011Retired72None
John R. Whitten
(1946)
DirectorSince 2008Retired72Onto Innovation Inc. (2019 to 2020); Rudolph Technologies, Inc. (2006 to 2019)
Stephen E. Yates
(1948)
Director and Chairman of the BoardSince 2012 (Chairman since 2018)Retired107None
Interested Director
Jonathan S. Thomas
(1963)
DirectorSince 2007President and Chief Executive Officer, ACC (2007 to present). Also serves as Chief Executive Officer, ACS; Director, ACC and other ACC subsidiaries145None
The Statement of Additional Information has additional information about the fund's directors and is available without charge, upon request, by calling 1-800-345-2021.
30


Officers

The following table presents certain information about the executive officers of the funds. Each officer serves as an officer for 16 (in the case of Robert J. Leach, 15) investment companies in the American Century family of funds. No officer is compensated for his or her service as an officer of the funds. The listed officers are interested persons of the funds and are appointed or re-appointed on an annual basis. The mailing address for each officer listed below is 4500 Main Street, Kansas City, Missouri 64111.
Name
(Year of Birth)
Offices with the FundsPrincipal Occupation(s) During the Past Five Years
Patrick Bannigan
(1965)
President since 2019Executive Vice President and Director, ACC (2012 to present); Chief Financial Officer, Chief Accounting Officer and Treasurer, ACC (2015 to present). Also serves as President, ACS; Vice President, ACIM; Chief Financial Officer, Chief Accounting Officer and/or Director, ACIM, ACS and other ACC subsidiaries
R. Wes Campbell
(1974)
Chief Financial Officer and Treasurer since 2018Vice President, ACS, (2020 to present); Investment Operations and Investment Accounting, ACS (2000 to present)
Amy D. Shelton
(1964)
Chief Compliance Officer and Vice President since 2014Chief Compliance Officer, American Century funds, (2014 to present); Chief Compliance Officer, ACIM (2014 to present); Chief Compliance Officer, ACIS (2009 to present). Also serves as Vice President, ACIS
John Pak
(1968)
General Counsel and
Senior Vice President since 2021
General Counsel and Senior Vice President, ACC (2021 to present). Also serves as General Counsel and Senior Vice President, ACIM, ACS and ACIS. Chief Legal Officer of Investment and Wealth Management, The Bank of New York Mellon (2014 to 2021)
C. Jean Wade
(1964)
Vice President since 2012Senior Vice President, ACS (2017 to present); Vice President, ACS (2000 to 2017)
Robert J. Leach
(1966)
Vice President since 2006 Vice President, ACS (2000 to present)
David H. Reinmiller
(1963)
Vice President since 2000Attorney, ACC (1994 to present). Also serves as Vice President, ACIM and ACS
Ward D. Stauffer
(1960)
Secretary since 2005Attorney, ACC (2003 to present)





31


Approval of Management Agreement

At a meeting held on June 30, 2021, the Fund’s Board of Directors (the "Board") unanimously approved the renewal of the management agreement pursuant to which American Century Investment Management, Inc. (the “Advisor”) acts as the investment advisor for the Fund. Under Section 15(c) of the Investment Company Act, contracts for investment advisory services are required to be reviewed, evaluated, and approved by a majority of a fund’s directors (the “Directors”), including a majority of the independent Directors, each year.

Prior to its consideration of the renewal of the management agreement, the Directors requested and reviewed extensive data and information compiled by the Advisor and certain independent providers of evaluation data concerning the Fund and the services provided to the Fund by the Advisor. This review was in addition to the oversight and evaluation undertaken by the Board and its committees on a continual basis and the information received was supplemental to the extensive information that the Board and its committees receive and consider throughout the year.

In connection with its consideration of the renewal of the management agreement, the Board’s review and evaluation of the services provided by the Advisor and its affiliates included, but was not limited to, the following:

the nature, extent, and quality of investment management, shareholder services, and other services provided and to be provided to the Fund including without limitation portfolio management and trading services, shareholder and intermediary services, compliance and legal services, fund accounting and financial reporting, and fund share distribution;
the wide range of other programs and services provided and to be provided to the Fund and its shareholders on a routine and non-routine basis;
the Fund’s investment performance, including data comparing the Fund's performance to appropriate benchmarks and/or a peer group of other mutual funds with similar investment objectives and strategies;
the cost of owning the Fund compared to the cost of owning similar funds;
the compliance policies, procedures, and regulatory experience of the Advisor and the Fund's service providers;
the Advisor’s strategic plans, COVID-19 pandemic response, vendor management practices, and social justice initiatives;
the Advisor’s business continuity plans and cyber security practices;
financial data showing the cost of services provided to the Fund, the profitability of the Fund to the Advisor, and the overall profitability of the Advisor;
possible economies of scale associated with the Advisor’s management of the Fund and other accounts;
services provided and charges to the Advisor's other investment management clients;
acquired fund fees and expenses;
payments and practices in connection with financial intermediaries holding shares of the Fund and the services provided by intermediaries in connection therewith; and
possible collateral benefits to the Advisor from the management of the Fund.

The Board held two meetings to consider the renewal and formed a subcommittee to evaluate the Fund’s competitive market. The independent Directors also met in private session three times to review and discuss the information provided in response to their request. The independent Directors held active discussions with the Advisor regarding the renewal of the management agreement, requesting supplemental information, and reviewing information provided by the Advisor in response thereto. The independent Directors had the benefit of the advice of their independent counsel throughout the process.


32


Factors Considered

The Directors considered all of the information provided by the Advisor, the independent data providers, and independent counsel in connection with the approval. They determined that the information was sufficient for them to evaluate the management agreement for the Fund. In connection with their review, the Directors did not identify any single factor as being all-important or controlling, and each Director may have attributed different levels of importance to different factors. In deciding to renew the management agreement, the Board based its decision on a number of factors, including without limitation the following:

Nature, Extent and Quality of Services — Generally. Under the management agreement, the Advisor is responsible for providing or arranging for all services necessary for the operation of the Fund. The Board noted that the Advisor provides or arranges at its own expense a wide variety of services which include the following:

constructing and designing the Fund
portfolio research and security selection
initial capitalization/funding
securities trading
Fund administration
custody of Fund assets
daily valuation of the Fund’s portfolio
liquidity monitoring and management
risk management, including cyber security
shareholder servicing and transfer agency, including shareholder confirmations, recordkeeping, and communications
legal services (except the independent Directors’ counsel)
regulatory and portfolio compliance
financial reporting
marketing and distribution (except amounts paid by the Fund under Rule 12b-1 plans)

The Board noted that many of these services have expanded over time in terms of both quantity and complexity in response to shareholder demands, competition in the industry, changing distribution channels, and the changing regulatory environment.

Investment Management Services. The nature of the investment management services provided to the Fund is quite complex and allows Fund shareholders access to professional money management, instant diversification of their investments within an asset class, the opportunity to easily diversify among asset classes by investing in or exchanging among various American Century Investments funds, and liquidity. In evaluating investment performance, the Board expects the Advisor to manage the Fund in accordance with its investment objectives and approved strategies. Further, the Directors recognize that the Advisor has an obligation to monitor trading activities, and in particular to seek the best execution of fund trades, and to evaluate the use of and payment for research. In providing these services, the Advisor utilizes teams of investment professionals (portfolio managers, analysts, research assistants, and securities traders) who require extensive information technology, research, training, compliance, and other systems to conduct their business. The Board, directly and through its Fund Performance Review Committee, provides oversight of the investment performance process. It regularly reviews investment performance information for the Fund, together with comparative information for appropriate benchmarks and/or peer groups of similarly-managed funds, over different time horizons. The Directors also review investment performance information during the management agreement renewal process. If performance concerns are identified, the Fund receives special reviews until performance improves, during which the Board discusses with the Advisor the reasons for such results (e.g., market conditions, security selection) and any efforts being undertaken to improve performance. The Fund’s performance was below its benchmark for the one-, three-, five-, and ten-year periods reviewed by the Board. The Board discussed the Fund's performance with the Advisor, including steps being taken to address underperformance, and was satisfied with the efforts being undertaken by the Advisor. The Board found the investment management services
33


provided by the Advisor to the Fund to be satisfactory and consistent with the management agreement.

Shareholder and Other Services. Under the management agreement, the Advisor provides the Fund with a comprehensive package of transfer agency, shareholder, and other services. The Board, directly and through its various committees, regularly reviews reports and evaluations of such services at its regular meetings. These reports include, but are not limited to, information regarding the operational efficiency and accuracy of the shareholder and transfer agency services provided, staffing levels, shareholder satisfaction, technology support (including cyber security), new products and services offered to Fund shareholders, securities trading activities, portfolio valuation services, auditing services, and legal and operational compliance activities. The Board found the services provided by the Advisor to the Fund under the management agreement to be competitive and of high quality.

Costs of Services and Profitability. The Advisor provides detailed information concerning its cost of providing various services to the Fund, its profitability in managing the Fund (pre- and post-distribution), its overall profitability, and its financial condition. The Directors have reviewed with the Advisor the methodology used to prepare this financial information. This information is considered in evaluating the Advisor’s financial condition, its ability to continue to provide services under the management agreement, and the reasonableness of the current management fee. The Board concluded that the Advisor’s profits were reasonable in light of the services provided to the Fund.

Ethics. The Board generally considers the Advisor’s commitment to providing quality services to shareholders and to conducting its business ethically. They noted that the Advisor’s practices generally meet or exceed industry best practices.

Economies of Scale. The Board also reviewed information provided by the Advisor regarding the possible existence of economies of scale in connection with the management of the Fund. The Board concluded that economies of scale are difficult to measure and predict with precision, especially on a fund-by-fund basis. The Board concluded that the Advisor is sharing economies of scale, to the extent they exist, through its competitive fee structure, offering competitive fees from fund inception, and through reinvestment in its business, infrastructure, investment capabilities and initiatives to provide shareholders additional content and services.

Comparison to Other Funds’ Fees. The management agreement provides that the Fund pays the Advisor a single, all-inclusive (or unified) management fee for providing all services necessary for the management and operation of the Fund, other than brokerage expenses, expenses attributable to short sales, taxes, interest, extraordinary expenses, fees and expenses of the Fund’s independent Directors (including their independent legal counsel), and expenses incurred in connection with the provision of shareholder services and distribution services under a plan adopted pursuant to Rule 12b-1 under the Investment Company Act. Under the unified fee structure, the Advisor is responsible for providing all investment advisory, custody, audit, administrative, compliance, recordkeeping, marketing and shareholder services, or arranging and supervising third parties to provide such services. By contrast, most other funds are charged a variety of fees, including an investment advisory fee, a transfer agency fee, an administrative fee, distribution charges, and other expenses. Other than their investment advisory fees and any applicable Rule 12b-1 distribution fees, all other components of the total fees charged by these other funds may be increased without shareholder approval. The Board believes the unified fee structure is a benefit to Fund shareholders because it clearly discloses to shareholders the cost of owning Fund shares, and, since the unified fee cannot be increased without a vote of Fund shareholders, it shifts to the Advisor the risk of increased costs of operating the Fund and provides a direct incentive to minimize administrative inefficiencies. Part of the Board’s analysis of fee levels involves reviewing certain evaluative data compiled by an independent provider comparing the Fund’s unified fee to the total expense ratios of its peers. The unified fee charged to shareholders of the Fund was above the median of the total expense ratios of the Fund’s peer expense universe. In addition, the Board reviewed the Fund’s position relative to the narrower set of its expense group peers. The Board and the Advisor agreed to a temporary reduction of the Fund's fee schedule that should have the effect of lowering the Fund's annual unified management fee by approximately 0.036% (e.g., the Investor Class unified fee will be reduced from 0.99% to 0.954%), for at least one
34


year, beginning August 1, 2021. The Board concluded that the management fee paid by the Fund to the Advisor under the management agreement is reasonable in light of the services provided to the Fund.

Comparison to Fees and Services Provided to Other Clients of the Advisor. The Board also requested and received information from the Advisor concerning the nature of the services, fees, costs, and profitability of its advisory services to advisory clients other than the Fund. They observed that these varying types of client accounts require different services and involve different regulatory and entrepreneurial risks than the management of the Fund. The Board analyzed this information and concluded that the fees charged and services provided to the Fund were reasonable by comparison.

Payments to Intermediaries. The Directors also requested and received a description of payments made to intermediaries by the Fund and the Advisor and services provided in response thereto. These payments include various payments made by the Fund or the Advisor to different types of intermediaries and recordkeepers for distribution and service activities provided for the Fund. The Directors reviewed such information and received representations from the Advisor that all such payments by the Fund were made pursuant to the Fund's Rule 12b-1 Plan and that all such payments by the Advisor were made from the Advisor’s resources and reasonable profits. The Board found such payments to be reasonable in scope and purpose.

Collateral or “Fall-Out” Benefits Derived by the Advisor. The Board considered the possible existence of collateral benefits the Advisor may receive as a result of its relationship with the Fund. They concluded that the Advisor’s primary business is managing funds and it generally does not use fund or shareholder information to generate profits in other lines of business, and therefore does not derive any significant collateral benefits from them. To the extent there are potential collateral benefits, the Board has been advised and has taken this into consideration in its review of the management contract with the Fund. The Board noted that additional assets from other clients may offer the Advisor some benefit from increased leverage with service providers and counterparties. Additionally, the Advisor may receive proprietary research from broker-dealers that execute fund portfolio transactions, which the Board concluded is likely to benefit other clients of the Advisor, as well as Fund shareholders. The Board also determined that the Advisor is able to provide investment management services to certain clients other than the Fund, at least in part, due to its existing infrastructure built to serve the fund complex. The Board concluded that appropriate allocation methodologies had been employed to assign resources and the cost of those resources to these other clients.

Existing Relationship. The Board also considered whether there was any reason for not continuing the existing arrangement with the Advisor. In this regard, the Board was mindful of the potential disruptions of the Fund’s operations and various risks, uncertainties, and other effects that could occur as a result of a decision not to continue such relationship. In particular, the Board recognized that most shareholders have invested in the Fund on the strength of the Advisor’s industry standing and reputation and in the expectation that the Advisor will have a continuing role in providing advisory services to the Fund.

Conclusion of the Directors. As a result of this process, the Board, including all of the independent Directors, taking into account all of the factors discussed above and the information provided by the Advisor and others in connection with its review and throughout the year, determined that the management fee is fair and reasonable in light of the services provided and that the investment management agreement between the Fund and the Advisor should be renewed.
35


Additional Information

Retirement Account Information

As required by law, distributions you receive from certain retirement accounts are subject to federal income tax withholding, unless you elect not to have withholding apply*. Tax will be withheld on the total amount withdrawn even though you may be receiving amounts that are not subject to withholding, such as nondeductible contributions. In such case, excess amounts of withholding could occur. You may adjust your withholding election so that a greater or lesser amount will be withheld.
If you don’t want us to withhold on this amount, you must notify us to not withhold the federal income tax. You may notify us in writing or in certain situations by telephone or through other electronic means. For systematic withdrawals, your withholding election will remain in effect until revoked or changed by filing a new election. You have the right to revoke your election at any time and change your withholding percentage for future distributions.
Remember, even if you elect not to have income tax withheld, you are liable for paying income tax on the taxable portion of your withdrawal. If you elect not to have income tax withheld or you don’t have enough income tax withheld, you may be responsible for payment of estimated tax. You may incur penalties under the estimated tax rules if your withholding and estimated tax payments are not sufficient. You can reduce or defer the income tax on a distribution by directly or indirectly rolling such distribution over to another IRA or eligible plan. You should consult your tax advisor for additional information.
State tax will be withheld if, at the time of your distribution, your address is within one of the mandatory withholding states and you have federal income tax withheld (or as otherwise required by state law). State taxes will be withheld from your distribution in accordance with the respective state rules.
*Some 403(b), 457 and qualified retirement plan distributions may be subject to 20% mandatory withholding, as they are subject to special tax and withholding rules.  Your plan administrator or plan sponsor is required to provide you with a special tax notice explaining those rules at the time you request a distribution.  If applicable, federal and/or state taxes may be withheld from your distribution amount.

Proxy Voting Policies

A description of the policies that the fund's investment advisor uses in exercising the voting rights associated with the securities purchased and/or held by the fund is available without charge, upon request, by calling 1-800-345-2021. It is also available on American Century Investments’ website at americancentury.com/proxy and on the Securities and Exchange Commission’s website at sec.gov. Information regarding how the investment advisor voted proxies relating to portfolio securities during the most recent 12-month period ended June 30 is available on americancentury.com/proxy. It is also available at sec.gov.


Quarterly Portfolio Disclosure

The fund files its complete schedule of portfolio holdings with the Securities and Exchange Commission (SEC) for the first and third quarters of each fiscal year as an exhibit to its reports on Form N-PORT. These portfolio holdings are available on the fund's website at americancentury.com and, upon request, by calling 1-800-345-2021. The fund’s Form N-PORT reports are available on the SEC’s website at sec.gov.





36


Other Tax Information

The following information is provided pursuant to provisions of the Internal Revenue Code.

The fund hereby designates $257,611,201, or up to the maximum amount allowable, as long-term capital gain distributions (20% rate gain distributions) for the fiscal year ended October 31, 2021.
37


Notes
38


Notes
39


Notes




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American Century Mutual Funds, Inc.
Investment Advisor:
American Century Investment Management, Inc.
Kansas City, Missouri
This report and the statements it contains are submitted for the general information of our shareholders. The report is not authorized for distribution to prospective investors unless preceded or accompanied by an effective prospectus.
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CL-ANN-90969 2112




    


image8.jpg
Annual Report
October 31, 2021
Small Cap Growth Fund
Investor Class (ANOIX)
I Class (ANONX)
Y Class (ANOYX)
A Class (ANOAX)
C Class (ANOCX)
R Class (ANORX)
R5 Class (ANOGX)
R6 Class (ANODX)
G Class (ANOHX)

















Table of Contents
 
President’s Letter
Performance
Portfolio Commentary
Fund Characteristics
Shareholder Fee Example
Schedule of Investments
Statement of Assets and Liabilities
Statement of Operations
Statement of Changes in Net Assets
Notes to Financial Statements
Financial Highlights
Report of Independent Registered Public Accounting Firm
Management
Approval of Management Agreement
Additional Information

















Any opinions expressed in this report reflect those of the author as of the date of the report, and do not necessarily represent the opinions of American Century Investments® or any other person in the American Century Investments organization. Any such opinions are subject to change at any time based upon market or other conditions and American Century Investments disclaims any responsibility to update such opinions. These opinions may not be relied upon as investment advice and, because investment decisions made by American Century Investments funds are based on numerous factors, may not be relied upon as an indication of trading intent on behalf of any American Century Investments fund. Security examples are used for representational purposes only and are not intended as recommendations to purchase or sell securities. Performance information for comparative indices and securities is provided to American Century Investments by third party vendors. To the best of American Century Investments’ knowledge, such information is accurate at the time of printing.



President’s Letter
image30.jpg Jonathan Thomas

Dear Investor:

Thank you for reviewing this annual report for the period ended October 31, 2021. Annual reports help convey important information about fund returns, including market factors that affected performance. For additional investment insights, please visit americancentury.com.
Economic, Earnings Gains Fueled Rally Among Risk-On Assets

Stocks and other risk-on assets rallied for the 12-month period, despite lingering pandemic-related challenges. Upbeat data on U.S. manufacturing, employment and housing, along with central bank and federal government support and positive vaccine developments, helped boost corporate earnings and promote investor optimism. Outside the U.S., most economies recovered, but generally at a slower pace. Virus outbreaks and slower vaccine rollouts, particularly in emerging markets, led to lingering lockdowns in some regions.

As the period progressed, steady economic gains combined with ongoing monetary and fiscal support, rising energy prices and severe supply chain disruptions pushed global interest rates and inflation higher. In the U.S., year-over-year headline inflation climbed to 6.2% in October 2021, the largest 12-month increase in nearly 31 years.
Late in the period, the Federal Reserve (Fed) confirmed it would start tapering its bond buying in November. Yet despite inflation’s surge, the Fed left short-term interest rates unchanged. Central banks in Europe and the U.K. maintained their supportive interest rate and bond-buying programs as inflation ticked higher.

Overall, stocks delivered stellar performance for the 12-month period, highlighted by the S&P 500 Index’s gain of nearly 43%. Assets offering inflation-fighting potential, including real estate investment trusts, fared even better. Meanwhile, global bonds retreated as interest rates rose. However, emerging markets bonds largely advanced, benefiting from risk-on sentiment.
Several Factors Shaping Market Dynamics

The return to pre-pandemic life is progressing, albeit somewhat cautiously due to COVID-19’s lingering effects. As the economy and markets respond to this fluid backdrop, investors will face opportunities and ongoing challenges. Economic growth, inflation, the virus’s trajectory, supply chain normalization and fiscal and monetary policy likely will sway market dynamics.

We appreciate your confidence in us during these extraordinary times. Our firm has a long history of helping clients weather unpredictable markets, and we’re confident we will continue to meet today’s challenges.

Sincerely,
image19.jpg
Jonathan Thomas
President and Chief Executive Officer
American Century Investments
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Performance
Total Returns as of October 31, 2021
Average Annual Returns
Ticker
Symbol
1 year5 years10 yearsSince
Inception
Inception
Date
Investor ClassANOIX38.56%24.65%17.09%6/1/01
Russell 2000 Growth Index38.45%17.89%14.56%
I ClassANONX38.81%24.89%17.32%5/18/07
Y ClassANOYX39.02%23.80%4/10/17
A ClassANOAX1/31/03
No sales charge38.22%24.34%16.80%
With sales charge30.28%22.88%16.11%
C ClassANOCX37.19%23.41%15.94%1/31/03
R ClassANORX37.88%24.02%16.52%9/28/07
R5 ClassANOGX38.84%23.62%4/10/17
R6 ClassANODX39.04%25.08%16.69%7/26/13
G ClassANOHX40.15%30.16%4/1/19
Average annual returns since inception are presented when ten years of performance history is not available. G Class returns would have been lower if a portion of the fees had not been waived. Extraordinary performance is attributable in part to unusually favorable market conditions and may not be repeated or consistently achieved in the future.

C Class shares will automatically convert to A Class shares after being held for approximately eight years. C Class average annual returns do not reflect this conversion.

Sales charges include initial sales charges and contingent deferred sales charges (CDSCs), as applicable. A Class shares have a 5.75% maximum initial sales charge and may be subject to a maximum CDSC of 1.00%. C Class shares redeemed within 12 months of purchase are subject to a maximum CDSC of 1.00%. The SEC requires that mutual funds provide performance information net of maximum sales charges in all cases where charges could be applied.












Data presented reflect past performance. Past performance is no guarantee of future results. Current performance may be higher or lower than the performance shown. Total returns for periods less than one year are not annualized. Investment return and principal value will fluctuate, and redemption value may be more or less than original cost. Data assumes reinvestment of dividends and capital gains, and none of the charts reflect the deduction of taxes that a shareholder would pay on fund distributions or the redemption of fund shares. To obtain performance data current to the most recent month end, please call 1-800-345-2021 or visit americancentury.com. For additional information about the fund, please consult the prospectus.
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Growth of $10,000 Over 10 Years
$10,000 investment made October 31, 2011
Performance for other share classes will vary due to differences in fee structure.
chart-42f45734a7e34ca2804a.jpg
Value on October 31, 2021
Investor Class — $48,513
Russell 2000 Growth Index — $38,977

Total Annual Fund Operating Expenses
Investor ClassI ClassY ClassA ClassC ClassR ClassR5 ClassR6 ClassG Class
1.22%1.02%0.87%1.47%2.22%1.72%1.02%0.87%0.87%
The total annual fund operating expenses shown is as stated in the fund’s prospectus current as of the date of this report. The prospectus may vary from the expense ratio shown elsewhere in this report because it is based on a different time period, includes acquired fund fees and expenses, and, if applicable, does not include fee waivers or expense reimbursements.


















Data presented reflect past performance. Past performance is no guarantee of future results. Current performance may be higher or lower than the performance shown. Total returns for periods less than one year are not annualized. Investment return and principal value will fluctuate, and redemption value may be more or less than original cost. Data assumes reinvestment of dividends and capital gains, and none of the charts reflect the deduction of taxes that a shareholder would pay on fund distributions or the redemption of fund shares. To obtain performance data current to the most recent month end, please call 1-800-345-2021 or visit americancentury.com. For additional information about the fund, please consult the prospectus.
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Portfolio Commentary

Portfolio Managers: Jackie Wagner and Jeff Hoernemann

Performance Summary

Small Cap Growth returned 38.56%* for the 12 months ended October 31, 2021, versus the 38.45% return of the fund’s benchmark, the Russell 2000 Growth Index.

U.S. stocks posted strong returns during the reporting period, supported by federal government stimulus and low interest rates. The rollout of COVID-19 vaccines allowed the economy to reopen, and despite concerns about the delta variant, inflationary pressures and supply chain constraints, several market indices ended the 12-month period at record highs. Within the Russell 2000 Growth Index, all sectors posted double-digit gains, led by energy, which benefited from strong demand and limited supply as the economy began to reopen. Information technology and consumer discretionary were also strong performers. Health care was the weakest sector.

Stock choices within the consumer discretionary and information technology sectors helped drive outperformance relative to the benchmark. Stock selection in the health care sector detracted.

Consumer Discretionary Stocks Benefited Performance

Stock selection across consumer discretionary industries was helpful, led by the textiles, apparel and luxury goods industry. Crocs was a top contributor in the sector. The manufacturer of footwear and accessories experienced strong demand for its core clog footwear offerings, strong pricing power and high attach rate—add-on products—of higher margin Jibbitz accessories.

Software holdings led performance in the information technology sector. Sprout Social outperformed. The provider of social media management software solutions released new products intended to expand the average revenue per user, and this was evident as its most recent quarterly results surprised to the upside with record new customer additions and an acceleration in average recurring revenue growth. Manhattan Associates provides cloud-based supply chain management software. The company reported better-than-expected quarterly earnings throughout the year. Manhattan Associates benefited from the restrictions due to the pandemic, and we believe the transition to online buying and curbside pickup are secular trends that fit with the company’s strengths. Elsewhere in information technology, Perficient, a consulting and IT services firm, was a top contributor. Demand accelerated for digital transformation services as projects that were delayed due to COVID-19 resumed in 2021.

Other significant contributors included Triumph Bancorp, a niche bank that focuses on the transportation industry. Its 60-branch network generates deposits that are used to fund the growth in its receivables book for transportation companies. Triumph is a leader in the transportation industry payments space, and its TriumphPay solution has experienced rapid adoption.

Health Care Weighed on Performance

Stock decisions in the biotechnology industry hampered performance in the health care sector. ACADIA Pharmaceuticals underperformed. The biopharmaceutical company focused on central nervous system disorders saw the expected label expansion of its lead drug Pimavanserin delayed and eventually rejected by the Food and Drug Administration. Despite breakthrough designation for the drug from the agency, last-minute changes made it likely that the company would need more clinical trials for the drug’s approval in dementia-related psychosis. We eliminated our holding. Eargo manufactures and markets hearing aids for mild to moderate hearing loss. While the



*All fund returns referenced in this commentary are for Investor Class shares. Performance for other share classes will vary due to differences in fee structure; when Investor Class performance exceeds that of the fund’s benchmark, other share classes may not. See page 3 for returns for all share classes.
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company continued to beat expectations for sales and has compelling new technology, it disclosed that it was being audited and that the audit had turned into a criminal investigation. We eliminated the holding.

Other key detractors included the online education company Chegg, which fell on concerns that fewer students were returning to college this school year. The online insurance broker eHealth is primarily focused on the Medicare Advantage market. The company saw customer churn and lower sales representative productivity that resulted in revenue and earnings well below expectations. The company is significantly restructuring its approach to the market as a result, with uncertain results at this point. We eliminated our holding. Plug Power, a maker of hydrogen fuel cells used in forklifts, benefited from excitement around all forms of alternative energy. The company executed well on the sales of energy systems for small vehicles meant to be operated indoors. We did not own this stock, which appreciated significantly in the period.

Outlook

Small Cap Growth’s investment process focuses on smaller companies demonstrating accelerating, sustainable growth. By focusing on inflection points in a company’s business, we strive to benefit from the market’s inefficiency in evaluating companies that are undergoing changing fundamentals. We believe that active investments in such companies will generate outperformance over time compared with the Russell 2000 Growth Index.

The portfolio positioning remains largely stock specific, with few thematic trends. As of October 31, 2021, consumer discretionary was the largest overweight sector relative to the benchmark. Health care was the largest underweight sector.
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Fund Characteristics
OCTOBER 31, 2021
Types of Investments in Portfolio% of net assets
Common Stocks98.0%
Temporary Cash Investments2.5%
Temporary Cash Investments - Securities Lending Collateral0.6%
Other Assets and Liabilities(1.1)%
Top Five Industries% of net assets
Biotechnology11.5%
Software10.6%
Semiconductors and Semiconductor Equipment5.2%
Health Care Providers and Services4.9%
Hotels, Restaurants and Leisure4.5%

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Shareholder Fee Example 

Fund shareholders may incur two types of costs: (1) transaction costs, including sales charges (loads) on purchase payments and redemption/exchange fees; and (2) ongoing costs, including management fees; distribution and service (12b-1) fees; and other fund expenses. This example is intended to help you understand your ongoing costs (in dollars) of investing in your fund and to compare these costs with the ongoing cost of investing in other mutual funds.

The example is based on an investment of $1,000 made at the beginning of the period and held for the entire period from May 1, 2021 to October 31, 2021.

Actual Expenses

The table provides information about actual account values and actual expenses for each class. You may use the information, together with the amount you invested, to estimate the expenses that you paid over the period. First, identify the share class you own. Then simply divide your account value by $1,000 (for example, an $8,600 account value divided by $1,000 = 8.6), then multiply the result by the number under the heading “Expenses Paid During Period” to estimate the expenses you paid on your account during this period.

If you hold Investor Class shares of any American Century Investments fund, or I Class shares of the American Century Diversified Bond Fund, in an American Century Investments account (i.e., not through a financial intermediary or employer-sponsored retirement plan account), American Century Investments may charge you a $25.00 annual account maintenance fee if the value of those shares is less than $10,000. We will redeem shares automatically in one of your accounts to pay the $25.00 fee. In determining your total eligible investment amount, we will include your investments in all personal accounts (including American Century Investments brokerage accounts) registered under your Social Security number. Personal accounts include individual accounts, joint accounts, UGMA/UTMA accounts, personal trusts, Coverdell Education Savings Accounts and IRAs (including traditional, Roth, Rollover, SEP-, SARSEP- and SIMPLE-IRAs), and certain other retirement accounts. If you have only business, business retirement, employer-sponsored or American Century Investments brokerage accounts, you are currently not subject to this fee. If you are subject to the account maintenance fee, your account value could be reduced by the fee amount.

Hypothetical Example for Comparison Purposes

The table also provides information about hypothetical account values and hypothetical expenses based on the actual expense ratio of each class of your fund and an assumed rate of return of 5% per year before expenses, which is not the actual return of a fund’s share class. The hypothetical account values and expenses may not be used to estimate the actual ending account balance or expenses you paid for the period. You may use this information to compare the ongoing costs of investing in your fund and other funds. To do so, compare this 5% hypothetical example with the 5% hypothetical examples that appear in the shareholder reports of the other funds.

Please note that the expenses shown in the table are meant to highlight your ongoing costs only and do not reflect any transactional costs, such as sales charges (loads) or redemption/exchange fees. Therefore, the table is useful in comparing ongoing costs only, and will not help you determine the relative total costs of owning different funds. In addition, if these transactional costs were included, your costs would have been higher.

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Beginning
Account Value
5/1/21
Ending
Account Value
10/31/21
Expenses Paid
During Period(1)
5/1/21 - 10/31/21
Annualized
Expense Ratio(1)
Actual
Investor Class$1,000$1,039.60$6.011.17%
I Class$1,000$1,040.30$4.990.97%
Y Class$1,000$1,041.20$4.220.82%
A Class$1,000$1,038.10$7.291.42%
C Class$1,000$1,034.70$11.132.17%
R Class$1,000$1,037.20$8.581.67%
R5 Class$1,000$1,040.70$4.990.97%
R6 Class$1,000$1,041.20$4.220.82%
G Class$1,000$1,045.30$0.00
0.00%(2)
Hypothetical
Investor Class$1,000$1,019.31$5.961.17%
I Class$1,000$1,020.32$4.940.97%
Y Class$1,000$1,021.07$4.180.82%
A Class$1,000$1,018.05$7.221.42%
C Class$1,000$1,014.27$11.022.17%
R Class$1,000$1,016.79$8.491.67%
R5 Class$1,000$1,020.32$4.940.97%
R6 Class$1,000$1,021.07$4.180.82%
G Class$1,000$1,025.21$0.00
0.00%(2)
(1)Expenses are equal to the class's annualized expense ratio listed in the table above, multiplied by the average account value over the period, multiplied by 184, the number of days in the most recent fiscal half-year, divided by 365, to reflect the one-half year period. Annualized expense ratio reflects actual expenses, including any applicable fee waivers or expense reimbursements and excluding any acquired fund fees and expenses.
(2)Other expenses, which include directors' fees and expenses, did not exceed 0.005%.
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Schedule of Investments

OCTOBER 31, 2021
SharesValue
COMMON STOCKS — 98.0%


Aerospace and Defense — 1.1%
Mercury Systems, Inc.(1)
311,505 $16,054,968 
Spirit AeroSystems Holdings, Inc., Class A207,839 8,581,672 
24,636,640 
Auto Components — 0.9%
Fox Factory Holding Corp.(1)
133,348 21,462,361 
Banks — 2.3%
Bancorp, Inc. (The)(1)
450,859 13,773,742 
Silvergate Capital Corp., Class A(1)
97,580 15,282,980 
Triumph Bancorp, Inc.(1)
203,023 23,814,598 
52,871,320 
Beverages — 0.5%
MGP Ingredients, Inc.170,309 10,935,541 
Biotechnology — 11.5%
Acceleron Pharma, Inc.(1)
72,219 12,579,105 
ADC Therapeutics SA(1)
377,348 10,939,319 
Arcutis Biotherapeutics, Inc.(1)
386,678 8,189,840 
Arena Pharmaceuticals, Inc.(1)
127,265 7,303,738 
Biohaven Pharmaceutical Holding Co. Ltd.(1)
140,365 19,976,747 
Blueprint Medicines Corp.(1)
142,503 16,030,163 
Bridgebio Pharma, Inc.(1)
237,394 11,722,516 
CareDx, Inc.(1)
175,691 8,960,241 
Centessa Pharmaceuticals plc, ADR(1)
398,837 6,859,996 
Cytokinetics, Inc.(1)
324,392 11,324,525 
Deciphera Pharmaceuticals, Inc.(1)
272,239 9,090,060 
Erasca, Inc.(1)
271,000 5,360,380 
Fate Therapeutics, Inc.(1)
118,864 6,394,883 
Global Blood Therapeutics, Inc.(1)
315,532 11,523,229 
Halozyme Therapeutics, Inc.(1)
399,865 15,222,861 
Heron Therapeutics, Inc.(1)
302,728 3,333,035 
Immunovant, Inc.(1)
230,898 1,856,420 
Insmed, Inc.(1)
523,847 15,793,987 
Intellia Therapeutics, Inc.(1)
64,273 8,547,024 
Invitae Corp.(1)(2)
217,908 5,774,562 
Iovance Biotherapeutics, Inc.(1)
138,333 3,362,875 
KalVista Pharmaceuticals, Inc.(1)
290,365 5,220,763 
Karuna Therapeutics, Inc.(1)
118,208 16,594,039 
Kinnate Biopharma, Inc.(1)(2)
191,186 4,544,491 
Kymera Therapeutics, Inc.(1)
150,031 8,833,825 
Natera, Inc.(1)
144,613 16,568,311 
Relay Therapeutics, Inc.(1)
182,741 6,076,138 
Sigilon Therapeutics, Inc.(1)
332,160 1,790,342 
259,773,415 
Building Products — 1.6%
Masonite International Corp.(1)
162,443 19,494,784 
Trex Co., Inc.(1)
160,317 17,057,729 
36,552,513 
10


SharesValue
Capital Markets — 1.3%
GCM Grosvenor, Inc., Class A800,369 $9,164,225 
Open Lending Corp., Class A(1)
661,673 20,855,933 
30,020,158 
Chemicals — 1.3%
Diversey Holdings Ltd.(1)
1,078,465 18,765,291 
Element Solutions, Inc.447,409 10,160,658 
28,925,949 
Commercial Services and Supplies — 3.7%
Brink's Co. (The)343,656 23,671,025 
Clean Harbors, Inc.(1)
262,971 29,594,757 
Driven Brands Holdings, Inc.(1)
936,860 30,419,844 
83,685,626 
Construction Materials — 1.3%
Eagle Materials, Inc.116,624 17,302,337 
Summit Materials, Inc., Class A(1)
374,467 13,349,748 
30,652,085 
Containers and Packaging — 0.5%
Intertape Polymer Group, Inc.533,390 12,119,366 
Diversified Consumer Services — 1.4%
Chegg, Inc.(1)
203,024 12,067,747 
European Wax Center, Inc., Class A(1)
615,904 19,635,019 
31,702,766 
Electrical Equipment — 1.0%
Sensata Technologies Holding plc(1)
410,296 22,607,310 
Electronic Equipment, Instruments and Components — 1.9%
Fabrinet(1)
91,727 8,805,792 
Jabil, Inc.150,098 8,999,876 
National Instruments Corp.295,651 12,556,298 
nLight, Inc.(1)
436,777 12,282,169 
42,644,135 
Equity Real Estate Investment Trusts (REITs) — 2.1%
DigitalBridge Group, Inc.(1)
1,588,970 10,646,099 
Innovative Industrial Properties, Inc.(2)
55,874 14,699,891 
Ryman Hospitality Properties, Inc.(1)
249,279 21,323,325 
46,669,315 
Food and Staples Retailing — 0.3%
Grocery Outlet Holding Corp.(1)
306,215 6,794,911 
Food Products — 1.3%
Sovos Brands, Inc.(1)
1,106,775 17,885,484 
Whole Earth Brands, Inc.(1)
1,031,071 12,506,891 
30,392,375 
Health Care Equipment and Supplies — 4.4%
Inari Medical, Inc.(1)
203,191 18,392,849 
NeuroPace, Inc.(1)
478,179 7,249,194 
Ortho Clinical Diagnostics Holdings plc(1)
935,705 18,498,888 
SI-BONE, Inc.(1)
572,423 12,908,139 
Silk Road Medical, Inc.(1)
308,664 18,121,663 
Tandem Diabetes Care, Inc.(1)
175,023 23,860,886 
99,031,619 
Health Care Providers and Services — 4.9%
Covetrus, Inc.(1)
413,192 8,342,347 
11


SharesValue
Encompass Health Corp.190,743 $12,123,625 
HealthEquity, Inc.(1)
347,872 23,022,169 
Progyny, Inc.(1)
306,275 18,814,473 
R1 RCM, Inc.(1)
1,116,423 24,226,379 
RadNet, Inc.(1)
390,223 12,132,033 
Tenet Healthcare Corp.(1)
187,886 13,463,911 
112,124,937 
Health Care Technology — 1.9%
Health Catalyst, Inc.(1)
443,254 23,332,891 
OptimizeRx Corp.(1)
198,370 19,182,379 
42,515,270 
Hotels, Restaurants and Leisure — 4.5%
Churchill Downs, Inc.102,878 23,661,940 
Planet Fitness, Inc., Class A(1)
200,882 15,980,163 
SeaWorld Entertainment, Inc.(1)
373,058 23,689,183 
Wingstop, Inc.120,829 20,839,378 
Wyndham Hotels & Resorts, Inc.199,618 16,861,732 
101,032,396 
Household Durables — 1.7%
Lovesac Co. (The)(1)
248,335 19,372,614 
Sonos, Inc.(1)
574,452 18,738,624 
38,111,238 
Insurance — 3.0%
Goosehead Insurance, Inc., Class A96,224 13,885,123 
Kinsale Capital Group, Inc.119,465 22,357,875 
Palomar Holdings, Inc.(1)
161,871 14,803,103 
Ryan Specialty Group Holdings, Inc., Class A(1)
426,015 16,099,107 
67,145,208 
Interactive Media and Services — 1.9%
Eventbrite, Inc., Class A(1)
678,654 13,735,957 
fuboTV, Inc.(1)(2)
348,813 10,398,116 
QuinStreet, Inc.(1)
1,318,000 18,452,000 
42,586,073 
Internet and Direct Marketing Retail — 0.6%
Revolve Group, Inc.(1)
174,036 13,059,661 
IT Services — 4.0%
DigitalOcean Holdings, Inc.(1)
226,915 22,144,635 
I3 Verticals, Inc., Class A(1)
320,898 7,184,906 
MAXIMUS, Inc.305,769 25,858,884 
Perficient, Inc.(1)
162,014 20,024,930 
Remitly Global, Inc.(1)
94,140 2,882,567 
Repay Holdings Corp.(1)
230,272 4,838,015 
Thoughtworks Holding, Inc.(1)
276,044 7,974,911 
90,908,848 
Leisure Products — 3.0%
Brunswick Corp.214,610 19,978,045 
Callaway Golf Co.(1)
752,676 20,359,886 
Hayward Holdings, Inc.(1)
994,374 23,059,533 
Solo Brands, Inc., Class A(1)
258,202 4,740,588 
68,138,052 
Life Sciences Tools and Services — 0.8%
NeoGenomics, Inc.(1)
403,529 18,562,334 
12


SharesValue
Machinery — 2.7%
AGCO Corp.138,614 $16,940,017 
Astec Industries, Inc.236,123 12,604,246 
John Bean Technologies Corp.151,907 22,444,259 
Timken Co. (The)139,079 9,867,655 
61,856,177 
Oil, Gas and Consumable Fuels — 2.3%
Matador Resources Co.684,220 28,634,607 
Whitecap Resources, Inc.3,813,979 22,897,434 
51,532,041 
Pharmaceuticals — 1.5%
Arvinas, Inc.(1)
117,841 10,202,674 
Edgewise Therapeutics, Inc.(1)(2)
272,174 4,490,871 
Harmony Biosciences Holdings, Inc.(1)(2)
174,635 7,242,114 
Reata Pharmaceuticals, Inc., Class A(1)
59,903 5,751,287 
Ventyx Biosciences, Inc.(1)
352,126 7,155,200 
34,842,146 
Professional Services — 2.6%
ASGN, Inc.(1)
133,515 15,976,405 
First Advantage Corp.(1)
1,092,313 20,426,253 
Hireright Holdings Corp.(1)
773,450 13,342,013 
Sterling Check Corp.(1)
417,547 8,956,383 
58,701,054 
Real Estate Management and Development — 2.1%
Altus Group Ltd.(2)
229,415 12,032,424 
Colliers International Group, Inc.63,331 9,206,428 
Newmark Group, Inc., Class A1,001,974 14,909,373 
Tricon Residential, Inc.860,918 12,528,388 
48,676,613 
Semiconductors and Semiconductor Equipment — 5.2%
Ichor Holdings Ltd.(1)
489,793 21,413,750 
MACOM Technology Solutions Holdings, Inc.(1)
387,402 27,048,407 
Onto Innovation, Inc.(1)
257,163 20,369,881 
Power Integrations, Inc.185,737 19,169,916 
Semtech Corp.(1)
362,156 30,794,125 
118,796,079 
Software — 10.6%
Enfusion, Inc., Class A(1)
370,810 7,649,810 
Everbridge, Inc.(1)
102,350 16,305,379 
Lightspeed Commerce, Inc.(1)
88,785 8,653,955 
Manhattan Associates, Inc.(1)
186,811 33,913,669 
Model N, Inc.(1)
444,213 14,396,943 
nCino, Inc.(1)
245,450 17,834,397 
Paycor HCM, Inc.(1)
555,355 18,015,716 
Paylocity Holding Corp.(1)
95,625 29,179,013 
SailPoint Technologies Holdings, Inc.(1)
334,922 16,069,558 
Sprout Social, Inc., Class A(1)
240,024 30,646,264 
SPS Commerce, Inc.(1)
114,073 17,422,369 
Tenable Holdings, Inc.(1)
564,110 30,038,857 
240,125,930 
Specialty Retail — 2.4%
Arko Corp.(1)
1,037,949 9,953,931 
13


SharesValue
Leslie's, Inc.(1)
1,063,595 $21,995,144 
National Vision Holdings, Inc.(1)
365,845 22,550,686 
54,499,761 
Textiles, Apparel and Luxury Goods — 1.8%
Capri Holdings Ltd.(1)
173,852 9,255,880 
Crocs, Inc.(1)
193,200 31,192,140 
40,448,020 
Trading Companies and Distributors — 2.1%
Finning International, Inc.837,904 24,806,725 
H&E Equipment Services, Inc.329,776 14,866,302 
NOW, Inc.(1)
1,153,639 8,329,273 
48,002,300 
TOTAL COMMON STOCKS
(Cost $1,766,932,916)
2,223,141,543 
TEMPORARY CASH INVESTMENTS — 2.5%


Repurchase Agreement, BMO Capital Markets Corp., (collateralized by various U.S. Treasury obligations, 2.00%, 11/15/26, valued at $13,034,155), in a joint trading account at 0.01%, dated 10/29/21, due 11/1/21 (Delivery value $12,763,072)12,763,061 
Repurchase Agreement, Fixed Income Clearing Corp., (collateralized by various U.S. Treasury obligations, 2.25% - 4.75%, 2/15/41 - 5/15/41, valued at $43,401,079), at 0.01%, dated 10/29/21, due 11/1/21 (Delivery value $42,550,035)42,550,000 
State Street Institutional U.S. Government Money Market Fund, Premier Class1,702,502 1,702,502 
TOTAL TEMPORARY CASH INVESTMENTS
(Cost $57,015,563)
57,015,563 
TEMPORARY CASH INVESTMENTS - SECURITIES LENDING COLLATERAL(3) — 0.6%
State Street Navigator Securities Lending Government Money Market Portfolio
(Cost $12,623,373)
12,623,373 12,623,373 
TOTAL INVESTMENT SECURITIES — 101.1%
(Cost $1,836,571,852)

2,292,780,479 
OTHER ASSETS AND LIABILITIES — (1.1)%

(25,799,268)
TOTAL NET ASSETS — 100.0%

$2,266,981,211 

FORWARD FOREIGN CURRENCY EXCHANGE CONTRACTS
Currency PurchasedCurrency SoldCounterpartySettlement DateUnrealized Appreciation
(Depreciation)
CAD3,536,466 USD2,794,972 Morgan Stanley12/31/21$63,019 
USD74,491,132 CAD94,840,992 Morgan Stanley12/31/21(2,154,535)
USD1,764,002 CAD2,242,701 Morgan Stanley12/31/21(48,434)
USD2,086,737 CAD2,626,878 Morgan Stanley12/31/21(36,173)
USD2,028,911 CAD2,531,140 Morgan Stanley12/31/21(16,628)
USD2,435,321 CAD3,011,880 Morgan Stanley12/31/211,273 
USD2,224,796 CAD2,753,533 Morgan Stanley12/31/21(469)
$(2,191,947)

14


NOTES TO SCHEDULE OF INVESTMENTS
ADR-American Depositary Receipt
CAD-Canadian Dollar
USD-United States Dollar
(1)Non-income producing.
(2)Security, or a portion thereof, is on loan. At the period end, the aggregate value of securities on loan was $25,882,052. The amount of securities on loan indicated may not correspond with the securities on loan identified because securities with pending sales are in the process of recall from the brokers.
(3)Investment of cash collateral from securities on loan. At the period end, the aggregate value of the collateral held by the fund was $26,725,287, which includes securities collateral of $14,101,914.


See Notes to Financial Statements.
15


Statement of Assets and Liabilities
OCTOBER 31, 2021
Assets
Investment securities, at value (cost of $1,823,948,479) — including $25,882,052 of securities on loan$2,280,157,106 
Investment made with cash collateral received for securities on loan, at value
(cost of $12,623,373)
12,623,373 
Total investment securities, at value (cost of $1,836,571,852)2,292,780,479 
Receivable for investments sold14,310,354 
Receivable for capital shares sold5,646,522 
Unrealized appreciation on forward foreign currency exchange contracts64,292 
Dividends and interest receivable67,156 
Securities lending receivable12,699 
2,312,881,502 
Liabilities
Payable for collateral received for securities on loan12,623,373 
Payable for investments purchased28,357,586 
Payable for capital shares redeemed1,045,879 
Unrealized depreciation on forward foreign currency exchange contracts2,256,239 
Accrued management fees1,575,372 
Distribution and service fees payable41,842 
45,900,291 
Net Assets$2,266,981,211 
Net Assets Consist of:
Capital (par value and paid-in surplus)$1,444,464,064 
Distributable earnings822,517,147 
$2,266,981,211 

Net AssetsShares OutstandingNet Asset Value Per Share
Investor Class, $0.01 Par Value
$716,869,06226,240,077$27.32
I Class, $0.01 Par Value
$464,632,08416,377,581$28.37
Y Class, $0.01 Par Value
$202,168,9717,011,485$28.83
A Class, $0.01 Par Value
$134,366,7335,193,452 $25.87*
C Class, $0.01 Par Value
$10,587,338479,576$22.08
R Class, $0.01 Par Value
$12,689,755510,894$24.84
R5 Class, $0.01 Par Value
$6,395,861225,297$28.39
R6 Class, $0.01 Par Value
$337,131,60811,696,717$28.82
G Class, $0.01 Par Value
$382,139,79912,938,790$29.53
*Maximum offering price $27.45 (net asset value divided by 0.9425).


See Notes to Financial Statements.

16


Statement of Operations
YEAR ENDED OCTOBER 31, 2021
Investment Income (Loss)
Income:
Dividends (net of foreign taxes withheld of $153,694)$6,009,694 
Securities lending, net902,248 
Interest8,035 
6,919,977 
Expenses:
Management fees19,796,250 
Distribution and service fees:
A Class312,718 
C Class82,795 
R Class57,447 
Directors' fees and expenses50,172 
Other expenses
755
20,300,137 
Fees waived - G Class(2,839,327)
17,460,810 
Net investment income (loss)(10,540,833)
Realized and Unrealized Gain (Loss)
Net realized gain (loss) on:
Investment transactions441,364,820 
Forward foreign currency exchange contract transactions(1,141,286)
Foreign currency translation transactions(43,249)
440,180,285 
Change in net unrealized appreciation (depreciation) on:
Investments168,080,246 
Forward foreign currency exchange contracts(2,146,982)
Translation of assets and liabilities in foreign currencies6,557 
165,939,821 
Net realized and unrealized gain (loss)606,120,106 
Net Increase (Decrease) in Net Assets Resulting from Operations$595,579,273 


See Notes to Financial Statements.
17


Statement of Changes in Net Assets
YEARS ENDED OCTOBER 31, 2021 AND OCTOBER 31, 2020
Increase (Decrease) in Net AssetsOctober 31, 2021October 31, 2020
Operations
Net investment income (loss)$(10,540,833)$(6,420,221)
Net realized gain (loss)440,180,285 182,275,922 
Change in net unrealized appreciation (depreciation)165,939,821 161,853,294 
Net increase (decrease) in net assets resulting from operations595,579,273 337,708,995 
Distributions to Shareholders
From earnings:
Investor Class(62,781,510)(25,227,608)
I Class(43,474,342)(16,816,143)
Y Class(15,461,227)(535,213)
A Class(12,881,120)(4,721,985)
C Class(823,392)(312,537)
R Class(1,137,082)(381,103)
R5 Class(1,134)(395)
R6 Class(14,189,017)(2,829,940)
G Class(31,492,935)(9,051,157)
Decrease in net assets from distributions(182,241,759)(59,876,081)
Capital Share Transactions
Net increase (decrease) in net assets from capital share transactions (Note 5)353,243,408 369,858,485 
Net increase (decrease) in net assets766,580,922 647,691,399 
Net Assets
Beginning of period1,500,400,289 852,708,890 
End of period$2,266,981,211 $1,500,400,289 


See Notes to Financial Statements.

18


Notes to Financial Statements

OCTOBER 31, 2021

1. Organization

American Century Mutual Funds, Inc. (the corporation) is registered under the Investment Company Act of 1940, as amended (the 1940 Act), as an open-end management investment company and is organized as a Maryland corporation. Small Cap Growth Fund (the fund) is one fund in a series issued by the corporation. The fund’s investment objective is to seek long-term capital growth.

The fund offers the Investor Class, I Class, Y Class, A Class, C Class, R Class, R5 Class, R6 Class and G Class. The A Class may incur an initial sales charge. The A Class and C Class may be subject to a contingent deferred sales charge.

2. Significant Accounting Policies

The following is a summary of significant accounting policies consistently followed by the fund in preparation of its financial statements. The fund is an investment company and follows accounting and reporting guidance in accordance with accounting principles generally accepted in the United States of America. This may require management to make certain estimates and assumptions at the date of the financial statements. Actual results could differ from these estimates. Management evaluated the impact of events or transactions occurring through the date the financial statements were issued that would merit recognition or disclosure.

Investment Valuations — The fund determines the fair value of its investments and computes its net asset value (NAV) per share at the close of regular trading (usually 4 p.m. Eastern time) on the New York Stock Exchange (NYSE) on each day the NYSE is open. The Board of Directors has adopted valuation policies and procedures to guide the investment advisor in the fund’s investment valuation process and to provide methodologies for the oversight of the fund’s pricing function.
Equity securities that are listed or traded on a domestic securities exchange are valued at the last reported sales price or at the official closing price as provided by the exchange. Equity securities traded on foreign securities exchanges are generally valued at the closing price of such securities on the exchange where primarily traded or at the close of the NYSE, if that is earlier. If no last sales price is reported, or if local convention or regulation so provides, the mean of the latest bid and asked prices may be used. Securities traded over-the-counter are valued at the mean of the latest bid and asked prices, the last sales price, or the official closing price. Equity securities initially expressed in local currencies are translated into U.S. dollars at the mean of the appropriate currency exchange rate at the close of the NYSE as provided by an independent pricing service.
Open-end management investment companies are valued at the reported NAV per share. Repurchase agreements are valued at cost, which approximates fair value. Forward foreign currency exchange contracts are valued at the mean of the appropriate forward exchange rate at the close of the NYSE as provided by an independent pricing service.
If the fund determines that the market price for an investment is not readily available or the valuation methods mentioned above do not reflect an investment’s fair value, such investment is valued as determined in good faith by the Board of Directors or its delegate, in accordance with policies and procedures adopted by the Board of Directors. In its determination of fair value, the fund may review several factors including, but not limited to, market information regarding the specific investment or comparable investments and correlation with other investment types, futures indices or general market indicators. Circumstances that may cause the fund to use these procedures to value an investment include, but are not limited to: an investment has been declared in default or is distressed; trading in a security has been suspended during the trading day or a security is not actively trading on its principal exchange; prices received from a regular pricing source are deemed unreliable; or there is a foreign market holiday and no trading occurred.
19


The fund monitors for significant events occurring after the close of an investment’s primary exchange but before the fund’s NAV per share is determined. Significant events may include, but are not limited to: corporate announcements and transactions; governmental action and political unrest that could impact a specific investment or an investment sector; or armed conflicts, natural disasters and similar events that could affect investments in a specific country or region. The fund also monitors for significant fluctuations between domestic and foreign markets, as evidenced by the U.S. market or such other indicators that the Board of Directors, or its delegate, deems appropriate. The fund may apply a model-derived factor to the closing price of equity securities traded on foreign securities exchanges. The factor is based on observable market data as provided by an independent pricing service.
Security Transactions — Security transactions are accounted for as of the trade date. Net realized gains and losses are determined on the identified cost basis, which is also used for federal income tax purposes.
Investment Income — Dividend income less foreign taxes withheld, if any, is recorded as of the ex-dividend date. Distributions received on securities that represent a return of capital or long-term capital gain are recorded as a reduction of cost of investments and/or as a realized gain. The fund may estimate the components of distributions received that may be considered nontaxable distributions or long-term capital gain distributions for income tax purposes. Interest income is recorded on the accrual basis and includes accretion of discounts and amortization of premiums. Securities lending income is net of fees and rebates earned by the lending agent for its services.
Foreign Currency Translations — All assets and liabilities initially expressed in foreign currencies are translated into U.S. dollars at prevailing exchange rates at period end. The fund may enter into spot foreign currency exchange contracts to facilitate transactions denominated in a foreign currency. Purchases and sales of investment securities, dividend and interest income, spot foreign currency exchange contracts, and expenses are translated at the rates of exchange prevailing on the respective dates of such transactions. Net realized and unrealized foreign currency exchange gains or losses related to investment securities are a component of net realized gain (loss) on investment transactions and change in net unrealized appreciation (depreciation) on investments, respectively.
Repurchase Agreements — The fund may enter into repurchase agreements with institutions that American Century Investment Management, Inc. (ACIM) (the investment advisor) has determined are creditworthy pursuant to criteria adopted by the Board of Directors. The fund requires that the collateral, represented by securities, received in a repurchase transaction be transferred to the custodian in a manner sufficient to enable the fund to obtain those securities in the event of a default under the repurchase agreement. ACIM monitors, on a daily basis, the securities transferred to ensure the value, including accrued interest, of the securities under each repurchase agreement is equal to or greater than amounts owed to the fund under each repurchase agreement.
Joint Trading Account — Pursuant to an Exemptive Order issued by the Securities and Exchange Commission, the fund, along with certain other funds in the American Century Investments family of funds, may transfer uninvested cash balances into a joint trading account. These balances are invested in one or more repurchase agreements that are collateralized by U.S. Treasury or Agency obligations.
Segregated Assets — In accordance with the 1940 Act, the fund segregates assets on its books and records to cover certain types of investment securities and other financial instruments. ACIM monitors, on a daily basis, the securities segregated to ensure the fund designates a sufficient amount of liquid assets, marked-to-market daily. The fund may also receive assets or be required to pledge assets at the custodian bank or with a broker for collateral requirements.
Income Tax Status — It is the fund’s policy to distribute substantially all net investment income and net realized gains to shareholders and to otherwise qualify as a regulated investment company under provisions of the Internal Revenue Code. Accordingly, no provision has been made for income taxes. The fund files U.S. federal, state, local and non-U.S. tax returns as applicable. The fund's tax returns are subject to examination by the relevant taxing authority until expiration of the applicable statute of limitations, which is generally three years from the date of filing but can be longer in certain jurisdictions. At this time, management believes there are no uncertain tax positions which, based on their technical merit, would not be sustained upon examination and for which it is reasonably possible that the total amounts of unrecognized tax benefits will significantly change in the next twelve months.
20


Multiple Class — All shares of the fund represent an equal pro rata interest in the net assets of the class to which such shares belong, and have identical voting, dividend, liquidation and other rights and the same terms and conditions, except for class specific expenses and exclusive rights to vote on matters affecting only individual classes. Income, non-class specific expenses, and realized and unrealized capital gains and losses of the fund are allocated to each class of shares based on their relative net assets.
Distributions to Shareholders — Distributions from net investment income and net realized gains, if any, are generally declared and paid annually. The fund may elect to treat a portion of its payment to a redeeming shareholder, which represents the pro rata share of undistributed net investment income and net realized gains, as a distribution for federal income tax purposes (tax equalization).
Indemnifications — Under the corporation’s organizational documents, its officers and directors are indemnified against certain liabilities arising out of the performance of their duties to the fund. In addition, in the normal course of business, the fund enters into contracts that provide general indemnifications. The maximum exposure under these arrangements is unknown as this would involve future claims that may be made against a fund. The risk of material loss from such claims is considered by management to be remote.
Securities Lending — Securities are lent to qualified financial institutions and brokers. State Street Bank & Trust Co. serves as securities lending agent to the fund pursuant to a Securities Lending Agreement. The lending of securities exposes the fund to risks such as: the borrowers may fail to return the loaned securities, the borrowers may not be able to provide additional collateral, the fund may experience delays in recovery of the loaned securities or delays in access to collateral, or the fund may experience losses related to the investment collateral. To minimize certain risks, loan counterparties pledge collateral in the form of cash and/or securities. The lending agent has agreed to indemnify the fund in the case of default of any securities borrowed. Cash collateral received is invested in the State Street Navigator Securities Lending Government Money Market Portfolio, a money market mutual fund registered under the 1940 Act. The loans may also be secured by U.S. government securities in an amount at least equal to the market value of the securities loaned, plus accrued interest and dividends, determined on a daily basis and adjusted accordingly. By lending securities, the fund seeks to increase its net investment income through the receipt of interest and fees. Such income is reflected separately within the Statement of Operations. The value of loaned securities and related collateral outstanding at period end, if any, are shown on a gross basis within the Schedule of Investments and Statement of Assets and Liabilities.

The following table reflects a breakdown of transactions accounted for as secured borrowings, the gross obligation by the type of collateral pledged, and the remaining contractual maturity of those transactions as of October 31, 2021.
Remaining Contractual Maturity of Agreements
Overnight and
Continuous
<30 days
Between
30 & 90 days
>90 daysTotal
Securities Lending Transactions(1)
Common Stocks$12,623,373 — — — $12,623,373 
Gross amount of recognized liabilities for securities lending transactions$12,623,373 
(1)Amount represents the payable for cash collateral received for securities on loan. This will generally be in the Overnight and Continuous column as the securities are typically callable on demand.

3. Fees and Transactions with Related Parties

Certain officers and directors of the corporation are also officers and/or directors of American Century Companies, Inc. (ACC). The corporation’s investment advisor, ACIM, the corporation's distributor, American Century Investment Services, Inc. (ACIS), and the corporation’s transfer agent, American Century Services, LLC, are wholly owned, directly or indirectly, by ACC. Various funds issued by American Century Asset Allocation Portfolios, Inc. own, in aggregate, 13% of the shares of the fund.
21


Management Fees — The corporation has entered into a management agreement with ACIM, under which ACIM provides the fund with investment advisory and management services in exchange for a single, unified management fee (the fee) per class. The agreement provides that ACIM will pay all expenses of managing and operating the fund, except brokerage expenses, taxes, interest, fees and expenses of the independent directors (including legal counsel fees), extraordinary expenses, and expenses incurred in connection with the provision of shareholder services and distribution services under a plan adopted pursuant to Rule 12b-1 under the 1940 Act. The fee is computed and accrued daily based on each class's daily net assets and paid monthly in arrears. The difference in the fee among the classes is a result of their separate arrangements for non-Rule 12b-1 shareholder services. It is not the result of any difference in advisory or custodial fees or other expenses related to the management of the fund’s assets, which do not vary by class. The rate of the fee is determined by applying a fee rate calculation formula. This formula takes into account the fund’s assets as well as certain assets, if any, of other clients of the investment advisor outside the American Century Investments family of funds (such as subadvised funds and separate accounts) that use very similar investment teams and strategies (strategy assets). The investment advisor agreed to waive the G Class's management fee in its entirety. The investment advisor expects this waiver to remain in effect permanently and cannot terminate it without the approval of the Board of Directors.

The management fee schedule range and the effective annual management fee for each class for the period ended October 31, 2021 are as follows:
Management Fee
Schedule Range
Effective Annual
Management Fee
Investor Class1.100% to 1.500%1.17%
I Class0.900% to 1.300%0.97%
Y Class0.750% to 1.150%0.82%
A Class1.100% to 1.500%1.17%
C Class1.100% to 1.500%1.17%
R Class1.100% to 1.500%1.17%
R5 Class0.900% to 1.300%0.97%
R6 Class0.750% to 1.150%0.82%
G Class0.750% to 1.150%
0.00%(1)
(1)Effective annual management fee before waiver was 0.82%.

Distribution and Service Fees — The Board of Directors has adopted a separate Master Distribution and Individual Shareholder Services Plan for each of the A Class, C Class and R Class (collectively the plans), pursuant to Rule 12b-1 of the 1940 Act. The plans provide that the A Class will pay ACIS an annual distribution and service fee of 0.25%. The plans provide that the C Class will pay ACIS an annual distribution and service fee of 1.00%, of which 0.25% is paid for individual shareholder services and 0.75% is paid for distribution services. The plans provide that the R Class will pay ACIS an annual distribution and service fee of 0.50%. The fees are computed and accrued daily based on each class’s daily net assets and paid monthly in arrears. The fees are used to pay financial intermediaries for distribution and individual shareholder services. Fees incurred under the plans during the period ended October 31, 2021 are detailed in the Statement of Operations.
Directors' Fees and Expenses — The Board of Directors is responsible for overseeing the investment advisor’s management and operations of the fund. The directors receive detailed information about the fund and its investment advisor regularly throughout the year, and meet at least quarterly with management of the investment advisor to review reports about fund operations. The fund’s officers do not receive compensation from the fund.
Interfund Transactions — The fund may enter into security transactions with other American Century Investments funds and other client accounts of the investment advisor, in accordance with the 1940 Act rules and procedures adopted by the Board of Directors. The rules and procedures require, among other things, that these transactions be effected at the independent current market price of the security. During the period, the interfund purchases and sales were $2,006,480 and $2,519,047, respectively. The effect of interfund transactions on the Statement of Operations was $100,296 in net realized gain (loss) on investment transactions.

4. Investment Transactions

Purchases and sales of investment securities, excluding short-term investments, for the period ended October 31, 2021 were $2,009,695,229 and $1,866,344,988, respectively.

22


5. Capital Share Transactions
Transactions in shares of the fund were as follows:
Year ended
October 31, 2021
Year ended
October 31, 2020
SharesAmountSharesAmount
Investor Class/Shares Authorized335,000,000 

335,000,000 
Sold5,201,148 $132,383,799 9,921,702 $179,032,931 
Issued in reinvestment of distributions2,479,907 58,274,650 1,317,045 23,588,268 
Redeemed(5,592,502)(141,184,376)(9,495,829)(181,400,499)
2,088,553 49,474,073 1,742,918 21,220,700 
I Class/Shares Authorized210,000,000 

210,000,000 
Sold8,344,806 219,598,270 14,257,641 281,464,270 
Issued in reinvestment of distributions1,708,377 41,616,070 161,247 2,976,627 
Redeemed(7,651,690)(206,252,981)(17,359,714)(315,563,803)
2,401,493 54,961,359 (2,940,826)(31,122,906)
Y Class/Shares Authorized30,000,000 

30,000,000 
Sold2,146,541 58,617,976 6,761,561 126,431,953 
Issued in reinvestment of distributions125,315 3,097,792 28,652 535,213 
Redeemed(949,794)(25,673,469)(1,451,198)(30,110,005)
1,322,062 36,042,299 5,339,015 96,857,161 
A Class/Shares Authorized70,000,000 

70,000,000 
Sold893,567 21,725,400 635,430 10,992,905 
Issued in reinvestment of distributions557,328 12,428,385 267,760 4,586,734 
Redeemed(933,351)(22,599,792)(990,674)(17,325,103)
517,544 11,553,993 (87,484)(1,745,464)
C Class/Shares Authorized30,000,000 

30,000,000 
Sold256,593 5,394,290 75,490 1,255,719 
Issued in reinvestment of distributions42,909 822,132 18,317 276,405 
Redeemed(108,201)(2,217,451)(126,131)(1,977,877)
191,301 3,998,971 (32,324)(445,753)
R Class/Shares Authorized30,000,000 

30,000,000 
Sold203,005 4,752,618 215,915 3,705,057 
Issued in reinvestment of distributions51,236 1,097,821 22,612 375,133 
Redeemed(161,724)(3,809,826)(193,648)(3,188,549)
92,517 2,040,613 44,879 891,641 
R5 Class/Shares Authorized30,000,000 

30,000,000 
Sold265,537 6,981,382 — — 
Issued in reinvestment of distributions47 1,134 22 395 
Redeemed(40,704)(1,098,894)— — 
224,880 5,883,622 22 395 
R6 Class/Shares Authorized50,000,000 

50,000,000 
Sold9,462,609 256,807,769 3,584,510 69,966,478 
Issued in reinvestment of distributions574,222 14,189,017 151,577 2,829,940 
Redeemed(3,069,413)(83,050,016)(1,680,729)(33,221,028)
6,967,418 187,946,770 2,055,358 39,575,390 
G Class/Shares Authorized140,000,000 

140,000,000 
Sold1,374,992 38,113,576 16,326,187 329,098,341 
Issued in reinvestment of distributions1,252,702 31,492,935 481,445 9,051,157 
Redeemed(2,531,086)(68,264,803)(4,419,358)(93,522,177)
96,608 1,341,708 12,388,274 244,627,321 
Net increase (decrease)13,902,376 $353,243,408 18,509,832 $369,858,485 

23


6. Fair Value Measurements

The fund’s investments valuation process is based on several considerations and may use multiple inputs to determine the fair value of the investments held by the fund. In conformity with accounting principles generally accepted in the United States of America, the inputs used to determine a valuation are classified into three broad levels.

Level 1 valuation inputs consist of unadjusted quoted prices in an active market for identical investments.

Level 2 valuation inputs consist of direct or indirect observable market data (including quoted prices for comparable investments, evaluations of subsequent market events, interest rates, prepayment speeds, credit risk, etc.). These inputs also consist of quoted prices for identical investments initially expressed in local currencies that are adjusted through translation into U.S. dollars.

Level 3 valuation inputs consist of unobservable data (including a fund’s own assumptions).

The level classification is based on the lowest level input that is significant to the fair valuation measurement. The valuation inputs are not necessarily an indication of the risks associated with investing in these securities or other financial instruments.
The following is a summary of the level classifications as of period end. The Schedule of Investments provides additional information on the fund’s portfolio holdings.
Level 1Level 2Level 3
Assets
Investment Securities
Common Stocks$2,130,103,251 $93,038,292 — 
Temporary Cash Investments1,702,502 55,313,061 — 
Temporary Cash Investments - Securities Lending Collateral12,623,373 — — 
$2,144,429,126 $148,351,353 — 
Other Financial Instruments
Forward Foreign Currency Exchange Contracts— $64,292 — 
Liabilities
Other Financial Instruments
Forward Foreign Currency Exchange Contracts— $2,256,239 — 

7. Derivative Instruments

Foreign Currency Risk — The fund is subject to foreign currency exchange rate risk in the normal course of pursuing its investment objectives. The value of foreign investments held by a fund may be significantly affected by changes in foreign currency exchange rates. The dollar value of a foreign security generally decreases when the value of the dollar rises against the foreign currency in which the security is denominated and tends to increase when the value of the dollar declines against such foreign currency. A fund may enter into forward foreign currency exchange contracts to reduce a fund's exposure to foreign currency exchange rate fluctuations. The net U.S. dollar value of foreign currency underlying all contractual commitments held by a fund and the resulting unrealized appreciation or depreciation are determined daily. Realized gain or loss is recorded upon settlement of the contract. Net realized and unrealized gains or losses occurring during the holding period of forward foreign currency exchange contracts are a component of net realized gain (loss) on forward foreign currency exchange contract transactions and change in net unrealized appreciation (depreciation) on forward foreign currency exchange contracts, respectively. A fund bears the risk of an unfavorable change in the foreign currency exchange rate underlying the forward contract. Additionally, losses, up to the fair value, may arise if the counterparties do not perform under the contract terms. The fund's average U.S. dollar exposure to foreign currency risk derivative instruments held during the period was $68,952,543.
24


The value of foreign currency risk derivative instruments as of October 31, 2021, is disclosed on the Statement of Assets and Liabilities as an asset of $64,292 in unrealized appreciation on forward foreign currency exchange contracts and a liability of $2,256,239 in unrealized depreciation on forward foreign currency exchange contracts. For the year ended October 31, 2021, the effect of foreign currency risk derivative instruments on the Statement of Operations was $(1,141,286) in net realized gain (loss) on forward foreign currency exchange contract transactions and $(2,146,982) in change in net unrealized appreciation (depreciation) on forward foreign currency exchange contracts.
8. Risk Factors

The value of the fund’s shares will go up and down, sometimes rapidly or unpredictably, based on the performance of the securities owned by the fund and other factors generally affecting the securities market. Market risks, including political, regulatory, economic and social developments, can affect the value of the fund’s investments. Natural disasters, public health emergencies, terrorism and other unforeseeable events may lead to increased market volatility and may have adverse long-term effects on world economies and markets generally.
The fund invests in common stocks of small companies. Because of this, the fund may be subject to greater risk and market fluctuations than a fund investing in larger, more established companies.
9. Federal Tax Information
On December 7, 2021, the fund declared and paid a per-share distribution from net realized gains to shareholders of record on December 6, 2021 of $4.6123 for the Investor Class, I Class, Y Class, A Class, C Class, R Class, R5 Class, R6 Class and G Class.

The tax character of distributions paid during the years ended October 31, 2021 and October 31, 2020 were as follows:
20212020
Distributions Paid From
Ordinary income$35,338,601 — 
Long-term capital gains$146,903,158 $59,876,081 

The book-basis character of distributions made during the year from net investment income or net realized gains may differ from their ultimate characterization for federal income tax purposes. These differences reflect the differing character of certain income items and net realized gains and losses for financial statement and tax purposes, and may result in reclassification among certain capital accounts on the financial statements.
The reclassifications, which are primarily due to tax equalization, were made to capital $36,314,014 and distributable earnings $(36,314,014).

As of period end, the federal tax cost of investments and the components of distributable earnings on a tax-basis were as follows:

Federal tax cost of investments$1,846,463,316 
Gross tax appreciation of investments$534,196,920 
Gross tax depreciation of investments(87,879,757)
Net tax appreciation (depreciation) of investments446,317,163 
Net tax appreciation (depreciation) on derivatives and translation of assets and
liabilities in foreign currencies
(198)
Net tax appreciation (depreciation) $446,316,965 
Undistributed ordinary income$169,172,381 
Accumulated long-term gains$207,027,801 

The difference between book-basis and tax-basis unrealized appreciation (depreciation) is attributable primarily to the tax deferral of losses on wash sales.
25


Financial Highlights
For a Share Outstanding Throughout the Years Ended October 31 (except as noted)
Per-Share DataRatios and Supplemental Data
Income From Investment Operations:Ratio to Average Net Assets of:
Net Asset
Value,
Beginning
of Period
Net
Investment
Income
(Loss)(1)
Net
Realized
and
Unrealized
Gain (Loss)
Total From
Investment
Operations
Distributions From Net Realized GainsNet Asset
Value,
End
of Period
Total
Return(2)
Operating
Expenses
Operating
Expenses
(before
expense
waiver)
Net
Investment
Income
(Loss)
Net
Investment
Income
(Loss)
(before
expense
waiver)
Portfolio
Turnover
Rate
Net
Assets,
End of
Period
(in thousands)
Investor Class
2021$22.00(0.21)8.258.04(2.72)$27.3238.56%1.17%1.17%(0.82)%(0.82)%96%$716,869 
2020$17.54(0.15)5.615.46(1.00)$22.0032.43%1.22%1.22%(0.81)%(0.81)%141%$531,353 
2019$18.08(0.12)1.911.79(2.33)$17.5413.00%1.28%1.28%(0.70)%(0.70)%92%$392,956 
2018$16.70(0.17)1.651.48(0.10)$18.088.89%1.27%1.27%(0.93)%(0.93)%116%$386,455 
2017$12.96(0.13)4.454.32(0.58)$16.7033.36%1.36%1.36%(0.83)%(0.83)%70%$361,029 
I Class
2021$22.71(0.17)8.558.38(2.72)$28.3738.81%0.97%0.97%(0.62)%(0.62)%96%$464,632 
2020$18.04(0.11)5.785.67(1.00)$22.7132.76%1.02%1.02%(0.61)%(0.61)%141%$317,466 
2019$18.50(0.09)1.961.87(2.33)$18.0413.16%1.08%1.08%(0.50)%(0.50)%92%$305,249 
2018$17.04(0.14)1.701.56(0.10)$18.509.18%1.07%1.07%(0.73)%(0.73)%116%$371,030 
2017$13.20(0.09)4.514.42(0.58)$17.0433.51%1.16%1.16%(0.63)%(0.63)%70%$219,881 



For a Share Outstanding Throughout the Years Ended October 31 (except as noted)
Per-Share DataRatios and Supplemental Data
Income From Investment Operations:Ratio to Average Net Assets of:
Net Asset
Value,
Beginning
of Period
Net
Investment
Income
(Loss)(1)
Net
Realized
and
Unrealized
Gain (Loss)
Total From
Investment
Operations
Distributions From Net Realized GainsNet Asset
Value,
End
of Period
Total
Return(2)
Operating
Expenses
Operating
Expenses
(before
expense
waiver)
Net
Investment
Income
(Loss)
Net
Investment
Income
(Loss)
(before
expense
waiver)
Portfolio
Turnover
Rate
Net
Assets,
End of
Period
(in thousands)
Y Class
2021$23.02(0.13)8.668.53(2.72)$28.8339.02%0.82%0.82%(0.47)%(0.47)%96%$202,169 
2020$18.24(0.10)5.885.78(1.00)$23.0232.96%0.87%0.87%(0.46)%(0.46)%141%$130,958 
2019$18.65(0.06)1.981.92(2.33)$18.2413.34%0.93%0.93%(0.35)%(0.35)%92%$6,392 
2018$17.16(0.07)1.661.59(0.10)$18.659.29%0.92%0.92%(0.58)%(0.58)%116%$1,778 
2017(3)
$15.34(0.06)2.462.40(0.58)$17.1615.67%
1.01%(4)
1.01%(4)
(0.61)%(4)
(0.61)%(4)
70%(5)
$6 
A Class
2021$21.00(0.26)7.857.59(2.72)$25.8738.22%1.42%1.42%(1.07)%(1.07)%96%$134,367 
2020$16.82(0.19)5.375.18(1.00)$21.0032.14%1.47%1.47%(1.06)%(1.06)%141%$98,200 
2019$17.49(0.16)1.821.66(2.33)$16.8212.72%1.53%1.53%(0.95)%(0.95)%92%$80,127 
2018$16.19(0.21)1.611.40(0.10)$17.498.61%1.52%1.52%(1.18)%(1.18)%116%$77,764 
2017$12.61(0.16)4.324.16(0.58)$16.1933.02%1.61%1.61%(1.08)%(1.08)%70%$80,654 
C Class
2021$18.38(0.38)6.806.42(2.72)$22.0837.19%2.17%2.17%(1.82)%(1.82)%96%$10,587 
2020$14.94(0.28)4.724.44(1.00)$18.3831.18%2.22%2.22%(1.81)%(1.81)%141%$5,298 
2019$15.92(0.25)1.601.35(2.33)$14.9411.84%2.28%2.28%(1.70)%(1.70)%92%$4,790 
2018$14.86(0.32)1.481.16(0.10)$15.927.83%2.27%2.27%(1.93)%(1.93)%116%$6,227 
2017$11.70(0.25)3.993.74(0.58)$14.8631.99%2.36%2.36%(1.83)%(1.83)%70%$9,958 



For a Share Outstanding Throughout the Years Ended October 31 (except as noted)
Per-Share DataRatios and Supplemental Data
Income From Investment Operations:Ratio to Average Net Assets of:
Net Asset
Value,
Beginning
of Period
Net
Investment
Income
(Loss)(1)
Net
Realized
and
Unrealized
Gain (Loss)
Total From
Investment
Operations
Distributions From Net Realized GainsNet Asset
Value,
End
of Period
Total
Return(2)
Operating
Expenses
Operating
Expenses
(before
expense
waiver)
Net
Investment
Income
(Loss)
Net
Investment
Income
(Loss)
(before
expense
waiver)
Portfolio
Turnover
Rate
Net
Assets,
End of
Period
(in thousands)
R Class
2021$20.30(0.31)7.577.26(2.72)$24.8437.88%1.67%1.67%(1.32)%(1.32)%96%$12,690 
2020$16.33(0.23)5.204.97(1.00)$20.3031.80%1.72%1.72%(1.31)%(1.31)%141%$8,492 
2019$17.09(0.19)1.761.57(2.33)$16.3312.39%1.78%1.78%(1.20)%(1.20)%92%$6,099 
2018$15.86(0.25)1.581.33(0.10)$17.098.41%1.77%1.77%(1.43)%(1.43)%116%$5,687 
2017$12.40(0.19)4.234.04(0.58)$15.8632.61%1.86%1.86%(1.33)%(1.33)%70%$3,761 
R5 Class
2021$22.73(0.18)8.568.38(2.72)$28.3938.84%0.97%0.97%(0.62)%(0.62)%96%$6,396 
2020$18.05(0.12)5.805.68(1.00)$22.7332.74%1.02%1.02%(0.61)%(0.61)%141%$9 
2019$18.51(0.08)1.951.87(2.33)$18.0513.21%1.08%1.08%(0.50)%(0.50)%92%$7 
2018$17.05(0.14)1.701.56(0.10)$18.519.12%1.07%1.07%(0.73)%(0.73)%116%$7 
2017(3)
$15.26(0.07)2.442.37(0.58)$17.0515.56%
1.16%(4)
1.16%(4)
(0.76)%(4)
(0.76)%(4)
70%(5)
$6 
R6 Class
2021$23.01(0.13)8.668.53(2.72)$28.8239.04%0.82%0.82%(0.47)%(0.47)%96%$337,132 
2020$18.24(0.09)5.865.77(1.00)$23.0132.91%0.87%0.87%(0.46)%(0.46)%141%$108,820 
2019$18.65(0.06)1.981.92(2.33)$18.2413.40%0.93%0.93%(0.35)%(0.35)%92%$48,763 
2018$17.15(0.11)1.711.60(0.10)$18.659.30%0.92%0.92%(0.58)%(0.58)%116%$39,687 
2017$13.26(0.08)4.554.47(0.58)$17.1533.74%1.01%1.01%(0.48)%(0.48)%70%$28,077 



For a Share Outstanding Throughout the Years Ended October 31 (except as noted)
Per-Share DataRatios and Supplemental Data
Income From Investment Operations:Ratio to Average Net Assets of:
Net Asset
Value,
Beginning
of Period
Net
Investment
Income
(Loss)(1)
Net
Realized
and
Unrealized
Gain (Loss)
Total From
Investment
Operations
Distributions From Net Realized GainsNet Asset
Value,
End
of Period
Total
Return(2)
Operating
Expenses
Operating
Expenses
(before
expense
waiver)
Net
Investment
Income
(Loss)
Net
Investment
Income
(Loss)
(before
expense
waiver)
Portfolio
Turnover
Rate
Net
Assets,
End of
Period
(in thousands)
G Class
2021$23.350.108.808.90(2.72)$29.5340.15%
0.00%(6)
0.82%0.35%(0.47)%96%$382,140 
2020$18.340.085.936.01(1.00)$23.3534.09%0.01%0.87%0.40%(0.46)%141%$299,803 
2019(7)
$17.430.050.860.91$18.345.22%
0.00%(4)(6)
0.93%(4)
0.52%(4)
(0.41)%(4)
92%(8)
$8,326 
Notes to Financial Highlights
(1)Computed using average shares outstanding throughout the period.
(2)Total returns are calculated based on the net asset value of the last business day and do not reflect applicable sales charges, if any. Total returns for periods less than one year are not annualized.
(3)April 10, 2017 (commencement of sale) through October 31, 2017.
(4)Annualized.
(5)Portfolio turnover is calculated at the fund level. Percentage indicated was calculated for the year ended October 31, 2017.
(6)Ratio was less than 0.005%.
(7)April 1, 2019 (commencement of sale) through October 31, 2019.
(8)Portfolio turnover is calculated at the fund level. Percentage indicated was calculated for the year ended October 31, 2019.


See Notes to Financial Statements.



Report of Independent Registered Public Accounting Firm

To the Shareholders and the Board of Directors of American Century Mutual Funds, Inc.:

Opinion on the Financial Statements and Financial Highlights

We have audited the accompanying statement of assets and liabilities, including the schedule of investments, of Small Cap Growth Fund (the “Fund”), one of the funds constituting the American Century Mutual Funds, Inc., as of October 31, 2021, the related statement of operations for the year then ended, the statements of changes in net assets for each of the two years in the period then ended, the financial highlights for each of the five years in the period then ended, and the related notes. In our opinion, the financial statements and financial highlights present fairly, in all material respects, the financial position of Small Cap Growth Fund of the American Century Mutual Funds, Inc. as of October 31, 2021, and the results of its operations for the year then ended, the changes in its net assets for each of the two years in the period then ended, and the financial highlights for each of the five years in the period then ended, in conformity with accounting principles generally accepted in the United States of America.

Basis for Opinion

These financial statements and financial highlights are the responsibility of the Fund's management. Our responsibility is to express an opinion on the Fund’s financial statements and financial highlights based on our audits. We are a public accounting firm registered with the Public Company Accounting Oversight Board (United States) (PCAOB) and are required to be independent with respect to the Fund in accordance with the U.S. federal securities laws and the applicable rules and regulations of the Securities and Exchange Commission and the PCAOB.

We conducted our audits in accordance with the standards of the PCAOB. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements and financial highlights are free of material misstatement, whether due to error or fraud. The Fund is not required to have, nor were we engaged to perform, an audit of its internal control over financial reporting. As part of our audits we are required to obtain an understanding of internal control over financial reporting but not for the purpose of expressing an opinion on the effectiveness of the Fund’s internal control over financial reporting. Accordingly, we express no such opinion.

Our audits included performing procedures to assess the risks of material misstatement of the financial statements and financial highlights, whether due to error or fraud, and performing procedures that respond to those risks. Such procedures included examining, on a test basis, evidence regarding the amounts and disclosures in the financial statements and financial highlights. Our audits also included evaluating the accounting principles used and significant estimates made by management, as well as evaluating the overall presentation of the financial statements and financial highlights. Our procedures included confirmation of securities owned as of October 31, 2021, by correspondence with the custodian and brokers; when replies were not received from brokers, we performed other auditing procedures. We believe that our audits provide a reasonable basis for our opinion.

/s/ Deloitte & Touche LLP

Kansas City, Missouri
December 15, 2021

We have served as the auditor of one or more American Century investment companies since 1997.
30


Management

The Board of Directors

The individuals listed below serve as directors of the funds. Each director will continue to serve in this capacity until death, retirement, resignation or removal from office. The board has adopted a mandatory retirement age for directors who are not “interested persons,” as that term is defined in the Investment Company Act (independent directors). Independent directors shall retire by December 31 of the year in which they reach their 75th birthday.
Jonathan S.Thomas is an “interested person” because he currently serves as President and Chief Executive Officer of American Century Companies, Inc. (ACC), the parent company of American Century Investment Management, Inc. (ACIM or the advisor). The other directors (more than three-fourths of the total number) are independent. They are not employees, directors or officers of, and have no financial interest in, ACC or any of its wholly owned, direct or indirect, subsidiaries, including ACIM, American Century Investment Services, Inc. (ACIS) and American Century Services, LLC (ACS), and they do not have any other affiliations, positions or relationships that would cause them to be considered “interested persons” under the Investment Company Act. The directors serve in this capacity for seven (in the case of Jonathan S. Thomas, 16; and Stephen E. Yates, 8) registered investment companies in the American Century Investments family of funds.
The following table presents additional information about the directors. The mailing address for each director is 4500 Main Street, Kansas City, Missouri 64111.
Name
(Year of Birth)
Position(s) Held with FundsLength of Time ServedPrincipal Occupation(s) During Past 5 YearsNumber of American Century Portfolios Overseen by DirectorOther Directorships Held During Past 5 Years
Independent Directors
Thomas W. Bunn (1953)DirectorSince 2017Retired72SquareTwo Financial; Barings (formerly Babson Capital Funds Trust) (2013 to 2016)
Chris H. Cheesman
(1962)
DirectorSince 2019
Retired. Senior Vice President & Chief Audit Executive, AllianceBernstein (1999 to 2018)72Alleghany Corporation
Barry Fink
(1955)
DirectorSince 2012 (independent since 2016)Retired72None
Rajesh K. Gupta
(1960)
DirectorSince 2019
Partner Emeritus, SeaCrest Investment Management and SeaCrest Wealth Management (2019 to Present); Chief Executive Officer and Chief Investment Officer, SeaCrest Investment Management (2006 to 2019); Chief Executive Officer and Chief Investment Officer, SeaCrest Wealth Management (2008 to 2019)72None
31


Name
(Year of Birth)
Position(s) Held with FundsLength of Time ServedPrincipal Occupation(s) During Past 5 YearsNumber of American Century Portfolios Overseen by DirectorOther Directorships Held During Past 5 Years
Independent Directors
Lynn Jenkins
(1963)
DirectorSince 2019
Consultant, LJ Strategies (2019 to present); United States Representative, U.S. House of Representatives (2009 to 2018)72MGP Ingredients, Inc. (2019 to 2021)
Jan M. Lewis
(1957)
DirectorSince 2011Retired72None
John R. Whitten
(1946)
DirectorSince 2008Retired72Onto Innovation Inc. (2019 to 2020); Rudolph Technologies, Inc. (2006 to 2019)
Stephen E. Yates
(1948)
Director and Chairman of the BoardSince 2012 (Chairman since 2018)Retired107None
Interested Director
Jonathan S. Thomas
(1963)
DirectorSince 2007President and Chief Executive Officer, ACC (2007 to present). Also serves as Chief Executive Officer, ACS; Director, ACC and other ACC subsidiaries145None
The Statement of Additional Information has additional information about the fund's directors and is available without charge, upon request, by calling 1-800-345-2021.
32


Officers

The following table presents certain information about the executive officers of the funds. Each officer serves as an officer for 16 (in the case of Robert J. Leach, 15) investment companies in the American Century family of funds. No officer is compensated for his or her service as an officer of the funds. The listed officers are interested persons of the funds and are appointed or re-appointed on an annual basis. The mailing address for each officer listed below is 4500 Main Street, Kansas City, Missouri 64111.
Name
(Year of Birth)
Offices with the FundsPrincipal Occupation(s) During the Past Five Years
Patrick Bannigan
(1965)
President since 2019Executive Vice President and Director, ACC (2012 to present); Chief Financial Officer, Chief Accounting Officer and Treasurer, ACC (2015 to present). Also serves as President, ACS; Vice President, ACIM; Chief Financial Officer, Chief Accounting Officer and/or Director, ACIM, ACS and other ACC subsidiaries
R. Wes Campbell
(1974)
Chief Financial Officer and Treasurer since 2018Vice President, ACS, (2020 to present); Investment Operations and Investment Accounting, ACS (2000 to present)
Amy D. Shelton
(1964)
Chief Compliance Officer and Vice President since 2014Chief Compliance Officer, American Century funds, (2014 to present); Chief Compliance Officer, ACIM (2014 to present); Chief Compliance Officer, ACIS (2009 to present). Also serves as Vice President, ACIS
John Pak
(1968)
General Counsel and
Senior Vice President since 2021
General Counsel and Senior Vice President, ACC (2021 to present). Also serves as General Counsel and Senior Vice President, ACIM, ACS and ACIS. Chief Legal Officer of Investment and Wealth Management, The Bank of New York Mellon (2014 to 2021)
C. Jean Wade
(1964)
Vice President since 2012Senior Vice President, ACS (2017 to present); Vice President, ACS (2000 to 2017)
Robert J. Leach
(1966)
Vice President since 2006 Vice President, ACS (2000 to present)
David H. Reinmiller
(1963)
Vice President since 2000Attorney, ACC (1994 to present). Also serves as Vice President, ACIM and ACS
Ward D. Stauffer
(1960)
Secretary since 2005Attorney, ACC (2003 to present)





33


Approval of Management Agreement

At a meeting held on June 30, 2021, the Fund’s Board of Directors (the "Board") unanimously approved the renewal of the management agreement pursuant to which American Century Investment Management, Inc. (the “Advisor”) acts as the investment advisor for the Fund. Under Section 15(c) of the Investment Company Act, contracts for investment advisory services are required to be reviewed, evaluated, and approved by a majority of a fund’s directors (the “Directors”), including a majority of the independent Directors, each year.

Prior to its consideration of the renewal of the management agreement, the Directors requested and reviewed extensive data and information compiled by the Advisor and certain independent providers of evaluation data concerning the Fund and the services provided to the Fund by the Advisor. This review was in addition to the oversight and evaluation undertaken by the Board and its committees on a continual basis and the information received was supplemental to the extensive information that the Board and its committees receive and consider throughout the year.

In connection with its consideration of the renewal of the management agreement, the Board’s review and evaluation of the services provided by the Advisor and its affiliates included, but was not limited to, the following:

the nature, extent, and quality of investment management, shareholder services, and other services provided and to be provided to the Fund including without limitation portfolio management and trading services, shareholder and intermediary services, compliance and legal services, fund accounting and financial reporting, and fund share distribution;
the wide range of other programs and services provided and to be provided to the Fund and its shareholders on a routine and non-routine basis;
the Fund’s investment performance, including data comparing the Fund's performance to appropriate benchmarks and/or a peer group of other mutual funds with similar investment objectives and strategies;
the cost of owning the Fund compared to the cost of owning similar funds;
the compliance policies, procedures, and regulatory experience of the Advisor and the Fund's service providers;
the Advisor’s strategic plans, COVID-19 pandemic response, vendor management practices, and social justice initiatives;
the Advisor’s business continuity plans and cyber security practices;
financial data showing the cost of services provided to the Fund, the profitability of the Fund to the Advisor, and the overall profitability of the Advisor;
possible economies of scale associated with the Advisor’s management of the Fund and other accounts;
services provided and charges to the Advisor's other investment management clients;
acquired fund fees and expenses;
payments and practices in connection with financial intermediaries holding shares of the Fund and the services provided by intermediaries in connection therewith; and
possible collateral benefits to the Advisor from the management of the Fund.

The Board held two meetings to consider the renewal. The independent Directors also met in private session three times to review and discuss the information provided in response to their request. The independent Directors held active discussions with the Advisor regarding the renewal of the management agreement, requesting supplemental information, and reviewing information provided by the Advisor in response thereto. The independent Directors had the benefit of the advice of their independent counsel throughout the process.



34


Factors Considered

The Directors considered all of the information provided by the Advisor, the independent data providers, and independent counsel in connection with the approval. They determined that the information was sufficient for them to evaluate the management agreement for the Fund. In connection with their review, the Directors did not identify any single factor as being all-important or controlling, and each Director may have attributed different levels of importance to different factors. In deciding to renew the management agreement, the Board based its decision on a number of factors, including without limitation the following:

Nature, Extent and Quality of Services — Generally. Under the management agreement, the Advisor is responsible for providing or arranging for all services necessary for the operation of the Fund. The Board noted that the Advisor provides or arranges at its own expense a wide variety of services which include the following:

constructing and designing the Fund
portfolio research and security selection
initial capitalization/funding
securities trading
Fund administration
custody of Fund assets
daily valuation of the Fund’s portfolio
liquidity monitoring and management
risk management, including cyber security
shareholder servicing and transfer agency, including shareholder confirmations, recordkeeping, and communications
legal services (except the independent Directors’ counsel)
regulatory and portfolio compliance
financial reporting
marketing and distribution (except amounts paid by the Fund under Rule 12b-1 plans)

The Board noted that many of these services have expanded over time in terms of both quantity and complexity in response to shareholder demands, competition in the industry, changing distribution channels, and the changing regulatory environment.

Investment Management Services. The nature of the investment management services provided to the Fund is quite complex and allows Fund shareholders access to professional money management, instant diversification of their investments within an asset class, the opportunity to easily diversify among asset classes by investing in or exchanging among various American Century Investments funds, and liquidity. In evaluating investment performance, the Board expects the Advisor to manage the Fund in accordance with its investment objectives and approved strategies. Further, the Directors recognize that the Advisor has an obligation to monitor trading activities, and in particular to seek the best execution of fund trades, and to evaluate the use of and payment for research. In providing these services, the Advisor utilizes teams of investment professionals (portfolio managers, analysts, research assistants, and securities traders) who require extensive information technology, research, training, compliance, and other systems to conduct their business. The Board, directly and through its Fund Performance Review Committee, provides oversight of the investment performance process. It regularly reviews investment performance information for the Fund, together with comparative information for appropriate benchmarks and/or peer groups of similarly-managed funds, over different time horizons. The Directors also review investment performance information during the management agreement renewal process. If performance concerns are identified, the Fund receives special reviews until performance improves, during which the Board discusses with the Advisor the reasons for such results (e.g., market conditions, security selection) and any efforts being undertaken to improve performance. The Fund’s performance was above its benchmark for the one-, three-, five-, and ten-year periods reviewed by the Board. The Board found the investment management services provided by the Advisor to the Fund to be satisfactory and consistent with the management agreement.
35


Shareholder and Other Services. Under the management agreement, the Advisor provides the Fund with a comprehensive package of transfer agency, shareholder, and other services. The Board, directly and through its various committees, regularly reviews reports and evaluations of such services at its regular meetings. These reports include, but are not limited to, information regarding the operational efficiency and accuracy of the shareholder and transfer agency services provided, staffing levels, shareholder satisfaction, technology support (including cyber security), new products and services offered to Fund shareholders, securities trading activities, portfolio valuation services, auditing services, and legal and operational compliance activities. The Board found the services provided by the Advisor to the Fund under the management agreement to be competitive and of high quality.

Costs of Services and Profitability. The Advisor provides detailed information concerning its cost of providing various services to the Fund, its profitability in managing the Fund (pre- and post-distribution), its overall profitability, and its financial condition. The Directors have reviewed with the Advisor the methodology used to prepare this financial information. This information is considered in evaluating the Advisor’s financial condition, its ability to continue to provide services under the management agreement, and the reasonableness of the current management fee. The Board concluded that the Advisor’s profits were reasonable in light of the services provided to the Fund.

Ethics. The Board generally considers the Advisor’s commitment to providing quality services to shareholders and to conducting its business ethically. They noted that the Advisor’s practices generally meet or exceed industry best practices.

Economies of Scale. The Board also reviewed information provided by the Advisor regarding the possible existence of economies of scale in connection with the management of the Fund. The Board concluded that economies of scale are difficult to measure and predict with precision, especially on a fund-by-fund basis. The Board concluded that the Advisor is sharing economies of scale, to the extent they exist, through its competitive fee structure, offering competitive fees from fund inception, and through reinvestment in its business, infrastructure, investment capabilities and initiatives to provide shareholders additional content and services. The Board also noted that economies of scale are shared with the Fund and its shareholders through management fee breakpoints that serve to reduce the effective management fee as the assets of the Fund grow.

Comparison to Other Funds’ Fees. The management agreement provides that the Fund pays the Advisor a single, all-inclusive (or unified) management fee for providing all services necessary for the management and operation of the Fund, other than brokerage expenses, expenses attributable to short sales, taxes, interest, extraordinary expenses, fees and expenses of the Fund’s independent Directors (including their independent legal counsel), and expenses incurred in connection with the provision of shareholder services and distribution services under a plan adopted pursuant to Rule 12b-1 under the Investment Company Act. Under the unified fee structure, the Advisor is responsible for providing all investment advisory, custody, audit, administrative, compliance, recordkeeping, marketing and shareholder services, or arranging and supervising third parties to provide such services. By contrast, most other funds are charged a variety of fees, including an investment advisory fee, a transfer agency fee, an administrative fee, distribution charges, and other expenses. Other than their investment advisory fees and any applicable Rule 12b-1 distribution fees, all other components of the total fees charged by these other funds may be increased without shareholder approval. The Board believes the unified fee structure is a benefit to Fund shareholders because it clearly discloses to shareholders the cost of owning Fund shares, and, since the unified fee cannot be increased without a vote of Fund shareholders, it shifts to the Advisor the risk of increased costs of operating the Fund and provides a direct incentive to minimize administrative inefficiencies. Part of the Board’s analysis of fee levels involves reviewing certain evaluative data compiled by an independent provider comparing the Fund’s unified fee to the total expense ratios of its peers. The unified fee charged to shareholders of the Fund was above the median of the total expense ratios of the Fund’s peer expense universe. In addition, the Board reviewed the Fund’s position relative to the narrower set of its expense group peers. The Board concluded that the management fee paid by the Fund to the Advisor under the management agreement is reasonable in light of the services provided to the Fund.


36


Comparison to Fees and Services Provided to Other Clients of the Advisor. The Board also requested and received information from the Advisor concerning the nature of the services, fees, costs, and profitability of its advisory services to advisory clients other than the Fund. They observed that these varying types of client accounts require different services and involve different regulatory and entrepreneurial risks than the management of the Fund. The Board analyzed this information and concluded that the fees charged and services provided to the Fund were reasonable by comparison.

Payments to Intermediaries. The Directors also requested and received a description of payments made to intermediaries by the Fund and the Advisor and services provided in response thereto. These payments include various payments made by the Fund or the Advisor to different types of intermediaries and recordkeepers for distribution and service activities provided for the Fund. The Directors reviewed such information and received representations from the Advisor that all such payments by the Fund were made pursuant to the Fund's Rule 12b-1 Plan and that all such payments by the Advisor were made from the Advisor’s resources and reasonable profits. The Board found such payments to be reasonable in scope and purpose.

Collateral or “Fall-Out” Benefits Derived by the Advisor. The Board considered the possible existence of collateral benefits the Advisor may receive as a result of its relationship with the Fund. They concluded that the Advisor’s primary business is managing funds and it generally does not use fund or shareholder information to generate profits in other lines of business, and therefore does not derive any significant collateral benefits from them. To the extent there are potential collateral benefits, the Board has been advised and has taken this into consideration in its review of the management contract with the Fund. The Board noted that additional assets from other clients may offer the Advisor some benefit from increased leverage with service providers and counterparties. Additionally, the Advisor may receive proprietary research from broker-dealers that execute fund portfolio transactions, which the Board concluded is likely to benefit other clients of the Advisor, as well as Fund shareholders. The Board also determined that the Advisor is able to provide investment management services to certain clients other than the Fund, at least in part, due to its existing infrastructure built to serve the fund complex. The Board concluded that appropriate allocation methodologies had been employed to assign resources and the cost of those resources to these other clients and, where expressly provided, these other client assets may be included with the assets of the Fund to determine breakpoints in the management fee schedule.

Existing Relationship. The Board also considered whether there was any reason for not continuing the existing arrangement with the Advisor. In this regard, the Board was mindful of the potential disruptions of the Fund’s operations and various risks, uncertainties, and other effects that could occur as a result of a decision not to continue such relationship. In particular, the Board recognized that most shareholders have invested in the Fund on the strength of the Advisor’s industry standing and reputation and in the expectation that the Advisor will have a continuing role in providing advisory services to the Fund.

Conclusion of the Directors. As a result of this process, the Board, including all of the independent Directors, taking into account all of the factors discussed above and the information provided by the Advisor and others in connection with its review and throughout the year, determined that the management fee is fair and reasonable in light of the services provided and that the investment management agreement between the Fund and the Advisor should be renewed.
37


Additional Information

Retirement Account Information

As required by law, distributions you receive from certain retirement accounts are subject to federal income tax withholding, unless you elect not to have withholding apply*. Tax will be withheld on the total amount withdrawn even though you may be receiving amounts that are not subject to withholding, such as nondeductible contributions. In such case, excess amounts of withholding could occur. You may adjust your withholding election so that a greater or lesser amount will be withheld.
If you don’t want us to withhold on this amount, you must notify us to not withhold the federal income tax. You may notify us in writing or in certain situations by telephone or through other electronic means. For systematic withdrawals, your withholding election will remain in effect until revoked or changed by filing a new election. You have the right to revoke your election at any time and change your withholding percentage for future distributions.
Remember, even if you elect not to have income tax withheld, you are liable for paying income tax on the taxable portion of your withdrawal. If you elect not to have income tax withheld or you don’t have enough income tax withheld, you may be responsible for payment of estimated tax. You may incur penalties under the estimated tax rules if your withholding and estimated tax payments are not sufficient. You can reduce or defer the income tax on a distribution by directly or indirectly rolling such distribution over to another IRA or eligible plan. You should consult your tax advisor for additional information.
State tax will be withheld if, at the time of your distribution, your address is within one of the mandatory withholding states and you have federal income tax withheld (or as otherwise required by state law). State taxes will be withheld from your distribution in accordance with the respective state rules.
*Some 403(b), 457 and qualified retirement plan distributions may be subject to 20% mandatory withholding, as they are subject to special tax and withholding rules.  Your plan administrator or plan sponsor is required to provide you with a special tax notice explaining those rules at the time you request a distribution.  If applicable, federal and/or state taxes may be withheld from your distribution amount.


Proxy Voting Policies

A description of the policies that the fund's investment advisor uses in exercising the voting rights associated with the securities purchased and/or held by the fund is available without charge, upon request, by calling 1-800-345-2021. It is also available on American Century Investments’ website at americancentury.com/proxy and on the Securities and Exchange Commission’s website at sec.gov. Information regarding how the investment advisor voted proxies relating to portfolio securities during the most recent 12-month period ended June 30 is available on americancentury.com/proxy. It is also available at sec.gov.


Quarterly Portfolio Disclosure

The fund files its complete schedule of portfolio holdings with the Securities and Exchange Commission (SEC) for the first and third quarters of each fiscal year as an exhibit to its reports on Form N-PORT. These portfolio holdings are available on the fund's website at americancentury.com and, upon request, by calling 1-800-345-2021. The fund’s Form N-PORT reports are available on the SEC’s website at sec.gov.



38


Other Tax Information

The following information is provided pursuant to provisions of the Internal Revenue Code.

The fund hereby designates up to the maximum amount allowable as qualified dividend income for the fiscal year ended October 31, 2021.

For corporate taxpayers, the fund hereby designates $7,006,884, or up to the maximum amount allowable, of ordinary income distributions paid during the fiscal year ended October 31, 2021 as qualified for the corporate dividends received deduction.

The fund hereby designates $166,508,196, or up to the maximum amount allowable, as long-term capital gain distributions (20% rate gain distributions) for the fiscal year ended October 31, 2021.

The fund hereby designates $52,047,577 as qualified short-term capital gain distributions for purposes of Internal Revenue Code Section 871 for the fiscal year ended October 31, 2021.

The fund utilized earnings and profits of $36,314,014 distributed to shareholders on redemption of shares as part of the dividends paid deduction (tax equalization).
39


Notes

40






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American Century Mutual Funds, Inc.
Investment Advisor:
American Century Investment Management, Inc.
Kansas City, Missouri
This report and the statements it contains are submitted for the general information of our shareholders. The report is not authorized for distribution to prospective investors unless preceded or accompanied by an effective prospectus.
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CL-ANN-90978 2112




    


image8.jpg
Annual Report
October 31, 2021
Sustainable Equity Fund
Investor Class (AFDIX)
I Class (AFEIX)
Y Class (AFYDX)
A Class (AFDAX)
C Class (AFDCX)
R Class (AFDRX)
R5 Class (AFDGX)
R6 Class (AFEDX)
G Class (AFEGX)





















Table of Contents
President's Letter
Performance
Portfolio Commentary
Fund Characteristics
Shareholder Fee Example
Schedule of Investments
Statement of Assets and Liabilities
Statement of Operations
Statement of Changes in Net Assets
Notes to Financial Statements
Financial Highlights
Report of Independent Registered Public Accounting Firm
Management
Approval of Management Agreement
Additional Information























Any opinions expressed in this report reflect those of the author as of the date of the report, and do not necessarily represent the opinions of American Century Investments® or any other person in the American Century Investments organization. Any such opinions are subject to change at any time based upon market or other conditions and American Century Investments disclaims any responsibility to update such opinions. These opinions may not be relied upon as investment advice and, because investment decisions made by American Century Investments funds are based on numerous factors, may not be relied upon as an indication of trading intent on behalf of any American Century Investments fund. Security examples are used for representational purposes only and are not intended as recommendations to purchase or sell securities. Performance information for comparative indices and securities is provided to American Century Investments by third party vendors. To the best of American Century Investments’ knowledge, such information is accurate at the time of printing.



President’s Letter
image30.jpg Jonathan Thomas

Dear Investor:

Thank you for reviewing this annual report for the period ended October 31, 2021. Annual reports help convey important information about fund returns, including market factors that affected performance. For additional investment insights, please visit americancentury.com.
Economic, Earnings Gains Fueled Rally Among Risk-On Assets

Stocks and other risk-on assets rallied for the 12-month period, despite lingering pandemic-related challenges. Upbeat data on U.S. manufacturing, employment and housing, along with central bank and federal government support and positive vaccine developments, helped boost corporate earnings and promote investor optimism. Outside the U.S., most economies recovered, but generally at a slower pace. Virus outbreaks and slower vaccine rollouts, particularly in emerging markets, led to lingering lockdowns in some regions.

As the period progressed, steady economic gains combined with ongoing monetary and fiscal support, rising energy prices and severe supply chain disruptions pushed global interest rates and inflation higher. In the U.S., year-over-year headline inflation climbed to 6.2% in October 2021, the largest 12-month increase in nearly 31 years.
Late in the period, the Federal Reserve (Fed) confirmed it would start tapering its bond buying in November. Yet despite inflation’s surge, the Fed left short-term interest rates unchanged. Central banks in Europe and the U.K. maintained their supportive interest rate and bond-buying programs as inflation ticked higher.

Overall, stocks delivered stellar performance for the 12-month period, highlighted by the S&P 500 Index’s gain of nearly 43%. Assets offering inflation-fighting potential, including real estate investment trusts, fared even better. Meanwhile, global bonds retreated as interest rates rose. However, emerging markets bonds largely advanced, benefiting from risk-on sentiment.
Several Factors Shaping Market Dynamics

The return to pre-pandemic life is progressing, albeit somewhat cautiously due to COVID-19’s lingering effects. As the economy and markets respond to this fluid backdrop, investors will face opportunities and ongoing challenges. Economic growth, inflation, the virus’s trajectory, supply chain normalization and fiscal and monetary policy likely will sway market dynamics.

We appreciate your confidence in us during these extraordinary times. Our firm has a long history of helping clients weather unpredictable markets, and we’re confident we will continue to meet today’s challenges.

Sincerely,
image19.jpg
Jonathan Thomas
President and Chief Executive Officer
American Century Investments
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Performance
Total Returns as of October 31, 2021
  Average Annual Returns
 Ticker
Symbol
1 year5 years10 yearsSince InceptionInception
Date
Investor ClassAFDIX43.50%20.13%16.11%7/29/05
S&P 500 Index42.91%18.91%16.20%
I ClassAFEIX43.78%20.38%16.34%7/29/05
Y ClassAFYDX44.01%19.96%4/10/17
A ClassAFDAX11/30/04
No sales charge43.13%19.84%15.83%
With sales charge34.90%18.43%15.14%
C ClassAFDCX42.08%18.95%14.96%11/30/04
R ClassAFDRX42.78%19.54%15.53%7/29/05
R5 ClassAFDGX43.78%19.78%4/10/17
R6 ClassAFEDX44.03%24.23%4/1/19
G ClassAFEGX44.61%24.77%4/1/19
Average annual returns since inception are presented when ten years of performance history is not available.
Fund returns would have been lower if a portion of the fees had not been waived. Extraordinary performance is attributable in part to unusually favorable market conditions and may not be repeated or consistently achieved in the future.

C Class shares will automatically convert to A Class shares after being held for approximately eight years. C Class average annual returns do not reflect this conversion.

Sales charges include initial sales charges and contingent deferred sales charges (CDSCs), as applicable. A Class shares have a 5.75% maximum initial sales charge and may be subject to a maximum CDSC of 1.00%. C Class shares redeemed within 12 months of purchase are subject to a maximum CDSC of 1.00%. The SEC requires that mutual funds provide performance information net of maximum sales charges in all cases where charges could be applied.

















Data presented reflect past performance. Past performance is no guarantee of future results. Current performance may be higher or lower than the performance shown. Total returns for periods less than one year are not annualized. Investment return and principal value will fluctuate, and redemption value may be more or less than original cost. Data assumes reinvestment of dividends and capital gains, and none of the charts reflect the deduction of taxes that a shareholder would pay on fund distributions or the redemption of fund shares. To obtain performance data current to the most recent month end, please call 1-800-345-2021 or visit americancentury.com. For additional information about the fund, please consult the prospectus.
3


Growth of $10,000 Over 10 Years
$10,000 investment made October 31, 2011
Performance for other share classes will vary due to differences in fee structure.
chart-b2b198fad5c14ee58b6a.jpg
Value on October 31, 2021
Investor Class — $44,576
S&P 500 Index — $44,939
Ending value of Investor Class would have been lower if a portion of the fees had not been waived.

Total Annual Fund Operating Expenses
Investor ClassI ClassY ClassA ClassC ClassR ClassR5 ClassR6 ClassG Class
0.79%0.59%0.44%1.04%1.79%1.29%0.59%0.44%0.44%
The total annual fund operating expenses shown is as stated in the fund’s prospectus current as of the date of this report. The prospectus may vary from the expense ratio shown elsewhere in this report because it is based on a different time period, includes acquired fund fees and expenses, and, if applicable, does not include fee waivers or expense reimbursements.



















Data presented reflect past performance. Past performance is no guarantee of future results. Current performance may be higher or lower than the performance shown. Total returns for periods less than one year are not annualized. Investment return and principal value will fluctuate, and redemption value may be more or less than original cost. Data assumes reinvestment of dividends and capital gains, and none of the charts reflect the deduction of taxes that a shareholder would pay on fund distributions or the redemption of fund shares. To obtain performance data current to the most recent month end, please call 1-800-345-2021 or visit americancentury.com. For additional information about the fund, please consult the prospectus.
4


Portfolio Commentary

Portfolio Managers: Justin Brown, Joe Reiland and Rob Bove

Greg Woodhams left the portfolio management team September 1, 2021. He is retiring, effective December 31, 2021.

Performance Summary

Sustainable Equity returned 43.50%* for the 12 months ended October 31, 2021, outpacing the 42.91% return of the fund’s benchmark, the S&P 500 Index.

U.S. stocks posted strong returns during the reporting period, supported by federal government stimulus and low interest rates. The rollout of COVID-19 vaccines allowed the economy to reopen, and despite concerns about the delta variant, inflationary pressures and supply chain constraints, several market indices ended the 12-month period at record highs. Within the S&P 500 Index, all sectors posted strong gains, led by energy, which surged on demand and limited supply as the economy began to reopen. Utilities was the weakest sector.

Stock selection in the information technology and communication services sectors helped drive outperformance relative to the benchmark. Stock choices in the materials sector and an underweight allocation to energy detracted.

Information Technology Led Performance

In the information technology sector, stock choices in the semiconductors and semiconductor equipment industry benefited relative performance. ASML Holding, a Netherlands-based semiconductor equipment manufacturer, outperformed due to strong demand for its extreme ultraviolet lithography technology that allows semiconductor manufacturers to make smaller and more efficient chips. Demand for semiconductors has been strong and manufacturers need new equipment to increase production. Other top contributors in the sector included NVIDIA, a gaming and artificial intelligence chipmaker. NVIDIA reported better-than-expected earnings and offered positive forward guidance based on strength in data center and gaming central processing units. Microsoft reported strong revenue and earnings growth, and the stock also received a tailwind from large-capitalization software returning to favor.

Elsewhere, Morgan Stanley’s stock was helped by improving sentiment for financials due to positive vaccine news, recovery hopes and rising interest rates. The recent acquisitions of E-Trade Financial and Eaton Vance are shifting the business toward more wealth and asset management, which we think should be beneficial. ConocoPhillips was a top contributor. The oil giant’s stock price jumped on the announcement that it would buy Royal Dutch Shell’s Permian Basin assets. ConocoPhillips also announced a significant dividend increase.

Materials Stocks Detracted

Stock selection in the materials sector weighed on performance relative to the benchmark. Packaging company Ball was a significant detractor in the sector. While demand for aluminum cans remained strong, the company lagged the broader market earlier in the reporting period on concerns about increasing competition and more recently on supply chain disruptions.

Underweighting Tesla detracted. The electric carmaker continued to benefit from solid fundamental reports and strong demand for its vehicles. The stock also got a boost when it was added to the S&P 500 Index. NextEra Energy underperformed. The company has an attractive renewable energy business but also has a utility segment, and utilities broadly underperformed as they



*All fund returns referenced in this commentary are for Investor Class shares. Performance for other share classes will vary due to differences in fee structure; when Investor Class performance exceeds that of the fund’s benchmark, other share classes may not. See page 3 for returns for all share classes.
5


typically do in a rising rate environment. There was also a notable pullback in clean energy stocks after a very strong year in 2020.

Not owning Exxon Mobil detracted as the oil and gas company benefited from higher oil prices amid increased demand and limited supply. Defense contractor Lockheed Martin lagged despite posting better-than-expected earnings. Investors focused on fewer sales, especially its F-35 fighter, and the company offered disappointing guidance.

Outlook

The portfolio invests in a blend of large value and large growth stocks. We seek to outperform the S&P 500 Index without taking on significant additional risk. We believe that companies exhibiting both improving business fundamentals and sustainable corporate behaviors will outperform over time. We use a quantitative model that combines fundamental measures of a stock’s value and growth potential with environmental, social and governance (ESG) metrics.

As of October 31, 2021, the portfolio’s largest overweight position relative to the benchmark was in the industrials sector. Communication services ended the period as the largest underweight sector.






































When portfolio managers incorporate Environmental, Social and Governance (ESG) factors into an investment strategy, they consider those issues in conjunction with traditional financial analysis. Therefore, ESG factors may limit the investment opportunities available, and the portfolio may perform differently than those that do not incorporate ESG factors. Portfolio managers have ultimate discretion in how ESG issues may impact a portfolio’s holdings, and depending on their analysis, investment decisions may not be affected by ESG factors.
6


Fund Characteristics
OCTOBER 31, 2021
Types of Investments in Portfolio% of net assets
Common Stocks96.8%
Temporary Cash Investments3.0%
Other Assets and Liabilities0.2%
Top Five Industries% of net assets
Software10.5%
Interactive Media and Services6.4%
Semiconductors and Semiconductor Equipment5.7%
Capital Markets4.9%
IT Services4.7%
7


Shareholder Fee Example

Fund shareholders may incur two types of costs: (1) transaction costs, including sales charges (loads) on purchase payments and redemption/exchange fees; and (2) ongoing costs, including management fees; distribution and service (12b-1) fees; and other fund expenses. This example is intended to help you understand your ongoing costs (in dollars) of investing in your fund and to compare these costs with the ongoing cost of investing in other mutual funds.

The example is based on an investment of $1,000 made at the beginning of the period and held for the entire period from May 1, 2021 to October 31, 2021.

Actual Expenses

The table provides information about actual account values and actual expenses for each class. You may use the information, together with the amount you invested, to estimate the expenses that you paid over the period. First, identify the share class you own. Then simply divide your account value by $1,000 (for example, an $8,600 account value divided by $1,000 = 8.6), then multiply the result by the number under the heading “Expenses Paid During Period” to estimate the expenses you paid on your account during this period.

If you hold Investor Class shares of any American Century Investments fund, or I Class shares of the American Century Diversified Bond Fund, in an American Century Investments account (i.e., not through a financial intermediary or employer-sponsored retirement plan account), American Century Investments may charge you a $25.00 annual account maintenance fee if the value of those shares is less than $10,000. We will redeem shares automatically in one of your accounts to pay the $25.00 fee. In determining your total eligible investment amount, we will include your investments in all personal accounts (including American Century Investments brokerage accounts) registered under your Social Security number. Personal accounts include individual accounts, joint accounts, UGMA/UTMA accounts, personal trusts, Coverdell Education Savings Accounts and IRAs (including traditional, Roth, Rollover, SEP-, SARSEP- and SIMPLE-IRAs), and certain other retirement accounts. If you have only business, business retirement, employer-sponsored or American Century Investments brokerage accounts, you are currently not subject to this fee. If you are subject to the account maintenance fee, your account value could be reduced by the fee amount.

Hypothetical Example for Comparison Purposes

The table also provides information about hypothetical account values and hypothetical expenses based on the actual expense ratio of each class of your fund and an assumed rate of return of 5% per year before expenses, which is not the actual return of a fund’s share class. The hypothetical account values and expenses may not be used to estimate the actual ending account balance or expenses you paid for the period. You may use this information to compare the ongoing costs of investing in your fund and other funds. To do so, compare this 5% hypothetical example with the 5% hypothetical examples that appear in the shareholder reports of the other funds.

Please note that the expenses shown in the table are meant to highlight your ongoing costs only and do not reflect any transactional costs, such as sales charges (loads) or redemption/exchange fees. Therefore, the table is useful in comparing ongoing costs only, and will not help you determine the relative total costs of owning different funds. In addition, if these transactional costs were included, your costs would have been higher.
8


Beginning
Account Value
5/1/21
Ending
Account Value
10/31/21
Expenses Paid
During Period(1)
5/1/21 - 10/31/21
Annualized
Expense Ratio(1)
Actual
Investor Class$1,000$1,124.20$4.230.79%
I Class$1,000$1,125.60$3.160.59%
Y Class$1,000$1,126.30$2.360.44%
A Class$1,000$1,122.90$5.561.04%
C Class$1,000$1,119.00$9.561.79%
R Class$1,000$1,121.60$6.901.29%
R5 Class$1,000$1,125.50$3.160.59%
R6 Class$1,000$1,126.50$2.360.44%
G Class$1,000$1,128.80$0.00
0.00%(2)
Hypothetical
Investor Class$1,000$1,021.22$4.020.79%
I Class$1,000$1,022.23$3.010.59%
Y Class$1,000$1,022.99$2.240.44%
A Class$1,000$1,019.96$5.301.04%
C Class$1,000$1,016.18$9.101.79%
R Class$1,000$1,018.70$6.561.29%
R5 Class$1,000$1,022.23$3.010.59%
R6 Class$1,000$1,022.99$2.240.44%
G Class$1,000$1,025.21$0.00
0.00%(2)
(1)Expenses are equal to the class's annualized expense ratio listed in the table above, multiplied by the average account value over the period, multiplied by 184, the number of days in the most recent fiscal half-year, divided by 365, to reflect the one-half year period. Annualized expense ratio reflects actual expenses, including any applicable fee waivers or expense reimbursements and excluding any acquired fund fees and expenses.
(2)Other expenses, which include directors' fees and expenses, did not exceed 0.005%.
9


Schedule of Investments

OCTOBER 31, 2021
SharesValue
COMMON STOCKS — 96.8%


Aerospace and Defense — 0.8%
Lockheed Martin Corp.89,367 $29,698,441 
Air Freight and Logistics — 1.0%
Expeditors International of Washington, Inc.20,109 2,478,635 
United Parcel Service, Inc., Class B175,611 37,487,680 
39,966,315 
Auto Components — 1.1%
Aptiv plc(1)
242,050 41,848,024 
Automobiles — 1.3%
Tesla, Inc.(1)
45,105 50,246,970 
Banks — 4.6%
Bank of America Corp.1,257,085 60,063,521 
JPMorgan Chase & Co.412,054 70,003,854 
Regions Financial Corp.2,036,813 48,231,732 
178,299,107 
Beverages — 1.4%
PepsiCo, Inc.325,637 52,622,939 
Biotechnology — 0.6%
Amgen, Inc.72,788 15,064,932 
Vertex Pharmaceuticals, Inc.(1)
33,914 6,271,716 
21,336,648 
Building Products — 1.7%
Johnson Controls International plc622,880 45,700,706 
Masco Corp.318,390 20,870,464 
66,571,170 
Capital Markets — 4.9%
Ameriprise Financial, Inc.80,779 24,405,759 
BlackRock, Inc.38,532 36,353,401 
Intercontinental Exchange, Inc.129,838 17,977,369 
Morgan Stanley639,044 65,680,942 
S&P Global, Inc.92,885 44,042,352 
188,459,823 
Chemicals — 2.6%
Air Products and Chemicals, Inc.56,303 16,880,202 
Ecolab, Inc.69,562 15,458,068 
Linde plc141,853 45,279,477 
Sherwin-Williams Co. (The)74,934 23,724,854 
101,342,601 
Communications Equipment — 1.1%
Cisco Systems, Inc.722,600 40,443,922 
Consumer Finance — 0.8%
American Express Co.179,152 31,133,035 
Containers and Packaging — 0.6%
Ball Corp.246,732 22,571,043 
Diversified Telecommunication Services — 0.2%
Verizon Communications, Inc.141,935 7,521,136 
Electric Utilities — 1.8%
NextEra Energy, Inc.835,753 71,314,803 
10


SharesValue
Electrical Equipment — 1.3%
Eaton Corp. plc159,852 $26,337,215 
Rockwell Automation, Inc.73,062 23,336,003 
49,673,218 
Electronic Equipment, Instruments and Components — 2.1%
CDW Corp.155,546 29,032,661 
Cognex Corp.198,041 17,346,411 
Keysight Technologies, Inc.(1)
188,524 33,938,091 
80,317,163 
Energy Equipment and Services — 0.9%
Schlumberger NV1,119,612 36,118,683 
Entertainment — 1.8%
Electronic Arts, Inc.108,600 15,231,150 
Walt Disney Co. (The)(1)
328,667 55,567,730 
70,798,880 
Equity Real Estate Investment Trusts (REITs) — 2.1%
Prologis, Inc.569,321 82,528,772 
Food and Staples Retailing — 1.5%
Costco Wholesale Corp.45,284 22,258,898 
Sysco Corp.465,677 35,810,561 
58,069,459 
Food Products — 0.7%
Mondelez International, Inc., Class A415,712 25,250,347 
Vital Farms, Inc.(1)
135,355 2,222,529 
27,472,876 
Health Care Equipment and Supplies — 1.9%
Edwards Lifesciences Corp.(1)
311,823 37,362,632 
Medtronic plc231,537 27,752,025 
ResMed, Inc.30,421 7,997,985 
73,112,642 
Health Care Providers and Services — 3.6%
Cigna Corp.176,711 37,747,237 
CVS Health Corp.380,876 34,004,609 
Humana, Inc.35,107 16,260,158 
UnitedHealth Group, Inc.114,338 52,649,219 
140,661,223 
Hotels, Restaurants and Leisure — 1.8%
Booking Holdings, Inc.(1)
9,747 23,595,342 
Chipotle Mexican Grill, Inc.(1)
10,594 18,847,044 
Expedia Group, Inc.(1)
169,868 27,927,998 
70,370,384 
Household Products — 1.4%
Colgate-Palmolive Co.193,008 14,705,280 
Procter & Gamble Co. (The)268,875 38,446,436 
53,151,716 
Industrial Conglomerates — 1.2%
Honeywell International, Inc.205,009 44,819,068 
Insurance — 1.6%
Marsh & McLennan Cos., Inc.137,593 22,950,512 
Prudential Financial, Inc.157,551 17,338,488 
Travelers Cos., Inc. (The)134,134 21,579,478 
61,868,478 
11


SharesValue
Interactive Media and Services — 6.4%
Alphabet, Inc., Class A(1)
67,080 $198,618,514 
Meta Platforms, Inc., Class A(1)
148,865 48,168,248 
246,786,762 
Internet and Direct Marketing Retail — 3.6%
Amazon.com, Inc.(1)
41,667 140,519,041 
IT Services — 4.7%
Accenture plc, Class A131,283 47,103,028 
Mastercard, Inc., Class A129,500 43,449,840 
PayPal Holdings, Inc.(1)
197,737 45,991,649 
Visa, Inc., Class A213,068 45,121,410 
181,665,927 
Life Sciences Tools and Services — 2.1%
Agilent Technologies, Inc.250,628 39,471,404 
Thermo Fisher Scientific, Inc.64,714 40,968,492 
80,439,896 
Machinery — 2.1%
Cummins, Inc.117,282 28,128,915 
Parker-Hannifin Corp.112,009 33,220,749 
Xylem, Inc.153,606 20,059,408 
81,409,072 
Media — 0.5%
Comcast Corp., Class A382,795 19,687,147 
Multiline Retail — 0.5%
Target Corp.75,846 19,691,139 
Oil, Gas and Consumable Fuels — 1.2%
ConocoPhillips635,873 47,366,180 
Personal Products — 0.4%
Estee Lauder Cos., Inc. (The), Class A52,424 17,002,676 
Pharmaceuticals — 3.2%
Bristol-Myers Squibb Co.580,099 33,877,782 
Merck & Co., Inc.366,421 32,263,369 
Novo Nordisk A/S, B Shares188,432 20,662,484 
Zoetis, Inc.167,457 36,204,203 
123,007,838 
Professional Services — 0.2%
IHS Markit Ltd.60,473 7,905,031 
Road and Rail — 1.1%
Norfolk Southern Corp.80,697 23,648,256 
Union Pacific Corp.75,359 18,191,662 
41,839,918 
Semiconductors and Semiconductor Equipment — 5.7%
Advanced Micro Devices, Inc.(1)
188,401 22,651,452 
Applied Materials, Inc.245,150 33,499,748 
ASML Holding NV47,501 38,613,544 
NVIDIA Corp.342,806 87,645,210 
Texas Instruments, Inc.208,563 39,101,391 
221,511,345 
Software — 10.5%
Adobe, Inc.(1)
58,054 37,756,000 
Microsoft Corp.963,579 319,542,068 
salesforce.com, Inc.(1)
91,019 27,277,484 
12


Shares/Principal AmountValue
ServiceNow, Inc.(1)
13,500 $9,419,760 
Workday, Inc., Class A(1)
39,229 11,375,625 
405,370,937 
Specialty Retail — 2.8%
Home Depot, Inc. (The)194,151 72,173,693 
TJX Cos., Inc. (The)346,067 22,663,928 
Tractor Supply Co.54,350 11,803,189 
106,640,810 
Technology Hardware, Storage and Peripherals — 3.8%
Apple, Inc.989,439 148,217,962 
Textiles, Apparel and Luxury Goods — 1.6%
Deckers Outdoor Corp.(1)
33,122 13,093,458 
NIKE, Inc., Class B292,720 48,969,129 
62,062,587 
TOTAL COMMON STOCKS
(Cost $2,324,717,128)
3,743,462,807 
TEMPORARY CASH INVESTMENTS — 3.0%


Federal Farm Credit Discount Notes, 0.00%, 11/1/21(2)
$25,000,000 25,000,000 
Repurchase Agreement, BMO Capital Markets Corp., (collateralized by various U.S. Treasury obligations, 2.00%, 11/15/26, valued at $21,140,635), in a joint trading account at 0.01%, dated 10/29/21, due 11/1/21 (Delivery value $20,700,955)20,700,938 
Repurchase Agreement, Fixed Income Clearing Corp., (collateralized by various U.S. Treasury obligations, 1.875% - 4.75%, 2/15/41, valued at $70,395,517), at 0.01%, dated 10/29/21, due 11/1/21 (Delivery value $69,015,058)69,015,000 
State Street Institutional U.S. Government Money Market Fund, Premier Class2,270,124 2,270,124 
TOTAL TEMPORARY CASH INVESTMENTS
(Cost $116,986,062)
116,986,062 
TOTAL INVESTMENT SECURITIES — 99.8%
(Cost $2,441,703,190)

3,860,448,869 
OTHER ASSETS AND LIABILITIES — 0.2%

6,147,882 
TOTAL NET ASSETS — 100.0%

$3,866,596,751 

FORWARD FOREIGN CURRENCY EXCHANGE CONTRACTS
Currency PurchasedCurrency SoldCounterpartySettlement DateUnrealized Appreciation
(Depreciation)
EUR706,577USD819,301Credit Suisse AG12/31/21$(1,194)
EUR613,713USD714,245Credit Suisse AG12/31/21(3,661)
EUR843,855USD981,104Credit Suisse AG12/31/21(4,052)
EUR1,045,735USD1,217,092Credit Suisse AG12/31/21(6,294)
EUR880,194USD1,030,362Credit Suisse AG12/31/21(11,236)
EUR2,087,431USD2,426,931Credit Suisse AG12/31/21(10,012)
USD1,180,888EUR1,021,509Credit Suisse AG12/31/21(1,860)
USD1,373,033EUR1,183,012Credit Suisse AG12/31/213,289 
USD791,271EUR678,314Credit Suisse AG12/31/215,889 
USD1,566,694EUR1,348,553Credit Suisse AG12/31/215,280 
USD34,056,457EUR28,969,672Credit Suisse AG12/31/21514,104 
USD1,007,301EUR855,968Credit Suisse AG12/31/2116,224 
$506,477 

13


FUTURES CONTRACTS PURCHASED
Reference EntityContractsExpiration DateNotional
Amount
Unrealized Appreciation
(Depreciation)^
S&P 500 E-Mini
494
December 2021$113,545,900 $3,702,966 
^Amount represents value and unrealized appreciation (depreciation).

NOTES TO SCHEDULE OF INVESTMENTS
EUR-Euro
USD-United States Dollar
(1)Non-income producing.
(2)The rate indicated is the yield to maturity at purchase.


See Notes to Financial Statements.
14


Statement of Assets and Liabilities
OCTOBER 31, 2021
Assets
Investment securities, at value (cost of $2,441,703,190)$3,860,448,869 
Cash491,235 
Deposits with broker for futures contracts5,681,000 
Receivable for capital shares sold1,130,869 
Receivable for variation margin on futures contracts234,650 
Unrealized appreciation on forward foreign currency exchange contracts544,786 
Dividends and interest receivable2,896,603 
Securities lending receivable166 
3,871,428,178 
Liabilities
Payable for capital shares redeemed3,889,611 
Unrealized depreciation on forward foreign currency exchange contracts38,309 
Accrued management fees864,692 
Distribution and service fees payable38,815 
4,831,427 
Net Assets$3,866,596,751 
Net Assets Consist of:
Capital (par value and paid-in surplus)$2,407,963,792 
Distributable earnings1,458,632,959 
$3,866,596,751 

Net AssetsShares OutstandingNet Asset Value Per Share
Investor Class, $0.01 Par Value$835,452,97117,382,672$48.06
I Class, $0.01 Par Value$469,839,8869,741,803$48.23
Y Class, $0.01 Par Value$18,938,841391,953$48.32
A Class, $0.01 Par Value$97,032,2882,031,191
$47.77*
C Class, $0.01 Par Value$14,426,783313,727$45.99
R Class, $0.01 Par Value$18,043,585381,241$47.33
R5 Class, $0.01 Par Value$5,819,264120,587$48.26
R6 Class, $0.01 Par Value$46,680,788965,164$48.37
G Class, $0.01 Par Value$2,360,362,34548,626,147$48.54
*Maximum offering price $50.68 (net asset value divided by 0.9425).


See Notes to Financial Statements.
15


Statement of Operations
YEAR ENDED OCTOBER 31, 2021
Investment Income (Loss)
Income:
Dividends (net of foreign taxes withheld of $67,087)$42,604,208 
Interest16,045 
Securities lending, net1,915 
42,622,168 
Expenses:
Management fees18,496,142 
Distribution and service fees:
A Class198,815 
C Class120,085 
R Class66,040 
Directors' fees and expenses86,263 
Other expenses21,017 
18,988,362 
Fees waived - G Class(9,440,368)
9,547,994 
Net investment income (loss)33,074,174 
Realized and Unrealized Gain (Loss)
Net realized gain (loss) on:
Investment transactions104,264,355 
Forward foreign currency exchange contract transactions562,137 
Futures contract transactions16,994,019 
Foreign currency translation transactions(8,287)
121,812,224 
Change in net unrealized appreciation (depreciation) on:
Investments1,045,331,990 
Forward foreign currency exchange contracts405,316 
Futures contracts5,986,860 
Translation of assets and liabilities in foreign currencies(935)
1,051,723,231 
Net realized and unrealized gain (loss)1,173,535,455 
Net Increase (Decrease) in Net Assets Resulting from Operations$1,206,609,629 


See Notes to Financial Statements.
16


Statement of Changes in Net Assets
YEARS ENDED OCTOBER 31, 2021 AND OCTOBER 31, 2020
Increase (Decrease) in Net Assets
October 31, 2021October 31, 2020
Operations
Net investment income (loss)$33,074,174 $28,320,276 
Net realized gain (loss)121,812,224 (112,981,612)
Change in net unrealized appreciation (depreciation)1,051,723,231 281,635,809 
Net increase (decrease) in net assets resulting from operations1,206,609,629 196,974,473 
Distributions to Shareholders
From earnings:
Investor Class(2,859,800)(3,259,073)
I Class(1,771,656)(962,442)
Y Class(77,746)(510,247)
A Class(103,188)(364,241)
C Class— (67,854)
R Class— (31,560)
R5 Class(21,739)(11,626)
R6 Class(59,111)(18,679)
G Class(23,737,820)(14,189,132)
Decrease in net assets from distributions(28,631,060)(19,414,854)
Capital Share Transactions
Net increase (decrease) in net assets from capital share transactions (Note 5)(43,906,130)1,707,601,522 
Net increase (decrease) in net assets1,134,072,439 1,885,161,141 
Net Assets
Beginning of period2,732,524,312 847,363,171 
End of period$3,866,596,751 $2,732,524,312 


See Notes to Financial Statements.
17


Notes to Financial Statements

OCTOBER 31, 2021

1. Organization

American Century Mutual Funds, Inc. (the corporation) is registered under the Investment Company Act of 1940, as amended (the 1940 Act), as an open-end management investment company and is organized as a Maryland corporation. Sustainable Equity Fund (the fund) is one fund in a series issued by the corporation. The fund’s investment objective is to seek long-term capital growth. Income is a secondary objective.

The fund offers the Investor Class, I Class, Y Class, A Class, C Class, R Class, R5 Class, R6 Class and G Class. The A Class may incur an initial sales charge. The A Class and C Class may be subject to a contingent deferred sales charge.

2. Significant Accounting Policies

The following is a summary of significant accounting policies consistently followed by the fund in preparation of its financial statements. The fund is an investment company and follows accounting and reporting guidance in accordance with accounting principles generally accepted in the United States of America. This may require management to make certain estimates and assumptions at the date of the financial statements. Actual results could differ from these estimates. Management evaluated the impact of events or transactions occurring through the date the financial statements were issued that would merit recognition or disclosure.

Investment Valuations — The fund determines the fair value of its investments and computes its net asset value (NAV) per share at the close of regular trading (usually 4 p.m. Eastern time) on the New York Stock Exchange (NYSE) on each day the NYSE is open. The Board of Directors has adopted valuation policies and procedures to guide the investment advisor in the fund’s investment valuation process and to provide methodologies for the oversight of the fund’s pricing function.

Equity securities that are listed or traded on a domestic securities exchange are valued at the last reported sales price or at the official closing price as provided by the exchange. Equity securities traded on foreign securities exchanges are generally valued at the closing price of such securities on the exchange where primarily traded or at the close of the NYSE, if that is earlier. If no last sales price is reported, or if local convention or regulation so provides, the mean of the latest bid and asked prices may be used. Securities traded over-the-counter are valued at the mean of the latest bid and asked prices, the last sales price, or the official closing price. Equity securities initially expressed in local currencies are translated into U.S. dollars at the mean of the appropriate currency exchange rate at the close of the NYSE as provided by an independent pricing service.

Fixed income securities are valued at the evaluated mean as provided by independent pricing services or at the mean of the most recent bid and asked prices as provided by investment dealers. U.S. Treasury and Government Agency securities are valued using market models that consider trade data, quotations from dealers and active market makers, relevant yield curve and spread data, creditworthiness, trade data or market information on comparable securities, and other relevant security specific information.

Open-end management investment companies are valued at the reported NAV per share. Repurchase agreements are valued at cost, which approximates fair value. Exchange-traded futures contracts are valued at the settlement price as provided by the appropriate exchange. Forward foreign currency exchange contracts are valued at the mean of the appropriate forward exchange rate at the close of the NYSE as provided by an independent pricing service.

18


If the fund determines that the market price for an investment is not readily available or the valuation methods mentioned above do not reflect an investment’s fair value, such investment is valued as determined in good faith by the Board of Directors or its delegate, in accordance with policies and procedures adopted by the Board of Directors. In its determination of fair value, the fund may review several factors including, but not limited to, market information regarding the specific investment or comparable investments and correlation with other investment types, futures indices or general market indicators. Circumstances that may cause the fund to use these procedures to value an investment include, but are not limited to: an investment has been declared in default or is distressed; trading in a security has been suspended during the trading day or a security is not actively trading on its principal exchange; prices received from a regular pricing source are deemed unreliable; or there is a foreign market holiday and no trading occurred.

The fund monitors for significant events occurring after the close of an investment’s primary exchange but before the fund’s NAV per share is determined. Significant events may include, but are not limited to: corporate announcements and transactions; governmental action and political unrest that could impact a specific investment or an investment sector; or armed conflicts, natural disasters and similar events that could affect investments in a specific country or region. The fund also monitors for significant fluctuations between domestic and foreign markets, as evidenced by the U.S. market or such other indicators that the Board of Directors, or its delegate, deems appropriate. The fund may apply a model-derived factor to the closing price of equity securities traded on foreign securities exchanges. The factor is based on observable market data as provided by an independent pricing service.

Security Transactions — Security transactions are accounted for as of the trade date. Net realized gains and losses are determined on the identified cost basis, which is also used for federal income tax purposes.

Investment Income — Dividend income less foreign taxes withheld, if any, is recorded as of the ex-dividend date. Distributions received on securities that represent a return of capital or long-term capital gain are recorded as a reduction of cost of investments and/or as a realized gain. The fund may estimate the components of distributions received that may be considered nontaxable distributions or long-term capital gain distributions for income tax purposes. Interest income is recorded on the accrual basis and includes accretion of discounts and amortization of premiums. Securities lending income is net of fees and rebates earned by the lending agent for its services.

Foreign Currency Translations — All assets and liabilities initially expressed in foreign currencies are translated into U.S. dollars at prevailing exchange rates at period end. The fund may enter into spot foreign currency exchange contracts to facilitate transactions denominated in a foreign currency. Purchases and sales of investment securities, dividend and interest income, spot foreign currency exchange contracts, and expenses are translated at the rates of exchange prevailing on the respective dates of such transactions. Net realized and unrealized foreign currency exchange gains or losses related to investment securities are a component of net realized gain (loss) on investment transactions and change in net unrealized appreciation (depreciation) on investments, respectively.

Repurchase Agreements — The fund may enter into repurchase agreements with institutions that American Century Investment Management, Inc. (ACIM) (the investment advisor) has determined are creditworthy pursuant to criteria adopted by the Board of Directors. The fund requires that the collateral, represented by securities, received in a repurchase transaction be transferred to the custodian in a manner sufficient to enable the fund to obtain those securities in the event of a default under the repurchase agreement. ACIM monitors, on a daily basis, the securities transferred to ensure the value, including accrued interest, of the securities under each repurchase agreement is equal to or greater than amounts owed to the fund under each repurchase agreement.

Joint Trading Account — Pursuant to an Exemptive Order issued by the Securities and Exchange Commission, the fund, along with certain other funds in the American Century Investments family of funds, may transfer uninvested cash balances into a joint trading account. These balances are invested in one or more repurchase agreements that are collateralized by U.S. Treasury or Agency obligations.

Segregated Assets — In accordance with the 1940 Act, the fund segregates assets on its books and records to cover certain types of investment securities and other financial instruments. ACIM monitors, on a daily basis, the securities segregated to ensure the fund designates a sufficient amount of liquid assets, marked-to-market daily. The fund may also receive assets or be required to pledge assets at the custodian bank or with a broker for collateral requirements.

19


Income Tax Status — It is the fund’s policy to distribute substantially all net investment income and net realized gains to shareholders and to otherwise qualify as a regulated investment company under provisions of the Internal Revenue Code. Accordingly, no provision has been made for income taxes. The fund files U.S. federal, state, local and non-U.S. tax returns as applicable. The fund's tax returns are subject to examination by the relevant taxing authority until expiration of the applicable statute of limitations, which is generally three years from the date of filing but can be longer in certain jurisdictions. At this time, management believes there are no uncertain tax positions which, based on their technical merit, would not be sustained upon examination and for which it is reasonably possible that the total amounts of unrecognized tax benefits will significantly change in the next twelve months.

Multiple Class — All shares of the fund represent an equal pro rata interest in the net assets of the class to which such shares belong, and have identical voting, dividend, liquidation and other rights and the same terms and conditions, except for class specific expenses and exclusive rights to vote on matters affecting only individual classes. Income, non-class specific expenses, and realized and unrealized capital gains and losses of the fund are allocated to each class of shares based on their relative net assets.

Distributions to Shareholders — Distributions from net investment income and net realized gains, if any, are generally declared and paid annually.

Indemnifications — Under the corporation’s organizational documents, its officers and directors are indemnified against certain liabilities arising out of the performance of their duties to the fund. In addition, in the normal course of business, the fund enters into contracts that provide general indemnifications. The maximum exposure under these arrangements is unknown as this would involve future claims that may be made against a fund. The risk of material loss from such claims is considered by management to be remote.

Securities Lending — Securities are lent to qualified financial institutions and brokers. State Street Bank & Trust Co. serves as securities lending agent to the fund pursuant to a Securities Lending Agreement. The lending of securities exposes the fund to risks such as: the borrowers may fail to return the loaned securities, the borrowers may not be able to provide additional collateral, the fund may experience delays in recovery of the loaned securities or delays in access to collateral, or the fund may experience losses related to the investment collateral. To minimize certain risks, loan counterparties pledge collateral in the form of cash and/or securities. The lending agent has agreed to indemnify the fund in the case of default of any securities borrowed. Cash collateral received is invested in the State Street Navigator Securities Lending Government Money Market Portfolio, a money market mutual fund registered under the 1940 Act. The loans may also be secured by U.S. government securities in an amount at least equal to the market value of the securities loaned, plus accrued interest and dividends, determined on a daily basis and adjusted accordingly. By lending securities, the fund seeks to increase its net investment income through the receipt of interest and fees. Such income is reflected separately within the Statement of Operations. The value of loaned securities and related collateral outstanding at period end, if any, are shown on a gross basis within the Schedule of Investments and Statement of Assets and Liabilities.

3. Fees and Transactions with Related Parties

Certain officers and directors of the corporation are also officers and/or directors of American Century Companies, Inc. (ACC). The corporation’s investment advisor, ACIM, the corporation's distributor, American Century Investment Services, Inc. (ACIS), and the corporation’s transfer agent, American Century Services, LLC, are wholly owned, directly or indirectly, by ACC. Various funds issued by American Century Asset Allocation Portfolios, Inc. own, in aggregate, 45% of the shares of the fund. Related parties do not invest in the fund for the purpose of exercising management or control.

20


Management Fees — The corporation has entered into a management agreement with ACIM, under which ACIM provides the fund with investment advisory and management services in exchange for a single, unified management fee (the fee) per class. The agreement provides that ACIM will pay all expenses of managing and operating the fund, except brokerage expenses, taxes, interest, fees and expenses of the independent directors (including legal counsel fees), extraordinary expenses, and expenses incurred in connection with the provision of shareholder services and distribution services under a plan adopted pursuant to Rule 12b-1 under the 1940 Act. The fee is computed and accrued daily based on each class's daily net assets and paid monthly in arrears. The difference in the fee among the classes is a result of their separate arrangements for non-Rule 12b-1 shareholder services. It is not the result of any difference in advisory or custodial fees or other expenses related to the management of the fund’s assets, which do not vary by class. The rate of the fee is determined by applying a fee rate calculation formula. This formula takes into account the fund’s assets as well as certain assets, if any, of other clients of the investment advisor outside the American Century Investments family of funds (such as subadvised funds and separate accounts) that use very similar investment teams and strategies (strategy assets). The investment advisor agreed to waive the G Class's management fee in its entirety. The investment advisor expects this waiver to remain in effect permanently and cannot terminate it without the approval of the Board of Directors.

The management fee schedule range and the effective annual management fee for each class for the period ended October 31, 2021 are as follows:
Management Fee
Schedule Range
Effective Annual
Management Fee
Investor Class0.750% to 0.790%0.79%
I Class0.550% to 0.590%0.59%
Y Class0.400% to 0.440%0.44%
A Class0.750% to 0.790%0.79%
C Class0.750% to 0.790%0.79%
R Class0.750% to 0.790%0.79%
R5 Class0.550% to 0.590%0.59%
R6 Class0.400% to 0.440%0.44%
G Class0.400% to 0.440%
0.00%(1)
(1)Effective annual management fee before waiver was 0.44%.

Distribution and Service Fees — The Board of Directors has adopted a separate Master Distribution and Individual Shareholder Services Plan for each of the A Class, C Class and R Class (collectively the plans), pursuant to Rule 12b-1 of the 1940 Act. The plans provide that the A Class will pay ACIS an annual distribution and service fee of 0.25%. The plans provide that the C Class will pay ACIS an annual distribution and service fee of 1.00%, of which 0.25% is paid for individual shareholder services and 0.75% is paid for distribution services. The plans provide that the R Class will pay ACIS an annual distribution and service fee of 0.50%. The fees are computed and accrued daily based on each class’s daily net assets and paid monthly in arrears. The fees are used to pay financial intermediaries for distribution and individual shareholder services. Fees incurred under the plans during the period ended October 31, 2021 are detailed in the Statement of Operations.

Directors' Fees and Expenses — The Board of Directors is responsible for overseeing the investment advisor’s management and operations of the fund. The directors receive detailed information about the fund and its investment advisor regularly throughout the year, and meet at least quarterly with management of the investment advisor to review reports about fund operations. The fund’s officers do not receive compensation from the fund.

Interfund Transactions — The fund may enter into security transactions with other American Century Investments funds and other client accounts of the investment advisor, in accordance with the 1940 Act rules and procedures adopted by the Board of Directors. The rules and procedures require, among other things, that these transactions be effected at the independent current market price of the security. There were no interfund transactions during the period.

4. Investment Transactions

Purchases and sales of investment securities, excluding short-term investments, for the period ended October 31, 2021 were $601,965,108 and $654,904,367, respectively.

21


5. Capital Share Transactions

Transactions in shares of the fund were as follows:
Year ended
October 31, 2021
Year ended
October 31, 2020
SharesAmountSharesAmount
Investor Class/Shares Authorized230,000,000 

230,000,000 
Sold2,943,466 $119,867,395 17,239,793 $543,096,618 
Issued in reinvestment of distributions74,177 2,795,217 100,919 3,228,400 
Redeemed(3,342,394)(138,556,743)(3,521,917)(109,408,579)
(324,751)(15,894,131)13,818,795 436,916,439 
I Class/Shares Authorized50,000,000 

50,000,000 
Sold4,571,811 189,617,073 5,143,550 162,491,745 
Issued in reinvestment of distributions43,915 1,657,803 26,744 857,150 
Redeemed(2,155,752)(91,287,995)(1,372,675)(42,143,506)
2,459,974 99,986,881 3,797,619 121,205,389 
Y Class/Shares Authorized30,000,000 

30,000,000 
Sold202,749 8,486,726 817,327 25,138,027 
Issued in reinvestment of distributions2,039 77,027 15,895 509,737 
Redeemed(52,839)(2,276,009)(2,263,503)(74,266,512)
151,949 6,287,744 (1,430,281)(48,618,748)
A Class/Shares Authorized50,000,000 

50,000,000 
Sold656,928 26,696,842 333,847 10,430,358 
Issued in reinvestment of distributions2,368 88,920 10,059 320,586 
Redeemed(262,551)(10,817,846)(501,546)(15,535,923)
396,745 15,967,916 (157,640)(4,784,979)
C Class/Shares Authorized30,000,000 

30,000,000 
Sold111,500 4,558,582 89,054 2,800,693 
Issued in reinvestment of distributions— — 1,854 57,571 
Redeemed(112,229)(4,368,283)(119,796)(3,670,138)
(729)190,299 (28,888)(811,874)
R Class/Shares Authorized30,000,000 

30,000,000 
Sold208,379 8,474,299 215,132 6,842,044 
Issued in reinvestment of distributions— — 997 31,560 
Redeemed(99,077)(3,852,366)(92,477)(2,693,315)
109,302 4,621,933 123,652 4,180,289 
R5 Class/Shares Authorized30,000,000 

30,000,000 
Sold48,027 1,988,519 58,252 1,990,201 
Issued in reinvestment of distributions344 12,998 350 11,238 
Redeemed(22,394)(924,057)(7,052)(207,323)
25,977 1,077,460 51,550 1,794,116 
R6 Class/Shares Authorized50,000,000 

50,000,000 
Sold1,386,839 58,488,762 250,249 7,873,896 
Issued in reinvestment of distributions1,563 59,111 582 18,679 
Redeemed(575,395)(23,155,920)(228,865)(7,676,224)
813,007 35,391,953 21,966 216,351 
G Class/Shares Authorized525,000,000 

525,000,000 
Sold3,978,313 167,298,284 48,405,679 1,575,927,164 
Issued in reinvestment of distributions627,985 23,737,820 442,167 14,189,132 
Redeemed(9,001,254)(382,572,289)(12,070,100)(392,611,757)
(4,394,956)(191,536,185)36,777,746 1,197,504,539 
Net increase (decrease)(763,482)$(43,906,130)52,974,519 $1,707,601,522 
22


6. Fair Value Measurements

The fund’s investments valuation process is based on several considerations and may use multiple inputs to determine the fair value of the investments held by the fund. In conformity with accounting principles generally accepted in the United States of America, the inputs used to determine a valuation are classified into three broad levels.

Level 1 valuation inputs consist of unadjusted quoted prices in an active market for identical investments.

Level 2 valuation inputs consist of direct or indirect observable market data (including quoted prices for comparable investments, evaluations of subsequent market events, interest rates, prepayment speeds, credit risk, etc.). These inputs also consist of quoted prices for identical investments initially expressed in local currencies that are adjusted through translation into U.S. dollars.

Level 3 valuation inputs consist of unobservable data (including a fund’s own assumptions).

The level classification is based on the lowest level input that is significant to the fair valuation measurement. The valuation inputs are not necessarily an indication of the risks associated with investing in these securities or other financial instruments.

The following is a summary of the level classifications as of period end. The Schedule of Investments provides additional information on the fund’s portfolio holdings.
Level 1Level 2Level 3
Assets
Investment Securities
Common Stocks$3,684,186,779 $59,276,028 — 
Temporary Cash Investments2,270,124 114,715,938 — 
$3,686,456,903 $173,991,966 — 
Other Financial Instruments
Futures Contracts$3,702,966 — — 
Forward Foreign Currency Exchange Contracts— $544,786 — 
$3,702,966 $544,786 — 
Liabilities
Other Financial Instruments
Forward Foreign Currency Exchange Contracts— $38,309 — 

7. Derivative Instruments

Equity Price Risk — The fund is subject to equity price risk in the normal course of pursuing its investment objectives. A fund may enter into futures contracts based on an equity index in order to manage its exposure to changes in market conditions. A fund may purchase futures contracts to gain exposure to increases in market value or sell futures contracts to protect against a decline in market value. Upon entering into a futures contract, a fund is required to deposit either cash or securities in an amount equal to a certain percentage of the contract value (initial margin). Subsequent payments (variation margin) are made or received daily, in cash, by a fund. The variation margin is equal to the daily change in the contract value and is recorded as unrealized gains and losses. A fund recognizes a realized gain or loss when the contract is closed or expires. Net realized and unrealized gains or losses occurring during the holding period of futures contracts are a component of net realized gain (loss) on futures contract transactions and change in net unrealized appreciation (depreciation) on futures contracts, respectively. One of the risks of entering into futures contracts is the possibility that the change in value of the contract may not correlate with the changes in value of the underlying securities. The fund's average notional exposure to equity price risk derivative instruments held during the period was $56,671,056 futures contracts purchased.

23


Foreign Currency Risk — The fund is subject to foreign currency exchange rate risk in the normal course of pursuing its investment objectives. The value of foreign investments held by a fund may be significantly affected by changes in foreign currency exchange rates. The dollar value of a foreign security generally decreases when the value of the dollar rises against the foreign currency in which the security is denominated and tends to increase when the value of the dollar declines against such foreign currency. A fund may enter into forward foreign currency exchange contracts to reduce a fund's exposure to foreign currency exchange rate fluctuations. The net U.S. dollar value of foreign currency underlying all contractual commitments held by a fund and the resulting unrealized appreciation or depreciation are determined daily. Realized gain or loss is recorded upon settlement of the contract. Net realized and unrealized gains or losses occurring during the holding period of forward foreign currency exchange contracts are a component of net realized gain (loss) on forward foreign currency exchange contract transactions and change in net unrealized appreciation (depreciation) on forward foreign currency exchange contracts, respectively. A fund bears the risk of an unfavorable change in the foreign currency exchange rate underlying the forward contract. Additionally, losses, up to the fair value, may arise if the counterparties do not perform under the contract terms. The fund's average U.S. dollar exposure to foreign currency risk derivative instruments held during the period was $36,528,399.

Value of Derivative Instruments as of October 31, 2021
Asset Derivatives
Liability Derivatives
Type of Risk ExposureLocation on Statement of Assets and Liabilities
Value
Location on Statement of Assets and Liabilities
Value
Equity Price RiskReceivable for variation margin on futures contracts*$234,650 Payable for variation margin on futures contracts*— 
Foreign Currency RiskUnrealized appreciation on forward foreign currency exchange contracts544,786Unrealized depreciation on forward foreign currency exchange contracts$38,309 
$779,436 $38,309 
*Included in the unrealized appreciation (depreciation) on futures contracts, as reported in the Schedule of Investments.

Effect of Derivative Instruments on the Statement of Operations for the Year Ended October 31, 2021
Net Realized Gain (Loss)
Change in Net Unrealized
Appreciation (Depreciation)
Type of Risk ExposureLocation on Statement of Operations
Value
Location on Statement of Operations
Value
Equity Price RiskNet realized gain (loss) on futures contract transactions$16,994,019 Change in net unrealized appreciation (depreciation) on futures contracts$5,986,860 
Foreign Currency RiskNet realized gain (loss) on forward foreign currency exchange contract transactions562,137 Change in net unrealized appreciation (depreciation) on forward foreign currency exchange contracts405,316 
$17,556,156 $6,392,176 

8. Risk Factors

The value of the fund’s shares will go up and down, sometimes rapidly or unpredictably, based on the performance of the securities owned by the fund and other factors generally affecting the securities market. Market risks, including political, regulatory, economic and social developments, can affect the value of the fund’s investments. Natural disasters, public health emergencies, terrorism and other unforeseeable events may lead to increased market volatility and may have adverse long-term effects on world economies and markets generally.

24


9. Federal Tax Information

On December 7, 2021, the fund declared and paid a per-share distribution from net realized gains to
shareholders of record on December 6, 2021 of $0.9622 for the Investor Class, I Class, Y Class, A Class, C
Class, R Class, R5 Class, R6 Class and G Class.

On December 7,2021, the fund declared and paid the following per-share distributions from net investment income to shareholders of record on December 6, 2021:
Investor ClassI ClassY ClassA ClassC ClassR ClassR5 ClassR6 ClassG Class
$0.1914$0.2870$0.3587$0.0718$0.2870$0.3587$0.5692

The tax character of distributions paid during the years ended October 31, 2021 and October 31, 2020 were as follows:
20212020
Distributions Paid From
Ordinary income$28,631,060 $7,163,302 
Long-term capital gains— $12,251,552 

The book-basis character of distributions made during the year from net investment income or net realized gains may differ from their ultimate characterization for federal income tax purposes. These differences reflect the differing character of certain income items and net realized gains and losses for financial statement and tax purposes, and may result in reclassification among certain capital accounts on the financial statements.

As of period end, the federal tax cost of investments and the components of distributable earnings on a tax-basis were as follows:

Federal tax cost of investments$2,464,862,452 
Gross tax appreciation of investments$1,403,690,412 
Gross tax depreciation of investments(8,103,995)
Net tax appreciation (depreciation) of investments1,395,586,417 
Net tax appreciation (depreciation) on derivatives and translation of assets and liabilities in foreign currencies 365 
Net tax appreciation (depreciation)$1,395,586,782 
Undistributed ordinary income$27,923,499 
Accumulated long-term gains$74,774,757 
Accumulated short-term capital losses$(39,652,079)

The difference between book-basis and tax-basis unrealized appreciation (depreciation) is attributable primarily to the tax deferral of losses on wash sales.

Accumulated capital losses represent net capital loss carryovers that may be used to offset future realized capital gains for federal income tax purposes. The capital loss carryovers may be carried forward for an unlimited period. As a result of a shift in ownership of the fund, the utilization of these capital losses in any given year are limited. Any remaining accumulated gains after application of this limitation will be distributed to shareholders.
25


Financial Highlights
For a Share Outstanding Throughout the Years Ended October 31 (except as noted)
Per-Share DataRatios and Supplemental Data
Income From Investment Operations:Distributions From:Ratio to Average Net Assets of:
Net Asset
Value,
Beginning
of Period
Net
Investment
Income
(Loss)(1)
Net
Realized
and
Unrealized
Gain (Loss)
Total From
Investment
Operations
 Net
Investment
Income
Net
Realized
Gains
Total
Distributions
Net Asset
Value,
End
of Period
Total
Return(2)
Operating
Expenses
Operating
Expenses
(before
expense
waiver)
Net
Investment
Income
(Loss)
Net
Investment
Income
(Loss)
(before
expense
waiver)
Portfolio
Turnover
Rate
Net
Assets,
End of
Period
(in thousands)
Investor Class
2021$33.630.1914.4014.59(0.16)(0.16)$48.0643.50%0.79%0.79%0.46%0.46%18%$835,453 
2020$30.400.283.153.43(0.20)(0.20)$33.6311.33%0.79%0.83%0.88%0.84%36%$595,557 
2019$28.190.333.774.10(0.22)(1.67)(1.89)$30.4016.10%0.80%0.84%1.14%1.10%33%$118,225 
2018$27.220.261.521.78(0.20)(0.61)(0.81)$28.196.60%0.95%0.95%0.91%0.91%41%$142,923 
2017$21.750.235.515.74(0.27)(0.27)$27.2226.61%1.00%1.00%0.95%0.95%18%$135,315 
I Class
2021$33.750.2714.4414.71(0.23)(0.23)$48.2343.78%0.59%0.59%0.66%0.66%18%$469,840 
2020$30.500.353.163.51(0.06)(0.20)(0.26)$33.7511.55%0.59%0.63%1.08%1.04%36%$245,759 
2019$28.270.373.814.18(0.28)(1.67)(1.95)$30.5016.37%0.60%0.64%1.34%1.30%33%$106,268 
2018$27.300.331.511.84(0.26)(0.61)(0.87)$28.276.80%0.75%0.75%1.11%1.11%41%$38,188 
2017$21.810.275.535.80(0.31)(0.31)$27.3026.88%0.80%0.80%1.15%1.15%18%$19,776 



For a Share Outstanding Throughout the Years Ended October 31 (except as noted)
Per-Share DataRatios and Supplemental Data
Income From Investment Operations:Distributions From:Ratio to Average Net Assets of:
Net Asset
Value,
Beginning
of Period
Net
Investment
Income
(Loss)(1)
Net
Realized
and
Unrealized
Gain (Loss)
Total From
Investment
Operations
 Net
Investment
Income
Net
Realized
Gains
Total
Distributions
Net Asset
Value,
End
of Period
Total
Return(2)
Operating
Expenses
Operating
Expenses
(before
expense
waiver)
Net
Investment
Income
(Loss)
Net
Investment
Income
(Loss)
(before
expense
waiver)
Portfolio
Turnover
Rate
Net
Assets,
End of
Period
(in thousands)
Y Class
2021$33.810.3414.4614.80(0.29)(0.29)$48.3244.01%0.44%0.44%0.81%0.81%18%$18,939 
2020$30.560.433.123.55(0.10)(0.20)(0.30)$33.8111.70%0.44%0.48%1.23%1.19%36%$8,115 
2019$28.320.413.824.23(0.32)(1.67)(1.99)$30.5616.56%0.45%0.49%1.49%1.45%33%$51,037 
2018$27.330.361.521.88(0.28)(0.61)(0.89)$28.326.93%0.60%0.60%1.26%1.26%41%$14,485 
2017(3)
$23.890.163.283.44$27.3314.40%
0.65%(4)
0.65%(4)
1.10%(4)
1.10%(4)
18%(5)
$383 
A Class
2021$33.430.0814.3214.40(0.06)(0.06)$47.7743.13%1.04%1.04%0.21%0.21%18%$97,032 
2020$30.290.213.133.34(0.20)(0.20)$33.4311.07%1.04%1.08%0.63%0.59%36%$54,638 
2019$28.090.253.784.03(0.16)(1.67)(1.83)$30.2915.81%1.05%1.09%0.89%0.85%33%$54,290 
2018$27.130.191.511.70(0.13)(0.61)(0.74)$28.096.31%1.20%1.20%0.66%0.66%41%$50,489 
2017$21.670.175.505.67(0.21)(0.21)$27.1326.34%1.25%1.25%0.70%0.70%18%$51,396 
C Class
2021$32.37(0.22)13.8413.62$45.9942.08%1.79%1.79%(0.54)%(0.54)%18%$14,427 
2020$29.56(0.02)3.033.01(0.20)(0.20)$32.3710.22%1.79%1.83%(0.12)%(0.16)%36%$10,178 
2019$27.480.043.713.75(1.67)(1.67)$29.5614.98%1.80%1.84%0.14%0.10%33%$10,149 
2018$26.63(0.03)1.491.46(0.61)(0.61)$27.485.51%1.95%1.95%(0.09)%(0.09)%41%$11,277 
2017$21.27(0.01)5.415.40(0.04)(0.04)$26.6325.40%2.00%2.00%(0.05)%(0.05)%18%$17,904 



For a Share Outstanding Throughout the Years Ended October 31 (except as noted)
Per-Share DataRatios and Supplemental Data
Income From Investment Operations:Distributions From:Ratio to Average Net Assets of:
Net Asset
Value,
Beginning
of Period
Net
Investment
Income
(Loss)(1)
Net
Realized
and
Unrealized
Gain (Loss)
Total From
Investment
Operations
 Net
Investment
Income
Net
Realized
Gains
Total
Distributions
Net Asset
Value,
End
of Period
Total
Return(2)
Operating
Expenses
Operating
Expenses
(before
expense
waiver)
Net
Investment
Income
(Loss)
Net
Investment
Income
(Loss)
(before
expense
waiver)
Portfolio
Turnover
Rate
Net
Assets,
End of
Period
(in thousands)
R Class
2021$33.15(0.02)14.2014.18$47.3342.78%1.29%1.29%(0.04)%(0.04)%18%$18,044 
2020$30.120.123.113.23(0.20)(0.20)$33.1510.77%1.29%1.33%0.38%0.34%36%$9,014 
2019$27.930.183.773.95(0.09)(1.67)(1.76)$30.1215.56%1.30%1.34%0.64%0.60%33%$4,466 
2018$26.980.111.511.62(0.06)(0.61)(0.67)$27.936.04%1.45%1.45%0.41%0.41%41%$3,223 
2017$21.550.115.475.58(0.15)(0.15)$26.9826.03%1.50%1.50%0.45%0.45%18%$3,910 
R5 Class
2021$33.770.2714.4514.72(0.23)(0.23)$48.2643.78%0.59%0.59%0.66%0.66%18%$5,819 
2020$30.520.343.173.51(0.06)(0.20)(0.26)$33.7711.55%0.59%0.63%1.08%1.04%36%$3,195 
2019$28.290.383.804.18(0.28)(1.67)(1.95)$30.5216.36%0.60%0.64%1.34%1.30%33%$1,314 
2018$27.300.321.521.84(0.24)(0.61)(0.85)$28.296.82%0.75%0.75%1.11%1.11%41%$1,344 
2017(3)
$23.890.153.263.41$27.3014.27%
0.80%(4)
0.80%(4)
1.07%(4)
1.07%(4)
18%(5)
$6 
R6 Class
2021$33.840.3214.5014.82(0.29)(0.29)$48.3744.03%0.44%0.44%0.81%0.81%18%$46,681 
2020$30.560.393.173.56(0.08)(0.20)(0.28)$33.8411.70%0.44%0.48%1.23%1.19%36%$5,150 
2019(6)
$28.050.212.302.51$30.568.95%
0.44%(4)
0.49%(4)
1.18%(4)
1.13%(4)
33%(7)
$3,979 
G Class
2021$33.970.5314.4915.02(0.45)(0.45)$48.5444.61%
0.00%(8)
0.44%1.25%0.81%18%$2,360,362 
2020$30.640.543.183.72(0.19)(0.20)(0.39)$33.9712.21%
0.00%(8)
0.48%1.67%1.19%36%$1,800,919 
2019(6)
$28.050.372.222.59$30.649.23%
0.00%(4)(8)
0.49%(4)
2.04%(4)
1.55%(4)
33%(7)
$497,635 



Notes to Financial Highlights
(1)Computed using average shares outstanding throughout the period.
(2)Total returns are calculated based on the net asset value of the last business day and do not reflect applicable sales charges, if any. Total returns for periods less than one year are not annualized.
(3)April 10, 2017 (commencement of sale) through October 31, 2017.
(4)Annualized.
(5)Portfolio turnover is calculated at the fund level. Percentage indicated was calculated for the year ended October 31, 2017.
(6)April 1, 2019 (commencement of sale) through October 31, 2019.
(7)Portfolio turnover is calculated at the fund level. Percentage indicated was calculated for the year ended October 31, 2019.
(8)Ratio was less than 0.005%.


See Notes to Financial Statements.



Report of Independent Registered Public Accounting Firm

To the Shareholders and the Board of Directors of American Century Mutual Funds, Inc.:

Opinion on the Financial Statements and Financial Highlights

We have audited the accompanying statement of assets and liabilities, including the schedule of investments, of Sustainable Equity Fund (the “Fund”), one of the funds constituting the American Century Mutual Funds, Inc., as of October 31, 2021, the related statement of operations for the year then ended, the statements of changes in net assets for each of the two years in the period then ended, the financial highlights for each of the five years in the period then ended, and the related notes. In our opinion, the financial statements and financial highlights present fairly, in all material respects, the financial position of Sustainable Equity Fund of the American Century Mutual Funds, Inc. as of October 31, 2021, and the results of its operations for the year then ended, the changes in its net assets for each of the two years in the period then ended, and the financial highlights for each of the five years in the period then ended, in conformity with accounting principles generally accepted in the United States of America.

Basis for Opinion

These financial statements and financial highlights are the responsibility of the Fund's management. Our responsibility is to express an opinion on the Fund’s financial statements and financial highlights based on our audits. We are a public accounting firm registered with the Public Company Accounting Oversight Board (United States) (PCAOB) and are required to be independent with respect to the Fund in accordance with the U.S. federal securities laws and the applicable rules and regulations of the Securities and Exchange Commission and the PCAOB.

We conducted our audits in accordance with the standards of the PCAOB. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements and financial highlights are free of material misstatement, whether due to error or fraud. The Fund is not required to have, nor were we engaged to perform, an audit of its internal control over financial reporting. As part of our audits we are required to obtain an understanding of internal control over financial reporting but not for the purpose of expressing an opinion on the effectiveness of the Fund’s internal control over financial reporting. Accordingly, we express no such opinion.

Our audits included performing procedures to assess the risks of material misstatement of the financial statements and financial highlights, whether due to error or fraud, and performing procedures that respond to those risks. Such procedures included examining, on a test basis, evidence regarding the amounts and disclosures in the financial statements and financial highlights. Our audits also included evaluating the accounting principles used and significant estimates made by management, as well as evaluating the overall presentation of the financial statements and financial highlights. Our procedures included confirmation of securities owned as of October 31, 2021, by correspondence with the custodian and brokers; when replies were not received from brokers, we performed other auditing procedures. We believe that our audits provide a reasonable basis for our opinion.

/s/ Deloitte & Touche LLP

Kansas City, Missouri
December 15, 2021

We have served as the auditor of one or more American Century investment companies since 1997.
30


Management

The Board of Directors

The individuals listed below serve as directors of the funds. Each director will continue to serve in this capacity until death, retirement, resignation or removal from office. The board has adopted a mandatory retirement age for directors who are not “interested persons,” as that term is defined in the Investment Company Act (independent directors). Independent directors shall retire by December 31 of the year in which they reach their 75th birthday.
Jonathan S.Thomas is an “interested person” because he currently serves as President and Chief Executive Officer of American Century Companies, Inc. (ACC), the parent company of American Century Investment Management, Inc. (ACIM or the advisor). The other directors (more than three-fourths of the total number) are independent. They are not employees, directors or officers of, and have no financial interest in, ACC or any of its wholly owned, direct or indirect, subsidiaries, including ACIM, American Century Investment Services, Inc. (ACIS) and American Century Services, LLC (ACS), and they do not have any other affiliations, positions or relationships that would cause them to be considered “interested persons” under the Investment Company Act. The directors serve in this capacity for seven (in the case of Jonathan S. Thomas, 16; and Stephen E. Yates, 8) registered investment companies in the American Century Investments family of funds.
The following table presents additional information about the directors. The mailing address for each director is 4500 Main Street, Kansas City, Missouri 64111.
Name
(Year of Birth)
Position(s) Held with FundsLength of Time ServedPrincipal Occupation(s) During Past 5 YearsNumber of American Century Portfolios Overseen by DirectorOther Directorships Held During Past 5 Years
Independent Directors
Thomas W. Bunn (1953)DirectorSince 2017Retired72SquareTwo Financial; Barings (formerly Babson Capital Funds Trust) (2013 to 2016)
Chris H. Cheesman
(1962)
DirectorSince 2019
Retired. Senior Vice President & Chief Audit Executive, AllianceBernstein (1999 to 2018)72Alleghany Corporation
Barry Fink
(1955)
DirectorSince 2012 (independent since 2016)Retired72None
Rajesh K. Gupta
(1960)
DirectorSince 2019
Partner Emeritus, SeaCrest Investment Management and SeaCrest Wealth Management (2019 to Present); Chief Executive Officer and Chief Investment Officer, SeaCrest Investment Management (2006 to 2019); Chief Executive Officer and Chief Investment Officer, SeaCrest Wealth Management (2008 to 2019)72None
31


Name
(Year of Birth)
Position(s) Held with FundsLength of Time ServedPrincipal Occupation(s) During Past 5 YearsNumber of American Century Portfolios Overseen by DirectorOther Directorships Held During Past 5 Years
Independent Directors
Lynn Jenkins
(1963)
DirectorSince 2019
Consultant, LJ Strategies (2019 to present); United States Representative, U.S. House of Representatives (2009 to 2018)72MGP Ingredients, Inc. (2019 to 2021)
Jan M. Lewis
(1957)
DirectorSince 2011Retired72None
John R. Whitten
(1946)
DirectorSince 2008Retired72Onto Innovation Inc. (2019 to 2020); Rudolph Technologies, Inc. (2006 to 2019)
Stephen E. Yates
(1948)
Director and Chairman of the BoardSince 2012 (Chairman since 2018)Retired107None
Interested Director
Jonathan S. Thomas
(1963)
DirectorSince 2007President and Chief Executive Officer, ACC (2007 to present). Also serves as Chief Executive Officer, ACS; Director, ACC and other ACC subsidiaries145None
The Statement of Additional Information has additional information about the fund's directors and is available without charge, upon request, by calling 1-800-345-2021.
32


Officers

The following table presents certain information about the executive officers of the funds. Each officer serves as an officer for 16 (in the case of Robert J. Leach, 15) investment companies in the American Century family of funds. No officer is compensated for his or her service as an officer of the funds. The listed officers are interested persons of the funds and are appointed or re-appointed on an annual basis. The mailing address for each officer listed below is 4500 Main Street, Kansas City, Missouri 64111.
Name
(Year of Birth)
Offices with the FundsPrincipal Occupation(s) During the Past Five Years
Patrick Bannigan
(1965)
President since 2019Executive Vice President and Director, ACC (2012 to present); Chief Financial Officer, Chief Accounting Officer and Treasurer, ACC (2015 to present). Also serves as President, ACS; Vice President, ACIM; Chief Financial Officer, Chief Accounting Officer and/or Director, ACIM, ACS and other ACC subsidiaries
R. Wes Campbell
(1974)
Chief Financial Officer and Treasurer since 2018Vice President, ACS, (2020 to present); Investment Operations and Investment Accounting, ACS (2000 to present)
Amy D. Shelton
(1964)
Chief Compliance Officer and Vice President since 2014Chief Compliance Officer, American Century funds, (2014 to present); Chief Compliance Officer, ACIM (2014 to present); Chief Compliance Officer, ACIS (2009 to present). Also serves as Vice President, ACIS
John Pak
(1968)
General Counsel and
Senior Vice President since 2021
General Counsel and Senior Vice President, ACC (2021 to present). Also serves as General Counsel and Senior Vice President, ACIM, ACS and ACIS. Chief Legal Officer of Investment and Wealth Management, The Bank of New York Mellon (2014 to 2021)
C. Jean Wade
(1964)
Vice President since 2012Senior Vice President, ACS (2017 to present); Vice President, ACS (2000 to 2017)
Robert J. Leach
(1966)
Vice President since 2006 Vice President, ACS (2000 to present)
David H. Reinmiller
(1963)
Vice President since 2000Attorney, ACC (1994 to present). Also serves as Vice President, ACIM and ACS
Ward D. Stauffer
(1960)
Secretary since 2005Attorney, ACC (2003 to present)





33


Approval of Management Agreement

At a meeting held on June 30, 2021, the Fund’s Board of Directors (the "Board") unanimously approved the renewal of the management agreement pursuant to which American Century Investment Management, Inc. (the “Advisor”) acts as the investment advisor for the Fund. Under Section 15(c) of the Investment Company Act, contracts for investment advisory services are required to be reviewed, evaluated, and approved by a majority of a fund’s directors (the “Directors”), including a majority of the independent Directors, each year.

Prior to its consideration of the renewal of the management agreement, the Directors requested and reviewed extensive data and information compiled by the Advisor and certain independent providers of evaluation data concerning the Fund and the services provided to the Fund by the Advisor. This review was in addition to the oversight and evaluation undertaken by the Board and its committees on a continual basis and the information received was supplemental to the extensive information that the Board and its committees receive and consider throughout the year.

In connection with its consideration of the renewal of the management agreement, the Board’s review and evaluation of the services provided by the Advisor and its affiliates included, but was not limited to, the following:

the nature, extent, and quality of investment management, shareholder services, and other services provided and to be provided to the Fund including without limitation portfolio management and trading services, shareholder and intermediary services, compliance and legal services, fund accounting and financial reporting, and fund share distribution;
the wide range of other programs and services provided and to be provided to the Fund and its shareholders on a routine and non-routine basis;
the Fund’s investment performance, including data comparing the Fund's performance to appropriate benchmarks and/or a peer group of other mutual funds with similar investment objectives and strategies;
the cost of owning the Fund compared to the cost of owning similar funds;
the compliance policies, procedures, and regulatory experience of the Advisor and the Fund's service providers;
the Advisor’s strategic plans, COVID-19 pandemic response, vendor management practices, and social justice initiatives;
the Advisor’s business continuity plans and cyber security practices;
financial data showing the cost of services provided to the Fund, the profitability of the Fund to the Advisor, and the overall profitability of the Advisor;
possible economies of scale associated with the Advisor’s management of the Fund and other accounts;
services provided and charges to the Advisor's other investment management clients;
acquired fund fees and expenses;
payments and practices in connection with financial intermediaries holding shares of the Fund and the services provided by intermediaries in connection therewith; and
possible collateral benefits to the Advisor from the management of the Fund.

The Board held two meetings to consider the renewal. The independent Directors also met in private session three times to review and discuss the information provided in response to their request. The independent Directors held active discussions with the Advisor regarding the renewal of the management agreement, requesting supplemental information, and reviewing information provided by the Advisor in response thereto. The independent Directors had the benefit of the advice of their independent counsel throughout the process.



34


Factors Considered

The Directors considered all of the information provided by the Advisor, the independent data providers, and independent counsel in connection with the approval. They determined that the information was sufficient for them to evaluate the management agreement for the Fund. In connection with their review, the Directors did not identify any single factor as being all-important or controlling, and each Director may have attributed different levels of importance to different factors. In deciding to renew the management agreement, the Board based its decision on a number of factors, including without limitation the following:

Nature, Extent and Quality of Services — Generally. Under the management agreement, the Advisor is responsible for providing or arranging for all services necessary for the operation of the Fund. The Board noted that the Advisor provides or arranges at its own expense a wide variety of services which include the following:

constructing and designing the Fund
portfolio research and security selection
initial capitalization/funding
securities trading
Fund administration
custody of Fund assets
daily valuation of the Fund’s portfolio
liquidity monitoring and management
risk management, including cyber security
shareholder servicing and transfer agency, including shareholder confirmations, recordkeeping, and communications
legal services (except the independent Directors’ counsel)
regulatory and portfolio compliance
financial reporting
marketing and distribution (except amounts paid by the Fund under Rule 12b-1 plans)

The Board noted that many of these services have expanded over time in terms of both quantity and complexity in response to shareholder demands, competition in the industry, changing distribution channels, and the changing regulatory environment.

Investment Management Services. The nature of the investment management services provided to the Fund is quite complex and allows Fund shareholders access to professional money management, instant diversification of their investments within an asset class, the opportunity to easily diversify among asset classes by investing in or exchanging among various American Century Investments funds, and liquidity. In evaluating investment performance, the Board expects the Advisor to manage the Fund in accordance with its investment objectives and approved strategies. Further, the Directors recognize that the Advisor has an obligation to monitor trading activities, and in particular to seek the best execution of fund trades, and to evaluate the use of and payment for research. In providing these services, the Advisor utilizes teams of investment professionals (portfolio managers, analysts, research assistants, and securities traders) who require extensive information technology, research, training, compliance, and other systems to conduct their business. The Board, directly and through its Fund Performance Review Committee, provides oversight of the investment performance process. It regularly reviews investment performance information for the Fund, together with comparative information for appropriate benchmarks and/or peer groups of similarly-managed funds, over different time horizons. The Directors also review investment performance information during the management agreement renewal process. If performance concerns are identified, the Fund receives special reviews until performance improves, during which the Board discusses with the Advisor the reasons for such results (e.g., market conditions, security selection) and any efforts being undertaken to improve performance. The Fund’s performance was above its benchmark for the one-, three-, five-, and ten-year periods reviewed by the Board. The Board found the investment management services provided by the Advisor to the Fund to be satisfactory and consistent with the management agreement.
35


Shareholder and Other Services. Under the management agreement, the Advisor provides the Fund with a comprehensive package of transfer agency, shareholder, and other services. The Board, directly and through its various committees, regularly reviews reports and evaluations of such services at its regular meetings. These reports include, but are not limited to, information regarding the operational efficiency and accuracy of the shareholder and transfer agency services provided, staffing levels, shareholder satisfaction, technology support (including cyber security), new products and services offered to Fund shareholders, securities trading activities, portfolio valuation services, auditing services, and legal and operational compliance activities. The Board found the services provided by the Advisor to the Fund under the management agreement to be competitive and of high quality.

Costs of Services and Profitability. The Advisor provides detailed information concerning its cost of providing various services to the Fund, its profitability in managing the Fund (pre- and post-distribution), its overall profitability, and its financial condition. The Directors have reviewed with the Advisor the methodology used to prepare this financial information. This information is considered in evaluating the Advisor’s financial condition, its ability to continue to provide services under the management agreement, and the reasonableness of the current management fee. The Board concluded that the Advisor’s profits were reasonable in light of the services provided to the Fund.

Ethics. The Board generally considers the Advisor’s commitment to providing quality services to shareholders and to conducting its business ethically. They noted that the Advisor’s practices generally meet or exceed industry best practices.

Economies of Scale. The Board also reviewed information provided by the Advisor regarding the possible existence of economies of scale in connection with the management of the Fund. The Board concluded that economies of scale are difficult to measure and predict with precision, especially on a fund-by-fund basis. The Board concluded that the Advisor is sharing economies of scale, to the extent they exist, through its competitive fee structure, offering competitive fees from fund inception, and through reinvestment in its business, infrastructure, investment capabilities and initiatives to provide shareholders additional content and services. The Board also noted that economies of scale are shared with the Fund and its shareholders through management fee breakpoints that serve to reduce the effective management fee as the assets of the Fund grow.

Comparison to Other Funds’ Fees. The management agreement provides that the Fund pays the Advisor a single, all-inclusive (or unified) management fee for providing all services necessary for the management and operation of the Fund, other than brokerage expenses, expenses attributable to short sales, taxes, interest, extraordinary expenses, fees and expenses of the Fund’s independent Directors (including their independent legal counsel), and expenses incurred in connection with the provision of shareholder services and distribution services under a plan adopted pursuant to Rule 12b-1 under the Investment Company Act. Under the unified fee structure, the Advisor is responsible for providing all investment advisory, custody, audit, administrative, compliance, recordkeeping, marketing and shareholder services, or arranging and supervising third parties to provide such services. By contrast, most other funds are charged a variety of fees, including an investment advisory fee, a transfer agency fee, an administrative fee, distribution charges, and other expenses. Other than their investment advisory fees and any applicable Rule 12b-1 distribution fees, all other components of the total fees charged by these other funds may be increased without shareholder approval. The Board believes the unified fee structure is a benefit to Fund shareholders because it clearly discloses to shareholders the cost of owning Fund shares, and, since the unified fee cannot be increased without a vote of Fund shareholders, it shifts to the Advisor the risk of increased costs of operating the Fund and provides a direct incentive to minimize administrative inefficiencies. Part of the Board’s analysis of fee levels involves reviewing certain evaluative data compiled by an independent provider comparing the Fund’s unified fee to the total expense ratios of its peers. The unified fee charged to shareholders of the Fund was below the median of the total expense ratios of the Fund’s peer expense universe. In addition, the Board reviewed the Fund’s position relative to the narrower set of its expense group peers. The Board concluded that the management fee paid by the Fund to the Advisor under the management agreement is reasonable in light of the services provided to the Fund.


36


Comparison to Fees and Services Provided to Other Clients of the Advisor. The Board also requested and received information from the Advisor concerning the nature of the services, fees, costs, and profitability of its advisory services to advisory clients other than the Fund. They observed that these varying types of client accounts require different services and involve different regulatory and entrepreneurial risks than the management of the Fund. The Board analyzed this information and concluded that the fees charged and services provided to the Fund were reasonable by comparison.

Payments to Intermediaries. The Directors also requested and received a description of payments made to intermediaries by the Fund and the Advisor and services provided in response thereto. These payments include various payments made by the Fund or the Advisor to different types of intermediaries and recordkeepers for distribution and service activities provided for the Fund. The Directors reviewed such information and received representations from the Advisor that all such payments by the Fund were made pursuant to the Fund's Rule 12b-1 Plan and that all such payments by the Advisor were made from the Advisor’s resources and reasonable profits. The Board found such payments to be reasonable in scope and purpose.

Collateral or “Fall-Out” Benefits Derived by the Advisor. The Board considered the possible existence of collateral benefits the Advisor may receive as a result of its relationship with the Fund. They concluded that the Advisor’s primary business is managing funds and it generally does not use fund or shareholder information to generate profits in other lines of business, and therefore does not derive any significant collateral benefits from them. To the extent there are potential collateral benefits, the Board has been advised and has taken this into consideration in its review of the management contract with the Fund. The Board noted that additional assets from other clients may offer the Advisor some benefit from increased leverage with service providers and counterparties. Additionally, the Advisor may receive proprietary research from broker-dealers that execute fund portfolio transactions, which the Board concluded is likely to benefit other clients of the Advisor, as well as Fund shareholders. The Board also determined that the Advisor is able to provide investment management services to certain clients other than the Fund, at least in part, due to its existing infrastructure built to serve the fund complex. The Board concluded that appropriate allocation methodologies had been employed to assign resources and the cost of those resources to these other clients and, where expressly provided, these other client assets may be included with the assets of the Fund to determine breakpoints in the management fee schedule.

Existing Relationship. The Board also considered whether there was any reason for not continuing the existing arrangement with the Advisor. In this regard, the Board was mindful of the potential disruptions of the Fund’s operations and various risks, uncertainties, and other effects that could occur as a result of a decision not to continue such relationship. In particular, the Board recognized that most shareholders have invested in the Fund on the strength of the Advisor’s industry standing and reputation and in the expectation that the Advisor will have a continuing role in providing advisory services to the Fund.

Conclusion of the Directors. As a result of this process, the Board, including all of the independent Directors, taking into account all of the factors discussed above and the information provided by the Advisor and others in connection with its review and throughout the year, determined that the management fee is fair and reasonable in light of the services provided and that the investment management agreement between the Fund and the Advisor should be renewed.
37


Additional Information

Retirement Account Information

As required by law, distributions you receive from certain retirement accounts are subject to federal income tax withholding, unless you elect not to have withholding apply*. Tax will be withheld on the total amount withdrawn even though you may be receiving amounts that are not subject to withholding, such as nondeductible contributions. In such case, excess amounts of withholding could occur. You may adjust your withholding election so that a greater or lesser amount will be withheld.
If you don’t want us to withhold on this amount, you must notify us to not withhold the federal income tax. You may notify us in writing or in certain situations by telephone or through other electronic means. For systematic withdrawals, your withholding election will remain in effect until revoked or changed by filing a new election. You have the right to revoke your election at any time and change your withholding percentage for future distributions.
Remember, even if you elect not to have income tax withheld, you are liable for paying income tax on the taxable portion of your withdrawal. If you elect not to have income tax withheld or you don’t have enough income tax withheld, you may be responsible for payment of estimated tax. You may incur penalties under the estimated tax rules if your withholding and estimated tax payments are not sufficient. You can reduce or defer the income tax on a distribution by directly or indirectly rolling such distribution over to another IRA or eligible plan. You should consult your tax advisor for additional information.
State tax will be withheld if, at the time of your distribution, your address is within one of the mandatory withholding states and you have federal income tax withheld (or as otherwise required by state law). State taxes will be withheld from your distribution in accordance with the respective state rules.
*Some 403(b), 457 and qualified retirement plan distributions may be subject to 20% mandatory withholding, as they are subject to special tax and withholding rules.  Your plan administrator or plan sponsor is required to provide you with a special tax notice explaining those rules at the time you request a distribution.  If applicable, federal and/or state taxes may be withheld from your distribution amount.


Proxy Voting Policies

A description of the policies that the fund's investment advisor uses in exercising the voting rights associated with the securities purchased and/or held by the fund is available without charge, upon request, by calling 1-800-345-2021. It is also available on American Century Investments’ website at americancentury.com/proxy and on the Securities and Exchange Commission’s website at sec.gov. Information regarding how the investment advisor voted proxies relating to portfolio securities during the most recent 12-month period ended June 30 is available on americancentury.com/proxy. It is also available at sec.gov.


Quarterly Portfolio Disclosure

The fund files its complete schedule of portfolio holdings with the Securities and Exchange Commission (SEC) for the first and third quarters of each fiscal year as an exhibit to its reports on Form N-PORT. These portfolio holdings are available on the fund's website at americancentury.com and, upon request, by calling 1-800-345-2021. The fund’s Form N-PORT reports are available on the SEC’s website at sec.gov.



38


Other Tax Information

The following information is provided pursuant to provisions of the Internal Revenue Code.

The fund hereby designates up to the maximum amount allowable as qualified dividend income for the fiscal year ended October 31, 2021.

For corporate taxpayers, the fund hereby designates $28,631,060, or up to the maximum amount allowable, of ordinary income distributions paid during the fiscal year ended October 31, 2021 as qualified for the corporate dividends received deduction.











39


Notes
40






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Contact Usamericancentury.com
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or 816-531-5575
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American Century Mutual Funds, Inc.
Investment Advisor:
American Century Investment Management, Inc.
Kansas City, Missouri
This report and the statements it contains are submitted for the general information of our shareholders. The report is not authorized for distribution to prospective investors unless preceded or accompanied by an effective prospectus.
©2021 American Century Proprietary Holdings, Inc. All rights reserved.
CL-ANN-90971 2112




    


image8.jpg
Annual Report
October 31, 2021
Ultra® Fund
Investor Class (TWCUX)
I Class (TWUIX)
Y Class (AULYX)
A Class (TWUAX)
C Class (TWCCX)
R Class (AULRX)
R5 Class (AULGX)
R6 Class (AULDX)
G Class (AULNX)


















Table of Contents
 
President’s Letter
Performance
Portfolio Commentary
Fund Characteristics
Shareholder Fee Example
Schedule of Investments
Statement of Assets and Liabilities
Statement of Operations
Statement of Changes in Net Assets
Notes to Financial Statements
Financial Highlights
Report of Independent Registered Public Accounting Firm
Management
Approval of Management Agreement
Additional Information

















Any opinions expressed in this report reflect those of the author as of the date of the report, and do not necessarily represent the opinions of American Century Investments® or any other person in the American Century Investments organization. Any such opinions are subject to change at any time based upon market or other conditions and American Century Investments disclaims any responsibility to update such opinions. These opinions may not be relied upon as investment advice and, because investment decisions made by American Century Investments funds are based on numerous factors, may not be relied upon as an indication of trading intent on behalf of any American Century Investments fund. Security examples are used for representational purposes only and are not intended as recommendations to purchase or sell securities. Performance information for comparative indices and securities is provided to American Century Investments by third party vendors. To the best of American Century Investments’ knowledge, such information is accurate at the time of printing.



President’s Letter
image30.jpg Jonathan Thomas

Dear Investor:

Thank you for reviewing this annual report for the period ended October 31, 2021. Annual reports help convey important information about fund returns, including market factors that affected performance. For additional investment insights, please visit americancentury.com.
Economic, Earnings Gains Fueled Rally Among Risk-On Assets

Stocks and other risk-on assets rallied for the 12-month period, despite lingering pandemic-related challenges. Upbeat data on U.S. manufacturing, employment and housing, along with central bank and federal government support and positive vaccine developments, helped boost corporate earnings and promote investor optimism. Outside the U.S., most economies recovered, but generally at a slower pace. Virus outbreaks and slower vaccine rollouts, particularly in emerging markets, led to lingering lockdowns in some regions.

As the period progressed, steady economic gains combined with ongoing monetary and fiscal support, rising energy prices and severe supply chain disruptions pushed global interest rates and inflation higher. In the U.S., year-over-year headline inflation climbed to 6.2% in October 2021, the largest 12-month increase in nearly 31 years.
Late in the period, the Federal Reserve (Fed) confirmed it would start tapering its bond buying in November. Yet despite inflation’s surge, the Fed left short-term interest rates unchanged. Central banks in Europe and the U.K. maintained their supportive interest rate and bond-buying programs as inflation ticked higher.

Overall, stocks delivered stellar performance for the 12-month period, highlighted by the S&P 500 Index’s gain of nearly 43%. Assets offering inflation-fighting potential, including real estate investment trusts, fared even better. Meanwhile, global bonds retreated as interest rates rose. However, emerging markets bonds largely advanced, benefiting from risk-on sentiment.
Several Factors Shaping Market Dynamics

The return to pre-pandemic life is progressing, albeit somewhat cautiously due to COVID-19’s lingering effects. As the economy and markets respond to this fluid backdrop, investors will face opportunities and ongoing challenges. Economic growth, inflation, the virus’s trajectory, supply chain normalization and fiscal and monetary policy likely will sway market dynamics.

We appreciate your confidence in us during these extraordinary times. Our firm has a long history of helping clients weather unpredictable markets, and we’re confident we will continue to meet today’s challenges.

Sincerely,
image19.jpg
Jonathan Thomas
President and Chief Executive Officer
American Century Investments
2


Performance
Total Returns as of October 31, 2021
   Average Annual Returns 
 Ticker
Symbol
1 year5 years10 yearsSince
Inception
Inception
Date
Investor ClassTWCUX44.70%27.39%19.87%11/2/81
Russell 1000 Growth Index43.21%25.47%19.41%
S&P 500 Index42.91%18.91%16.20%
I ClassTWUIX45.00%27.65%20.11%11/14/96
Y ClassAULYX45.21%27.72%4/10/17
A ClassTWUAX10/2/96
No sales charge44.35%27.08%19.57%
With sales charge36.06%25.58%18.86%
C ClassTWCCX43.28%26.12%18.68%10/29/01
R ClassAULRX44.00%26.75%19.27%8/29/03
R5 ClassAULGX45.00%27.53%4/10/17
R6 ClassAULDX45.22%27.84%20.82%7/26/13
G ClassAULNX46.08%38.37%8/1/19
Average annual returns since inception are presented when ten years of performance history is not available.
Fund returns would have been lower if a portion of the fees had not been waived. Extraordinary performance is attributable in part to unusually favorable market conditions and may not be repeated or consistently achieved in the future.

C Class shares will automatically convert to A Class shares after being held for approximately eight years. C Class average annual returns do not reflect this conversion.

Sales charges include initial sales charges and contingent deferred sales charges (CDSCs), as applicable. A Class shares have a 5.75% maximum initial sales charge and may be subject to a maximum CDSC of 1.00%. C Class shares redeemed within 12 months of purchase are subject to a maximum CDSC of 1.00%. The SEC requires that mutual funds provide performance information net of maximum sales charges in all cases where charges could be applied.












Data presented reflect past performance. Past performance is no guarantee of future results. Current performance may be higher or lower than the performance shown. Total returns for periods less than one year are not annualized. Investment return and principal value will fluctuate, and redemption value may be more or less than original cost. Data assumes reinvestment of dividends and capital gains, and none of the charts reflect the deduction of taxes that a shareholder would pay on fund distributions or the redemption of fund shares. To obtain performance data current to the most recent month end, please call 1-800-345-2021 or visit americancentury.com. For additional information about the fund, please consult the prospectus.
3


Growth of $10,000 Over 10 Years
$10,000 investment made October 31, 2011
Performance for other share classes will vary due to differences in fee structure.
chart-87f91034d7f944f8beda.jpg
Value on October 31, 2021
Investor Class — $61,320
Russell 1000 Growth Index — $59,008
S&P 500 Index — $44,939
Ending value of Investor Class would have been lower if a portion of the fees had not been waived.

Total Annual Fund Operating Expenses
Investor ClassI ClassY ClassA ClassC ClassR ClassR5 ClassR6 ClassG Class
0.97%0.77%0.62%1.22%1.97%1.47%0.77%0.62%0.62%
The total annual fund operating expenses shown is as stated in the fund’s prospectus current as of the date of this report. The prospectus may vary from the expense ratio shown elsewhere in this report because it is based on a different time period, includes acquired fund fees and expenses, and, if applicable, does not include fee waivers or expense reimbursements.
















Data presented reflect past performance. Past performance is no guarantee of future results. Current performance may be higher or lower than the performance shown. Total returns for periods less than one year are not annualized. Investment return and principal value will fluctuate, and redemption value may be more or less than original cost. Data assumes reinvestment of dividends and capital gains, and none of the charts reflect the deduction of taxes that a shareholder would pay on fund distributions or the redemption of fund shares. To obtain performance data current to the most recent month end, please call 1-800-345-2021 or visit americancentury.com. For additional information about the fund, please consult the prospectus.
4


Portfolio Commentary

Portfolio Managers: Keith Lee, Michael Li and Jeff Bourke

Performance Summary

Ultra returned 44.70%* for the 12 months ended October 31, 2021, outpacing the 43.21% return of the fund’s benchmark, the Russell 1000 Growth Index.

U.S. stocks posted strong returns during the reporting period, supported by federal government stimulus and low interest rates. The rollout of COVID-19 vaccines allowed the economy to reopen, and despite concerns about the delta variant, inflationary pressures and supply chain constraints, several market indices ended the 12-month period at record highs. Within the Russell 1000 Growth Index, all sectors posted double-digit gains, led by energy, which surged on demand and limited supply as the economy began to reopen. Materials was the weakest sector.

Stock selection in the consumer discretionary sector contributed most to outperformance relative to the benchmark. Stock decisions in the information technology sector detracted.

Consumer Discretionary Stocks Were Top Contributors

The automobiles industry led outperformance in the consumer discretionary sector. The leading contribution to relative performance came from electric car company Tesla, which benefited from solid fundamental reports and strong demand for its vehicles. Tesla continued to meet its production goals despite the supply chain constraints. The stock was added to the S&P 500 Index, which gave it a further boost. We view Tesla as an innovative, early stage technology company whose superior products offer advantages over competitors that should help ensure attractive growth well into the future.

Other top contributors included Alphabet. Google’s parent company reported revenue and earnings well above expectations on a strong rebound in advertising spending. Revenue from its YouTube business was especially strong. MSCI, a leading provider of global financial market indices and software, outperformed after posting better-than-expected revenue and earnings. The company enjoyed high recurring revenues and operating margins, and we think it is positioned for long-term growth thanks to its analytics business and role as a key provider of environmental, sustainability and governance data. Square, an early stage mobile payments company, reported better-than-expected earnings. The company benefited from optimism about continued growth trends in its Cash App business, while its merchant-based business showed signs of stabilizing after being negatively impacted by customer shutdowns stemming from COVID-19 restrictions.

We think EOG Resources, a leading U.S. oil and gas exploration and production firm, has created a durable competitive advantage through the use of technology to more efficiently develop production assets. EOG reported strong revenue and earnings growth as rising demand for oil pushed prices higher and led to a rally in the energy sector. Intuitive Surgical was another top contributor. The maker of robotic surgery systems posted revenue and earnings that beat expectations. The company reported strong growth in installations of its da Vinci system amid renewed growth in elective procedures as the pandemic eased.

Information Technology Holdings Detracted

Stock selection in the software industry hampered relative performance in the information technology sector. Underweighting Microsoft relative to the benchmark detracted. The software




*All fund returns referenced in this commentary are for Investor Class shares. Fund returns would have been lower if a portion of the fees had not been waived. Performance for other share classes will vary due to differences in fee structure; when Investor Class performance exceeds that of the fund’s benchmark, other share classes may not. See page 3 for returns for all share classes.
5


giant reported better-than-expected revenue and earnings, aided by the strong performance of its Azure cloud segment. An overweight position in salesforce.com, a leader in enterprise digital transformation, detracted from performance compared with the benchmark. The company has grown organically and through acquisitions, having produced solid results. The stock performed well in absolute terms but rose less than the benchmark.

Elsewhere in information technology, our lack of exposure to NVIDIA detracted from performance compared with the benchmark. We don’t dispute that NVIDIA has a very strong position in certain chips and applications. But from our perspective, we see greater opportunity in the users of the company’s technology that have exceptionally large addressable markets, such as Alphabet, Tesla, Meta Platforms (formerly Facebook) and Amazon, among others.

In IT services, Mastercard and Visa detracted. The credit card companies’ stocks lagged on concerns that the delta variant of COVID-19 might lead to renewed lockdowns that would slow economic growth, impacting consumer spending and travel.

Not owning Moderna detracted from relative performance. The biotechnology company’s stock surged on excitement around its successful COVID-19 vaccine, booster shots and the potential for annual boosters beyond 2021. While we are impressed by the speed of development and effectiveness of Moderna’s messenger RNA drug development technology, the market seemed to be ascribing much long-term value to COVID-19 vaccine revenue, which is highly uncertain in relation to the pandemic.

Outlook

We remain confident in our belief that high-quality companies with a capability for sustained long-term growth can outperform over time. Our portfolio positioning reflects where we are finding attractive, well-run companies as a result of the application of that philosophy and process. As of October 31, 2021, communication services and health care were the portfolio’s largest overweight allocations relative to the benchmark. Industrials and information technology were the largest underweight sectors.
6


Fund Characteristics
OCTOBER 31, 2021
Types of Investments in Portfolio% of net assets
Common Stocks99.8%
Temporary Cash Investments0.1%
Other Assets and Liabilities0.1%
Top Five Industries% of net assets
IT Services14.8%
Interactive Media and Services12.4%
Technology Hardware, Storage and Peripherals11.9%
Software11.0%
Internet and Direct Marketing Retail6.6%

7


Shareholder Fee Example 

Fund shareholders may incur two types of costs: (1) transaction costs, including sales charges (loads) on purchase payments and redemption/exchange fees; and (2) ongoing costs, including management fees; distribution and service (12b-1) fees; and other fund expenses. This example is intended to help you understand your ongoing costs (in dollars) of investing in your fund and to compare these costs with the ongoing cost of investing in other mutual funds.

The example is based on an investment of $1,000 made at the beginning of the period and held for the entire period from May 1, 2021 to October 31, 2021.

Actual Expenses

The table provides information about actual account values and actual expenses for each class. You may use the information, together with the amount you invested, to estimate the expenses that you paid over the period. First, identify the share class you own. Then simply divide your account value by $1,000 (for example, an $8,600 account value divided by $1,000 = 8.6), then multiply the result by the number under the heading “Expenses Paid During Period” to estimate the expenses you paid on your account during this period.

If you hold Investor Class shares of any American Century Investments fund, or I Class shares of the American Century Diversified Bond Fund, in an American Century Investments account (i.e., not through a financial intermediary or employer-sponsored retirement plan account), American Century Investments may charge you a $25.00 annual account maintenance fee if the value of those shares is less than $10,000. We will redeem shares automatically in one of your accounts to pay the $25.00 fee. In determining your total eligible investment amount, we will include your investments in all personal accounts (including American Century Investments brokerage accounts) registered under your Social Security number. Personal accounts include individual accounts, joint accounts, UGMA/UTMA accounts, personal trusts, Coverdell Education Savings Accounts and IRAs (including traditional, Roth, Rollover, SEP-, SARSEP- and SIMPLE-IRAs), and certain other retirement accounts. If you have only business, business retirement, employer-sponsored or American Century Investments brokerage accounts, you are currently not subject to this fee. If you are subject to the account maintenance fee, your account value could be reduced by the fee amount.

Hypothetical Example for Comparison Purposes

The table also provides information about hypothetical account values and hypothetical expenses based on the actual expense ratio of each class of your fund and an assumed rate of return of 5% per year before expenses, which is not the actual return of a fund’s share class. The hypothetical account values and expenses may not be used to estimate the actual ending account balance or expenses you paid for the period. You may use this information to compare the ongoing costs of investing in your fund and other funds. To do so, compare this 5% hypothetical example with the 5% hypothetical examples that appear in the shareholder reports of the other funds.

Please note that the expenses shown in the table are meant to highlight your ongoing costs only and do not reflect any transactional costs, such as sales charges (loads) or redemption/exchange fees. Therefore, the table is useful in comparing ongoing costs only, and will not help you determine the relative total costs of owning different funds. In addition, if these transactional costs were included, your costs would have been higher.
8


Beginning
Account Value
5/1/21
Ending
Account Value
10/31/21
Expenses Paid
During Period(1)
5/1/21 - 10/31/21
Annualized
Expense Ratio(1)
Actual
Investor Class$1,000$1,139.80$5.070.94%
I Class$1,000$1,140.90$3.990.74%
Y Class$1,000$1,141.70$3.180.59%
A Class$1,000$1,138.40$6.411.19%
C Class$1,000$1,134.00$10.431.94%
R Class$1,000$1,136.90$7.761.44%
R5 Class$1,000$1,140.80$3.990.74%
R6 Class$1,000$1,141.80$3.190.59%
G Class$1,000$1,145.10$0.00
0.00%(2)
Hypothetical
Investor Class$1,000$1,020.47$4.790.94%
I Class$1,000$1,021.48$3.770.74%
Y Class$1,000$1,022.23$3.010.59%
A Class$1,000$1,019.21$6.061.19%
C Class$1,000$1,015.43$9.861.94%
R Class$1,000$1,017.95$7.321.44%
R5 Class$1,000$1,021.48$3.770.74%
R6 Class$1,000$1,022.23$3.010.59%
G Class$1,000$1,025.21$0.00
0.00%(2)
(1)Expenses are equal to the class's annualized expense ratio listed in the table above, multiplied by the average account value over the period, multiplied by 184, the number of days in the most recent fiscal half-year, divided by 365, to reflect the one-half year period. Annualized expense ratio reflects actual expenses, including any applicable fee waivers or expense reimbursements and excluding any acquired fund fees and expenses.
(2)Other expenses, which include directors' fees and expenses, did not exceed 0.005%.
9


Schedule of Investments

OCTOBER 31, 2021
SharesValue
COMMON STOCKS — 99.8%


Automobiles — 5.5%
Tesla, Inc.(1)
1,087,000 $1,210,918,000 
Banks — 1.1%
JPMorgan Chase & Co.1,032,435 175,400,382 
U.S. Bancorp998,000 60,249,260 
235,649,642 
Beverages — 0.9%
Constellation Brands, Inc., Class A936,673 203,080,073 
Biotechnology — 2.3%
Biogen, Inc.(1)
488,000 130,139,840 
Regeneron Pharmaceuticals, Inc.(1)
599,000 383,324,060 
513,463,900 
Capital Markets — 1.6%
MSCI, Inc.537,000 357,040,560 
Chemicals — 0.2%
Ecolab, Inc.239,000 53,110,580 
Commercial Services and Supplies — 0.5%
Copart, Inc.(1)
682,000 105,907,780 
Electrical Equipment — 1.1%
Acuity Brands, Inc.710,000 145,855,300 
Rockwell Automation, Inc.275,000 87,835,000 
233,690,300 
Electronic Equipment, Instruments and Components — 0.6%
Cognex Corp.657,000 57,546,630 
Keyence Corp.127,900 77,202,323 
134,748,953 
Entertainment — 2.9%
Netflix, Inc.(1)
560,000 386,573,600 
Roku, Inc.(1)
310,000 94,519,000 
Walt Disney Co. (The)(1)
959,000 162,138,130 
643,230,730 
Food and Staples Retailing — 1.8%
Costco Wholesale Corp.802,820 394,618,143 
Health Care Equipment and Supplies — 6.1%
ABIOMED, Inc.(1)
90,000 29,883,600 
DexCom, Inc.(1)
217,000 135,236,570 
Edwards Lifesciences Corp.(1)
2,108,000 252,580,560 
IDEXX Laboratories, Inc.(1)
313,000 208,501,820 
Insulet Corp.(1)
183,000 56,733,660 
Intuitive Surgical, Inc.(1)
1,826,430 659,578,666 
1,342,514,876 
Health Care Providers and Services — 2.9%
Guardant Health, Inc.(1)
287,000 33,518,730 
UnitedHealth Group, Inc.1,336,000 615,187,920 
648,706,650 
Hotels, Restaurants and Leisure — 2.7%
Chipotle Mexican Grill, Inc.(1)
205,000 364,701,150 
10


SharesValue
Starbucks Corp.1,190,000 $126,223,300 
Wingstop, Inc.676,000 116,589,720 
607,514,170 
Household Products — 0.4%
Colgate-Palmolive Co.1,252,000 95,389,880 
Interactive Media and Services — 12.4%
Alphabet, Inc., Class A(1)
288,955 855,572,639 
Alphabet, Inc., Class C(1)
343,000 1,017,135,630 
Meta Platforms, Inc., Class A(1)
2,676,000 865,873,320 
2,738,581,589 
Internet and Direct Marketing Retail — 6.6%
Amazon.com, Inc.(1)
436,294 1,471,370,974 
IT Services — 14.8%
Adyen NV(1)
122,000 368,111,716 
Mastercard, Inc., Class A2,308,875 774,673,740 
Okta, Inc.(1)
446,000 110,242,280 
PayPal Holdings, Inc.(1)
2,528,716 588,154,054 
Shopify, Inc., Class A(1)
220,453 323,345,029 
Square, Inc., Class A(1)
1,415,000 360,117,500 
Visa, Inc., Class A3,519,000 745,218,630 
3,269,862,949 
Machinery — 1.5%
Donaldson Co., Inc.704,557 42,280,466 
Nordson Corp.322,200 81,906,462 
Westinghouse Air Brake Technologies Corp.1,365,607 123,901,523 
Yaskawa Electric Corp.1,951,800 84,536,475 
332,624,926 
Oil, Gas and Consumable Fuels — 0.6%
EOG Resources, Inc.1,513,000 139,891,980 
Personal Products — 1.4%
Estee Lauder Cos., Inc. (The), Class A961,000 311,681,130 
Road and Rail — 0.8%
J.B. Hunt Transport Services, Inc.879,000 173,330,010 
Semiconductors and Semiconductor Equipment — 4.8%
Analog Devices, Inc.1,258,000 218,250,420 
Applied Materials, Inc.2,816,000 384,806,400 
Xilinx, Inc.2,595,000 467,100,000 
1,070,156,820 
Software — 11.0%
DocuSign, Inc.(1)
1,465,000 407,694,850 
Microsoft Corp.4,520,765 1,499,176,089 
Paycom Software, Inc.(1)
312,000 170,929,200 
salesforce.com, Inc.(1)
716,000 214,578,040 
Zscaler, Inc.(1)
491,000 156,560,260 
2,448,938,439 
Technology Hardware, Storage and Peripherals — 11.9%
Apple, Inc.17,597,356 2,636,083,929 
Textiles, Apparel and Luxury Goods — 3.4%
lululemon athletica, Inc.(1)
803,000 374,206,030 
NIKE, Inc., Class B2,302,000 385,101,580 
759,307,610 
TOTAL COMMON STOCKS
(Cost $4,981,639,012)
22,131,414,593 
11


SharesValue
TEMPORARY CASH INVESTMENTS — 0.1%


Repurchase Agreement, BMO Capital Markets Corp., (collateralized by various U.S. Treasury obligations, 2.00%, 11/15/26, valued at $7,271,973), in a joint trading account at 0.01%, dated 10/29/21, due 11/1/21 (Delivery value $7,120,732)$7,120,726 
Repurchase Agreement, Fixed Income Clearing Corp., (collateralized by various U.S. Treasury obligations, 4.75%, 2/15/41, valued at $24,210,776), at 0.01%, dated 10/29/21, due 11/1/21 (Delivery value $23,736,020)23,736,000 
State Street Institutional U.S. Government Money Market Fund, Premier Class949,206 949,206 
TOTAL TEMPORARY CASH INVESTMENTS
(Cost $31,805,932)
31,805,932 
TOTAL INVESTMENT SECURITIES — 99.9%
(Cost $5,013,444,944)

22,163,220,525 
OTHER ASSETS AND LIABILITIES — 0.1%

13,534,450 
TOTAL NET ASSETS — 100.0%

$22,176,754,975 

FORWARD FOREIGN CURRENCY EXCHANGE CONTRACTS
Currency PurchasedCurrency SoldCounterpartySettlement DateUnrealized Appreciation
(Depreciation)
EUR13,679,250 USD15,904,043 Credit Suisse AG12/31/21$(65,610)
EUR6,780,150 USD7,880,039 Credit Suisse AG12/31/21(29,685)
EUR6,542,250 USD7,571,156 Credit Suisse AG12/31/213,747 
USD249,188,519 EUR211,968,900 Credit Suisse AG12/31/213,761,660 
USD7,820,739 EUR6,740,500 Credit Suisse AG12/31/2116,294 
USD10,170,142 EUR8,762,650 Credit Suisse AG12/31/2124,363 
USD9,460,169 EUR8,128,250 Credit Suisse AG12/31/2148,926 
JPY477,496,950 USD4,284,098 Bank of America N.A.12/30/21(91,370)
JPY399,317,100 USD3,568,237 Bank of America N.A.12/30/21(61,978)
JPY397,460,350 USD3,501,916 Bank of America N.A.12/30/21(11,961)
USD68,375,701 JPY7,489,122,200 Bank of America N.A.12/30/212,616,435 
$6,210,821 

NOTES TO SCHEDULE OF INVESTMENTS
EUR-Euro
JPY-Japanese Yen
USD-United States Dollar
(1)Non-income producing.


See Notes to Financial Statements.
12


Statement of Assets and Liabilities
OCTOBER 31, 2021
Assets
Investment securities, at value (cost of $5,013,444,944)$22,163,220,525 
Receivable for investments sold20,471,873 
Receivable for capital shares sold4,342,710 
Unrealized appreciation on forward foreign currency exchange contracts6,471,425 
Dividends and interest receivable3,836,623 
Securities lending receivable1,501 
22,198,344,657 
Liabilities
Payable for capital shares redeemed4,653,818 
Unrealized depreciation on forward foreign currency exchange contracts260,604 
Accrued management fees16,578,277 
Distribution and service fees payable96,983 
21,589,682 
Net Assets$22,176,754,975 
Net Assets Consist of:
Capital (par value and paid-in surplus)$3,716,502,184 
Distributable earnings18,460,252,791 
$22,176,754,975 

Net AssetsShares OutstandingNet Asset Value Per Share
Investor Class, $0.01 Par Value$20,198,764,603216,325,905$93.37
I Class, $0.01 Par Value$841,255,3608,609,026$97.72
Y Class, $0.01 Par Value$3,098,74231,504$98.36
A Class, $0.01 Par Value$256,161,4142,911,422
$87.98*
C Class, $0.01 Par Value$34,751,066491,246$70.74
R Class, $0.01 Par Value$41,560,901491,154$84.62
R5 Class, $0.01 Par Value$370,6053,790$97.78
R6 Class, $0.01 Par Value$800,781,9258,150,857$98.25
G Class, $0.01 Par Value$10,359104$99.61
*Maximum offering price $93.35 (net asset value divided by 0.9425).


See Notes to Financial Statements.
13


Statement of Operations
YEAR ENDED OCTOBER 31, 2021
Investment Income (Loss)
Income:
Dividends (net of foreign taxes withheld of $91,632)$94,292,394 
Interest11,724 
Securities lending, net2,681 
94,306,799 
Expenses:
Management fees181,782,838 
Distribution and service fees:
A Class526,308 
C Class301,442 
R Class175,586 
Directors' fees and expenses497,373 
Other expenses2,010 
183,285,557 
Fees waived(1)
(235,683)
183,049,874 
Net investment income (loss)(88,743,075)
Realized and Unrealized Gain (Loss)
Net realized gain (loss) on:
Investment transactions1,435,979,502 
Forward foreign currency exchange contract transactions7,192,579 
Foreign currency translation transactions54,747 
1,443,226,828 
Change in net unrealized appreciation (depreciation) on:
Investments5,638,549,516 
Forward foreign currency exchange contracts5,990,909 
Translation of assets and liabilities in foreign currencies(20,190)
5,644,520,235 
Net realized and unrealized gain (loss)7,087,747,063 
Net Increase (Decrease) in Net Assets Resulting from Operations$6,999,003,988 
(1)Amount consists of $214,945, $8,885, $32, $2,678, $367, $438, $4, $8,280 and $54 for Investor Class, I Class, Y Class, A Class, C Class, R Class, R5 Class R6 Class and G Class, respectively.


See Notes to Financial Statements.
14


Statement of Changes in Net Assets
YEARS ENDED OCTOBER 31, 2021 AND OCTOBER 31, 2020
Increase (Decrease) in Net AssetsOctober 31, 2021October 31, 2020
Operations
Net investment income (loss)$(88,743,075)$(48,823,135)
Net realized gain (loss)1,443,226,828 523,675,440 
Change in net unrealized appreciation (depreciation)5,644,520,235 3,983,065,119 
Net increase (decrease) in net assets resulting from operations6,999,003,988 4,457,917,424 
Distributions to Shareholders
From earnings:
Investor Class(467,326,500)(497,939,761)
I Class(17,883,963)(15,792,365)
Y Class(63,933)(53,531)
A Class(5,531,503)(5,351,781)
C Class(1,020,550)(935,790)
R Class(950,777)(850,029)
R5 Class(8,037)(4,210)
R6 Class(16,143,769)(16,454,953)
G Class(216)(217)
Decrease in net assets from distributions(508,929,248)(537,382,637)
Capital Share Transactions
Net increase (decrease) in net assets from capital share transactions (Note 5)(280,882,692)(240,034,647)
Net increase (decrease) in net assets6,209,192,048 3,680,500,140 
Net Assets
Beginning of period15,967,562,927 12,287,062,787 
End of period$22,176,754,975 $15,967,562,927 


See Notes to Financial Statements.
15


Notes to Financial Statements

OCTOBER 31, 2021

1. Organization

American Century Mutual Funds, Inc. (the corporation) is registered under the Investment Company Act of 1940, as amended (the 1940 Act), as an open-end management investment company and is organized as a Maryland corporation. Ultra Fund (the fund) is one fund in a series issued by the corporation. The fund's investment objective is to seek long-term capital growth.

The fund offers the Investor Class, I Class, Y Class, A Class, C Class, R Class, R5 Class, R6 Class and G Class. The A Class may incur an initial sales charge. The A Class and C Class may be subject to a contingent deferred sales charge.

2. Significant Accounting Policies

The following is a summary of significant accounting policies consistently followed by the fund in preparation of its financial statements. The fund is an investment company and follows accounting and reporting guidance in accordance with accounting principles generally accepted in the United States of America. This may require management to make certain estimates and assumptions at the date of the financial statements. Actual results could differ from these estimates. Management evaluated the impact of events or transactions occurring through the date the financial statements were issued that would merit recognition or disclosure.

Investment Valuations — The fund determines the fair value of its investments and computes its net asset value (NAV) per share at the close of regular trading (usually 4 p.m. Eastern time) on the New York Stock Exchange (NYSE) on each day the NYSE is open. The Board of Directors has adopted valuation policies and procedures to guide the investment advisor in the fund’s investment valuation process and to provide methodologies for the oversight of the fund’s pricing function.
Equity securities that are listed or traded on a domestic securities exchange are valued at the last reported sales price or at the official closing price as provided by the exchange. Equity securities traded on foreign securities exchanges are generally valued at the closing price of such securities on the exchange where primarily traded or at the close of the NYSE, if that is earlier. If no last sales price is reported, or if local convention or regulation so provides, the mean of the latest bid and asked prices may be used. Securities traded over-the-counter are valued at the mean of the latest bid and asked prices, the last sales price, or the official closing price. Equity securities initially expressed in local currencies are translated into U.S. dollars at the mean of the appropriate currency exchange rate at the close of the NYSE as provided by an independent pricing service.
Open-end management investment companies are valued at the reported NAV per share. Repurchase agreements are valued at cost, which approximates fair value. Forward foreign currency exchange contracts are valued at the mean of the appropriate forward exchange rate at the close of the NYSE as provided by an independent pricing service.
If the fund determines that the market price for an investment is not readily available or the valuation methods mentioned above do not reflect an investment’s fair value, such investment is valued as determined in good faith by the Board of Directors or its delegate, in accordance with policies and procedures adopted by the Board of Directors. In its determination of fair value, the fund may review several factors including, but not limited to, market information regarding the specific investment or comparable investments and correlation with other investment types, futures indices or general market indicators. Circumstances that may cause the fund to use these procedures to value an investment include, but are not limited to: an investment has been declared in default or is distressed; trading in a security has been suspended during the trading day or a security is not actively trading on its principal exchange; prices received from a regular pricing source are deemed unreliable; or there is a foreign market holiday and no trading occurred.
16


The fund monitors for significant events occurring after the close of an investment’s primary exchange but before the fund’s NAV per share is determined. Significant events may include, but are not limited to: corporate announcements and transactions; governmental action and political unrest that could impact a specific investment or an investment sector; or armed conflicts, natural disasters and similar events that could affect investments in a specific country or region. The fund also monitors for significant fluctuations between domestic and foreign markets, as evidenced by the U.S. market or such other indicators that the Board of Directors, or its delegate, deems appropriate. The fund may apply a model-derived factor to the closing price of equity securities traded on foreign securities exchanges. The factor is based on observable market data as provided by an independent pricing service.
Security Transactions — Security transactions are accounted for as of the trade date. Net realized gains and losses are determined on the identified cost basis, which is also used for federal income tax purposes.
Investment Income — Dividend income less foreign taxes withheld, if any, is recorded as of the ex-dividend date. Distributions received on securities that represent a return of capital or long-term capital gain are recorded as a reduction of cost of investments and/or as a realized gain. The fund may estimate the components of distributions received that may be considered nontaxable distributions or long-term capital gain distributions for income tax purposes. Interest income is recorded on the accrual basis and includes accretion of discounts and amortization of premiums. Securities lending income is net of fees and rebates earned by the lending agent for its services.
Foreign Currency Translations — All assets and liabilities initially expressed in foreign currencies are translated into U.S. dollars at prevailing exchange rates at period end. The fund may enter into spot foreign currency exchange contracts to facilitate transactions denominated in a foreign currency. Purchases and sales of investment securities, dividend and interest income, spot foreign currency exchange contracts, and expenses are translated at the rates of exchange prevailing on the respective dates of such transactions. Net realized and unrealized foreign currency exchange gains or losses related to investment securities are a component of net realized gain (loss) on investment transactions and change in net unrealized appreciation (depreciation) on investments, respectively.
Repurchase Agreements — The fund may enter into repurchase agreements with institutions that American Century Investment Management, Inc. (ACIM) (the investment advisor) has determined are creditworthy pursuant to criteria adopted by the Board of Directors. The fund requires that the collateral, represented by securities, received in a repurchase transaction be transferred to the custodian in a manner sufficient to enable the fund to obtain those securities in the event of a default under the repurchase agreement. ACIM monitors, on a daily basis, the securities transferred to ensure the value, including accrued interest, of the securities under each repurchase agreement is equal to or greater than amounts owed to the fund under each repurchase agreement.
Joint Trading Account — Pursuant to an Exemptive Order issued by the Securities and Exchange Commission, the fund, along with certain other funds in the American Century Investments family of funds, may transfer uninvested cash balances into a joint trading account. These balances are invested in one or more repurchase agreements that are collateralized by U.S. Treasury or Agency obligations.
Segregated Assets — In accordance with the 1940 Act, the fund segregates assets on its books and records to cover certain types of investment securities and other financial instruments. ACIM monitors, on a daily basis, the securities segregated to ensure the fund designates a sufficient amount of liquid assets, marked-to-market daily. The fund may also receive assets or be required to pledge assets at the custodian bank or with a broker for collateral requirements.
Income Tax Status — It is the fund’s policy to distribute substantially all net investment income and net realized gains to shareholders and to otherwise qualify as a regulated investment company under provisions of the Internal Revenue Code. Accordingly, no provision has been made for income taxes. The fund files U.S. federal, state, local and non-U.S. tax returns as applicable. The fund's tax returns are subject to examination by the relevant taxing authority until expiration of the applicable statute of limitations, which is generally three years from the date of filing but can be longer in certain jurisdictions. At this time, management believes there are no uncertain tax positions which, based on their technical merit, would not be sustained upon examination and for which it is reasonably possible that the total amounts of unrecognized tax benefits will significantly change in the next twelve months.
17


Multiple Class — All shares of the fund represent an equal pro rata interest in the net assets of the class to which such shares belong, and have identical voting, dividend, liquidation and other rights and the same terms and conditions, except for class specific expenses and exclusive rights to vote on matters affecting only individual classes. Income, non-class specific expenses, and realized and unrealized capital gains and losses of the fund are allocated to each class of shares based on their relative net assets.
Distributions to Shareholders — Distributions from net investment income and net realized gains, if any, are generally declared and paid annually.
Indemnifications — Under the corporation’s organizational documents, its officers and directors are indemnified against certain liabilities arising out of the performance of their duties to the fund. In addition, in the normal course of business, the fund enters into contracts that provide general indemnifications. The maximum exposure under these arrangements is unknown as this would involve future claims that may be made against a fund. The risk of material loss from such claims is considered by management to be remote.
Securities Lending — Securities are lent to qualified financial institutions and brokers. State Street Bank & Trust Co. serves as securities lending agent to the fund pursuant to a Securities Lending Agreement. The lending of securities exposes the fund to risks such as: the borrowers may fail to return the loaned securities, the borrowers may not be able to provide additional collateral, the fund may experience delays in recovery of the loaned securities or delays in access to collateral, or the fund may experience losses related to the investment collateral. To minimize certain risks, loan counterparties pledge collateral in the form of cash and/or securities. The lending agent has agreed to indemnify the fund in the case of default of any securities borrowed. Cash collateral received is invested in the State Street Navigator Securities Lending Government Money Market Portfolio, a money market mutual fund registered under the 1940 Act. The loans may also be secured by U.S. government securities in an amount at least equal to the market value of the securities loaned, plus accrued interest and dividends, determined on a daily basis and adjusted accordingly. By lending securities, the fund seeks to increase its net investment income through the receipt of interest and fees. Such income is reflected separately within the Statement of Operations. The value of loaned securities and related collateral outstanding at period end, if any, are shown on a gross basis within the Schedule of Investments and Statement of Assets and Liabilities.
3. Fees and Transactions with Related Parties

Certain officers and directors of the corporation are also officers and/or directors of American Century Companies, Inc. (ACC). The corporation’s investment advisor, ACIM, the corporation's distributor, American Century Investment Services, Inc. (ACIS), and the corporation’s transfer agent, American Century Services, LLC, are wholly owned, directly or indirectly, by ACC.
Management Fees — The corporation has entered into a management agreement with ACIM, under which ACIM provides the fund with investment advisory and management services in exchange for a single, unified management fee (the fee) per class. The agreement provides that ACIM will pay all expenses of managing and operating the fund, except brokerage expenses, taxes, interest, fees and expenses of the independent directors (including legal counsel fees), extraordinary expenses, and expenses incurred in connection with the provision of shareholder services and distribution services under a plan adopted pursuant to Rule 12b-1 under the 1940 Act. The fee is computed and accrued daily based on each class's daily net assets and paid monthly in arrears. The difference in the fee among the classes is a result of their separate arrangements for non-Rule 12b-1 shareholder services. It is not the result of any difference in advisory or custodial fees or other expenses related to the management of the fund’s assets, which do not vary by class. The rate of the fee is determined by applying a fee rate calculation formula. This formula takes into account the fund’s assets as well as certain assets, if any, of other clients of the investment advisor outside the American Century Investments family of funds (such as subadvised funds and separate accounts) that use very similar investment teams and strategies (strategy assets). Effective August 1, 2021, the investment advisor agreed to waive a portion of the fund’s management fee such that the management fee does not exceed 0.938% for Investor Class, A Class, C Class and R Class, 0.738% for I Class and R5 Class, and 0.588% for Y Class and R6 Class. The investment advisor expects this waiver arrangement to continue until July 31, 2022 and cannot terminate it prior to such date without the approval of the Board of Directors. The investment advisor agreed to waive the G Class's management fee in its entirety. The investment advisor expects this waiver to remain in effect permanently and cannot terminate it without the approval of the Board of Directors.
18


The management fee schedule range and the effective annual management fee before and after waiver for each class for the period ended October 31, 2021 are as follows:
Effective Annual Management Fee
Management Fee Schedule Range
Before Waiver
After Waiver
Investor Class
0.800% to 0.990%0.95%0.95%
I Class
0.600% to 0.790%0.75%0.75%
Y Class
0.450% to 0.640%0.60%0.60%
A Class
0.800% to 0.990%0.95%0.95%
C Class
0.800% to 0.990%0.95%0.95%
R Class
0.800% to 0.990%0.95%0.95%
R5 Class
0.600% to 0.790%0.75%0.75%
R6 Class
0.450% to 0.640%0.60%0.60%
G Class
0.450% to 0.640%0.60%0.00%

Distribution and Service Fees — The Board of Directors has adopted a separate Master Distribution and Individual Shareholder Services Plan for each of the A Class, C Class and R Class (collectively the plans), pursuant to Rule 12b-1 of the 1940 Act. The plans provide that the A Class will pay ACIS an annual distribution and service fee of 0.25%. The plans provide that the C Class will pay ACIS an annual distribution and service fee of 1.00%, of which 0.25% is paid for individual shareholder services and 0.75% is paid for distribution services. The plans provide that the R Class will pay ACIS an annual distribution and service fee of 0.50%. The fees are computed and accrued daily based on each class’s daily net assets and paid monthly in arrears. The fees are used to pay financial intermediaries for distribution and individual shareholder services. Fees incurred under the plans during the period ended October 31, 2021 are detailed in the Statement of Operations.
Directors' Fees and Expenses — The Board of Directors is responsible for overseeing the investment advisor’s management and operations of the fund. The directors receive detailed information about the fund and its investment advisor regularly throughout the year, and meet at least quarterly with management of the investment advisor to review reports about fund operations. The fund’s officers do not receive compensation from the fund.
Interfund Transactions — The fund may enter into security transactions with other American Century Investments funds and other client accounts of the investment advisor, in accordance with the 1940 Act rules and procedures adopted by the Board of Directors. The rules and procedures require, among other things, that these transactions be effected at the independent current market price of the security. There were no interfund transactions during the period.
4. Investment Transactions

Purchases and sales of investment securities, excluding short-term investments, for the period ended October 31, 2021 were $1,487,255,142 and $2,394,469,317, respectively.

19


5. Capital Share Transactions

Transactions in shares of the fund were as follows:
Year ended
October 31, 2021
Year ended
October 31, 2020
SharesAmountSharesAmount
Investor Class/Shares Authorized3,000,000,000 

3,000,000,000 
Sold7,547,892 $605,584,773 10,005,335 $565,084,480 
Issued in reinvestment of distributions5,974,884 441,487,528 9,306,297 478,901,904 
Redeemed(17,884,083)(1,445,704,546)(23,598,620)(1,325,972,063)
(4,361,307)(398,632,245)(4,286,988)(281,985,679)
I Class/Shares Authorized120,000,000 

120,000,000 
Sold2,267,799 193,001,088 3,516,331 210,134,766 
Issued in reinvestment of distributions199,466 15,400,784 257,034 13,774,479 
Redeemed(2,356,115)(195,101,975)(2,262,344)(130,239,567)
111,150 13,299,897 1,511,021 93,669,678 
Y Class/Shares Authorized30,000,000 

30,000,000 
Sold7,722 620,293 7,598 435,257 
Issued in reinvestment of distributions519 40,282 534 28,722 
Redeemed(1,275)(107,897)(7,612)(457,476)
6,966 552,678 520 6,503 
A Class/Shares Authorized60,000,000 

60,000,000 
Sold776,974 59,920,322 873,790 47,417,147 
Issued in reinvestment of distributions74,944 5,231,113 103,252 5,038,693 
Redeemed(610,136)(45,317,012)(747,854)(39,456,212)
241,782 19,834,423 229,188 12,999,628 
C Class/Shares Authorized30,000,000 

30,000,000 
Sold121,827 7,492,607 194,165 8,625,235 
Issued in reinvestment of distributions15,854 895,771 20,036 802,646 
Redeemed(121,137)(7,314,579)(160,091)(7,166,955)
16,544 1,073,799 54,110 2,260,926 
R Class/Shares Authorized30,000,000 

30,000,000 
Sold209,513 15,189,667 246,296 13,528,987 
Issued in reinvestment of distributions14,033 944,041 17,503 826,153 
Redeemed(173,293)(12,606,839)(195,157)(10,614,721)
50,253 3,526,869 68,642 3,740,419 
R5 Class/Shares Authorized30,000,000 

30,000,000 
Sold576 47,459 1,897 120,588 
Issued in reinvestment of distributions38 2,899 45 2,404 
Redeemed(545)(43,991)(28)(1,589)
69 6,367 1,914 121,403 
R6 Class/Shares Authorized110,000,000 

110,000,000 
Sold3,631,693 313,904,796 2,682,757 161,316,501 
Issued in reinvestment of distributions205,433 15,925,151 304,162 16,339,604 
Redeemed(3,016,020)(250,374,643)(4,473,539)(248,503,847)
821,106 79,455,304 (1,486,620)(70,847,742)
G Class/Shares Authorized80,000,000 

80,000,000 
Issued in reinvestment of distributions216 217 
Net increase (decrease)(3,113,435)$(280,882,692)(3,908,209)$(240,034,647)

20


6. Fair Value Measurements

The fund’s investments valuation process is based on several considerations and may use multiple inputs to determine the fair value of the investments held by the fund. In conformity with accounting principles generally accepted in the United States of America, the inputs used to determine a valuation are classified into three broad levels.

Level 1 valuation inputs consist of unadjusted quoted prices in an active market for identical investments.

Level 2 valuation inputs consist of direct or indirect observable market data (including quoted prices for comparable investments, evaluations of subsequent market events, interest rates, prepayment speeds, credit risk, etc.). These inputs also consist of quoted prices for identical investments initially expressed in local currencies that are adjusted through translation into U.S. dollars.

Level 3 valuation inputs consist of unobservable data (including a fund’s own assumptions).

The level classification is based on the lowest level input that is significant to the fair valuation measurement. The valuation inputs are not necessarily an indication of the risks associated with investing in these securities or other financial instruments.
The following is a summary of the level classifications as of period end. The Schedule of Investments provides additional information on the fund’s portfolio holdings.
Level 1Level 2Level 3
Assets
Investment Securities
Common Stocks$21,601,564,079 $529,850,514 — 
Temporary Cash Investments949,206 30,856,726 — 
$21,602,513,285 $560,707,240 — 
Other Financial Instruments
Forward Foreign Currency Exchange Contracts— $6,471,425 — 
Liabilities
Other Financial Instruments
Forward Foreign Currency Exchange Contracts— $260,604 — 

7. Derivative Instruments

Foreign Currency Risk — The fund is subject to foreign currency exchange rate risk in the normal course of pursuing its investment objectives. The value of foreign investments held by a fund may be significantly affected by changes in foreign currency exchange rates. The dollar value of a foreign security generally decreases when the value of the dollar rises against the foreign currency in which the security is denominated and tends to increase when the value of the dollar declines against such foreign currency. A fund may enter into forward foreign currency exchange contracts to reduce a fund's exposure to foreign currency exchange rate fluctuations. The net U.S. dollar value of foreign currency underlying all contractual commitments held by a fund and the resulting unrealized appreciation or depreciation are determined daily. Realized gain or loss is recorded upon settlement of the contract. Net realized and unrealized gains or losses occurring during the holding period of forward foreign currency exchange contracts are a component of net realized gain (loss) on forward foreign currency exchange contract transactions and change in net unrealized appreciation (depreciation) on forward foreign currency exchange contracts, respectively. A fund bears the risk of an unfavorable change in the foreign currency exchange rate underlying the forward contract. Additionally, losses, up to the fair value, may arise if the counterparties do not perform under the contract terms. The fund's average U.S. dollar exposure to foreign currency risk derivative instruments held during the period was $245,965,800.
21


The value of foreign currency risk derivative instruments as of October 31, 2021, is disclosed on the Statement of Assets and Liabilities as an asset of $6,471,425 in unrealized appreciation on forward foreign currency exchange contracts and a liability of $260,604 in unrealized depreciation on forward foreign currency exchange contracts. For the year ended October 31, 2021, the effect of foreign currency risk derivative instruments on the Statement of Operations was $7,192,579 in net realized gain (loss) on forward foreign currency exchange contract transactions and $5,990,909 in change in net unrealized appreciation (depreciation) on forward foreign currency exchange contracts.
8. Risk Factors

The value of the fund’s shares will go up and down, sometimes rapidly or unpredictably, based on the performance of the securities owned by the fund and other factors generally affecting the securities market. Market risks, including political, regulatory, economic and social developments, can affect the value of the fund’s investments. Natural disasters, public health emergencies, terrorism and other unforeseeable events may lead to increased market volatility and may have adverse long-term effects on world economies and markets generally.
9. Federal Tax Information

On December 7, 2021, the fund declared and paid a per-share distribution from net realized gains to shareholders of record on December 6, 2021 of $5.9406 for the Investor Class, I Class, Y Class, A Class, C Class, R Class, R5 Class, R6 Class and G Class.

The tax character of distributions paid during the years ended October 31, 2021 and October 31, 2020 were as follows:
20212020
Distributions Paid From
Ordinary income— — 
Long-term capital gains$508,929,248 $537,382,637 

The book-basis character of distributions made during the year from net investment income or net realized gains may differ from their ultimate characterization for federal income tax purposes. These differences reflect the differing character of certain income items and net realized gains and losses for financial statement and tax purposes, and may result in reclassification among certain capital accounts on the financial statements.
As of period end, the federal tax cost of investments and the components of distributable earnings on a tax-basis were as follows:
Federal tax cost of investments$5,022,224,596 
Gross tax appreciation of investments$17,167,883,533 
Gross tax depreciation of investments(26,887,604)
Net tax appreciation (depreciation) of investments17,140,995,929 
Net tax appreciation (depreciation) on derivatives and translation of assets and liabilities in foreign currencies(18,832)
Net tax appreciation (depreciation)$17,140,977,097 
Undistributed ordinary income— 
Accumulated long-term gains$1,405,938,756 
Late-year ordinary loss deferral$(86,663,062)

The difference between book-basis and tax-basis unrealized appreciation (depreciation) is attributable primarily to the tax deferral of losses on wash sales.
Loss deferrals represent certain qualified losses that the fund has elected to treat as having been incurred in the following fiscal year for federal income tax purposes.
22


Financial Highlights
For a Share Outstanding Throughout the Years Ended October 31 (except as noted)
Per-Share DataRatios and Supplemental Data
Income From Investment Operations:Distributions From:Ratio to Average Net Assets of:
Net Asset
Value,
Beginning
of Period
Net
Investment
Income
(Loss)
(1)
Net
Realized
and
Unrealized
Gain (Loss)
Total From
Investment
Operations
 Net
Investment
Income
Net
Realized
Gains
Total
Distributions
Net Asset
Value,
End
of Period
Total
Return
(2)
Operating
Expenses
Operating
Expenses
(before
expense
waiver)
Net
Investment
Income
(Loss)
Net
Investment
Income
(Loss)
(before
expense
waiver)
Portfolio
Turnover
Rate
Net
Assets,
End of
Period
(in thousands)
Investor Class
2021$66.38(0.38)29.4929.11(2.12)(2.12)$93.3744.70%0.95%0.95%(0.47)%(0.47)%8%$20,198,765 
2020$50.27(0.21)18.5518.34(2.23)(2.23)$66.3837.77%0.97%0.97%(0.36)%(0.36)%6%$14,648,925 
2019$47.74(0.06)5.925.86(3.33)(3.33)$50.2713.83%0.97%0.97%(0.13)%(0.13)%13%$11,308,500 
2018$44.59(0.06)5.825.76(0.07)(2.54)(2.61)$47.7413.44%0.97%0.97%(0.12)%(0.12)%17%$10,524,969 
2017$35.830.0710.3910.46(0.10)(1.60)(1.70)$44.5930.42%0.98%0.98%0.17%0.17%16%$9,593,102 
I Class
2021$69.25(0.23)30.8230.59(2.12)(2.12)$97.7245.00%0.75%0.75%(0.27)%(0.27)%8%$841,255 
2020$52.25(0.10)19.3319.23(2.23)(2.23)$69.2538.05%0.77%0.77%(0.16)%(0.16)%6%$588,451 
2019$49.390.036.166.19(3.33)(3.33)$52.2514.05%0.77%0.77%0.07%0.07%13%$365,036 
2018$46.040.036.026.05(0.16)(2.54)(2.70)$49.3913.68%0.77%0.77%0.08%0.08%17%$402,938 
2017$36.950.1410.7310.87(0.18)(1.60)(1.78)$46.0430.66%0.78%0.78%0.37%0.37%16%$322,059 



For a Share Outstanding Throughout the Years Ended October 31 (except as noted)
Per-Share DataRatios and Supplemental Data
Income From Investment Operations:Distributions From:Ratio to Average Net Assets of:
Net Asset
Value,
Beginning
of Period
Net
Investment
Income
(Loss)
(1)
Net
Realized
and
Unrealized
Gain (Loss)
Total From
Investment
Operations
 Net
Investment
Income
Net
Realized
Gains
Total
Distributions
Net Asset
Value,
End
of Period
Total
Return
(2)
Operating
Expenses
Operating
Expenses
(before
expense
waiver)
Net
Investment
Income
(Loss)
Net
Investment
Income
(Loss)
(before
expense
waiver)
Portfolio
Turnover
Rate
Net
Assets,
End of
Period
(in thousands)
Y Class
2021$69.59(0.11)31.0030.89(2.12)(2.12)$98.3645.21%0.60%0.60%(0.12)%(0.12)%8%$3,099 
2020$52.42(0.01)19.4119.40(2.23)(2.23)$69.5938.26%0.62%0.62%(0.01)%(0.01)%6%$1,708 
2019$49.470.106.186.28(3.33)(3.33)$52.4214.22%0.62%0.62%0.22%0.22%13%$1,259 
2018$46.070.116.026.13(0.19)(2.54)(2.73)$49.4713.85%0.62%0.62%0.23%0.23%17%$944 
2017(3)
$39.400.106.576.67$46.0716.93%
0.63%(4)
0.63%(4)
0.43%(4)
0.43%(4)
16%(5)
$6 
A Class
2021$62.81(0.56)27.8527.29(2.12)(2.12)$87.9844.35%1.20%1.20%(0.72)%(0.72)%8%$256,161 
2020$47.79(0.34)17.5917.25(2.23)(2.23)$62.8137.43%1.22%1.22%(0.61)%(0.61)%6%$167,682 
2019$45.67(0.17)5.625.45(3.33)(3.33)$47.7913.54%1.22%1.22%(0.38)%(0.38)%13%$116,630 
2018$42.80(0.17)5.585.41(2.54)(2.54)$45.6713.15%1.22%1.22%(0.37)%(0.37)%17%$102,806 
2017$34.45(0.04)10.009.96(0.01)(1.60)(1.61)$42.8030.10%1.23%1.23%(0.08)%(0.08)%16%$83,130 
C Class
2021$51.23(0.91)22.5421.63(2.12)(2.12)$70.7443.28%1.95%1.95%(1.47)%(1.47)%8%$34,751 
2020$39.65(0.62)14.4313.81(2.23)(2.23)$51.2336.39%1.97%1.97%(1.36)%(1.36)%6%$24,320 
2019$38.77(0.43)4.644.21(3.33)(3.33)$39.6512.69%1.97%1.97%(1.13)%(1.13)%13%$16,676 
2018$36.96(0.45)4.804.35(2.54)(2.54)$38.7712.32%1.97%1.97%(1.12)%(1.12)%17%$10,700 
2017$30.17(0.28)8.678.39(1.60)(1.60)$36.9629.12%1.98%1.98%(0.83)%(0.83)%16%$5,359 



For a Share Outstanding Throughout the Years Ended October 31 (except as noted)
Per-Share DataRatios and Supplemental Data
Income From Investment Operations:Distributions From:Ratio to Average Net Assets of:
Net Asset
Value,
Beginning
of Period
Net
Investment
Income
(Loss)
(1)
Net
Realized
and
Unrealized
Gain (Loss)
Total From
Investment
Operations
 Net
Investment
Income
Net
Realized
Gains
Total
Distributions
Net Asset
Value,
End
of Period
Total
Return
(2)
Operating
Expenses
Operating
Expenses
(before
expense
waiver)
Net
Investment
Income
(Loss)
Net
Investment
Income
(Loss)
(before
expense
waiver)
Portfolio
Turnover
Rate
Net
Assets,
End of
Period
(in thousands)
R Class
2021$60.62(0.72)26.8426.12(2.12)(2.12)$84.6244.00%1.45%1.45%(0.97)%(0.97)%8%$41,561 
2020$46.31(0.46)17.0016.54(2.23)(2.23)$60.6237.08%1.47%1.47%(0.86)%(0.86)%6%$26,729 
2019$44.47(0.28)5.455.17(3.33)(3.33)$46.3113.26%1.47%1.47%(0.63)%(0.63)%13%$17,240 
2018$41.84(0.28)5.455.17(2.54)(2.54)$44.4712.87%1.47%1.47%(0.62)%(0.62)%17%$15,137 
2017$33.79(0.12)9.779.65(1.60)(1.60)$41.8429.75%1.48%1.48%(0.33)%(0.33)%16%$11,345 
R5 Class
2021$69.29(0.23)30.8430.61(2.12)(2.12)$97.7845.00%0.75%0.75%(0.27)%(0.27)%8%$371 
2020$52.28(0.12)19.3619.24(2.23)(2.23)$69.2938.05%0.77%0.77%(0.16)%(0.16)%6%$258 
2019$49.420.016.186.19(3.33)(3.33)$52.2814.04%0.77%0.77%0.07%0.07%13%$94 
2018$46.040.046.026.06(0.14)(2.54)(2.68)$49.4213.69%0.77%0.77%0.08%0.08%17%$7 
2017(3)
$39.410.076.566.63$46.0416.82%
0.78%(4)
0.78%(4)
0.28%(4)
0.28%(4)
16%(5)
$6 
R6 Class
2021$69.51(0.11)30.9730.86(2.12)(2.12)$98.2545.22%0.60%0.60%(0.12)%(0.12)%8%$800,782 
2020$52.36
(6)
19.3819.38(2.23)(2.23)$69.5138.26%0.62%0.62%(0.01)%(0.01)%6%$509,484 
2019$49.420.106.176.27(3.33)(3.33)$52.3614.22%0.62%0.62%0.22%0.22%13%$461,623 
2018$46.070.106.026.12(0.23)(2.54)(2.77)$49.4213.85%0.62%0.62%0.23%0.23%17%$369,109 
2017$36.970.1810.7510.93(0.23)(1.60)(1.83)$46.0730.86%0.63%0.63%0.52%0.52%16%$233,309 



For a Share Outstanding Throughout the Years Ended October 31 (except as noted)
Per-Share DataRatios and Supplemental Data
Income From Investment Operations:Distributions From:Ratio to Average Net Assets of:
Net Asset
Value,
Beginning
of Period
Net
Investment
Income
(Loss)
(1)
Net
Realized
and
Unrealized
Gain (Loss)
Total From
Investment
Operations
 Net
Investment
Income
Net
Realized
Gains
Total
Distributions
Net Asset
Value,
End
of Period
Total
Return
(2)
Operating
Expenses
Operating
Expenses
(before
expense
waiver)
Net
Investment
Income
(Loss)
Net
Investment
Income
(Loss)
(before
expense
waiver)
Portfolio
Turnover
Rate
Net
Assets,
End of
Period
(in thousands)
G Class
2021$70.040.4231.2731.69(2.12)(2.12)$99.6146.08%
0.00%(7)
0.60%0.48%(0.12)%8%$10 
2020$52.440.3719.4619.83(2.23)(2.23)$70.0439.09%0.01%0.62%0.60%(0.01)%6%$7 
2019(8)
$51.280.101.061.16$52.442.26%
0.00%(4)(7)
0.62%(4)
0.78%(4)
0.16%(4)
13%(9)
$5 
Notes to Financial Highlights
(1)Computed using average shares outstanding throughout the period.
(2)Total returns are calculated based on the net asset value of the last business day and do not reflect applicable sales charges, if any. Total returns for periods less than one year are not annualized.
(3)April 10, 2017 (commencement of sale) through October 31, 2017.
(4)Annualized.
(5)Portfolio turnover is calculated at the fund level. Percentage indicated was calculated for the year ended October 31, 2017.
(6)Per-share amount was less than $0.005.
(7)Ratio was less than 0.005%.
(8)August 1, 2019 (commencement of sale) through October 31, 2019.
(9)Portfolio turnover is calculated at the fund level. Percentage indicated was calculated for the year ended October 31, 2019.


See Notes to Financial Statements.



Report of Independent Registered Public Accounting Firm

To the Shareholders and the Board of Directors of American Century Mutual Funds, Inc.:

Opinion on the Financial Statements and Financial Highlights

We have audited the accompanying statement of assets and liabilities, including the schedule of investments, of Ultra® Fund (the “Fund”), one of the funds constituting the American Century Mutual Funds, Inc., as of October 31, 2021, the related statement of operations for the year then ended, the statements of changes in net assets for each of the two years in the period then ended, the financial highlights for each of the five years in the period then ended, and the related notes. In our opinion, the financial statements and financial highlights present fairly, in all material respects, the financial position of Ultra® Fund of the American Century Mutual Funds, Inc. as of October 31, 2021, and the results of its operations for the year then ended, the changes in its net assets for each of the two years in the period then ended, and the financial highlights for each of the five years in the period then ended, in conformity with accounting principles generally accepted in the United States of America.

Basis for Opinion

These financial statements and financial highlights are the responsibility of the Fund's management. Our responsibility is to express an opinion on the Fund’s financial statements and financial highlights based on our audits. We are a public accounting firm registered with the Public Company Accounting Oversight Board (United States) (PCAOB) and are required to be independent with respect to the Fund in accordance with the U.S. federal securities laws and the applicable rules and regulations of the Securities and Exchange Commission and the PCAOB.

We conducted our audits in accordance with the standards of the PCAOB. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements and financial highlights are free of material misstatement, whether due to error or fraud. The Fund is not required to have, nor were we engaged to perform, an audit of its internal control over financial reporting. As part of our audits we are required to obtain an understanding of internal control over financial reporting but not for the purpose of expressing an opinion on the effectiveness of the Fund’s internal control over financial reporting. Accordingly, we express no such opinion.

Our audits included performing procedures to assess the risks of material misstatement of the financial statements and financial highlights, whether due to error or fraud, and performing procedures that respond to those risks. Such procedures included examining, on a test basis, evidence regarding the amounts and disclosures in the financial statements and financial highlights. Our audits also included evaluating the accounting principles used and significant estimates made by management, as well as evaluating the overall presentation of the financial statements and financial highlights. Our procedures included confirmation of securities owned as of October 31, 2021, by correspondence with the custodian and brokers; when replies were not received from brokers, we performed other auditing procedures. We believe that our audits provide a reasonable basis for our opinion.

/s/ Deloitte & Touche LLP

Kansas City, Missouri
December 15, 2021

We have served as the auditor of one or more American Century investment companies since 1997.
27


Management

The Board of Directors

The individuals listed below serve as directors of the funds. Each director will continue to serve in this capacity until death, retirement, resignation or removal from office. The board has adopted a mandatory retirement age for directors who are not “interested persons,” as that term is defined in the Investment Company Act (independent directors). Independent directors shall retire by December 31 of the year in which they reach their 75th birthday.
Jonathan S.Thomas is an “interested person” because he currently serves as President and Chief Executive Officer of American Century Companies, Inc. (ACC), the parent company of American Century Investment Management, Inc. (ACIM or the advisor). The other directors (more than three-fourths of the total number) are independent. They are not employees, directors or officers of, and have no financial interest in, ACC or any of its wholly owned, direct or indirect, subsidiaries, including ACIM, American Century Investment Services, Inc. (ACIS) and American Century Services, LLC (ACS), and they do not have any other affiliations, positions or relationships that would cause them to be considered “interested persons” under the Investment Company Act. The directors serve in this capacity for seven (in the case of Jonathan S. Thomas, 16; and Stephen E. Yates, 8) registered investment companies in the American Century Investments family of funds.
The following table presents additional information about the directors. The mailing address for each director is 4500 Main Street, Kansas City, Missouri 64111.
Name
(Year of Birth)
Position(s) Held with FundsLength of Time ServedPrincipal Occupation(s) During Past 5 YearsNumber of American Century Portfolios Overseen by DirectorOther Directorships Held During Past 5 Years
Independent Directors
Thomas W. Bunn (1953)DirectorSince 2017Retired72SquareTwo Financial; Barings (formerly Babson Capital Funds Trust) (2013 to 2016)
Chris H. Cheesman
(1962)
DirectorSince 2019
Retired. Senior Vice President & Chief Audit Executive, AllianceBernstein (1999 to 2018)72Alleghany Corporation
Barry Fink
(1955)
DirectorSince 2012 (independent since 2016)Retired72None
Rajesh K. Gupta
(1960)
DirectorSince 2019
Partner Emeritus, SeaCrest Investment Management and SeaCrest Wealth Management (2019 to Present); Chief Executive Officer and Chief Investment Officer, SeaCrest Investment Management (2006 to 2019); Chief Executive Officer and Chief Investment Officer, SeaCrest Wealth Management (2008 to 2019)72None
28


Name
(Year of Birth)
Position(s) Held with FundsLength of Time ServedPrincipal Occupation(s) During Past 5 YearsNumber of American Century Portfolios Overseen by DirectorOther Directorships Held During Past 5 Years
Independent Directors
Lynn Jenkins
(1963)
DirectorSince 2019
Consultant, LJ Strategies (2019 to present); United States Representative, U.S. House of Representatives (2009 to 2018)72MGP Ingredients, Inc. (2019 to 2021)
Jan M. Lewis
(1957)
DirectorSince 2011Retired72None
John R. Whitten
(1946)
DirectorSince 2008Retired72Onto Innovation Inc. (2019 to 2020); Rudolph Technologies, Inc. (2006 to 2019)
Stephen E. Yates
(1948)
Director and Chairman of the BoardSince 2012 (Chairman since 2018)Retired107None
Interested Director
Jonathan S. Thomas
(1963)
DirectorSince 2007President and Chief Executive Officer, ACC (2007 to present). Also serves as Chief Executive Officer, ACS; Director, ACC and other ACC subsidiaries145None
The Statement of Additional Information has additional information about the fund's directors and is available without charge, upon request, by calling 1-800-345-2021.
29


Officers

The following table presents certain information about the executive officers of the funds. Each officer serves as an officer for 16 (in the case of Robert J. Leach, 15) investment companies in the American Century family of funds. No officer is compensated for his or her service as an officer of the funds. The listed officers are interested persons of the funds and are appointed or re-appointed on an annual basis. The mailing address for each officer listed below is 4500 Main Street, Kansas City, Missouri 64111.
Name
(Year of Birth)
Offices with the FundsPrincipal Occupation(s) During the Past Five Years
Patrick Bannigan
(1965)
President since 2019Executive Vice President and Director, ACC (2012 to present); Chief Financial Officer, Chief Accounting Officer and Treasurer, ACC (2015 to present). Also serves as President, ACS; Vice President, ACIM; Chief Financial Officer, Chief Accounting Officer and/or Director, ACIM, ACS and other ACC subsidiaries
R. Wes Campbell
(1974)
Chief Financial Officer and Treasurer since 2018Vice President, ACS, (2020 to present); Investment Operations and Investment Accounting, ACS (2000 to present)
Amy D. Shelton
(1964)
Chief Compliance Officer and Vice President since 2014Chief Compliance Officer, American Century funds, (2014 to present); Chief Compliance Officer, ACIM (2014 to present); Chief Compliance Officer, ACIS (2009 to present). Also serves as Vice President, ACIS
John Pak
(1968)
General Counsel and
Senior Vice President since 2021
General Counsel and Senior Vice President, ACC (2021 to present). Also serves as General Counsel and Senior Vice President, ACIM, ACS and ACIS. Chief Legal Officer of Investment and Wealth Management, The Bank of New York Mellon (2014 to 2021)
C. Jean Wade
(1964)
Vice President since 2012Senior Vice President, ACS (2017 to present); Vice President, ACS (2000 to 2017)
Robert J. Leach
(1966)
Vice President since 2006 Vice President, ACS (2000 to present)
David H. Reinmiller
(1963)
Vice President since 2000Attorney, ACC (1994 to present). Also serves as Vice President, ACIM and ACS
Ward D. Stauffer
(1960)
Secretary since 2005Attorney, ACC (2003 to present)





30


Approval of Management Agreement

At a meeting held on June 30, 2021, the Fund’s Board of Directors (the "Board") unanimously approved the renewal of the management agreement pursuant to which American Century Investment Management, Inc. (the “Advisor”) acts as the investment advisor for the Fund. Under Section 15(c) of the Investment Company Act, contracts for investment advisory services are required to be reviewed, evaluated, and approved by a majority of a fund’s directors (the “Directors”), including a majority of the independent Directors, each year.

Prior to its consideration of the renewal of the management agreement, the Directors requested and reviewed extensive data and information compiled by the Advisor and certain independent providers of evaluation data concerning the Fund and the services provided to the Fund by the Advisor. This review was in addition to the oversight and evaluation undertaken by the Board and its committees on a continual basis and the information received was supplemental to the extensive information that the Board and its committees receive and consider throughout the year.

In connection with its consideration of the renewal of the management agreement, the Board’s review and evaluation of the services provided by the Advisor and its affiliates included, but was not limited to, the following:

the nature, extent, and quality of investment management, shareholder services, and other services provided and to be provided to the Fund including without limitation portfolio management and trading services, shareholder and intermediary services, compliance and legal services, fund accounting and financial reporting, and fund share distribution;
the wide range of other programs and services provided and to be provided to the Fund and its shareholders on a routine and non-routine basis;
the Fund’s investment performance, including data comparing the Fund's performance to appropriate benchmarks and/or a peer group of other mutual funds with similar investment objectives and strategies;
the cost of owning the Fund compared to the cost of owning similar funds;
the compliance policies, procedures, and regulatory experience of the Advisor and the Fund's service providers;
the Advisor’s strategic plans, COVID-19 pandemic response, vendor management practices, and social justice initiatives;
the Advisor’s business continuity plans and cyber security practices;
financial data showing the cost of services provided to the Fund, the profitability of the Fund to the Advisor, and the overall profitability of the Advisor;
possible economies of scale associated with the Advisor’s management of the Fund and other accounts;
services provided and charges to the Advisor's other investment management clients;
acquired fund fees and expenses;
payments and practices in connection with financial intermediaries holding shares of the Fund and the services provided by intermediaries in connection therewith; and
possible collateral benefits to the Advisor from the management of the Fund.

The Board held two meetings to consider the renewal and formed a subcommittee to evaluate the Fund’s competitive market. The independent Directors also met in private session three times to review and discuss the information provided in response to their request. The independent Directors held active discussions with the Advisor regarding the renewal of the management agreement, requesting supplemental information, and reviewing information provided by the Advisor in response thereto. The independent Directors had the benefit of the advice of their independent counsel throughout the process.


31


Factors Considered

The Directors considered all of the information provided by the Advisor, the independent data providers, and independent counsel in connection with the approval. They determined that the information was sufficient for them to evaluate the management agreement for the Fund. In connection with their review, the Directors did not identify any single factor as being all-important or controlling, and each Director may have attributed different levels of importance to different factors. In deciding to renew the management agreement, the Board based its decision on a number of factors, including without limitation the following:

Nature, Extent and Quality of Services — Generally. Under the management agreement, the Advisor is responsible for providing or arranging for all services necessary for the operation of the Fund. The Board noted that the Advisor provides or arranges at its own expense a wide variety of services which include the following:

constructing and designing the Fund
portfolio research and security selection
initial capitalization/funding
securities trading
Fund administration
custody of Fund assets
daily valuation of the Fund’s portfolio
liquidity monitoring and management
risk management, including cyber security
shareholder servicing and transfer agency, including shareholder confirmations, recordkeeping, and communications
legal services (except the independent Directors’ counsel)
regulatory and portfolio compliance
financial reporting
marketing and distribution (except amounts paid by the Fund under Rule 12b-1 plans)

The Board noted that many of these services have expanded over time in terms of both quantity and complexity in response to shareholder demands, competition in the industry, changing distribution channels, and the changing regulatory environment.

Investment Management Services. The nature of the investment management services provided to the Fund is quite complex and allows Fund shareholders access to professional money management, instant diversification of their investments within an asset class, the opportunity to easily diversify among asset classes by investing in or exchanging among various American Century Investments funds, and liquidity. In evaluating investment performance, the Board expects the Advisor to manage the Fund in accordance with its investment objectives and approved strategies. Further, the Directors recognize that the Advisor has an obligation to monitor trading activities, and in particular to seek the best execution of fund trades, and to evaluate the use of and payment for research. In providing these services, the Advisor utilizes teams of investment professionals (portfolio managers, analysts, research assistants, and securities traders) who require extensive information technology, research, training, compliance, and other systems to conduct their business. The Board, directly and through its Fund Performance Review Committee, provides oversight of the investment performance process. It regularly reviews investment performance information for the Fund, together with comparative information for appropriate benchmarks and/or peer groups of similarly-managed funds, over different time horizons. The Directors also review investment performance information during the management agreement renewal process. If performance concerns are identified, the Fund receives special reviews until performance improves, during which the Board discusses with the Advisor the reasons for such results (e.g., market conditions, security selection) and any efforts being undertaken to improve performance. The Fund’s performance was above its benchmark for the one-, three-, five-, and ten-year periods reviewed by the Board. The Board found the investment management services provided by the Advisor to the Fund to be satisfactory and consistent with the management agreement.
32


Shareholder and Other Services. Under the management agreement, the Advisor provides the Fund with a comprehensive package of transfer agency, shareholder, and other services. The Board, directly and through its various committees, regularly reviews reports and evaluations of such services at its regular meetings. These reports include, but are not limited to, information regarding the operational efficiency and accuracy of the shareholder and transfer agency services provided, staffing levels, shareholder satisfaction, technology support (including cyber security), new products and services offered to Fund shareholders, securities trading activities, portfolio valuation services, auditing services, and legal and operational compliance activities. The Board found the services provided by the Advisor to the Fund under the management agreement to be competitive and of high quality.

Costs of Services and Profitability. The Advisor provides detailed information concerning its cost of providing various services to the Fund, its profitability in managing the Fund (pre- and post-distribution), its overall profitability, and its financial condition. The Directors have reviewed with the Advisor the methodology used to prepare this financial information. This information is considered in evaluating the Advisor’s financial condition, its ability to continue to provide services under the management agreement, and the reasonableness of the current management fee. The Board concluded that the Advisor’s profits were reasonable in light of the services provided to the Fund.

Ethics. The Board generally considers the Advisor’s commitment to providing quality services to shareholders and to conducting its business ethically. They noted that the Advisor’s practices generally meet or exceed industry best practices.

Economies of Scale. The Board also reviewed information provided by the Advisor regarding the possible existence of economies of scale in connection with the management of the Fund. The Board concluded that economies of scale are difficult to measure and predict with precision, especially on a fund-by-fund basis. The Board concluded that the Advisor is sharing economies of scale, to the extent they exist, through its competitive fee structure, offering competitive fees from fund inception, and through reinvestment in its business, infrastructure, investment capabilities and initiatives to provide shareholders additional content and services.

Comparison to Other Funds’ Fees. The management agreement provides that the Fund pays the Advisor a single, all-inclusive (or unified) management fee for providing all services necessary for the management and operation of the Fund, other than brokerage expenses, expenses attributable to short sales, taxes, interest, extraordinary expenses, fees and expenses of the Fund’s independent Directors (including their independent legal counsel), and expenses incurred in connection with the provision of shareholder services and distribution services under a plan adopted pursuant to Rule 12b-1 under the Investment Company Act. Under the unified fee structure, the Advisor is responsible for providing all investment advisory, custody, audit, administrative, compliance, recordkeeping, marketing and shareholder services, or arranging and supervising third parties to provide such services. By contrast, most other funds are charged a variety of fees, including an investment advisory fee, a transfer agency fee, an administrative fee, distribution charges, and other expenses. Other than their investment advisory fees and any applicable Rule 12b-1 distribution fees, all other components of the total fees charged by these other funds may be increased without shareholder approval. The Board believes the unified fee structure is a benefit to Fund shareholders because it clearly discloses to shareholders the cost of owning Fund shares, and, since the unified fee cannot be increased without a vote of Fund shareholders, it shifts to the Advisor the risk of increased costs of operating the Fund and provides a direct incentive to minimize administrative inefficiencies. Part of the Board’s analysis of fee levels involves reviewing certain evaluative data compiled by an independent provider comparing the Fund’s unified fee to the total expense ratios of its peers. The unified fee charged to shareholders of the Fund was above the median of the total expense ratios of the Fund’s peer expense universe. In addition, the Board reviewed the Fund’s position relative to the narrower set of its expense group peers. The Board and the Advisor agreed to a temporary reduction of the Fund's fee schedule that should have the effect of lowering the Fund's annual unified management fee by approximately 0.032% (e.g., the Investor Class unified fee will be reduced from 0.97% to 0.938%), for at least one year, beginning August 1, 2021. The Board concluded that the management fee paid by the Fund to the Advisor under the management agreement is reasonable in light of the services provided to the Fund.

33


Comparison to Fees and Services Provided to Other Clients of the Advisor. The Board also requested and received information from the Advisor concerning the nature of the services, fees, costs, and profitability of its advisory services to advisory clients other than the Fund. They observed that these varying types of client accounts require different services and involve different regulatory and entrepreneurial risks than the management of the Fund. The Board analyzed this information and concluded that the fees charged and services provided to the Fund were reasonable by comparison.

Payments to Intermediaries. The Directors also requested and received a description of payments made to intermediaries by the Fund and the Advisor and services provided in response thereto. These payments include various payments made by the Fund or the Advisor to different types of intermediaries and recordkeepers for distribution and service activities provided for the Fund. The Directors reviewed such information and received representations from the Advisor that all such payments by the Fund were made pursuant to the Fund's Rule 12b-1 Plan and that all such payments by the Advisor were made from the Advisor’s resources and reasonable profits. The Board found such payments to be reasonable in scope and purpose.

Collateral or “Fall-Out” Benefits Derived by the Advisor. The Board considered the possible existence of collateral benefits the Advisor may receive as a result of its relationship with the Fund. They concluded that the Advisor’s primary business is managing funds and it generally does not use fund or shareholder information to generate profits in other lines of business, and therefore does not derive any significant collateral benefits from them. To the extent there are potential collateral benefits, the Board has been advised and has taken this into consideration in its review of the management contract with the Fund. The Board noted that additional assets from other clients may offer the Advisor some benefit from increased leverage with service providers and counterparties. Additionally, the Advisor may receive proprietary research from broker-dealers that execute fund portfolio transactions, which the Board concluded is likely to benefit other clients of the Advisor, as well as Fund shareholders. The Board also determined that the Advisor is able to provide investment management services to certain clients other than the Fund, at least in part, due to its existing infrastructure built to serve the fund complex. The Board concluded that appropriate allocation methodologies had been employed to assign resources and the cost of those resources to these other clients.

Existing Relationship. The Board also considered whether there was any reason for not continuing the existing arrangement with the Advisor. In this regard, the Board was mindful of the potential disruptions of the Fund’s operations and various risks, uncertainties, and other effects that could occur as a result of a decision not to continue such relationship. In particular, the Board recognized that most shareholders have invested in the Fund on the strength of the Advisor’s industry standing and reputation and in the expectation that the Advisor will have a continuing role in providing advisory services to the Fund.

Conclusion of the Directors. As a result of this process, the Board, including all of the independent Directors, taking into account all of the factors discussed above and the information provided by the Advisor and others in connection with its review and throughout the year, determined that the management fee is fair and reasonable in light of the services provided and that the investment management agreement between the Fund and the Advisor should be renewed.
34


Additional Information

Retirement Account Information

As required by law, distributions you receive from certain retirement accounts are subject to federal income tax withholding, unless you elect not to have withholding apply*. Tax will be withheld on the total amount withdrawn even though you may be receiving amounts that are not subject to withholding, such as nondeductible contributions. In such case, excess amounts of withholding could occur. You may adjust your withholding election so that a greater or lesser amount will be withheld.
If you don’t want us to withhold on this amount, you must notify us to not withhold the federal income tax. You may notify us in writing or in certain situations by telephone or through other electronic means. For systematic withdrawals, your withholding election will remain in effect until revoked or changed by filing a new election. You have the right to revoke your election at any time and change your withholding percentage for future distributions.
Remember, even if you elect not to have income tax withheld, you are liable for paying income tax on the taxable portion of your withdrawal. If you elect not to have income tax withheld or you don’t have enough income tax withheld, you may be responsible for payment of estimated tax. You may incur penalties under the estimated tax rules if your withholding and estimated tax payments are not sufficient. You can reduce or defer the income tax on a distribution by directly or indirectly rolling such distribution over to another IRA or eligible plan. You should consult your tax advisor for additional information.
State tax will be withheld if, at the time of your distribution, your address is within one of the mandatory withholding states and you have federal income tax withheld (or as otherwise required by state law). State taxes will be withheld from your distribution in accordance with the respective state rules.
*Some 403(b), 457 and qualified retirement plan distributions may be subject to 20% mandatory withholding, as they are subject to special tax and withholding rules.  Your plan administrator or plan sponsor is required to provide you with a special tax notice explaining those rules at the time you request a distribution.  If applicable, federal and/or state taxes may be withheld from your distribution amount.


Proxy Voting Policies

A description of the policies that the fund's investment advisor uses in exercising the voting rights associated with the securities purchased and/or held by the fund is available without charge, upon request, by calling 1-800-345-2021. It is also available on American Century Investments’ website at americancentury.com/proxy and on the Securities and Exchange Commission’s website at sec.gov. Information regarding how the investment advisor voted proxies relating to portfolio securities during the most recent 12-month period ended June 30 is available on americancentury.com/proxy. It is also available at sec.gov.


Quarterly Portfolio Disclosure

The fund files its complete schedule of portfolio holdings with the Securities and Exchange Commission (SEC) for the first and third quarters of each fiscal year as an exhibit to its reports on Form N-PORT. These portfolio holdings are available on the fund's website at americancentury.com and, upon request, by calling 1-800-345-2021. The fund’s Form N-PORT reports are available on the SEC’s website at sec.gov.




35


Other Tax Information

The following information is provided pursuant to provisions of the Internal Revenue Code.

The fund hereby designates $508,929,248, or up to the maximum amount allowable, as long-term capital gain distributions (20% rate gain distributions) for the fiscal year ended October 31, 2021.
36






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American Century Mutual Funds, Inc.
Investment Advisor:
American Century Investment Management, Inc.
Kansas City, Missouri
This report and the statements it contains are submitted for the general information of our shareholders. The report is not authorized for distribution to prospective investors unless preceded or accompanied by an effective prospectus.
©2021 American Century Proprietary Holdings, Inc. All rights reserved.
CL-ANN-90975 2112



(b) None.


ITEM 2. CODE OF ETHICS.

(a) The registrant has adopted a Code of Ethics for Senior Financial Officers that applies to the registrant’s principal executive officer, principal financial officer, principal accounting officer, and persons performing similar functions.

(b) No response required.

(c) None.

(d) None.

(e) Not applicable.

(f) The registrant’s Code of Ethics for Senior Financial Officers was filed as Exhibit 12 (a)(1) to American Century Asset Allocation Portfolios, Inc.’s Annual Certified Shareholder Report on Form N-CSR, File No. 811-21591, on September 29, 2005, and is incorporated herein by reference.


ITEM 3. AUDIT COMMITTEE FINANCIAL EXPERT.

(a)(1) The registrant’s board has determined that the registrant has at least one audit committee financial expert serving on its audit committee.

(a)(2) John R. Whitten, Chris H. Cheesman, Lynn M. Jenkins and Barry Fink are the registrant’s designated audit committee financial experts. They are “independent” as defined in Item 3 of Form N-CSR.

(a)(3) Not applicable.

(b) No response required.

(c) No response required.

(d) No response required.


ITEM 4. PRINCIPAL ACCOUNTANT FEES AND SERVICES.

(a) Audit Fees.

The aggregate fees billed for each of the last two fiscal years for professional services rendered by the principal accountant for the audit of the registrant’s annual financial statements or services that are normally provided by the accountant in connection with statutory and regulatory filings or engagements for those fiscal years were as follows:

FY 2020: $199,255
FY 2021: $162,200

(b) Audit-Related Fees.

The aggregate fees billed in each of the last two fiscal years for assurance and related services by the principal accountant that are reasonably related to the performance of the audit of the registrant’s financial statements and are not reported under paragraph (a) of this Item were as follows:




For services rendered to the registrant:

FY 2020: $0
FY 2021: $0

Fees required to be approved pursuant to paragraph (c)(7)(ii) of Rule 2-01 of Regulation S-X (relating to certain engagements for non-audit services with the registrant’s investment adviser and its affiliates):

FY 2020: $0
FY 2021: $0

(c) Tax Fees.

The aggregate fees billed in each of the last two fiscal years for professional services rendered by the principal accountant for tax compliance, tax advice, and tax planning were as follows:

For services rendered to the registrant:

FY 2020: $0
FY 2021: $0

Fees required to be approved pursuant to paragraph (c)(7)(ii) of Rule 2-01 of Regulation S-X (relating to certain engagements for non-audit services with the registrant’s investment adviser and its affiliates):

FY 2020: $0
FY 2021: $0

(d) All Other Fees.

The aggregate fees billed in each of the last two fiscal years for products and services provided by the principal accountant, other than the services reported in paragraphs (a) through (c) of this Item were as follows:

For services rendered to the registrant:

FY 2020: $0
FY 2021: $0

Fees required to be approved pursuant to paragraph (c)(7)(ii) of Rule 2-01 of Regulation S-X (relating to certain engagements for non-audit services with the registrant’s investment adviser and its affiliates):

FY 2020: $0
FY 2021: $0

(e)(1) In accordance with paragraph (c)(7)(i)(A) of Rule 2-01 of Regulation S-X, before the accountant is engaged by the registrant to render audit or non-audit services, the engagement is approved by the registrant’s audit committee. Pursuant to paragraph (c)(7)(ii) of Rule 2-01 of Regulation S-X, the registrant’s audit committee also pre-approves its accountant’s engagements for non-audit services with the registrant’s investment adviser, its parent company, and any entity controlled by, or under common control with the investment adviser that provides ongoing services to the registrant, if the engagement relates directly to the operations and financial reporting of the registrant.

(e)(2) All services described in each of paragraphs (b) through (d) of this Item were pre-approved before the engagement by the registrant’s audit committee pursuant to paragraph (c)(7)(i)(A) of Rule 2-01 of Regulation S-X. Consequently, none of such services were required to be approved by the audit committee pursuant to paragraph



(c)(7)(i)(C).

(f) The percentage of hours expended on the principal accountant’s engagement to audit the registrant’s financial statements for the most recent fiscal year that were attributed to work performed by persons other than the principal accountant’s full-time, permanent employees was less than 50%.

(g) The aggregate non-audit fees billed by the registrant’s accountant for services rendered to the registrant, and rendered to the registrant’s investment adviser (not including any sub-adviser whose role is primarily portfolio management and is subcontracted with or overseen by another investment adviser), and any entity controlling, controlled by, or under common control with the adviser that provides ongoing services to the registrant for each of the last two fiscal years of the registrant were as follows:

FY 2020: $0
FY 2021: $2,832,126

(h) The registrant’s investment adviser and accountant have notified the registrant’s audit committee of all non-audit services that were rendered by the registrant’s accountant to the registrant’s investment adviser, its parent company, and any entity controlled by, or under common control with the investment adviser that provides services to the registrant, which services were not required to be pre-approved pursuant to paragraph (c)(7)(ii) of Rule 2-01 of Regulation S-X. The notification provided to the registrant’s audit committee included sufficient details regarding such services to allow the registrant’s audit committee to consider the continuing independence of its principal accountant.


ITEM 5. AUDIT COMMITTEE OF LISTED REGISTRANTS.

Not applicable.


ITEM 6. INVESTMENTS.

(a) The schedule of investments is included as part of the report to stockholders filed under Item 1 of this Form.

(b) Not applicable.


ITEM 7. DISCLOSURE OF PROXY VOTING POLICIES AND PROCEDURES FOR CLOSED-END MANAGEMENT INVESTMENT COMPANIES.

Not applicable.


ITEM 8. PORTFOLIO MANAGERS OF CLOSED-END MANAGEMENT INVESTMENT COMPANIES.

Not applicable.


ITEM 9. PURCHASES OF EQUITY SECURITIES BY CLOSED-END MANAGEMENT INVESTMENT COMPANY AND AFFILIATED PURCHASERS.

Not applicable.


ITEM 10. SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS.




During the reporting period, there were no material changes to the procedures by which shareholders may recommend nominees to the registrant’s board.


ITEM 11. CONTROLS AND PROCEDURES.

(a) The registrant's principal executive officer and principal financial officer have concluded that the registrant's disclosure controls and procedures (as defined in Rule 30a-3(c) under the Investment Company Act of 1940) are effective based on their evaluation of these controls and procedures as of a date within 90 days of the filing date of this report.

(b) There were no changes in the registrant's internal control over financial reporting (as defined in Rule 30a-3(d) under the Investment Company Act of 1940) that occurred during the period covered by this report that have materially affected, or are reasonably likely to materially affect, the registrant's internal control over financial reporting.


ITEM 12. DISCLOSURE OF SECURITIES LENDING ACTIVITIES FOR CLOSED-END MANAGEMENT INVESTMENT COMPANIES.

Not applicable.






ITEM 13. EXHIBITS.

(a)(1) Registrant’s Code of Ethics for Senior Financial Officers, which is the subject of the disclosure required by Item 2 of Form N-CSR, was filed as Exhibit 12(a)(1) to American Century Asset Allocation Portfolios, Inc.’s Certified Shareholder Report on Form N-CSR, File No. 811-21591, on September 29, 2005.

(a)(2) Separate certifications by the registrant’s principal executive officer and principal financial officer, pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 and Rule 30a-2(a) under the Investment Company Act of 1940, are filed and attached hereto as EX-99.CERT.

(a)(3) Not applicable.

(a)(4) Not applicable.

(b) A certification by the registrant’s chief executive officer and chief financial officer, pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, is furnished and attached hereto as EX-99.906CERT.





SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934 and the Investment Company Act of 1940, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

Registrant:American Century Mutual Funds, Inc.
By:/s/ Patrick Bannigan
Name:Patrick Bannigan
Title:President
Date:December 29, 2021


Pursuant to the requirements of the Securities Exchange Act of 1934 and the Investment Company Act of 1940, this report has been signed below by the following persons on behalf of the registrant and in the capacities and on the dates indicated.

By:/s/ Patrick Bannigan
Name:Patrick Bannigan
Title:President
(principal executive officer)
Date:December 29, 2021

By:/s/ R. Wes Campbell
Name:R. Wes Campbell
Title:Treasurer and
Chief Financial Officer
(principal financial officer)
Date:December 29, 2021